scholarly journals Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis

2010 ◽  
Vol 391 (4) ◽  
Author(s):  
Michael Blaber ◽  
Hyesook Yoon ◽  
Maria A. Juliano ◽  
Isobel A. Scarisbrick ◽  
Sachiko I. Blaber
Keyword(s):  
Initial Conditions ◽  
Tissue Injury ◽  
Large Body ◽  
Therapeutic Agents ◽  
Specific Interactions ◽  
Complete Understanding ◽  
Functional Interaction ◽  
Regulatory Interactions ◽  
Normal Health ◽  
Over Time

Abstract A large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. The emerging network of specific interactions between these two protease families appears to be complex, and much work remains to elucidate it. Complete understanding how this functional network resolves over time, given specific initial conditions, and how it might be controllably manipulated, will probably contribute to the emergence of novel diagnostics and therapeutic agents for major diseases.

DYNAMICS OF THERMAL LOSSES BY CONVECTION AND RADIATION OF THE SPHERICAL HEAT ACCUMULATOR OF SOLAR PLANTS

2020 ◽  
Vol 4 (41) ◽  
pp. 57-62
Author(s):  
SHAVKAT KLYCHEV ◽  
◽  
BAKHRAMOV SAGDULLA ◽  
VALERIY KHARCHENKO ◽  
VLADIMIR PANCHENKO ◽  
...  
Keyword(s):  
Boundary Conditions ◽  
Heat Loss ◽  
Initial Conditions ◽  
Water System ◽  
Heat Losses ◽  
Research Purpose ◽  
Heat Accumulator ◽  
Water Heaters ◽  
Intrinsic Radiation ◽  
Over Time

There are needed energy (heat) accumulators to increase the efficiency of solar installations, including solar collectors (water heaters, air heaters, dryers). One of the tasks of designing heat accumulators is to ensure its minimal heat loss. The article considers the problem of determining the distribution of temperatures and heat losses by convection and radiation of the heat insulation-accumulating body (water) system for a ball heat accumulator under symmetric boundary conditions. The problem is solved numerically according to the program developed on the basis of the proposed «gap method». (Research purpose) The research purpose is in determining heat losses by convection and radiation of a two-layer ball heat accumulator with symmetric boundary conditions. (Materials and methods) Authors used the Fourier heat equation for spherical bodies. The article presents the determined boundary and initial conditions for bodies and their surfaces. (Results and discussion) The thickness of the insulation and the volume of the heat accumulator affect the dynamics and values of heat loss. The effect of increasing the thickness of the thermal insulation decreases with increasing its thickness, starting with a certain volume of the heat accumulator or with R > 0.3 meters, the heat losses change almost linearly over time. The dynamics of heat loss decreases with increasing shelf life, but the losses remain large. (Conclusions) Authors have developed a method and program for numerical calculation of heat loss and temperature over time in a spherical two-layer heat accumulator with symmetric boundary conditions, taking into account both falling and intrinsic radiation. The proposed method allows to unify the boundary conditions between contacting bodies.

scholarly journals The effectiveness of TiO2 additions to mortar to maintain initial conditions in terms of its reflectance to solar radiation

2017 ◽  
Vol 17 (3) ◽  
pp. 39-56 ◽  
Author(s):  
Sérgio Roberto Andrade Dantas ◽  
Fulvio Vittorino ◽  
Kai Loh
Keyword(s):  
Solar Radiation ◽  
Ultraviolet Radiation ◽  
Initial Conditions ◽  
Type A ◽  
Just Noticeable Difference ◽  
Type B ◽  
Climate Conditions ◽  
Type D ◽  
Type C ◽  
Over Time

