scholarly journals Graphene-based biosensors for disease theranostics: Development, applications, and recent advancements

2021 ◽  
Vol 11 (1) ◽  
pp. 96-116
Author(s):  
Hassan A. Alhazmi ◽  
Waquar Ahsan ◽  
Bharti Mangla ◽  
Shamama Javed ◽  
Mohd. Zaheen Hassan ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Biological Molecules ◽  
Long Term Stability ◽  
Accuracy And Precision ◽  
Sensing Platforms ◽  
Sensitivity And Selectivity ◽  
Optical And Mechanical Properties ◽  
Development Applications ◽  
Unique Chemical

Abstract Graphene, owing to its unique chemical structure and extraordinary chemical, electrical, thermal, optical, and mechanical properties, has opened up a new vista of applications, specifically as novel sensing platforms. The last decade has seen an extensive exploration of graphene and graphene-based materials either alone or modified with nanoparticles and polymers for the fabrication of nanoscale biosensors. These biosensors displayed excellent conductivity, high sensitivity, and selectivity, good accuracy, and precision, rapid detection with low detection limits as well as long-term stability. The unmatched properties of graphene and graphene-based materials have been applied for the detection of a number of chemical and biological molecules successfully for the diagnosis of a variety of diseases, pathogens, and biomarkers of the diseases. This review is aimed to cover the fabrication methods, functionalization techniques, and biomedical applications along with the recent advancements in the field of development of graphene-based biosensors. Recent clinical trials and patents as well as market trends and opportunities associated with graphene-based biosensors are also summarized. The application of graphene-based biosensors in the detection of SARS-CoV-2 causing COVID-19 is also reviewed.

Highly selective zirconia-based propene sensor attached with sol–gel derived NiO nanospheres

RSC Advances ◽  
2015 ◽  
Vol 5 (31) ◽  
pp. 24126-24131 ◽  
Author(s):  
Kamaraj Mahendraprabhu ◽  
Perumal Elumalai
Keyword(s):  
Electrochemical Sensor ◽  
Sol Gel ◽  
High Sensitivity ◽  
Term Stability ◽  
Long Term Stability ◽  
Sensitivity And Selectivity

An YSZ-based electrochemical sensor was fabricated using sol–gel derived NiO nanospheres. The sensor exhibited high sensitivity and selectivity to C3H6 (propene) with excellent long-term stability.

Chemical Stability of Si-SiC Nanostructures under Physiological Conditions

2017 ◽  
Vol 897 ◽  
pp. 638-641 ◽  
Author(s):  
Romain Bange ◽  
Edwige Bano ◽  
Laetitia Rapenne ◽  
Sébastien Labau ◽  
Bernard Pelissier ◽  
...  
Keyword(s):  
Chemical Stability ◽  
Silicon Nanowires ◽  
Direct Detection ◽  
Chemical Species ◽  
High Sensitivity ◽  
Biological Molecules ◽  
Physiological Conditions ◽  
Long Term Stability ◽  
Detection Of Biomolecules

The fast and direct detection of small quantities of biological and chemical species is of key importance for numerous biomedical applications. Extensive research has been conducted on nanoelectronic devices that can perform such detection with high sensitivity using silicon nanowires and nanostructures. However, it was recently demonstrated that Si material suffers a lack of long-term stability in physiological environments at nanometer scale [1,2], and is hence not suited for in situ sensing of biological molecules. The results presented here are two important steps toward the realization of core-shell Si-SiC NWFETs for the detection of biomolecules in liquid media. First, we show that SiC NWs exhibit higher chemical stability than Si NWs under physiological conditions. Second, we present the successful carburation of a thin film of Si resulting in a 3.6 nm thin SiC layer.

High-performance humidity sensors from Ni(SO4)0.3(OH)1.4 nanobelts

Nanoscale ◽  
2014 ◽  
Vol 6 (12) ◽  
pp. 6521-6525 ◽  
Author(s):  
Ming Zhuo ◽  
Yuejiao Chen ◽  
Tao Fu ◽  
Haonan Zhang ◽  
Zhi Xu ◽  
...  
Keyword(s):  
High Performance ◽  
Humidity Sensor ◽  
High Sensitivity ◽  
Fast Response ◽  
Humidity Sensors ◽  
Term Stability ◽  
Long Term Stability

Ni(SO4)0.3(OH)1.4 nanobelts are utilized in a humidity sensor by a facile method. The nanobelt based sensor shows a high sensitivity, fast response and long-term stability in the sensing process.

