Serum Neopterin Concentration in Children with Viral Gastroenteritis

Pteridines ◽  
2010 ◽  
Vol 21 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Katarzyna Plata-Nazar ◽  
Grazyna Luczak ◽  
Magdalena Gora-Gebka ◽  
Anna Liberek ◽  
Barbara Kaminska
Keyword(s):  
Blood Count ◽  
Control Group ◽  
Study Group ◽  
Viral Gastroenteritis ◽  
Adenovirus Infection ◽  
C Reactive Protein ◽  
Viral Etiology ◽  
Serum Neopterin ◽  
Reactive Protein ◽  
Neopterin Concentration

Abstract Increased neopterin concentrations are observed in many diseases in which cellular immunity is stimulated. Gastroenteritis is still a major cause of childhood morbidity and mortality worldwide. Over 75% of all cases are caused by viral infections. Therefore a non-specific, quick, sensitive, cheap and easy-to-perform marker of viral infection, such as neopterin concentration in serum, would be a cost-effective method of identifying patients with gastroenteritis into probable viral etiology and therefore it would optimize treatment and reduce inappropriate antibiotic treatment. This study evaluated whether serum neopterin concentration can be a reliable marker of viral etiology of gastroenteritis in children. The study group consisted of 67 children: 29 girls and 38 boys, aged from 0.1 to 16.1 years with symptoms of gastroenterits and with confirmed rotavirus or adenovirus infection; the control group consisted of 105 healthy children. Clinical examinations and laboratory test including whole blood count, serum C-reactive protein, procalcitonin, and creatinine concentration were conducted. The serum neopterin level was analyzed by Elisa. Serum neopterin concentration in the study group varied from 6.03 to 171 nmol/L (median 23.7 nmol/L) and it was significantly higher than in the control group (from 2.88 to 14.8 nmol/L; median 4.73 nmol/L) (P <0.001). Neopterin concentration was above the normal value (>11 nmol/L) in 58 children from the study group and only in 6 from the control group (86.6% sensitivity and 94.3% specificity). Serum neopterin concentration did not differ significantly between children with rotavirus and adenovirus infection (P = 0.47). The correlation between serum neopterin and C-reactive protein concentrations was of borderline significance (rs = 0.23, p = 0.06); and there was no correlation between serum concentrations of neopterin and procalcitonin, white blood count, lymphocytes count, monocytes count or the body temperature. Serum neopterin concentration is highly increased in children suffering from viral gastroenteritis, regardless of the virus type. When a cut-off of 11.0 nmol/L neopterin was applied, comparison yields 86.6% sensitivity and 94.3% specificity for the diagnosis of viral gastroenteritis in pediatric patients. Further studies are necessary for other etiological agents of gastroenteritis.

Is there any relationship between platelet indices and myocarditis in children?

2021 ◽  
pp. 1-5
Author(s):  
Damla Geçkalan Soysal ◽  
Rahmi Özdemir
Keyword(s):  
Troponin I ◽  
Low Voltage ◽  
Troponin T ◽  
Control Group ◽  
Study Group ◽  
C Reactive Protein ◽  
Distribution Width ◽  
Platelet Indices ◽  
Reactive Protein ◽  
Significant Difference

Abstract Background: Platelet indices are used to evaluate platelet activation and function which change in inflammatory diseases. We hypothesise that platelet indices such as plateletcrit, mean platelet volume, and platelet distribution width may be more useful as prognostic indicators for myopericarditis in children. Methods: A total of 60 children were included in this study. Group 1 consists of children with myopericarditis, Group 2 is those with respiratory infections, and Group 3 consists of control group children of similar age and gender with the patient groups. Complete blood count parameters, C-reactive protein, and troponin values of the whole study group were recorded. Myopericarditis was diagnosed based on acute chest pain, dyspnea, palpitations, heart failure signs, arrhythmia symptoms and ST/T wave change, low voltage, supraventricular tachycardia/ventricular tachycardia on ECG, or elevated troponin T/troponin I levels or functional abnormalities on echocardiography. A comparison of the platelet indices made during diagnosis and 2 weeks after treatment was done for the myopericarditis patients. Results: There was no statistically significant difference in platelet indicies values. However, the increase in platelets and plateletcrit values after the treatment of myopericarditis was statistically significant. This study pointed out that there was a negative correlation between platelet–plateletcrit values and the troponin I–C-reactive protein. Conclusion: We found that platelet count and plateletcrit values increased after treatment. This is important as it is the first study in children to investigate the possible role of platelet indications for myopericarditis in children.

scholarly journals Searching for methods to predict septic complications in surgical patients

