scholarly journals Evaluating different approaches to identify a three parameter gas exchange model

2016 ◽  
Vol 2 (1) ◽  
pp. 669-673 ◽  
Author(s):  
Jörn Kretschmer ◽  
Paul D. Docherty ◽  
Axel Riedlinger ◽  
Knut Möller
Keyword(s):  
Gas Exchange ◽  
Lower Order ◽  
Search Method ◽  
Direct Approach ◽  
Model Parameters ◽  
Hierarchical Approach ◽  
Gradient Based ◽  
Recorded Data ◽  
Parameter Values ◽  
Gas Exchange Model

AbstractMathematical models can be employed to simulate a patient’s individual physiology and can therefore be used to predict reactions to changes in the therapy. To be clinically useful, those models need to be identifiable from data available at the bedside. Gradient based methods to identify the values of the model parameters that represent the recorded data highly depend on the initial estimates. The proposed work implements a previously developed method to overcome those dependencies to identify a three parameter model of gas exchange. The proposed hierarchical method uses models of lower order related to the three parameter model to calculate valid initial estimates for the parameter identification. The presented approach was evaluated using 12 synthetic patients and compared to a traditional direct approach as well as a global search method. Results show that the direct approach is highly dependent on how well the initial estimates are selected, while the hierarchical approach was able to find correct parameter values in all tested patients.

Stable and Supported Semantics in Continuous Vector Spaces

2020 ◽  
Author(s):  
Yaniv Aspis ◽  
Krysia Broda ◽  
Alessandra Russo ◽  
Jorge Lobo
Keyword(s):  
Logic Program ◽  
Matrix Multiplication ◽  
Vector Spaces ◽  
Continuous Space ◽  
Continuous Vector ◽  
Novel Approach ◽  
Gradient Based ◽  
Normal Logic ◽  
Parameter Values ◽  
Normal Logic Program

We introduce a novel approach for the computation of stable and supported models of normal logic programs in continuous vector spaces by a gradient-based search method. Specifically, the application of the immediate consequence operator of a program reduct can be computed in a vector space. To do this, Herbrand interpretations of a propositional program are embedded as 0-1 vectors in $\mathbb{R}^N$ and program reducts are represented as matrices in $\mathbb{R}^{N \times N}$. Using these representations we prove that the underlying semantics of a normal logic program is captured through matrix multiplication and a differentiable operation. As supported and stable models of a normal logic program can now be seen as fixed points in a continuous space, non-monotonic deduction can be performed using an optimisation process such as Newton's method. We report the results of several experiments using synthetically generated programs that demonstrate the feasibility of the approach and highlight how different parameter values can affect the behaviour of the system.

scholarly journals Assimilation of Dynamic Combined Finite Discrete Element Methods Using the Ensemble Kalman Filter

2021 ◽  
Vol 11 (7) ◽  
pp. 2898
Author(s):  
Humberto C. Godinez ◽  
Esteban Rougier
Keyword(s):  
Kalman Filter ◽  
Ensemble Kalman Filter ◽  
Failure Modes ◽  
Split Hopkinson Pressure Bar ◽  
Peak Stress ◽  
Discrete Element ◽  
Material Behavior ◽  
Model Parameters ◽  
Hopkinson Pressure Bar ◽  
Parameter Values

Simulation of fracture initiation, propagation, and arrest is a problem of interest for many applications in the scientific community. There are a number of numerical methods used for this purpose, and among the most widely accepted is the combined finite-discrete element method (FDEM). To model fracture with FDEM, material behavior is described by specifying a combination of elastic properties, strengths (in the normal and tangential directions), and energy dissipated in failure modes I and II, which are modeled by incorporating a parameterized softening curve defining a post-peak stress-displacement relationship unique to each material. In this work, we implement a data assimilation method to estimate key model parameter values with the objective of improving the calibration processes for FDEM fracture simulations. Specifically, we implement the ensemble Kalman filter assimilation method to the Hybrid Optimization Software Suite (HOSS), a FDEM-based code which was developed for the simulation of fracture and fragmentation behavior. We present a set of assimilation experiments to match the numerical results obtained for a Split Hopkinson Pressure Bar (SHPB) model with experimental observations for granite. We achieved this by calibrating a subset of model parameters. The results show a steady convergence of the assimilated parameter values towards observed time/stress curves from the SHPB observations. In particular, both tensile and shear strengths seem to be converging faster than the other parameters considered.