Synthesis of Trilaminar Core–Shell Au/α-Fe2O3@SnO2Nanocomposites and their Application for Nonenzymatic Dopamine Electrochemical Sensing

NANO ◽  
2019 ◽  
Vol 14 (11) ◽  
pp. 1950138 ◽  
Author(s):  
Sai Zhang ◽  
Shijun Yue ◽  
Jiajia Li ◽  
Jianbin Zheng ◽  
Guojie Gao
Keyword(s):  
Electron Microscopy ◽  
High Sensitivity ◽  
Electrochemical Sensing ◽  
Synthesis Process ◽  
Core Shell ◽  
X Ray Diffraction ◽  
X Ray ◽  
Long Term Stability ◽  
Transmission Electron

Au nanoparticles anchored on core–shell [Formula: see text]-Fe2O3@SnO2 nanospindles were successfully constructed through hydrothermal synthesis process and used for fabricating a novel nonenzymatic dopamine (DA) sensor. The structure and morphology of the Au/[Formula: see text]-Fe2O3@SnO2 trilaminar nanohybrid film were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The electrochemical properties of the sensor were investigated by cyclic voltammetry and amperometry. The experimental results suggest that the composites have excellent catalytic property toward DA with a wide linear range from 0.5[Formula: see text][Formula: see text]M to 0.47[Formula: see text]mM, a low detection limit of 0.17[Formula: see text][Formula: see text]M (S/[Formula: see text]) and high sensitivity of 397.1[Formula: see text][Formula: see text]A[Formula: see text]mM[Formula: see text][Formula: see text]cm[Formula: see text]. In addition, the sensor exhibits long-term stability, good reproducibility and anti-interference.

scholarly journals NO2 and NH3 Sensing Characteristics of Inkjet Printing Graphene Gas Sensors

Sensors ◽  
2019 ◽  
Vol 19 (15) ◽  
pp. 3379 ◽  
Author(s):  
Caterina Travan ◽  
Alexander Bergmann
Keyword(s):  
Gas Sensors ◽  
Inkjet Printing ◽  
High Mobility ◽  
High Sensitivity ◽  
Low Noise ◽  
Manufacturing Method ◽  
Long Term Stability ◽  
Wide Range ◽  
Ideal Technique

Graphene is a good candidate for filling the market requirements for cheap, high sensitivity, robust towards contamination, low noise, and low power consumption gas sensors, thanks to its unique properties, i.e., large surface, high mobility, and long-term stability. Inkjet printing is a cheap additive manufacturing method allowing fast, relatively precise and contactless deposition of a wide range of materials; it can be considered therefore the ideal technique for fast deposition of graphene films on thin substrates. In this paper, the sensitivity of graphene-based chemiresistor gas sensors, fabricated through inkjet printing, is investigated using different concentrations of graphene in the inks. Samples have been produced and characterized in terms of response towards humidity, nitrogen dioxide, and ammonia. The presented results highlight the importance of tuning the layer thickness and achieving good film homogeneity in order to maximize the sensitivity of the sensor.

scholarly journals Electrodeposition of Pd-Pt Nanocomposites on Porous GaN for Electrochemical Nitrite Sensing

Sensors ◽  
2019 ◽  
Vol 19 (3) ◽  
pp. 606 ◽  
Author(s):  
Rui Xi ◽  
Shao-Hui Zhang ◽  
Long Zhang ◽  
Chao Wang ◽  
Lu-Jia Wang ◽  
...  
Keyword(s):  
Environmental Samples ◽  
Food Industry ◽  
Biological Process ◽  
High Sensitivity ◽  
Good Reproducibility ◽  
Practical Application ◽  
Long Term Stability ◽  
Nitrite Content

In recent years, nitrite pollution has become a subject of great concern for human lives, involving a number of fields, such as environment, food industry and biological process. However, the effective detection of nitrite is an instant demand as well as an unprecedented challenge. Here, a novel nitrite sensor was fabricated by electrochemical deposition of palladium and platinum (Pd-Pt) nanocomposites on porous gallium nitride (PGaN). The obtained Pd-Pt/PGaN sensor provides abundant electrocatalytic sites, endowing it with excellent performances for nitrite detection. The sensor also shows a low detection limit of 0.95 µM, superior linear ampere response and high sensitivity (150 µA/mM for 1 to 300 µM and 73 µA/mM for 300 to 3000 µM) for nitrite. In addition, the Pd-Pt/PGaN sensor was applied and evaluated in the determination of nitrite from the real environmental samples. The experimental results demonstrate that the sensor has good reproducibility and long-term stability. It provides a practical way for rapidly and effectively monitoring nitrite content in the practical application.