2015 ◽  
Vol 96 (3) ◽  
pp. 294-297
Author(s):  
T Z Zakiev ◽  
S R Tuysin ◽  
A R Gil’fanov ◽  
R D Sagdiev ◽  
I V Zakieva
Keyword(s):  
Acute Phase ◽  
Albumin Level ◽  
Main Group ◽  
Water Soluble ◽  
Control Group ◽  
Study Group ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Cell Counts

Aim. To assess the significance of acute stage reactants as the marker for purulent complications in surgical patients.Methods. We analyzed the results of treatment of 228 patients with purulent and inflammatory diseases of soft tissues, treated in 2011-2014. Acute phase reactants: C-reactive protein, albumin and fibrinogen were measured starting from the day of admission and surgical treatment and during the next 7 days. The control group (112 patients) included patients whowere treated conventionally by gauze bandage with water-soluble ointments and antiseptic solutions and broad-spectrum antibiotics. In the study group (116 patients) topical treatment of wounds was performed using «Poliderm» bandages.Results. Application of the «Poliderm» combined dressing reduced the wounds clearance term from 4.3±0.5 to 3.2±0.4 days, active inflammation term from 8.8±1.3 to 6.4±0.7 days, epithelialization of the wound from 10.1±0.8 to 8.4±0.6 days. C-reactive protein level was 87.3±4.3 g/l at the day of admission and decreased by day 7 to 34.13±1.2 g/l, compared to 51.83±3.6 g/l on the 7th day in the control group. Albumin level was 42.73±3.7 g/l in the study group with further decrease to 40.33±1.7 g/l on the 2nd and subsequent increase up to 45.13±1.3 g/l on the day 7. Patients of the control group had albumin level decreased on the 2nd and 3rd days with further increase up to 41.73±2.1 g/l on the day 7. At the treatment start, leukocyte intoxication index was 5.923±0.4 in the main group and 5.873±0.3 in the control group. On the 2nd day, this parameter decreased to 5.12 in the main group and to 5.41 in the control group.Conclusion. Measuring the levels of acute phase reactants (C-reactive protein, albumin, etc.) allows to assess the clinical course of a purulent and inflammatory disease, to register the good treatment effect on the 1-2nd day of treatment, even before the significant clinical changes, changes in the body temperature, white blood cell counts, erythrocyte sedimentation rate.

scholarly journals Evaluation of C-Reactive Protein Level in Patients with Pain Form of Temporomandibular Joint Dysfunction

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Malgorzata Pihut ◽  
Piotr Ceranowicz ◽  
Andrzej Gala
Keyword(s):  
Temporomandibular Joint ◽  
Soft Tissues ◽  
Temporomandibular Joint Disorders ◽  
Control Group ◽  
Study Group ◽  
C Reactive Protein ◽  
Level Of Evidence ◽  
Temporomandibular Joint Dysfunction ◽  
Mean Values ◽  
Reactive Protein

Temporomandibular joint dysfunction is a functional disorder concerned with the abnormal functioning of the muscles of the stomatognathic system and temporomandibular joints involved in the dynamic movements of the jaw and surrounding structures. The aim of the study was to compare the level of C-reactive protein in patients with pain and painless forms of temporomandibular joint dysfunction. Materials and methods. The study group consisted of 72 patients who reported to the prosthetic treatment because of temporomandibular joint dysfunction. The study group included 36 patients with pain form of dysfunction, and the control group included 36 patients with painless form of disorder. Each patient underwent specialized examination of functional disorders in order to diagnose the type of dysfunction and was commissioned to carry out a study of the blood test concerned with evaluation of the C-reactive protein (CRP) level in the same analytical laboratory. The results of the investigation were subjected to statistical analysis. The research obtained approval from the Ethics Committee of the Jagiellonian University (KBET/125/L/2013). Level of Evidence for primary research was established as type V. Results. The mean values of C-reactive protein levels in both groups were in the normal range and did not differ statistically significantly, which indicates the fact that the pain form of the temporomandibular joint disorders is not associated with inflammation of the soft tissues of the joint. Conclusion. Painful form of the temporomandibular joint dysfunctions is not connected with the inflammation of joints.

