Arsenic and breast cancer: a systematic review of epidemiologic studies

2017 ◽  
Vol 32 (3) ◽  
Author(s):  
Narges Khanjani ◽  
Abu-Bakr Jafarnejad ◽  
Leila Tavakkoli
Keyword(s):  
Breast Cancer ◽  
Heavy Metals ◽  
Systematic Review ◽  
Individual Differences ◽  
Human Health ◽  
Case Control ◽  
Epidemiologic Studies ◽  
International Agency ◽  
Different Populations ◽  
Group 1

AbstractIntroduction:Arsenic is one of the heavy metals known to be a cause of cancer and many other serious human health problems. The International Agency for Research on Cancer (IARC), has classified arsenic as a Group 1 carcinogen. Studies were performed in different populations to investigate the association between arsenic and breast cancer and the present paper attempts to review these studies.Methods and materials:Accessible electronic resources including, PubMed, Web of Knowledge, Science Direct and Scopus and Google Scholar were searched, with relevant phrases up to October 30, 2016. All articles were reviewed by two people separately and among them, original epidemiologic studies that investigated the association between breast cancer and exposure to arsenic were included.Results:Eventually seven articles were selected from 126 retrieved articles. Although three studies (one case-control and two ecological) were not able to show a significant affect, others provide some evidence of a relation between arsenic and breast cancer in specific subgroups.Conclusion:Exposure to arsenic may increase the risk of breast cancer. The strength of this relation can vary due to regional and individual differences.

scholarly journals Bovine Leukemia virus (BLV) and risk of breast cancer: a systematic review and meta-analysis of case-control studies

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Alireza Khatami ◽  
Ali Pormohammad ◽  
Rana Farzi ◽  
Hassan Saadati ◽  
Maryam Mehrabi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Bovine Leukemia Virus ◽  
Meta Analysis ◽  
Leukemia Virus ◽  
Case Control ◽  
Case Control Studies

scholarly journals Circulating Carnitine Levels and Breast Cancer: A Matched Case-Control Study

2021 ◽  
Author(s):  
Jiayi Zhang ◽  
Gang Wu ◽  
Hailong Zhu ◽  
Fengyuan Yang ◽  
Shuman Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Epidemiologic Studies ◽  
Female Breast Cancer ◽  
False Discovery Rates ◽  
Increased Risk ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract Background: The existing epidemiologic studies on the association between carnitine and breast cancer development are scarce. This study examined the association between circulating carnitine levels and breast cancer in females.Methods: This 1:1 age-matched case-control study identified 991 female breast cancer cases and 991 female controls without breast cancer. All cases and controls were confirmed with a pathological test. We measured 16 types of whole blood carnitine levels, such as free carnitine (C0) and octadecanoylcarnitine (C18), using targeted metabolomic technology. Results: The average age for cases and controls were 50.0 years (SD: 8.7 years) and 49.5 years (SD: 8.7 years), respectively. After adjusting for covariates, each SD increase in malonylcarnitine (C3DC; OR 0.91; 95% CI 0.83-1.00), decenoylcarnitine (C10:1; OR 0.87; 95% CI 0.79-0.96) and decadienoylcarnitine (C10:2; OR 0.90; 95% CI 0.82-0.99) level was associated with decreased odds of breast cancer. However, higher butyrylcarnitine (C4) levels were associated with increased risk of breast cancer (OR 1.12; 95% CI 1.02-1.23). We observed no relationship between other carnitines with breast cancer. The false discovery rates for C3DC, C4, C10:1 and C10:2 were 0.172, 0.120, 0.064 and 0.139, respectively. Conclusions: Higher levels of C3DC, C10:1, and C10:2 were protective factors for breast cancer, whereas increased C4 levels were a risk factor for breast cancer.

