scholarly journals The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging

2010 ◽  
Vol 391 (10) ◽  
Author(s):  
Scott F. Leiser ◽  
Matt Kaeberlein
Keyword(s):  
Transcription Factor ◽  
Caenorhabditis Elegans ◽  
Hypoxia Inducible Factor ◽  
Direct Connection ◽  
Hypoxic Response ◽  
The Past ◽  
Current State ◽  
Negative Modulator

Abstract In the past year and a half, five studies have independently established a direct connection between the hypoxic response transcription factor, HIF-1, and aging in Caenorhabditis elegans. These studies demonstrated that HIF-1 can both promote and limit longevity via pathways that are mechanistically distinct. Here, we review the current state of knowledge regarding modulation of aging by HIF-1 and speculate on potential aspects of HIF-1 function that could be relevant for mammalian longevity and healthspan.

Anticancer Activity of Natural Flavonoids: Inhibition of HIF-1α Signaling Pathway

2020 ◽  
Vol 23 (26) ◽  
pp. 2945-2959 ◽  
Author(s):  
Xiangping Deng ◽  
Yijiao Peng ◽  
Jingduo Zhao ◽  
Xiaoyong Lei ◽  
Xing Zheng ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Secondary Metabolites ◽  
Anticancer Agents ◽  
Hypoxia Inducible Factor ◽  
Tumor Hypoxia ◽  
Pharmacological Activities ◽  
Hypoxia Inducible Factor 1 ◽  
The Past ◽  
Low Toxicity ◽  
Tumor Blood Vessels

Rapid tumor growth is dependent on the capability of tumor blood vessels and glycolysis to provide oxygen and nutrients. Tumor hypoxia is a common characteristic of many solid tumors, and it essentially happens when the growth of the tumor exceeds the concomitant angiogenesis. Hypoxia-inducible factor 1 (HIF-1) as the critical transcription factor in hypoxia regulation is activated to adapt to this hypoxia situation. Flavonoids, widely distributed in plants, comprise many polyphenolic secondary metabolites, possessing broadspectrum pharmacological activities, including their potentiality as anticancer agents. Due to their low toxicity, intense efforts have been made for investigating natural flavonoids and their derivatives that can be used as HIF-1α inhibitors for cancer therapy during the past few decades. In this review, we sum up the findings concerning the inhibition of HIF-1α by natural flavonoids in the last few years and propose the idea of designing tumor vascular and glycolytic multi-target inhibitors with HIF-1α as one of the targets.

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases

2004 ◽  
Vol 32 (6) ◽  
pp. 943-945 ◽  
Author(s):  
D.E. Lancaster ◽  
M.A. McDonough ◽  
C.J. Schofield
Keyword(s):  
Transcription Factor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Crystal Structures ◽  
Hypoxia Inducible Factor ◽  
Binding Motif ◽  
Iron Binding ◽  
Sequence Analyses ◽  
Hypoxic Response ◽  
Epidermal Growth

FIH (Factor inhibiting hypoxia-inducible factor), an asparaginyl β-hydroxylase belonging to the super-family of 2-oxoglutarate and Fe(II)-dependent dioxygenases, catalyses hydroxylation of Asn-803 of hypoxia-inducible factor, a transcription factor that regulates the mammalian hypoxic response. Only one other asparaginyl β-hydroxylase, which catalyses hydroxylation of both aspartyl and asparaginyl residues in EGF (epidermal growth factor)-like domains, has been characterized. In the light of recent crystal structures of FIH, we compare FIH with the EGFH (EGF β-hydroxylase) and putative asparagine/asparaginyl hydroxylases. Sequence analyses imply that EGFH does not contain the HXD/E iron-binding motif characteristic of most of the 2-oxoglutarate oxygenases.

scholarly journals Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival

2001 ◽  
Vol 15 (21) ◽  
pp. 2865-2876
Author(s):  
Ernestina Schipani ◽  
Heather E. Ryan ◽  
Susanna Didrickson ◽  
Tatsuya Kobayashi ◽  
Melissa Knight ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Growth Plate ◽  
Hypoxia Inducible Factor ◽  
Growth Arrest ◽  
Brdu Incorporation ◽  
Independent Manner ◽  
Hypoxic Response ◽  
Surrounding Areas