scholarly journals Developments in Modelling Bone Screwing

2020 ◽  
Vol 6 (3) ◽  
pp. 111-114
Author(s):  
Jack Wilkie ◽  
Paul D. Docherty ◽  
Knut Möller
Keyword(s):  
Material Properties ◽  
Frictional Coefficient ◽  
Viscous Friction ◽  
Model Parameters ◽  
General Shape ◽  
Bone Material ◽  
Bone Material Properties ◽  
Modelling Methodology ◽  
Recorded Data ◽  
Friction Models

AbstractINTRODUCTION: A torque-rotation model of the bone-screwing process has been proposed. Identification of model parameters using recorded data could potentially be used to determine the material properties of bone. These properties can then be used to recommend tightening torques to avoid over or under-tightening of bone screws. This paper improves an existing model to formulate it in terms of material properties and remove some assumptions. METHOD: The modelling methodology considers a critical torque, which is required to overcome friction and advance the screw into the bone. Below this torque the screw may rotate with elastic deformation of the bone tissue, and above this the screw moves relative to the bone, and the speed is governed by a speed-torque model of the operator’s hand. The model is formulated in terms of elastic modulus, ultimite tensile strength, and frictional coefficient of the bone and the geometry of the screw and hole. RESULTS: The model output shows the speed decreasing and torque increasing as the screw advances into the bone, due to increasing resistance. The general shape of the torque and speed follow the input effort. Compared with the existing model, this model removes the assumption of viscous friction, models the increase in friction as the screw advances into the bone, and is directly in terms of the bone material properties. CONCLUSION: The model presented makes significant improvements on the existing model. However it is intended for use in parameter identification, which was not evaluated here. Further simulation and experimental validation is required to establish the accuracy and fitness of this model for identifying bone material properties.

scholarly journals An enhanced set of displacement parameter restraints in CRYSTALS

2018 ◽  
Vol 51 (4) ◽  
pp. 1059-1068 ◽  
Author(s):  
Pascal Parois ◽  
James Arnold ◽  
Richard Cooper
Keyword(s):  
Structural Model ◽  
Rigid Bodies ◽  
Model Parameters ◽  
Coordinate Systems ◽  
Principal Axes ◽  
Anisotropic Displacement Parameters ◽  
Set Up ◽  
Meaningful Relationships ◽  
Parameter Values ◽  
Total Model

Crystallographic restraints are widely used during refinement of small-molecule and macromolecular crystal structures. They can be especially useful for introducing additional observations and information into structure refinements against low-quality or low-resolution data (e.g. data obtained at high pressure) or to retain physically meaningful parameter values in disordered or unstable refinements. However, despite the fact that the anisotropic displacement parameters (ADPs) often constitute more than half of the total model parameters determined in a structure analysis, there are relatively few useful restraints for them, examples being Hirshfeld rigid-bond restraints, direct equivalence of parameters and SHELXL RIGU-type restraints. Conversely, geometric parameters can be subject to a multitude of restraints (e.g. absolute or relative distance, angle, planarity, chiral volume, and geometric similarity). This article presents a series of new ADP restraints implemented in CRYSTALS [Parois, Cooper & Thompson (2015), Chem. Cent. J. 9, 30] to give more control over ADPs by restraining, in a variety of ways, the directions and magnitudes of the principal axes of the ellipsoids in locally defined coordinate systems. The use of these new ADPs results in more realistic models, as well as a better user experience, through restraints that are more efficient and faster to set up. The use of these restraints is recommended to preserve physically meaningful relationships between displacement parameters in a structural model for rigid bodies, rotationally disordered groups and low-completeness data.