Breast Cancer With Relevance for Heavy Metals, Mycotoxines, and Pesticides

2019 ◽  
pp. 152-192
Author(s):  
Ait Sidi Brahim Malika ◽  
Kiai Hajar ◽  
Benidire Loubna ◽  
Omar El Hiba ◽  
Makbal Rachida ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Experimental Data ◽  
Heavy Metals ◽  
Human Health ◽  
Crucial Role ◽  
Molecular Mechanisms ◽  
Environmental Contaminants ◽  
Zinc Cadmium ◽  
Cadmium Lead ◽  
Copper Arsenic

Certain environmental contaminants such as heavy metals, pesticides, and mycotoxins are presumed to play a crucial role in the etiology of breast cancer, which is the most common tumor in women worldwide. In fact, the exposure to heavy metals poses risk in causing human cancers. Several investigations indicated strong contribution of heavy metals especially copper, arsenic, zinc, cadmium, lead, and aluminum in breast cancer. Furthermore, it has been reported that the excessive use of pesticides in agriculture in order to improve the productivity contaminates food materials and can be responsible to induce breast cancer in women. It is also noted that some fungi produce several type of mycotoxins such us zearalenone, aflatoxin, and ochratoxin that are dangerous for human health and can especially cause breast cancer. Thus, the objective of this chapter is to discuss the experimental data regarding the involvement of heavy metals, pesticides, and mycotoxins as well as the recent insights on the molecular mechanisms involved in the progress of breast cancer.

scholarly journals The association between ATM variants and risk of breast cancer: a systematic review and meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Masoumeh Moslemi ◽  
Yousef Moradi ◽  
Hojat Dehghanbanadaki ◽  
Hamed Afkhami ◽  
Mansoor Khaledi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Predictive Ability ◽  
Case Control ◽  
Ataxia Telangiectasia Mutated ◽  
Case Control Studies ◽  
Predisposing Factor ◽  
Increased Risk ◽  
Atm Gene

Abstract Background Ataxia telangiectasia-mutated (ATM) gene contributes to repair damaged DNA and to regulate cell cycle; therefore, ATM variants seem to increase breast cancer risk; however, the results are controversial. So we conducted a systematic review and meta-analysis to clarify the pooled association between various ATM variants and the risk of breast cancer. Methods The relevant studies were searched through Scopus, Web of Science, PubMed and Cochrane. Stratified and subgroup analyses were performed to explore heterogeneity between studies and assess effects of study quality. The pooled estimates logarithm with standard error logarithm of odds ratio and relative risk with confidence interval were calculated. Results This study revealed that there is association between ATM variants and the risk of breast cancer; according to the seven adjusted case-control studies, OR of this association was estimated as 1.67 (95%CI: 0.73–3.82), according to nine unadjusted case-control studies, the crude OR was 2.27 (95% CI: 1.17–4.40) and according to two cohorts, the RR was estimated as 1.68 (95% CI: 1.17–2.40). Conclusions The ATM variants are associated with an increased risk of breast cancer that ATM V2424G mutation is detected as the most predisposing factor while ATM D1853V, L546V, and S707P variants have the least predictive ability.

scholarly journals Evaluation of association studies and a systematic review and meta-analysis of CYP1A1 T3801C and A2455G polymorphisms in breast cancer risk

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249632
Author(s):  
Chen Yang ◽  
Xiao-Feng He
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Sensitivity Analysis ◽  
Breast Cancer Risk ◽  
Association Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Meta Analyses ◽  
Positive Results

Background Nine previous meta-analyses have been published to analyze the CYP1A1 T3801C and A2455G polymorphisms with BC risk. However, they did not assess the credibility of statistically significant associations. In addition, many new studies have been reported on the above themes. Hence, we conducted an updated systematic review and meta-analysis to further explore the above issues. Objectives To explore the association on the CYP1A1 T3801C and A2455G polymorphisms with BC risk. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses (The PRISMA) were used. Results In this study, there were 63 case–control studies from 56 publications on the CYP1A1 T3801C polymorphism (including 20,825 BC cases and 25,495 controls) and 51 case–control studies from 46 publications on the CYP1A1 A2455G polymorphism (including 20,124 BC cases and 29,183 controls). Overall, the CYP1A1 T3801C polymorphism was significantly increased BC risk in overall analysis, especially in Asians and Indians; the CYP1A1 A2455G polymorphism was associated with BC risk in overall analysis, Indians, and postmenopausal women. However, when we used BFDP correction, associations remained significant only in Indians (CC vs. TT + TC: BFDP < 0.001) for the CYP1A1 T3801C polymorphism with BC risk, but not in the CYP1A1 A2455G polymorphism. In addition, when we further performed sensitivity analysis, no significant association in overall analysis and any subgroup. Moreover, we found that all studies from Indians was low quality. Therefore, the results may be not credible. Conclusion This meta-analysis strongly indicates that there is no significant association between the CYP1A1 T3801C and A2455G polymorphisms and BC risk. The increased BC risk may most likely on account of false-positive results.