Predictive values of Ischemia modified albumin in neonatal sepsis

2017 ◽  
Vol 42 (3) ◽  
Author(s):  
Berna Hekimoğlu ◽  
Yakup Aslan ◽  
Mehmet Mutlu ◽  
Ahmet Menteşe ◽  
Süleyman Caner Karahan
Keyword(s):  
Early Diagnosis ◽  
Neonatal Sepsis ◽  
Patient Population ◽  
Control Group ◽  
Study Group ◽  
C Reactive Protein ◽  
Predictive Values ◽  
Blood Samples ◽  
Ischemia Modified Albumin ◽  
Reactive Protein

AbstractObjectiveThis study aims to identify whether ischemia-modified albumin (IMA) can be used as a marker in the diagnosis of sepsis in the term patient population.MethodsIn the study group 30 sepsis patients and 30 healthy neonatal, control group, whose gestational ages were ≥38 weeks were included. Blood samples were taken for IMA levels at baseline and on the 3rd and 10th days of the treatment. The IMA values obtained were compared with those for C-reactive protein (CRP).ResultsThe baseline CRP, IMA, and adjusted IMA levels of the patients in the study group were statistically higher compared to the control group (p<0.05). IMA and adjusted IMA values measured in the study group on the 3rd and 10th days decreased gradually and significantly compared to initial levels (p<0.0001). There was a positive correlation between the baseline IMA levels and CRP values among the patients with sepsis (r: 0.371, p<0.05). The diagnostic cut-off value of IMA in term of diagnosis of the neonatal sepsis was found to be 0.644 ABSU (p<0.0001), with a sensitivity of 93.3% and specificity of 66.7%.ConclusionWe suggest that IMA can be used as a useful biomarker in the early diagnosis of neonatal sepsis.

scholarly journals Bilirubin levels as an independent predictor of myocarditis in patients with COVID-19

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Muharrem Said Cosgun
Keyword(s):  
Total Bilirubin ◽  
Clinical Course ◽  
Independent Predictor ◽  
Total Bilirubin Level ◽  
Myocardial Damage ◽  
Control Group ◽  
Heme Oxygenase 1 ◽  
Study Group ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract Background Myocardial damage worsens the clinical course and prognosis of coronavirus disease 2019 (COVID-19) patients. High total bilirubin levels have been associated with a poor prognosis in COVID-19. This study aimed to investigate the predictive value of the total bilirubin level, a marker of heme oxygenase-1 enzyme activity, in determining myocarditis in patients with COVID-19. Results A total of 190 patients diagnosed with COVID-19 were enrolled in the study. The patients were divided into two groups based on their troponin positivity. The study group (n = 95) consisted of patients with high troponin, and the control group (n = 95) consisted of patients without high troponin levels. The D-dimer (727 [572–995] vs. 591 [440–790], p = 0.001), C-reactive protein (CRP) (30.0 [10–48] vs. 10.3 [5.8–15.9], p < 0.001), and total bilirubin (9.5 [8.2–12.1] vs. 7.0 [5.3–8.0], p < 0.001) levels were significantly higher in the study group. In multivariate analysis, CRP (odds ratio [OR]: 1.103; 95% confidence interval [CI]: 1.060–1.148; p < 0.001) and total bilirubin (OR: 1.612; 95% CI: 1.330–1.954; p < 0.001) levels were independent predictors of myocarditis in COVID-19. Conclusions Total bilirubin levels can be used as an early predictor of myocarditis in COVID-19 and can contribute to therapy management.

Total Convection Affects Serum β2 Microglobulin and C-Reactive Protein but Not Erythropoietin Requirement following Post-Dilutional Hemodiafiltration

2015 ◽  
Vol 41 (6) ◽  
pp. 494-501 ◽  
Author(s):  
Ezio Movilli ◽  
Corrado Camerini ◽  
Paola Gaggia ◽  
Roberto Zubani ◽  
Paolo Feller ◽  
...  
Keyword(s):  
Multiple Regression ◽  
Treatment Time ◽  
Transferrin Saturation ◽  
Inverse Correlation ◽  
Control Group ◽  
Study Group ◽  
C Reactive Protein ◽  
Β2 Microglobulin ◽  
Reactive Protein