Abstract Contact of facades with degradation agents and direct incidence of ultraviolet radiation on external coatings make them more opaque over time, affecting their colour and reflectance characteristics. This study evaluated the effect of adding different TiO2 contents to mortars applied in concrete substrates in order to verify the reflectance maintenance on surfaces after exposure over time. Mortar with different concentrations of TiO2 (1%, 5%, 10%) were produced in relation to the total dry premix, added as a powder and compared to unpainted mortar without TiO2 (type "A") and painted mortar without TiO2 (type "B"), both used as a reference for colour and reflectance. Exposed over 16 months to climate conditions in São Paulo, regarding the maintenance of reflectance and solar radiation, the results showed that type "B" (0%TiO2) painted mortar presented the best performance. Type "C" (1%TiO2) and type "D" (5%TiO2) unpainted mortar remained more stable. Type "A" (0%TiO2) and type "E" (10%TiO2) unpainted mortar showed greater differences according to the Just Noticeable Difference (JND) range caused by dirt pick up.

scholarly journals Finding the key to successful L2 learning in groups and individuals

2017 ◽  
Vol 7 (1) ◽  
pp. 127-148 ◽  
Author(s):  
Wander Lowie ◽  
Marijn Van Dijk ◽  
Huiping Chan ◽  
Marjolijn Verspoor
Keyword(s):  
Second Language ◽  
Individual Differences ◽  
Language Development ◽  
Language Learning ◽  
Second Language Learning ◽  
Large Body ◽  
Individual Characteristics ◽  
Learner Characteristics ◽  
Complex Dynamic ◽  
Over Time

A large body studies into individual differences in second language learning has shown that success in second language learning is strongly affected by a set of relevant learner characteristics ranging from the age of onset to motivation, aptitude, and personality. Most studies have concentrated on a limited number of learner characteristics and have argued for the relative importance of some of these factors. Clearly, some learners are more successful than others, and it is tempting to try to find the factor or combination of factors that can crack the code to success. However, isolating one or several global individual characteristics can only give a partial explanation of success in second language learning. The limitation of this approach is that it only reflects on rather general personality characteristics of learners at one point in time, while both language development and the factors affecting it are instances of complex dynamic processes that develop over time. Factors that have been labelled as “individual differences” as well as the development of proficiency are characterized by nonlinear relationships in the time domain, due to which the rate of success cannot be simply deduced from a combination of factors. Moreover, in complex dynamic systems theory (CDST) literature it has been argued that a generalization about the interaction of variables across individuals is not warranted when we acknowledge that language development is essentially an individual process (Molenaar, 2015). In this paper, the viability of these generalizations is investigated by exploring the L2 development over time for two identical twins in Taiwan who can be expected to be highly similar in all respects, from their environment to their level of English proficiency, to their exposure to English, and to their individual differences. In spite of the striking similarities between these learners, the development of their L2 English over time was very different. Developmental patterns for spoken and written language even showed opposite tendencies. These observations underline the individual nature of the process of second language development.

scholarly journals Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu

2020 ◽  
Author(s):  
Brittany A. Goods ◽  
Michael H. Askenase ◽  
Erica Markarian ◽  
Hannah E. Beatty ◽  
Riley Drake ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Single Cell ◽  
Brain Tissue ◽  
Cellular Response ◽  
Tissue Injury ◽  
Brain Inflammation ◽  
Therapeutic Interventions ◽  
Acute Injury ◽  
The Brain ◽  
Over Time

ABSTRACTIntracerebral hemorrhage (ICH) is a devastating form of stroke with a high mortality rate and few treatment options. Discovery of therapeutic interventions has been slow given the challenges associated with studying acute injury, particularly over time, in the human brain. Inflammation induced by exposure of brain tissue to blood appears to be a major part of brain tissue injury. Here we longitudinally profiled blood and cerebral hematoma effluent from a patient enrolled in the Minimally Invasive Surgery with Thrombolysis in Intracerebral Haemorrhage Evacuation (MISTIEIII) trial, offering a rare window into the local and systemic immune responses to acute brain injury. Using single-cell RNA-sequencing, we characterized the local cellular response during ICH in the brain of a living patient at single-cell resolution for the first time. Our analysis revealed rapid shifts in the activation states of myeloid and T cells in the brain over time, suggesting that leukocyte responses are dynamically reshaped by the hematoma microenvironment. Interestingly, the patient had an asymptomatic re-bleed (second local exposure to blood) that our transcriptional data indicated occurred more than 30 hours prior to detection by CT scan. This case highlights the rapid immune dynamics in the brain after ICH and suggests that sensitive methods like scRNA-seq can inform our understanding of complex intracerebral events.

