scholarly journals Association between hair cortisol concentration and metabolic syndrome

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 873-881
Author(s):  
Eglė Mazgelytė ◽  
Asta Mažeikienė ◽  
Neringa Burokienė ◽  
Rėda Matuzevičienė ◽  
Aušra Linkevičiūtė ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Blood Serum ◽  
Salivary Cortisol ◽  
High Performance ◽  
Cortisol Concentration ◽  
Hair Cortisol ◽  
Hair Samples ◽  
Lower Social Support ◽  
Cortisol Levels

Abstract Metabolic syndrome (MetS) is a highly prevalent disorder defined as a cluster of cardiometabolic risk factors including obesity, hyperglycemia, hypertension, and dyslipidemia. It is believed that excessive cortisol secretion due to psychosocial stress-induced hypothalamic-pituitary-adrenal axis activation might be involved in the pathogenesis of MetS. We sought to explore the association between MetS and psychosocial risk factors, as well as cortisol concentration measured in different biological specimens including saliva, blood serum, and hair samples. The study was conducted on a sample of 163 young and middle-aged men who were divided into groups according to the presence of MetS. Hair cortisol concentration (HCC) was determined using high performance liquid chromatography with UV detection, while blood serum and salivary cortisol levels were measured by enzyme-linked immunoassay. Lipid metabolism biomarkers were determined using routine laboratory methods. Anthropometric and lifestyle characteristics, as well as self-reported psychosocial indicators, were also examined. Significantly higher HCC and lower social support level among participants with MetS compared with individuals without MetS were found. However, no significant differences in blood serum and salivary cortisol levels were observed between men with and without MetS. In conclusion, chronically elevated cortisol concentration might be a potential contributing factor to the development of MetS.

scholarly journals Correlation analysis of cortisol concentration in hair versus concentrations in serum, saliva and urine.

2020 ◽  
Author(s):  
Lukasz Cieszynski ◽  
Jaroslaw Jendrzejewski ◽  
Piotr Wisniewski ◽  
Przemyslaw Klosowski ◽  
Krzysztof Sworczak
Keyword(s):  
Clinical Practice ◽  
Salivary Cortisol ◽  
Serum Cortisol ◽  
Individual Characteristics ◽  
Cortisol Concentration ◽  
Reference Ranges ◽  
Hair Cortisol ◽  
Free Cortisol ◽  
Hair Samples ◽  
Cortisol Levels

Abstract Background: Cortisol concentration is measured in blood, urine, and saliva samples. It has been recently proven that cortisol could be also detected in hair samples. Cortisol measurements in different samples have their own individual characteristics and clinical utility. We aimed to investigate the correlation between hair cortisol concentration and standard cortisol measurements used in clinical practice. Methods: Fifty adult volunteers with a negative history of endocrine disorders were enrolled into the study. Morning serum cortisol (MSC), evening serum cortisol (ESC), evening free salivary cortisol (EFSC), urine free cortisol (UFC) and hair cortisol were analyzed in all participants. Eventually, 41 volunteers were included into the study, whose cortisol concentration in the 1 mg overnight dexamethason suppression test (1mgONDST) were <50 nmol/l, and cortisol levels in serum, saliva and urine were within reference ranges. Hair cortisol concentration (HCC) was performed for 20 mg of hair strands of the proximal 1 cm hair segments. Results: HCC ranged from 0.3036 to 2.65 nmol/l/mg, and the average value was 0.8125±0.4834 nmol/l/mg. No significant correlations were found between HCC and MSC (rho=0.04419, p=0.7838), HCC and ESC (rho=-0.2071, p=0.1938), HCC and EFSC (rho=0.1005, p=0.532), and HCC and UFC (rho = 0.1793, p = 0.262). Conclusions : This work is another step in the discussion on the application of HCC determinations in clinical practice. Our results have showed no correlations between HCC and single point cortisol assessment in blood, saliva and urine in patients with reference cortisol levels. Keywords: Hair cortisol, Serum cortisol, Salivary cortisol, Urine cortisol, Cortisol assessment, Cortisol correlation

scholarly journals Unraveling the Complexity to Observe Associations Between Welfare Indicators and Hair Cortisol Concentration in Dairy Calves

2021 ◽  
Vol 2 ◽  
Author(s):  
Lena-Mari Tamminen ◽  
Linda J. Keeling ◽  
Anna Svensson ◽  
Laurie Briot ◽  
Ulf Emanuelson
Keyword(s):  
Coping Styles ◽  
Generalized Additive Models ◽  
Cortisol Concentration ◽  
Additive Models ◽  
Dairy Calves ◽  
Regularized Regression ◽  
Hair Cortisol ◽  
Welfare Indicators ◽  
Hair Samples ◽  
Cortisol Levels