scholarly journals A Systematic Review Protocol: Barriers and Facilitators of Breast Cancer Screening Among Women in Sub-Saharan Africa.

2021 ◽  
Author(s):  
Vida Nyagre Yakong ◽  
Agani Afaya ◽  
Robert Kaba Alhassan ◽  
Somin Sang ◽  
Salia Solomon Mohammed ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Grey Literature ◽  
Barriers And Facilitators ◽  
Sub Saharan Africa ◽  
Future Research ◽  
International Agency ◽  
Screening Uptake

Abstract Introduction: According to statistics released by the International Agency for Research on Cancer (IARC) in December 2020, female breast cancer (BC) has overtaken lung cancer as the world's most commonly diagnosed cancer. It is estimated that by 2050 the prevalence rate of breast cancer in SSA will double. Breast cancer screening aims to reduce mortalities related to cancer, and morbidity associated with advanced stages of the disease, through early detection in asymptomatic women. This study aims to review and analyze empirical and grey literature on barriers and facilitators to breast cancer screening among women in SSA.Methods: PubMed, Web of Science, EMBASE, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) including Google scholar will be searched to identify published studies on barriers and facilitators to breast cancer screening from January 2010 to 2021. Two reviewers independently assessed the quality of all the included studies using the Mixed Methods Appraisal Tool (MMAT) version 2018.Conclusion: We envisage that this review will adduce evidence on common barriers and facilitators to BC screening in SSA. Identifying these barriers and facilitators will help guide the initialization of effective interventions that will improve BC screening uptake among women in SSA. This review will also guide future research in developing, implementing, and evaluating appropriate interventions tailored towards increasing BC screening uptake.Systematic review registration: Open Science Framework (OSF) registration DOI: 10.17605/OSF.IO/KY3PF

scholarly journals Factors Affecting the Rate of Breast Cancer; Role of Heavy Metals

2020 ◽  
Vol 11 (3) ◽  
pp. 57-64
Author(s):  
Shabbir Hussain ◽  
Sumra Naseer ◽  
Muhammad Waqas ◽  
Samina Ashraf ◽  
Aisha Saddiqa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Redox Reactions ◽  
Chemical Structure ◽  
Epidemiologic Studies ◽  
Oxidation States ◽  
International Agency ◽  
Factors Affecting ◽  
Potential Risk Factors ◽  
Breast Cells

Breast cancer is caused by uncontrolled growth of breast cells. It is more common in women as compared tothat in men. The breast cancer may be interlinked with the drinking of alcohol, smoking, sex, hormonal therapy, obesity,family history and age. Various epidemiologic studies suggest the role of metals e.g., nickel (Ni), zinc (Zn), arsenic(As),selenium (Se)and cadmium (Cd)as potential risk factors in breast cancer. Humans are exposed to these metals bymeans of drinking water, food and air. The oxidative theory suspects that the complexes formed from these metals invivo, near the location of DNA, catalyze the redox reactions which results in oxidation of DNA. The metals like arsenic(As), chromium (Cr), aluminum (Al), cadmium (Cd) and chromium (Cr)which exist in trace amount are considered ascarcinogens for organisms by IARC (International Agency for Research on Cancer). The carcinogenicity of these metalsmainly depends upon their chemical structure and oxidation states.

scholarly journals Association Between Apolipoprotein Gene Polymorphisms and Hyperlipidemia: A Meta-analysis

2020 ◽  
Author(s):  
Xiao-Ning Zhao ◽  
Quan Sun ◽  
You-Qin Cao ◽  
Xiao Ran ◽  
Yu Cao
Keyword(s):  
Systematic Review ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Case Control Studies ◽  
Quality Of Data ◽  
Different Populations ◽  
The Impact