Breakdown or absence of vascular oxygen delivery is a hallmark of many common human diseases, including cancer, myocardial infarction, and stroke. The chief mediator of hypoxic response in mammalian tissues is the transcription factor hypoxia-inducible factor 1 (HIF-1), and its oxygen-sensitive component HIF-1α. A key question surrounding HIF-1α and the hypoxic response is the role of this transcription factor in cells removed from a functional vascular bed; in this regard there is evidence indicating that it can act as either a survival factor or induce growth arrest and apoptosis. To study more closely how HIF-1α functions in hypoxia in vivo, we used tissue-specific targeting to delete HIF-1α in an avascular tissue: the cartilaginous growth plate of developing bone. We show here the first evidence that the developmental growth plate in mammals is hypoxic, and that this hypoxia occurs in its interior rather than at its periphery. As a result of this developmental hypoxia, cells that lack HIF-1α in the interior of the growth plate die. This is coupled to decreased expression of the CDK inhibitor p57, and increased levels of BrdU incorporation in HIF-1α null growth plates, indicating defects in HIF-1α-regulated growth arrest occurs in these animals. Furthermore, we find that VEGF expression in the growth plate is regulated through both HIF-1α-dependent and -independent mechanisms. In particular, we provide evidence that VEGFexpression is up-regulated in a HIF-1α-independent manner in chondrocytes surrounding areas of cell death, and this in turn induces ectopic angiogenesis. Altogether, our findings have important implications for the role of hypoxic response and HIF-1α in development, and in cell survival in tissues challenged by interruption of vascular flow; they also illustrate the complexities of HIF-1α response in vivo, and they provide new insights into mechanisms of growth plate development.

Hypoxia. 5. Hypoxia and hematopoiesis

2011 ◽  
Vol 300 (6) ◽  
pp. C1215-C1222 ◽  
Author(s):  
Donghoon Yoon ◽  
Prem Ponka ◽  
Josef T Prchal
Keyword(s):  
Transcription Factor ◽  
Iron Metabolism ◽  
Oxygen Delivery ◽  
Hypoxia Inducible Factor ◽  
Tissue Oxygen ◽  
Master Regulator ◽  
Hypoxic Response ◽  
Tissue Oxygen Delivery

Our understanding of organismal responses to hypoxia has stemmed from studies of erythropoietin regulation by hypoxia that led to the discovery of the master regulator of the hypoxic response, i.e., hypoxia-inducible factor (HIF). This is a transcription factor that is now known to induce the expression of a battery of genes in response to hypoxia. HIF-1 and HIF-2 regulate many genes that are involved in erythropoiesis and iron metabolism, which are essential for tissue oxygen delivery.

Current state and main directions of preservation and strengthening of health of the working population of Russia

2020 ◽  
pp. 527-532 ◽  
Author(s):  
I. V. Bukhtiyarov
Keyword(s):  
Working Conditions ◽  
Russian Federation ◽  
Production Environment ◽  
Working Population ◽  
Industrial Enterprises ◽  
The Past ◽  
Production Factors ◽  
Current State ◽  
The Russian Federation

The article presents the results of the analysis of health, working conditions and prevalence of adverse production factors, the structure of the detected occupational pathology in the working population of the Russian Federation. The article presents Statistical data on the dynamics of the share of workplaces of industrial enterprises that do not meet hygienic standards, occupational morbidity in 2015-2018 for the main groups of adverse factors of the production environment and the labor process. The indicators of occupational morbidity over the past 6 years in the context of the main types of economic activity, individual subjects of the Russian Federation, classes of working conditions, levels of specialized occupational health care. The role of the research Institute of occupational pathology and occupational pathology centers in solving organizational, methodological and practical tasks for the detection, treatment, rehabilitation and prevention of occupational diseases is shown. The basic directions of activity in the field of preservation and strengthening of health of workers, and also safety at a workplace are defined.

Phytochemical and Pharmacological Review on Two Herbs of Baijiangcao: Patrinia scabiosaefolia Fisch. ex Trev. and Patrinia villosa (Thunb.) Juss

2020 ◽  
Vol 17 (5) ◽  
pp. 496-517
Author(s):  
Yangcheng Liu ◽  
Wei Liu ◽  
Jiaqi Wang ◽  
Yang Liu ◽  
Changlan Chen ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Volatile Components ◽  
Research Papers ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Scientific Databases ◽  
The Past ◽  
Current State ◽  
Patrinia Scabiosaefolia ◽  
Antiviral Activities