Background: Inflammation and increased erythropoiesis stimulating agents (ESA) requirement are frequently associated in patients on dialysis. On-line hemodiafiltration (ol-HDF), putting together high levels of diffusion, and convection could improve both conditions. However, it is still not known which depurative component plays a major role in determining this result. The aim of the study was to evaluate the role of convection and diffusion on long-term variations of serum β2 microglobulin (Δβ2M), high-sensitive C-reactive protein (ΔhsCRP) concentrations, and ESA requirement (ΔESA) in ol-HDF. Methods: Seventy-three patients prevalent on high flux HD (hfHD) were studied. Thirty-eight patients were switched from hfHD to post-dilutional ol-HDF (Study group); the other 35 patients were considered the Control group. At 6 and 12 months, the effects of ol-HDF and hfHD on ΔhsCRP, ΔB2M, and ΔESA (U/kg/week) were evaluated. Other variables considered were body weight (BW), serum albumin (sAlb), hemoglobin (Hb), and equilibrated Kt/V (eKt/V). Iron therapy and ESA were administered intravenously according to the K/DOQI guidelines in order to maintain transferrin saturation between 20 and 40%, serum ferritin between 150 and 500 ng/ml and Hb between 11 and 12 g/dl. Qb, treatment time and Qd remained constant. Ol-HDF and hfHD were performed using membranes of size 1.9-2.1 sqm. Ultrapure dialysate and substitution fluid were employed in both HDF and HD treatments. Data are expressed as mean ± SD. Paired t test, Mann-Whitney U test, and simple and multiple regression analyses were employed for statistical evaluation. Results: Study group: total convective volume (TCV) was 22.1 ± 1.9 l/session. A significant reduction of hsCRP: from 6.8 ± 7.1 to 2.3 ± 2.4 mg/dl (p < 0.001), β2M: from 36.5 ± 14.4 to 24.7 ± 8.6 mg/dl (p < 0.0001) and ESAdose: from 107 ± 67 to 65 ± 44 U/kg/week (p < 0.005) was observed. No significant variations of Hb, BW and sAlb were seen. A significant inverse correlation was found between TCV and Δβ2M (r = -0.627; p < 0.0001), and TCV and ΔhsCRP (r = -0.514; p < 0.0001); no correlation between TCV and ΔESAdose was observed. No correlation was found between eKt/V and Δβ2M, ΔhsCRP, and ΔESAdose. Multiple regression analysis with ΔESAdose as dependent variable showed ΔhsCRP as the only significantly associated independent factor (p < 0.01). Control group: no significant variations of hsCRP, β2M, and ESAdose were observed over time. Conclusions: Ol-HDF induces a long-term significant reduction in pre-dialysis β2M and hsCRP concentrations. The magnitude of reduction is directly correlated to the amount of TCV achieved but not on eKt/V. The observed reduction in ESAdose requirement is independent either on convection or diffusion, but is directly associated to the concomitant reduction of inflammation.

Serum Interleukin-33 as a Biomarker in Predicting Neonatal Sepsis in Premature Infants

2018 ◽  
Vol 21 (7) ◽  
pp. 510-515 ◽  
Author(s):  
Halit Halil ◽  
Cuneyt Tayman ◽  
Mehmet Buyuktiryaki ◽  
Nilufer Okur ◽  
Ufuk Cakır ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Neonatal Sepsis ◽  
Serum Levels ◽  
Control Group ◽  
Rapid Progression ◽  
Study Group ◽  
C Reactive Protein ◽  
Mortality And Morbidity ◽  
Interleukin 33 ◽  
Reactive Protein

Background: Neonatal sepsis is considered as the most frequent cause of death in newborns. Early diagnosis is important to reduce mortality and morbidity. The rapid progression of the disease requires proper use of biomarkers specific for prompt diagnosis and intervention. Objective: We aimed to evaluate the benefit of interleukin-33 serum levels in the diagnosis and treatment of neonatal sepsis. Method: We included 51 infants with neonatal sepsis as the main study group and 50 neonates without sepsis as the control group. Serum levels of interleukin-6, interleukin-33 and C-reactive protein were measured on the 1st, 3rd and 7th days of sepsis in the study group and on the 3rd postpartum day in the control group, respectively. Results: Serum levels of interleukin-6, interleukin-33 and C-reactive protein were significantly higher in the first day of sepsis. Serum levels of interleukin-6, interleukin-33 and C-reactive protein decreased significantly on the 3rd and the 7th days of antibiotic treatment. We found a significant relationship between interleukin-33 and C-reactive protein and between interleukin-6 and C-reactive protein on the first day of sepsis. Conclusion: Serum interleukin-33 level is up-regulated in neonatal sepsis, which might be used as a novel diagnostic marker and also a useful tool to predict prognosis in early neonatal sepsis.

scholarly journals Evaluation of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and C-Reactive Protein in Tension-Type Headache Patients

2021 ◽  
Author(s):  
Hasan Hüseyin Özdemir ◽  
Ahmet Dönder
Keyword(s):  
Systemic Inflammation ◽  
Tension Type Headache ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
C Reactive Protein ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Significant Difference ◽  
Type Headache