scholarly journals Modelling temperature variations in polar snow using DAISY

1997 ◽  
Vol 43 (143) ◽  
pp. 180-191 ◽  
Author(s):  
Ε. M. Morris ◽  
H. -P. Bader ◽  
P. Weilenmann
Keyword(s):  
Field Experiments ◽  
A Priori ◽  
Model Parameters ◽  
Data Set ◽  
International Geophysical Year ◽  
Snow Model ◽  
Using Data ◽  
Polar Snow ◽  
Parameter Values ◽  
The Antarctic

AbstractA physics-based snow model has been calibrated using data collected at Halley Bay, Antarctica, during the International Geophysical Year. Variations in snow temperature and density are well-simulated using values for the model parameters within the range reported from other polar field experiments. The effect of uncertainty in the parameter values on the accuracy of the predictions is no greater than the effect of instrumental error in the input data. Thus, this model can be used with parameters determined a priori rather than by optimization. The model has been validated using an independent data set from Halley Bay and then used to estimate 10 m temperatures on the Antarctic Peninsula plateau over the last half-century.

Torsional damping of a back-to-back gearbox rig: Experimental measurements and frequency domain modelling

2002 ◽  
Vol 216 (2) ◽  
pp. 157-168 ◽  
Author(s):  
S J Drew ◽  
B J Stone
Keyword(s):  
Frequency Domain ◽  
Natural Frequencies ◽  
Model Parameters ◽  
Modal Damping ◽  
Torsional Damping ◽  
Analysis Of Results ◽  
Torsional Frequency ◽  
Signal Processing Methods ◽  
Parameter Values ◽  
Future Work

This paper is concerned with the experimental measurement and modelling of the torsional damping levels of a back-to-back gearbox rig. The aims of the investigation were to experimentally measure and analyse modal damping levels for the first nine torsional natural frequencies; to optimize damping parameters for modelling and to assess any limitations of the models for future work. Standard signal processing methods were used to determine modal damping levels from measured torsional frequency responses, with good confidence in the results. A damping sensitivity analysis for the two frequency domain receptance (FDR) models was used to determine optimum damping parameter values. Damping levels for six of nine natural frequencies were well matched with the experimental data. Discrepancies at other frequencies were attributed mainly to torsional-transverse coupling, present in the rig but not the model. Analysis of results for the ninth natural frequency determined a very low level of damping for the gearbox. It was also concluded that the model parameters may be used with confidence in a time domain receptance model for future investigations related to the test gearbox damping.

scholarly journals Spatial and Temporal Transferability of a Distributed Energy-Balance Glacier Melt Model

2011 ◽  
Vol 24 (5) ◽  
pp. 1480-1498 ◽  
Author(s):  
Andrew H. MacDougall ◽  
Gwenn E. Flowers
Keyword(s):  
Energy Balance ◽  
Yukon Territory ◽  
Model Parameters ◽  
Distributed Energy ◽  
Meteorological Forcing ◽  
Model Parameter ◽  
Model Transferability ◽  
Space And Time ◽  
Surface Ablation ◽  
Parameter Values

Abstract Modeling melt from glaciers is crucial to assessing regional hydrology and eustatic sea level rise. The transferability of such models in space and time has been widely assumed but rarely tested. To investigate melt model transferability, a distributed energy-balance melt model (DEBM) is applied to two small glaciers of opposing aspects that are 10 km apart in the Donjek Range of the St. Elias Mountains, Yukon Territory, Canada. An analysis is conducted in four stages to assess the transferability of the DEBM in space and time: 1) locally derived model parameter values and meteorological forcing variables are used to assess model skill; 2) model parameter values are transferred between glacier sites and between years of study; 3) measured meteorological forcing variables are transferred between glaciers using locally derived parameter values; 4) both model parameter values and measured meteorological forcing variables are transferred from one glacier site to the other, treating the second glacier site as an extension of the first. The model parameters are transferable in time to within a <10% uncertainty in the calculated surface ablation over most or all of a melt season. Transferring model parameters or meteorological forcing variables in space creates large errors in modeled ablation. If select quantities (ice albedo, initial snow depth, and summer snowfall) are retained at their locally measured values, model transferability can be improved to achieve ≤15% uncertainty in the calculated surface ablation.

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