Using levels of the stress hormone cortisol as an indicator for welfare is a common, but debated practice. In this observational study, hair cortisol concentration (HCC) of samples from 196 dairy calves from 7 to 302 days of age collected from 12 Swedish farms was determined using a commercially available ELISA. An assessment of animal welfare, assessed using animal-based indicators, was performed on the day of sampling. First, methodological factors with the potential to impact HCC and the effect of age were analyzed using generalized additive models. This revealed a significant peak in hair cortisol in young calves (around 50 days of age) and an association between fecal contamination of hair samples and the level of cortisol extracted. Second, associations between welfare indicators and HCC were explored using cluster analysis and regularized regression. The results show a complex pattern, possibly related to different coping styles of the calves, and indicators of poor welfare were associated with both increased and decreased hair cortisol levels. High cortisol levels were associated with potential indicators of competition, while low cortisol levels were associated with the signs of poor health or a poor environment. When running the regularized regression analysis without the contaminated hair samples and with the contaminated samples (including a contamination score), the results did not change, indicating that it may be possible to use a contamination score to correct for contamination.

scholarly journals Metabolomic profiling in patients with metabolic syndrome

Kardiologiia ◽  
2020 ◽  
Vol 60 (3) ◽  
pp. 37-43
Author(s):  
E. O. Korobkova ◽  
M. V. Kozhevnikova ◽  
I. S. Ilgisonis ◽  
G. A. Shakaryants ◽  
S. A. Appolonova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mass Spectrometry ◽  
Metabolic Syndrome ◽  
Amino Acids ◽  
High Performance Liquid Chromatography ◽  
High Performance ◽  
Liquid Chromatography Mass Spectrometry ◽  
Metabolomic Profile ◽  
Additional Risk ◽  
Metabolomic Profiling

Objective. To identify biomarkers, which are most specific for patients with metabolic syndrome (MS) using metabolomic profiling.Materials and Methods. Metabolomic profiling of patients with MS and comparison of their profile with the profile of volunteers was performed using high-performance liquid chromatography-mass-spectrometry.Results. The metabolomic profile of MS patients differed in several amino acids, including choline, cysteine, and serine and in the acylcarnitine group (р<0.05 for all comparisons).Conclusion. The metabolites most specific for MS patients were identified. Increased concentrations of a combination of amino acids and carnitines can be considered as possible additional risk factors for cardiovascular diseases.

scholarly journals SALIVARY CORTISOL AND METABOLIC SYNDROME COMPONENT’S ASSOCIATION

2018 ◽  
Vol 31 (1) ◽  
Author(s):  
Grasiane Izidorio GARBELLOTTO ◽  
Fernanda Jardim REIS ◽  
Ana Maria Pandolfo FEOLI ◽  
Carla Haas PIOVESAN ◽  
Andréia da Silva GUSTAVO ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Metabolic Syndrome ◽  
Circadian Rhythm ◽  
Salivary Cortisol ◽  
Cross Sectional Study ◽  
Elevated Blood ◽  
Sectional Study ◽  
Cross Sectional ◽  
Pituitary Adrenal Axis

ABSTRACT Background: Actually the lifestyle exposes the population to several risk factors related to alimentary habits and less physical activity that contributes to chronic diseases appearance worldwide. Aim: To analyze the association between salivary cortisol and the components of metabolic syndrome. Methods: This is a cross-sectional study. As part of it, 28 individuals aged 30-59 years presenting three or more of the following findings: CA: ≥88 cm for women and ≥102 cm for men; SBP>130 mmHg and DBP>85 mmHg; GL>100 mg/dl; TG>150 mg/dl; HDL<40 mg/dl for men and <50 mg/dl for women. Was performed analysis of salivary cortisol (by radioimmunoassay) from 25 salivary samples collected throughout the day, for evaluating changes in the circadian rhythm of this hormone (8AM, noon and 8PM). Results: 28 evaluated individuals had a mean age of 51.9±7.5 years, mostly women (64.3%) and a mean of BMI 33.6±3.2 kg/m². The cortisol level from the 8AM averaged 18.7±4.8 ng/dlL. Individuals with FPG>110mg/dl, have significantly lower average levels of cortisol than ones with FPG <110 (12.8±5,2 vs. 17.3±4.2). Significant correlations were HOMA vs. WC (r=0,465; p˂0,005) and TG (r=0,473; p˂0,005), WC vs. FG (r=0,446; p˂0,005) and BMI (r=0,730; p˂0.0001); TG vs. HDL (r=0,441 p˂0,005) and FG (r=0,440; p˂0,005). Conclusion: Morning salivary cortisol in subjects with chronically elevated blood glucose can represent a downregulation of the hypothalamic-pituitary adrenal axis. This is an important finding not yet well investigated.