Abstract Objectives A tension headache is the most common type of headache, and its causes are multifactorial. A relationship has been shown between migraine headaches and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP). In this study, we investigated the NLR, PLR, and serum CRP levels in frequent episodic tension-type headache (FETTH) and chronic tension-type headache (CTTH) patients. Materials and Methods This retrospective study included 64 patients with FETTH, 80 patients with CTTH, and 60 healthy controls who were followed up in the neurology clinic. Hematological parameters were compared between the patient and control groups. Results In CTTH patients, platelets, NLR, PLR, and CRP values were statistically higher than in FETTH patients and patients in the control group. In FETTH patients, the PLR value was higher than in patients in the control group, but there was no statistically significant difference in NLR and CRP values between FETTH patients and patients in the control group. Also, there was no correlation between these values and age and gender. Conclusion Increase platelet count might have an effect on tension-type headache pathophysiology. Systemic inflammation parameters were shown to be significantly higher in CTTH patients. More comprehensive studies are needed to evaluate the effect of systemic inflammation on the chronicity of tension headaches.

scholarly journals Microinflammation Factors in the Common Diseases of the Heart and Kidneys

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Danijela Tasic ◽  
Sonja Radenkovic ◽  
Gordana Kocic ◽  
Marina Deljanin Ilic ◽  
Aleksandra Ignjatovic
Keyword(s):  
Kidney Diseases ◽  
Plasminogen Activator Inhibitor ◽  
Cardiorenal Syndrome ◽  
High Density Lipoproteins ◽  
Control Group ◽  
C Reactive Protein ◽  
Plasminogen Activator Inhibitor 1 ◽  
Reactive Protein ◽  
Lipid Status ◽  
Pai 1

Aim. To determine levels of interleukin-8 (IL-8) and plasminogen activator inhibitor-1 (PAI-1) in different cardiorenal syndrome (CRS) modalities and to compare findings to some already investigated direct and indirect parameters of inflammation and atherosclerosis.Materials and Methods. Testing involved 114 examinees, divided into control and clinical groups suffering from different modalities and were formed according to the basis of a valid classification for CRS.Results. C-reactive protein (CRP) was significantly higher in all CRSs in comparison to the control groupP<0.05. PAI-1 in CRSs was statistically higher than in the control group. IL-8 was increased in all CRSs, and especially in CRS-5, where no significance was found. PAI-1 correlated with IL-8 in all CRSs, with significant value in CRS-2 and CRS-5. Correlation for PAI-1 and high-density lipoproteins (HDL) was found in CRS-4, while IL-8 was found to be related to CRP level in all CRSs, with significance only in CRS-1P<0.001.Conclusions. C-reactive protein, IL-8, and PAI-1 could be useful for clinical differentiation of chronic modalities of CRSs. Inflammation was the most pronounced in CRS-4. Lipid status parameters could be useful for differentiation of CRSs. Furthermore, HDL in chronic primary kidney diseases and triglycerides and total cholesterol in CRS-5 could be valuable.

Association of increased C-Reactive Protein and hypocomplementemia with risk factors for thrombosis in women who have susceptibility for poor gestational outcome; importance of preconceptional counseling

2021 ◽  
pp. 1-6
Author(s):  
Mehmet Sinan Beksac ◽  
Hanife Guler Donmez
Keyword(s):  
Risk Factors ◽  
Inflammatory Diseases ◽  
Factor V Leiden ◽  
Care Program ◽  
Prothrombin G20210a ◽  
Study Group ◽  
Factor V ◽  
C Reactive Protein ◽  
Mthfr Polymorphisms ◽  
Reactive Protein

This study aimed to investigate the association of increased C-Reactive Protein (CRP) and hypocomplementemia with risk factors for thrombosis such as Factor V Leiden (FVLP) and Prothrombin G20210A polymorphisms (PP), increased Activated Protein C Resistance (APCR) and decreased anti-thrombin III (ATIII) activity in women who have metabolic (MTHFR polymorphisms) and immunological risk factors (autoimmune antibody positivity, autoimmune disorders, and chronic inflammatory diseases). All patients (n= 197) were evaluated in terms of risk factors for thrombosis including FVLP, PP, increased APCR, and decreased ATIII activity as well as CRP and complement (C) 3 and C4 levels within a framework of preconceptional care program. Patients with high CRP levels together with hypocomplementemia were included to the study group (n= 13), while women with normal levels of CRP, C3, and C4 were accepted as controls (n= 184). Decreased ATIII activity was found to be statistically more frequent in the study group compared to controls (p= 0.036). There were no significant differences between the study and control groups in terms of the presence of FVLP, PP and increased APCR (p= 0.386, p= 0.462, p= 0.625, respectively). Decreased ATIII activity should be the concern of preconceptional and antenatal care programs in risky patients with increased CRP levels and hypocomplementemia in order to prevent placental inflammation related gestational complications.

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