Synthesis and antimicrobial activity of 4-trifluoromethylpyridine nucleosides
Keyword(s):
Abstract4-Trifluoromethylpyridine derivatives 4–8 represent good candidates for the discovery of new antibacterial agents. Fluorinated pyridine nucleosides 4–7 and non-nucleoside analogues 8a,b were synthesized and evaluated for their antibacterial activities against Staphylococcus aureus, Bacillus infantis, Escherichia coli and Stenotrophomonas maltophilia. The minimum inhibitory concentrations (MICs) of the new nucleosides 4–7 range from 1.3 to 4.9 μg/mL and MICs of fluoroaryl derivatives 8a,b are in the range of 1.8–5.5 μg/mL. Activity of amoxicillin, the reference drug, is 1.0–2.0 μg/mL under similar conditions.
2021 ◽
Vol 21
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pp. 5120-5130
2021 ◽
Vol 68
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2017 ◽
Vol 82
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pp. 367-377
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2022 ◽
2010 ◽
Vol 5
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pp. 1934578X1000500
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2017 ◽
Vol 15
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pp. 21-32