scholarly journals Hair cortisol-a method to detect chronic cortisol levels in patients with Prader-Willi syndrome

2020 ◽  
Author(s):  
Hasanain Hamid Shukur ◽  
Yolanda B de Rijke ◽  
Elisabeth FC van Rossum ◽  
Laith Hussain-Alkhateeb ◽  
Charlotte Höybye
Keyword(s):  
Linear Regression ◽  
Regression Model ◽  
Behavioral Problems ◽  
Linear Regression Model ◽  
Neurodevelopmental Disorder ◽  
Prader Willi Syndrome ◽  
Hair Cortisol ◽  
Hair Samples ◽  
Cortisol Levels

Abstract Background: Prader-Willi syndrome (PWS) is a multisymptomatic, rare, genetic, neurodevelopmental disorder in adults mainly characterized by hyperphagia, cognitive dysfunction, behavioral problems and risk of morbid obesity. Although endocrine insufficiencies are common, hypocortisolism is rare and knowledge on long-term cortisol concentrations is lacking. The aim of this study was to evaluate long-term cortisol levels in PWS by measurements of hair cortisol. Methods: Twenty-nine adults with PWS, 15 men and 14 women, median age 29 years, median BMI 27 kg/m2, were included. Scalp hair samples were analyzed for cortisol content using liquid-chromatography tandem-mass spectrometry. In addition, a questionnaire on auxology, medication and stress were included. For comparison, 105 age- and sex-matched participants from the population-based Lifelines Cohort study were included as controls. The mean hair cortisol between the groups were compared and associations between BMI and stress were assessed by a generalized linear regression model. Results: In the PWS group large variations in hair cortisol was seen. Mean hair cortisol was 12.8±25.4 pg/mg compared to 3.8±7.3 pg/mg in controls (p=0.001). The linear regression model similarly showed higher cortisol levels in patients with PWS, which remained consistent after adjusting for BMI and stress (p=0.023). Furthermore, hair cortisol increased with BMI (p=0.012) and reported stress (p=0.014). Conclusion: Long-term cortisol concentrations were higher in patients with PWS compared to controls and increased with BMI and stress, suggesting an adequate cortisol response to chronic stress. Hair cortisol demonstrate promising applications in the context of PWS treatment and disease management.

scholarly journals Scalp hair sweating as a predictor of hair cortisol level in human compared to obesity and other confounders

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Darya S. Abdulateef
Keyword(s):  
Cortisol Level ◽  
Scalp Hair ◽  
Positive Association ◽  
Stressful Events ◽  
Hair Cortisol ◽  
Significant Positive Association ◽  
Factors Affecting ◽  
Hair Samples ◽  
Cortisol Levels ◽  
Study Participants

AbstractInconsistent results were found throughout the literature regarding factors affecting hair cortisol levels. Hair cortisol level in humans was not studied for its associations to scalp hair sweating or hair wash frequency in a patient-based way. Factors affecting hair cortisol levels must be precisely known in order to interpret the results correctly. The aims of the study are to assess if BMI, Perceived Stress Scale (PSS), hair wash frequency, and sweating with scalp hair affect hair cortisol levels. It will assess which of these factors are more significant predictors of hair cortisol levels. In a study on healthy adults, information about history, socio-demographics, PSS, hair wash frequency, hair treatment, and scalp hair sweating were collected, and hair samples were taken and analyzed for their hair cortisol level. Associations of hair cortisol levels with each of the variables were investigated and significant predictors of hair cortisol levels among the variables were found. Mean hair cortisol level in the study participants was 16.84 pg/mg hair. Hair cortisol has a significant positive association with weight, BMI, PSS, and scalp hair sweating, p < 0.05. Scalp hair sweating significantly predicts hair cortisol levels by 12.3%, while other variables did not significantly predict hair cortisol levels, p < 0.05. Scalp hair sweating significantly predicts hair cortisol levels. Age, hair wash frequency, hair treatment, and stressful events have no associations with hair cortisol levels. Although BMI and PSS are associated with hair cortisol levels, they do not significantly predict it. Obesity is significantly associated with profuse sweating, thus the increase in hair cortisol levels in obese individuals could partly be the result of a higher incidence of sweating in these individuals. Thus, scalp hair sweating should be taken into consideration during the study and interpretation of hair cortisol levels.