Long-Term Stability of High Sensitivity C Reactive Protein Levels in Healthy Adults

2007 ◽  
Vol 16 ◽  
pp. S68
Author(s):  
B.M. McQuillan ◽  
E. Rossi ◽  
J. Hung ◽  
P.L. Thompson ◽  
J.P. Beilby
Keyword(s):  
High Sensitivity ◽  
Healthy Adults ◽  
C Reactive Protein ◽  
Term Stability ◽  
Protein Levels ◽  
Long Term Stability ◽  
Reactive Protein

scholarly journals A Software Improvement Technique for Platinum Resistance Thermometers

Instruments ◽  
2020 ◽  
Vol 4 (2) ◽  
pp. 15 ◽  
Author(s):  
Andrew Chen ◽  
Hsuan-Yu Chen ◽  
Chiachung Chen
Keyword(s):  
High Sensitivity ◽  
Microprocessor System ◽  
Platinum Resistance ◽  
Long Term Stability ◽  
Accuracy And Precision ◽  
Platinum Resistance Thermometers ◽  
Resistance Thermometers ◽  
Temperature Ranges ◽  
The Difference ◽  
Calibration Equations

Temperature measurement is essential in industries. The advantages of resistance temperature detectors (RTDs) are high sensitivity, repeatability, and long-term stability. The measurement performance of this thermometer is of concern. The connection between RTDs and a novel microprocessor system provides a new method to improve the performance of RTDs. In this study, the adequate piecewise sections and the order of polynomial calibration equations were evaluated. Systematic errors were found when the relationship between temperature and resistance for PT-1000 data was expressed using the inverse Callendar-Van Dusen equation. The accuracy of these calibration equations can be improved significantly with two piecewise equations in different temperature ranges. Two datasets of the resistance of PT-1000 sensors in the range from 0 °C to 50 °C were measured. The first dataset was used to establish adequate calibration equations with regression analysis. In the second dataset, the prediction temperatures were calculated by these previously established calibration equations. The difference between prediction temperatures and the standard temperature was used as a criterion to evaluate the prediction performance. The accuracy and precision of PT-1000 sensors could be improved significantly with adequate calibration equations. The accuracy and precision were 0.027 °C and 0.126 °C, respectively. The technique developed in this study could be used for other RTD sensors and/or different temperature ranges.

Facile fabrication of highly sensitive and durable cotton fabric-based pressure sensors for motion and pulse monitoring

2021 ◽  
Author(s):  
Yinan Zhao ◽  
Lin Liu ◽  
zhen Li ◽  
Feifei Wang ◽  
Xinxin Chen ◽  
...  
Keyword(s):  
Cotton Fabric ◽  
Pressure Sensors ◽  
High Sensitivity ◽  
Wearable Electronics ◽  
Term Stability ◽  
Long Term Stability ◽  
Highly Sensitive ◽  
Facile Fabrication ◽  
Flexible Pressure Sensors

Design and development of flexible pressure sensors with high sensitivity, long-term stability and simple fabrication processes is a key procedure to fulfill the applications in wearable electronics, e-skin and medical...

Fabrication of long-range ordered, broccoli-like SERS arrays and application in detecting endocrine disrupting chemicals

2015 ◽  
Vol 3 (6) ◽  
pp. 1309-1318 ◽  
Author(s):  
Jing Chen ◽  
Gaowu Qin ◽  
Wen Shen ◽  
Yiyan Li ◽  
Biswajit Das
Keyword(s):  
Long Range ◽  
Endocrine Disrupting Chemicals ◽  
High Sensitivity ◽  
Term Stability ◽  
Long Term Stability ◽  
Endocrine Disrupting

3D periodic broccoli-like Au and Ag SERS arrays having reliability, reproducibility, long-term stability, and high-sensitivity have been fabricated and are used for detecting phthalates.

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