Medicinal inorganic chemistry: an updated review on the status of metallodrugs and prominent metallodrug candidates

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Victor M. Miranda
Keyword(s):  
Inorganic Chemistry ◽  
Clinical Trials ◽  
Modern Medicine ◽  
Current Status ◽  
Toxic Agents ◽  
Drug Designing ◽  
The Status ◽  
Therapy And Diagnosis ◽  
Medicinal Inorganic Chemistry ◽  
Extensive List

Abstract Metallodrugs correspond to a small portion of all available drugs in the market and, yet, some of them are among the most used and important drugs in modern medicine. However, medicinal inorganic chemistry remains an underestimated area within medicinal chemistry and the main reason is the mislead association of metals to toxic agents. Thus, in this review, the potential of medicinal inorganic chemistry in drug designing is highlighted through a description of the current status of metallodrugs and metallodrug candidates in advanced clinical trials. The broad spectrum of application of metal-based drugs in medicine for both therapy and diagnosis is addressed by the extensive list of examples presented herein.

scholarly journals Selenium Species: Current Status and Potentials in Cancer Prevention and Therapy

2018 ◽  
Vol 20 (1) ◽  
pp. 75 ◽  
Author(s):  
Heng Tan ◽  
Hai-Ying Mo ◽  
Andy Lau ◽  
Yan-Ming Xu
Keyword(s):  
Clinical Trials ◽  
Cancer Prevention ◽  
Current Status ◽  
Essential Trace Element ◽  
Biological Functions ◽  
Anticancer Properties ◽  
Oxidation Reduction ◽  
The Status ◽  
Underlying Mechanisms ◽  
Prevention And Therapy

Selenium (Se) acts as an essential trace element in the human body due to its unique biological functions, particularly in the oxidation-reduction system. Although several clinical trials indicated no significant benefit of Se in preventing cancer, researchers reported that some Se species exhibit superior anticancer properties. Therefore, a reassessment of the status of Se and Se compounds is necessary in order to provide clearer insights into the potentiality of Se in cancer prevention and therapy. In this review, we organize relevant forms of Se species based on the three main categories of Se—inorganic, organic, and Se-containing nanoparticles (SeNPs)—and overview their potential functions and applications in oncology. Here, we specifically focus on the SeNPs as they have tremendous potential in oncology and other fields. In general, to make better use of Se compounds in cancer prevention and therapy, extensive further study is still required to understand the underlying mechanisms of the Se compounds.

Antibody Therapy for the Control of Viral Diseases: An Update

2019 ◽  
Vol 20 (13) ◽  
pp. 1108-1121 ◽  
Author(s):  
Miriam Dibo ◽  
Eduardo C. Battocchio ◽  
Lucas M. dos Santos Souza ◽  
Matheus D. Veloso da Silva ◽  
Bruna K. Banin-Hirata ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Monoclonal Antibodies ◽  
Viral Antigen ◽  
Viral Infections ◽  
Antibody Therapy ◽  
Therapeutic Strategies ◽  
Viral Diseases ◽  
Specific Antibodies ◽  
The Status ◽  
Epidemiological Impact

The epidemiological impact of viral diseases, combined with the emergence and reemergence of some viruses, and the difficulties in identifying effective therapies, have encouraged several studies to develop new therapeutic strategies for viral infections. In this context, the use of immunotherapy for the treatment of viral diseases is increasing. One of the strategies of immunotherapy is the use of antibodies, particularly the monoclonal antibodies (mAbs) and multi-specific antibodies, which bind directly to the viral antigen and bring about activation of the immune system. With current advancements in science and technology, several such antibodies are being tested, and some are already approved and are undergoing clinical trials. The present work aims to review the status of mAb development for the treatment of viral diseases.

scholarly journals Animal and Human Vaccines against West Nile Virus

Pathogens ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1073
Author(s):  
Juan-Carlos Saiz
Keyword(s):  
Clinical Trials ◽  
West Nile Virus ◽  
Vaccine Development ◽  
Phase Iii ◽  
West Nile ◽  
Specific Therapy ◽  
Phase Iii Clinical Trials ◽  
Neuroinvasive Disease ◽  
The Us ◽  
The Status

West Nile virus (WNV) is a widely distributed enveloped flavivirus transmitted by mosquitoes, which main hosts are birds. The virus sporadically infects equids and humans with serious economic and health consequences, as infected individuals can develop a severe neuroinvasive disease that can even lead to death. Nowadays, no WNV-specific therapy is available and vaccines are only licensed for use in horses but not for humans. While several methodologies for WNV vaccine development have been successfully applied and have contributed to significantly reducing its incidence in horses in the US, none have progressed to phase III clinical trials in humans. This review addresses the status of WNV vaccines for horses, birds, and humans, summarizing and discussing the challenges they face for their clinical advance and their introduction to the market.