Patrinia scabiosaefolia Fisch. Trev. and Patrinia villosa (Thunb.) Juss, are two species of Patrinia recorded in the Chinese Pharmacopoeia with the same Chinese name “Baijiangcao” and similar therapeutic effect in traditional Chinese medicine. The present article is the first comprehensive review on the chemical composition and pharmacological activities of these herbs. In this review, data on chemical constituents and pharmacological profile of the two herbs are provided. This review discusses all the classes of the 223 compounds (phenylpropanoids, flavonoids, terpenes, saponins and volatile components, etc.) detected in the two herbs providing information on the current state of knowledge of the phytochemicals present in them. In the past three years, our research group has isolated and identified about more than 100 ingredients from the two herbs. Therefore, we published a systematic review of our research papers and studies on the two herbs were carried out using resources such as classic books about Chinese herbal medicine and scientific databases including Pubmed, Web of Science, SciFinder, CNKI. etc. The present review discusses the most thoroughly studied pharmacological activities (antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, antitumor and antiviral activities) of the two herbs. This comprehensive review will be informative for scientists searching for new properties of these herbs and will be important and significant for the discovery of bioactive compounds from the two herbs and in complete utilization of Patrinia scabiosaefolia Fisch. ex Trev. and Patrinia villosa (Thunb.) Juss.

Movie Envy

2019 ◽  
pp. 70-80
Author(s):  
Olivier Asselin
Keyword(s):  
Point Of View ◽  
Digital Revolution ◽  
The Past ◽  
Current State ◽  
Movie Theatre ◽  
The Relationship

“Canadian cinema.” The term may appear self-evident but is problematic. First, one may question the value of national approaches to culture, especially here, in Quebec and Canada, where the debates over the Nation seem interminable, and especially now, in an era of globalization. Next, one may question the value of media-centered approaches to culture, especially when the successive waves of the “digital revolution” have blurred the boundaries between technologies and among artistic practices. Rather than try to survey “important” fiction films for theatres in Quebec or Canada, this essay adopts another point of view to examine the presence of cinema in Montreal museums over the past few years by focusing on three singular exhibitions. It may well be symptomatic of the current state of film in Quebec and Canada—but also, paradoxically, everywhere else—and says much about the relationship between medium and nation, the expansion of cinema beyond the movie theatre, and the internationalization of culture.

scholarly journals Multi-Task Optimization and Multi-Task Evolutionary Computation in the Past Five Years: A Brief Review

Mathematics ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 864
Author(s):  
Qingzheng Xu ◽  
Na Wang ◽  
Lei Wang ◽  
Wei Li ◽  
Qian Sun
Keyword(s):  
Evolutionary Computation ◽  
Explicit Knowledge ◽  
Optimization Problems ◽  
Effective Means ◽  
Typical Application ◽  
The Past ◽  
Current State ◽  
Evolution Algorithms ◽  
Application Fields

Traditional evolution algorithms tend to start the search from scratch. However, real-world problems seldom exist in isolation and humans effectively manage and execute multiple tasks at the same time. Inspired by this concept, the paradigm of multi-task evolutionary computation (MTEC) has recently emerged as an effective means of facilitating implicit or explicit knowledge transfer across optimization tasks, thereby potentially accelerating convergence and improving the quality of solutions for multi-task optimization problems. An increasing number of works have thus been proposed since 2016. The authors collect the abundant specialized literature related to this novel optimization paradigm that was published in the past five years. The quantity of papers, the nationality of authors, and the important professional publications are analyzed by a statistical method. As a survey on state-of-the-art of research on this topic, this review article covers basic concepts, theoretical foundation, basic implementation approaches of MTEC, related extension issues of MTEC, and typical application fields in science and engineering. In particular, several approaches of chromosome encoding and decoding, intro-population reproduction, inter-population reproduction, and evaluation and selection are reviewed when developing an effective MTEC algorithm. A number of open challenges to date, along with promising directions that can be undertaken to help move it forward in the future, are also discussed according to the current state. The principal purpose is to provide a comprehensive review and examination of MTEC for researchers in this community, as well as promote more practitioners working in the related fields to be involved in this fascinating territory.

scholarly journals The EGL-13 SOX Domain Transcription Factor Affects the Uterine Cell Lineages in Caenorhabditis elegans

Genetics ◽  
2003 ◽  
Vol 165 (3) ◽  
pp. 1623-1628
Author(s):  
Hediye Nese Cinar ◽  
Keri L Richards ◽  
Kavita S Oommen ◽  
Anna P Newman
Keyword(s):  
Transcription Factor ◽  
Cell Division ◽  
Caenorhabditis Elegans ◽  
Cell Fate ◽  
Cell Lineages

Abstract We isolated egl-13 mutants in which the cells of the Caenorhabditis elegans uterus initially appeared to develop normally but then underwent an extra round of cell division. The data suggest that egl-13 is required for maintenance of the cell fate.

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