Propeptides as modulators of functional activity of proteases

2010 ◽  
Vol 1 (3-4) ◽  
pp. 305-322 ◽  
Author(s):  
Ilya V. Demidyuk ◽  
Andrey V. Shubin ◽  
Eugene V. Gasanov ◽  
Sergey V. Kostrov
Keyword(s):  
Mechanism Of Action ◽  
Functional Activity ◽  
Protein Function ◽  
Living Organism ◽  
Biological Properties ◽  
Biological Mechanism ◽  
Structural Elements ◽  
Specific Mechanism ◽  
Catalytic Domains ◽  
Cognate Protein

AbstractMost proteases are synthesized in the cell as precursor-containing propeptides. These structural elements can determine the folding of the cognate protein, function as an inhibitor/activator peptide, mediate enzyme sorting, and mediate the protease interaction with other molecules and supramolecular structures. The data presented in this review demonstrate modulatory activity of propeptides irrespective of the specific mechanism of action. Changes in propeptide structure, sometimes minor, can crucially alter protein function in the living organism. Modulatory activity coupled with high variation allows us to consider propeptides as specific evolutionary modules that can transform biological properties of proteases without significant changes in the highly conserved catalytic domains. As the considered properties of propeptides are not unique to proteases, propeptide-mediated evolution seems to be a universal biological mechanism.

scholarly journals Acute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease

Small ◽  
2020 ◽  
Vol 16 (21) ◽  
pp. 1907476 ◽  
Author(s):  
Niels Hadrup ◽  
Vadim Zhernovkov ◽  
Nicklas Raun Jacobsen ◽  
Carola Voss ◽  
Maximilian Strunz ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Acute Phase ◽  
Mechanism Of Action ◽  
Acute Phase Response ◽  
Phase Response ◽  
Biological Mechanism ◽  
Nano Particle

Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: A hypoxia specific mechanism of action

2013 ◽  
Vol 58 (4) ◽  
pp. 280-291 ◽  
Author(s):  
Aneta Radziwon-Balicka ◽  
Corey Ramer ◽  
Cesar Moncada de la Rosa ◽  
Barbara Zielnik-Drabik ◽  
Paul Jurasz
Keyword(s):  
Mechanism Of Action ◽  
Specific Mechanism

Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus

2019 ◽  
Vol 25 (37) ◽  
pp. 4929-4945 ◽  
Author(s):  
Silvia Tejada ◽  
Samuel Pinya ◽  
Miquel Martorell ◽  
Xavier Capó ◽  
Josep A. Tur ◽  
...  
Keyword(s):  
Large Family ◽  
Potential Effect ◽  
Biological Properties ◽  
High Concentration ◽  
Specific Mechanism ◽  
Bioactive Substances ◽  
Dietary Polyphenols ◽  
Beneficial Effects ◽  
Anti Inflammatory ◽  
Antioxidant Effects

Background: The benefits of the Mediterranean diet for protecting against many diseases are usually attributed to high consumption of certain foods, characterized by the presence of bioactive substances such as polyphenols. Inflammation plays an important role in the pathogenesis of numerous diseases such as arthritis, allergies or neurodegenerative disorders. Dietary polyphenols constitute a large family of bioactive substances with potential beneficial effects against a broad group of diseases. Citrus fruits and juices are a rich source of vitamin C and flavonoids, with a potential effect on the inflammatory response. Objective: The aim was to evidence the potential anti-inflammatory effects of the flavonoids hesperidin for its possible therapeutic application against diverse pathologies. Method: In the present review, available literature about the anti-inflammatory effects of hesperidin is reported and discussed. Moreover, we also discuss the chemistry, bioavailability and proposed mechanisms of action of hesperidin. Results: Hesperidin is a flavonoid present in high concentration in citrus species and has numerous biological properties, principally antioxidant and anti-inflammatory. Several studies have been performed in order to evaluate the effects of hesperidin as anti-inflammatory agent using cellular and animal models and few clinical trials. Hesperidin treatment decreased inflammatory mediators and exerted significant antioxidant effects. The molecular basis for its anti-inflammatory effects seems to be mediated by signalling pathways especially the nuclear factor κβ pathway. Conclusion: Although hesperidin evidenced anti-inflammatory effects, the specific mechanism of action is not completely known and additional studies are required for elucidation of the molecular targets.