scholarly journals Hair cortisol-a method to detect chronic cortisol levels in patients with Prader-Willi syndrome

2020 ◽  
Author(s):  
Hasanain Hamid Shukur ◽  
Yolanda B de Rijke ◽  
Elisabeth FC van Rossum ◽  
Laith Hussain-Alkhateeb ◽  
Charlotte Höybye
Keyword(s):  
Linear Regression ◽  
Regression Model ◽  
Behavioral Problems ◽  
Linear Regression Model ◽  
Neurodevelopmental Disorder ◽  
Prader Willi Syndrome ◽  
Hair Cortisol ◽  
Hair Samples ◽  
Cortisol Levels

Abstract Background: Prader-Willi syndrome (PWS) is a multisymptomatic, rare, genetic, neurodevelopmental disorder in adults mainly characterized by hyperphagia, cognitive dysfunction, behavioral problems and risk of morbid obesity. Although endocrine insufficiencies are common, hypocortisolism is rare and knowledge on long-term cortisol concentrations is lacking. The aim of this study was to evaluate long-term cortisol levels in PWS by measurements of hair cortisol.Methods: Twenty-nine adults with PWS, 15 men and 14 women, median age 29 years, median BMI 27 kg/m2, were included. Scalp hair samples were analyzed for cortisol content using liquid-chromatography tandem-mass spectrometry. In addition, a questionnaire on auxology, medication and stress were included. For comparison, 105 age- and sex-matched participants from the population-based Lifelines Cohort study were included as controls. The mean hair cortisol between the groups were compared and associations between BMI and stress were assessed by a generalized linear regression model.Results: In the PWS group large variations in hair cortisol was seen. Mean hair cortisol was 12.8±25.4 pg/mg compared to 3.8±7.3 pg/mg in controls (p=0.001). The linear regression model similarly showed higher cortisol levels in patients with PWS, which remained consistent after adjusting for BMI and stress (p=0.023). Furthermore, hair cortisol increased with BMI (p=0.012) and reported stress (p=0.014).Conclusion: Long-term cortisol concentrations were higher in patients with PWS compared to controls and increased with BMI and stress, suggesting an adequate cortisol response to chronic stress. Hair cortisol demonstrate promising applications in the context of PWS treatment and disease management.

scholarly journals Longitudinal Associations between Hair Cortisol, PTSD Symptoms, and Sleep Disturbances in a Sample of Firefighters with Duty-related Trauma Exposure

2021 ◽  
Author(s):  
Marie Roxanne Sopp ◽  
Tanja Michael ◽  
Johanna Lass-Hennemann ◽  
Shilat Haim-Nachum ◽  
Miriam J. J. Lommen
Keyword(s):  
Sleep Disturbances ◽  
Secondary Outcome ◽  
Secondary Outcome Measure ◽  
Ptsd Symptoms ◽  
Hair Cortisol ◽  
Trauma Severity ◽  
Work Related ◽  
Hair Samples ◽  
Average Work ◽  
Cortisol Levels

Several studies have found evidence of altered cortisol levels in patients with posttraumatic stress disorder (PTSD). Based on these findings, it is assumed that these patients may show signs of cortisol dysregulation after trauma. Posttrauma cortisol levels are thus considered a potential biomarker of PTSD. However, longitudinal studies using indicators of long-term cortisol secretion (such as hair cortisol concentrations; HCC) are scarce. The current study investigated prospective associations between HCC and PTSD symptoms in a sample of Dutch firefighters taking into account varying levels of work-related trauma severity. In addition, we assessed posttraumatic sleep disturbances as a secondary outcome measure to investigate whether effects generalize to this frequent comorbidity of PTSD. Three hundred seventy-one Dutch firefighters with a mean of 14.01 years of work experience were included in the analyses. Baseline assessment included the collection of hair samples and the measurement of work-related trauma severity, PTSD symptoms, and sleep disturbances. PTSD symptoms and sleep disturbance were re-assessed after six and twelve months. Multilevel analyses indicate a significant positive correlation between HCC and baseline PTSD symptoms in those with average or above-average work-related trauma severity. A similar pattern was evident for posttraumatic sleep disturbances at baseline. Moreover, higher HCC predicted more posttraumatic sleep disturbances after 6 months in participants with above-average work-related trauma severity. No other associations emerged for PTSD symptoms or posttraumatic sleep disturbances at six or twelve months. As such, our study supports the existence of a cross-sectional association between HCC and trauma symptoms, which may vary for different levels of subjective trauma severity. The longitudinal stability of this association should be reinvestigated by future research.

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