Current Status of Clinical Trials on Tau Immunotherapies

Drugs ◽  
2021 ◽  
Author(s):  
Changyi Ji ◽  
Einar M. Sigurdsson
Keyword(s):  
Clinical Trials ◽  
Current Status

scholarly journals Dental Applications of Carbon Nanotubes

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4423
Author(s):  
Marco A. Castro-Rojas ◽  
Yadira I. Vega-Cantu ◽  
Geoffrey A. Cordell ◽  
Aida Rodriguez-Garcia
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanotubes ◽  
Oral Cavity ◽  
Current Status ◽  
Glass Ionomer ◽  
Oral Infections ◽  
Functional Behavior ◽  
The Status ◽  
Comprehensive Survey ◽  
Dental Applications

Glass ionomer cements and resin-based composites are promising materials in restorative dentistry. However, their limited mechanical properties and the risk of bulk/marginal fracture compromise their lifespan. Intensive research has been conducted to understand and develop new materials that can mimic the functional behavior of the oral cavity. Nanotechnological approaches have emerged to treat oral infections and become a part of scaffolds for tissue regeneration. Carbon nanotubes are promising materials to create multifunctional platforms for dental applications. This review provides a comprehensive survey of and information on the status of this state-of-the-art technology and describes the development of glass ionomers reinforced with carbon nanotubes possessing improved mechanical properties. The applications of carbon nanotubes in drug delivery and tissue engineering for healing infections and lesions of the oral cavity are also described. The review concludes with a summary of the current status and presents a vision of future applications of carbon nanotubes in the practice of dentistry.

Institutional repositories in Africa: Regaining direction

2021 ◽  
pp. 026666692110154
Author(s):  
Usman Ahmed Adam ◽  
Kiran Kaur
Keyword(s):  
Open Access ◽  
Research Output ◽  
Current Status ◽  
African Countries ◽  
Institutional Repositories ◽  
Widespread Implementation ◽  
Typical Performance ◽  
The Status ◽  
Global Access ◽  
And Cluster Analysis

Institutional repositories are powerful tools to facilitate global access to intellectual output by members of the institution, particularly in assisting them to preserve and maximize access to their research output globally. This exploratory study of the status of institutional repositories implementation in African countries using the global Directory of Open Access Repositories (OpenDOAR) and Transparent Ranking: All Repositories by Google Scholar, reports on the operational status and the performance of repositories. Factor analysis and cluster analysis are used to analyze the operational level of institutional repositories in African countries. The analysis showed that the typical performance of institutional repositories remains below average. The possibility of global open access to research results through institutional repositories in South Africa, Kenya, Nigeria, Algeria, Sudan, and Egypt appeared to be relatively more feasible than other African countries. This study concludes that many organizations, institutions, and societies spend great efforts in support of open access implementation in Africa, however, the widespread implementation of institutional repositories is still very slow paced, and the performance of the implemented repositories was below expectation. Suggestions for regaining the intended direction of African institutional repositories are given based on the current status.

scholarly journals Development of a Vaccine against Human Cytomegalovirus: Advances, Barriers, and Implications for the Clinical Practice

Vaccines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 551
Author(s):  
Sara Scarpini ◽  
Francesca Morigi ◽  
Ludovica Betti ◽  
Arianna Dondi ◽  
Carlotta Biagi ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Human Cytomegalovirus ◽  
Congenital Infection ◽  
Health Concern ◽  
Live Vaccines ◽  
Target Populations ◽  
Immune Correlates ◽  
Common Causes ◽  
The Status ◽  
Life Threatening

Human cytomegalovirus (hCMV) is one of the most common causes of congenital infection in the post-rubella era, representing a major public health concern. Although most cases are asymptomatic in the neonatal period, congenital CMV (cCMV) disease can result in permanent impairment of cognitive development and represents the leading cause of non-genetic sensorineural hearing loss. Moreover, even if hCMV mostly causes asymptomatic or pauci-symptomatic infections in immunocompetent hosts, it may lead to severe and life-threatening disease in immunocompromised patients. Since immunity reduces the severity of disease, in the last years, the development of an effective and safe hCMV vaccine has been of great interest to pharmacologic researchers. Both hCMV live vaccines—e.g., live-attenuated, chimeric, viral-based—and non-living ones—subunit, RNA-based, virus-like particles, plasmid-based DNA—have been investigated. Encouraging data are emerging from clinical trials, but a hCMV vaccine has not been licensed yet. Major difficulties in the development of a satisfactory vaccine include hCMV’s capacity to evade the immune response, unclear immune correlates for protection, low number of available animal models, and insufficient general awareness. Moreover, there is a need to determine which may be the best target populations for vaccine administration. The aim of the present paper is to examine the status of hCMV vaccines undergoing clinical trials and understand barriers limiting their development.

scholarly journals Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms

Vaccines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 263
Author(s):  
Valéria L. Carvalho ◽  
Maureen T. Long
Keyword(s):  
Clinical Trials ◽  
Current Status ◽  
Wild Type ◽  
New Locations ◽  
The Creation ◽  
New Vaccines

Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials. Insect-specific viruses (ISVs) offer a unique platform for expression of arbovirus proteins, through the creation of ISV/arbovirus chimeras. Studies have shown promising results of these vaccines with several advantages over their wild-type counterparts. In this review, we discuss the current status of these potential vaccines using ISVs.

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