scholarly journals Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2336 ◽  
Author(s):  
Simon Remy ◽  
Marc Litaudon
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Virus Replication ◽  
Mechanism Of Action ◽  
Chikungunya Virus ◽  
Cytopathic Effect ◽  
Structural Diversity ◽  
Biological Properties ◽  
Kinase C ◽  
Structure Activity

Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of considerable interest due to their high structural diversity; and their therapeutically relevant biological properties. Over the last decade many studies have reported the ability of macrocyclic diterpenoids to inhibit in cellulo the cytopathic effect induced by the chikungunya virus. This review; which covers the years 2011 to 2019; lists all macrocyclic diterpenoids that have been evaluated for their ability to inhibit viral replication. The structure–activity relationships and the probable involvement of protein kinase C in their mechanism of action are also detailed.

scholarly journals Anticancer Properties and Mechanism of Action of Oblongifolin C, Guttiferone K and Related Polyprenylated Acylphloroglucinols

2021 ◽  
Author(s):  
Christian Bailly ◽  
Gérard Vergoten
Keyword(s):  
Mechanism Of Action ◽  
Biological Properties ◽  
Structural Basis ◽  
Anticancer Activities ◽  
Potent Inducer ◽  
Anticancer Properties ◽  
Potential Development ◽  
Tumor Growth And Metastasis

AbstractPolyprenylated acylphloroglucinols represent an important class of natural products found in many plants. Among them, the two related products oblongifolin C (Ob-C) and guttiferone K (Gt-K) isolated from Garcinia species (notably from edible fruits), have attracted attention due to their marked anticancer properties. The two compounds only differ by the nature of the C-6 side chain, prenyl (Gt-K) or geranyl (Ob-C) on the phloroglucinol core. Their origin, method of extraction and biological properties are presented here, with a focus on the targets and pathways implicated in their anticancer activities. Both compounds markedly reduce cancer cell proliferation in vitro, as well as tumor growth and metastasis in vivo. They are both potent inducer of tumor cell apoptosis, and regulation of autophagy flux is a hallmark of their mode of action. The distinct mechanism leading to autophagosome accumulation in cells and the implicated molecular targets are discussed. The specific role of the chaperone protein HSPA8, known to interact with Ob-C, is addressed. Molecular models of Gt-K and Ob-C bound to HSPA8 provide a structural basis to their common HSPA8-binding recognition capacity. The review shed light on the mechanism of action of these compounds, to encourage their studies and potential development.

scholarly journals Effects Of F-18 On KCL And Phenylephrine - Induced Contractions Of Rat Aorta

2021 ◽  
Vol 03 (06) ◽  
pp. 100-108
Author(s):  
Abdisalim Zaripov ◽  
◽  
Adilbay Esimbetov ◽  
Pulat Usmanov ◽  
Durdona Shokirova ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Smooth Muscle Cell ◽  
Mechanism Of Action ◽  
Isometric Contraction ◽  
Functional Activity ◽  
Rat Aorta ◽  
Relaxant Effect ◽  
Voltage Dependent ◽  
Ca2 Channels

The mechanism of action of the alkaloid 1-(2´-bromine-4´,5´-dimethoxyphenyl) - 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) on the functional activity of smooth muscle cells of the rat aorta was studied. Isometric contraction activity was recorded using a Grass FT – 03 (Grass Instrument, USA) mechanotron. The relaxant effect of the F-18 alkaloid was found to be associated with blockade of Ca2 + (IP3R) channels in the SR, along with voltage- dependent and receptor-operated Ca2+channels in the aorta smooth muscle cell plasmalemma.

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