scholarly journals The refined biomimetic NeuroDigm GEL™ Model of neuropathic pain in the mature rat

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2516 ◽  
Author(s):  
Mary R. Hannaman ◽  
Douglas A. Fitts ◽  
Rose M. Doss ◽  
David E. Weinstein ◽  
Joseph L. Bryant
Keyword(s):  
Neuropathic Pain ◽  
Recombinant Human Erythropoietin ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Pain Behavior ◽  
Neural Regeneration ◽  
Male Rat ◽  
Human Erythropoietin ◽  
Neural Remodeling ◽  
Over Time

Background:Many humans suffering with chronic pain have no clinical evidence of a lesion or disease. They are managed with a morass of drugs and invasive procedures. Opiates usually become less effective over time. In many, their persistent pain occurs after the healing of a soft tissue injury. Current animal models of neuropathic pain typically create direct neural damage with open surgeries using ligatures, neurectomies, chemicals or other forms of deliberate trauma. However, we have observed clinically that after an injury in humans, the naturally occurring process of tissue repair can cause chronic neural pain.Methods:We demonstrate how the refined biomimetic NeuroDigm GEL™ Model, in the mature male rat, gradually induces neuropathic pain behavior with a nonsurgical percutaneous implant of tissue-derived hydrogel in the musculo-fascial tunnel of the distal tibial nerve. Morphine, Celecoxib, Gabapentin and Duloxetine were each screened in the model three times each over 5 months after pain behaviors developed. A pilot study followed in which recombinant human erythropoietin was applied to the GEL neural procedure site.Results:The GEL Model gradually developed neuropathic pain behavior lasting months. Morphine, initially effective, had less analgesia over time. Celecoxib produced no analgesia, while gabapentin and duloxetine at low doses had profound analgesia at all times tested. The injected erythropoietin markedly decreased bilateral pain behavior that had been present for over 4 months. Histology revealed a site of focal neural remodeling, with neural regeneration, as in human biopsies.Conclusion:The refined NeuroDigm GEL™ Model induces localized neural remodeling resulting in robust neuropathic pain behavior. The analgesics responses in this model reflect known responses of humans with neuropathic pain. The targeted recombinant human erythropoietin appears to heal the ectopic focal neural site, as demonstrated by the extinguishing of neuropathic pain behavior present for over 4 months.

scholarly journals Small-data shock formation in solutions to 3D quasilinear wave equations: An overview

2016 ◽  
Vol 13 (01) ◽  
pp. 1-105 ◽  
Author(s):  
Gustav Holzegel ◽  
Sergiu Klainerman ◽  
Jared Speck ◽  
Willie Wai-Yeung Wong
Keyword(s):  
Wave Equations ◽  
Initial Conditions ◽  
Large Body ◽  
Small Data ◽  
Shock Formation ◽  
Time Behavior ◽  
Long Time ◽  
Remarkable Result ◽  
Quasilinear Wave Equations ◽  
Three Space

In his 2007 monograph, Christodoulou proved a remarkable result giving a detailed description of shock formation, for small [Formula: see text]-initial conditions (with [Formula: see text] sufficiently large), in solutions to the relativistic Euler equations in three space dimensions. His work provided a significant advancement over a large body of prior work concerning the long-time behavior of solutions to higher-dimensional quasilinear wave equations, initiated by John in the mid 1970’s and continued by Klainerman, Sideris, Hörmander, Lindblad, Alinhac, and others. Our goal in this paper is to give an overview of his result, outline its main new ideas, and place it in the context of the above mentioned earlier work. We also introduce the recent work of Speck, which extends Christodoulou’s result to show that for two important classes of quasilinear wave equations in three space dimensions, small-data shock formation occurs precisely when the quadratic nonlinear terms fail to satisfy the classic null condition.