Abstract Background: Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Over recent years, a number of studies have explored the impact of apolipoprotein genetic polymorphisms in hyperlipidemia, but considerable differences and uncertainty have been found in their association for different populations from different regions. Objective: To correlate apolipoprotein gene expression with hyperlipidemia through a systematic review of case-control studies. Methods: Comprehensive identification of relevant articles in Pubmed, Web of Science, ScienceDirect, CNKI, Wangfang, and VIP published to June 9, 2020. A systematic review of hyperlipidemia case-control studies was conducted to evaluate the quality of data in articles included in the review, and a meta-analysis was conducted using Stata 11 software. Results: A total of 59 articles were included, containing in total 13843 hyperlipidemia patients in the case group and 15398 healthy controls in the control group. Meta-analysis of the data indicated that APOA5-1131T>C, APOA1 -75bp, APOB XbaⅠand APOE gene polymorphisms were significantly associated with hyperlipidemia, with OR values of 1.996, 1.228, 1.444 and 1.710, respectively, for allele models. All P values were less than 0.05. Conclusions: Meta-analysis of the data indicated that the C allele of APOA5 1131T>C, the A allele at APOA1-75bp, the APOB XbaⅠ T allele, and the ε4 allele of APOE were each a risk factor for susceptibility for hyperlipidemia.

scholarly journals Mushroom Consumption Is Associated with Low Risk of Cancer: A Systematic Review and Meta-Analysis of Observation Studies

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 307-307 ◽  
Author(s):  
Djibril Ba ◽  
Paddy Ssentongo ◽  
Robert Beelman ◽  
Xiang Gao ◽  
John Richie
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Confidence Intervals ◽  
Dose Response ◽  
Lower Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Low Risk ◽  
Case Control Studies ◽  
Risk Of Cancer

Abstract Objectives The potential health benefits associated with mushroom consumption, including reductions in risk of cancer have gained recent research attention. We thus conducted a systematic review and meta-analysis to assess the association between mushrooms intake and risk of cancer at any site. Methods We searched MEDLINE, Web of Science, and Cochrane Library to identify relevant studies on mushrooms intake and cancer published from January 1, 1966 to October 1, 2019.  Observational studies with relative risks (RRs) or hazard ratios (HRs) or odds ratios (ORs) and 95% confidence intervals (CIs) of cancer risk for two or more categories of mushroom intake were eligible for the present studies.  Random-effects models were used to pool study results and to assess dose-response relationships between mushroom consumption and the risk of cancer. Results There were 17 studies (6 cohort and 11 case-control studies) for a total of 20,797 cancer cases. Mushroom consumption was associated with lower risk of cancer – the pooled RR was 0.66 (95% Confidence Intervals (CI): 0.55–0.78) for the highest vs lowest mushroom intakes groups. There was substantial heterogeneity between studies (I2 = 77%; p for heterogeneity &lt; 0.01). Mushroom consumption was associated with lower risk of cancer in cohort studies (RR = 0.90, 95% CI: 0.82–0.99; n = 6)  and case-control studies (RR = 0.52, 95% CI: 0.41–0.66; n = 11). Subgroup analysis showed that the significant mushroom cancer association was only observed in studies from non-western regions (RR = 0.58, 95% CI: 0.47–0.71, p = 0.02; n = 14). Mushroom  consumption was associated with low risk of  breast cancer (RR = 0.65, 95% CI: 0.52–0.81) compared to non-breast cancer. Dose-response analysis suggested that 10 g/day increase in mushroom intakes was associated with a 17% lower risk of cancer (RR = 0.83, 95% CI: 0.73–0.96, P-trend = 0.01). Conclusions The current meta-analysis showed a significant inverse association between greater mushroom consumption and low risk of cancer. In particular, breast cancer appeared to be the most affected site as significant association with mushroom intake were only observed for cancers at this site. Large prospective studies, ideally randomized  controlled trials, are needed to investigate the association between mushrooms intake and risk of cancer. Funding Sources There was no external or internal funding to support this study.

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