Analysis and Decision

2019 ◽  
pp. 161-186
Author(s):  
Jeffrey A. Friedman
Keyword(s):  
Foreign Policy ◽  
Probabilistic Reasoning ◽  
Large Body ◽  
Decision Makers ◽  
Risky Decision ◽  
High Stakes ◽  
Policy Choices ◽  
Foreign Policies ◽  
The U.S ◽  
Over Time

This chapter explains how decision makers can incorporate assessments of uncertainty into high-stakes foreign policy choices. It begins by describing a simple analytic tool called break-even analysis, with which leaders can use explicit probability assessments as a point of leverage for determining whether or not a risky decision is worthwhile. The chapter then explains how transparent probabilistic reasoning is especially important for assessing strategic progress. In some cases, it can actually be impossible to make rigorous judgments about the extent to which foreign policies are making acceptable progress without assessing subjective probabilities in detail. This argument departs from a large body of existing scholarship on learning in international politics that assumes leaders can use a straightforward logic of trial and error to determine how they should update their strategic perceptions over time. The chapter provides examples of these dynamics drawn from the U.S. occupation of Iraq.

Culture inside: Scale, intimacy, and chronotopic stance in situated narratives

2020 ◽  
pp. 1-23
Author(s):  
Sonya E. Pritzker ◽  
Sabina Perrino
Keyword(s):  
Linguistic Anthropology ◽  
Northern Italy ◽  
Specific Interactions ◽  
Embodied Experience ◽  
Time And Space ◽  
Discursive Strategies ◽  
Ethnographic Studies ◽  
Zoom In ◽  
Beijing China ◽  
Over Time

ABSTRACT This article focuses on what we define as scalar intimacy in the stories people tell about their embodied experience as sociohistorical beings. Our analysis, based on ethnographic studies in Northern Italy (Perrino) and Beijing, China (Pritzker), examines the ways in which speech participants draw upon various discursive strategies to ‘zoom in’ and ‘pan out’ of both time and space, placing themselves and their activities in relation to various people, ideologies, and practices. Scalar intimacy, we argue, provides a novel framework for understanding the multiple ways in which people use language to scale their embodied experience in relation to culturally situated ideas and forms. Scalar intimacy thus extends the study of scales and fractal recursivity in linguistic anthropology and sociolinguistics. It also contributes to scholarship focusing on how culturally situated meanings are reproduced and challenged over time through specific interactions. (China, chronotope, identity, intimacy, narrative, Northern Italy, scales)*

V. Therapeutic potential of nitric oxide donors and inhibitors

1999 ◽  
Vol 276 (6) ◽  
pp. G1313-G1316 ◽  
Author(s):  
Marcelo N. Muscará ◽  
John L. Wallace
Keyword(s):  
Nitric Oxide ◽  
Therapeutic Potential ◽  
Tissue Injury ◽  
Mucosal Injury ◽  
Therapeutic Agents ◽  
Gastrointestinal Physiology ◽  
Inflammatory Drugs ◽  
Nitric Oxide Releasing ◽  
Oxide Synthase

Nitric oxide is a crucial mediator of gastrointestinal mucosal defense, but, paradoxically, it also contributes to mucosal injury in several situations. Inhibitors of nitric oxide synthesis and compounds that release nitric oxide have been useful pharmacological tools for evaluating the role of nitric oxide in gastrointestinal physiology and pathophysiology. Newer inhibitors with selectivity for one of the isoforms of nitric oxide synthase are even more powerful tools and may have utility as therapeutic agents. Also, agents that can scavenge nitric oxide or peroxynitrite are promising as drugs to prevent nitric oxide-associated tissue injury. Compounds that release nitric oxide in small amounts over a prolonged period of time may also be very useful for prevention of gastrointestinal injury associated with shock and with the use of drugs that have ulcerogenic effects. Indeed, the coupling of a nitric oxide-releasing moiety to nonsteroidal anti-inflammatory drugs has proven to be a valid means of substantially reducing the gastrointestinal toxicity of these drugs without decreasing their efficacy.

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