Forming Diagnostic Opinions

Rhetorik ◽  
2018 ◽  
Vol 37 (1) ◽  
pp. 68-93
Author(s):  
Markus H. Woerner ◽  
Ricca Edmondson

Abstract Using an understanding of rhetoric as a method of communicative reasoning capable of providing grounds for conviction in those to whom it is addressed, this article argues that the formation of medical diagnoses shares a structure with Aristotle’s account of the rhetorical syllogism (the enthymeme). Here the argument itself (logos), together with characterological elements (ethos) and emotions (pathos), are welded together so that each affects the operation of the others. In the initial three sections of the paper, we contend, first, that diagnoses, as verdictive performatives, differ from scientific claims in being irreducibly personal and context-dependent; secondly, that they fit the structure of voluntary action as analysed by Aristotle and Aquinas; thirdly, that as practical syllogisms they differ from theoretical syllogisms, for example in taking effect in action, being ›addressed‹, and being intrinsically embedded in wider contexts of medical communication and practices. In the remaining sections we apply this account to textual evidence about diagnosis, drawing on work by the brain surgeon Henry Marsh. A rhetorical analysis of his observations on the formation of diagnostic opinions in situilluminates how moral, social and emotional features are fused with the cognitive aspects of medical judgement, making or marring how diagnoses and treatment are enacted. In other words, a philosophical- rhetorical account of diagnosis can help us to appreciate how medical diagnosis takes effect. We briefly conclude with some implications of our work for how diagnostic processes could in practice be better supported.

1992 ◽  
Vol 57 (1) ◽  
pp. 194-203 ◽  
Author(s):  
Karel Šindelář ◽  
Vojtěch Kmoníček ◽  
Marta Hrubantová ◽  
Zdeněk Polívka

(Arylthio)benzoic acids IIa - IIe and VIb - VId were transformed via the acid chlorides to the N,N-dimethylamides which were reduced either with diborane "in situ" or with lithium aluminium hydride to N,N-dimethyl-(arylthio)benzylamines Ia - Ie and Vb - Vd. Leuckart reaction of the aldehydes IX and X with dimethylformamide and formic acid afforded directly the amines Va and Ve. Demethylation of the methoxy compounds Ia and Ve with hydrobromic acid resulted in the phenolic amines If and Vf. The most interesting N,N-dimethyl-4-(phenylthio)benzylamine (Va) hydrochloride showed affinity to cholinergic and 5-HT2 serotonin receptors in the rat brain and some properties considered indicative of antidepressant activity (inhibition of serotonin re-uptake in the brain and potentiation of yohimbine toxicity in mice).


Development ◽  
1993 ◽  
Vol 119 (1) ◽  
pp. 247-261 ◽  
Author(s):  
B.A. Parr ◽  
M.J. Shea ◽  
G. Vassileva ◽  
A.P. McMahon

Mutation and expression studies have implicated the Wnt gene family in early developmental decision making in vertebrates and flies. In a detailed comparative analysis, we have used in situ hybridization of 8.0- to 9.5-day mouse embryos to characterize expression of all ten published Wnt genes in the central nervous system (CNS) and limb buds. Seven of the family members show restricted expression patterns in the brain. At least three genes (Wnt-3, Wnt-3a, and Wnt-7b) exhibit sharp boundaries of expression in the forebrain that may predict subdivisions of the region later in development. In the spinal cord, Wnt-1, Wnt-3, and Wnt-3a are expressed dorsally, Wnt-5a, Wnt-7a, and Wnt-7b more ventrally, and Wnt-4 both dorsally and in the floor plate. In the forelimb primordia, Wnt-3, Wnt-4, Wnt-6 and Wnt-7b are expressed fairly uniformly throughout the limb ectoderm. Wnt-5a RNA is distributed in a proximal to distal gradient through the limb mesenchyme and ectoderm. Along the limb's dorsal-ventral axis, Wnt-5a is expressed in the ventral ectoderm and Wnt-7a in the dorsal ectoderm. We discuss the significance of these patterns of restricted and partially overlapping domains of expression with respect to the putative function of Wnt signalling in early CNS and limb development.


2021 ◽  
pp. 1-12
Author(s):  
Joonkoo Park ◽  
Sonia Godbole ◽  
Marty G. Woldorff ◽  
Elizabeth M. Brannon

Abstract Whether and how the brain encodes discrete numerical magnitude differently from continuous nonnumerical magnitude is hotly debated. In a previous set of studies, we orthogonally varied numerical (numerosity) and nonnumerical (size and spacing) dimensions of dot arrays and demonstrated a strong modulation of early visual evoked potentials (VEPs) by numerosity and not by nonnumerical dimensions. Although very little is known about the brain's response to systematic changes in continuous dimensions of a dot array, some authors intuit that the visual processing stream must be more sensitive to continuous magnitude information than to numerosity. To address this possibility, we measured VEPs of participants viewing dot arrays that changed exclusively in one nonnumerical magnitude dimension at a time (size or spacing) while holding numerosity constant and compared this to a condition where numerosity was changed while holding size and spacing constant. We found reliable but small neural sensitivity to exclusive changes in size and spacing; however, changing numerosity elicited a much more robust modulation of the VEPs. Together with previous work, these findings suggest that sensitivity to magnitude dimensions in early visual cortex is context dependent: The brain is moderately sensitive to changes in size and spacing when numerosity is held constant, but sensitivity to these continuous variables diminishes to a negligible level when numerosity is allowed to vary at the same time. Neurophysiological explanations for the encoding and context dependency of numerical and nonnumerical magnitudes are proposed within the framework of neuronal normalization.


2017 ◽  
Vol 24 (3) ◽  
pp. 244
Author(s):  
B. Domingo-Arrué ◽  
R. Gil-Benso ◽  
J. Megías ◽  
L. Navarro ◽  
T. San-Miguel ◽  
...  

We report a case of a recurrent clear cell meningioma (ccm) in the frontal lobe of the brain of a 67-year-old man. The patient developed three recurrences: at 3, 10, and 12 years after his initial surgery. Histopathology observations revealed a grade 2 ccm with positivity for vimentin and epithelial membrane antigen. Expression of E-cadherin was positive only in the primary tumour and in the first available recurrence. Fluorescence in situ hybridization analyses demonstrated 1p and 14q deletions within the last recurrence. Multiplex ligation-dependent probe amplification studies revealed a heterozygous partial NF2 gene deletion, which progressed to total loss in the last recurrence. The last recurrence showed homozygous deletions in CDKN2A and CDKN2B. The RASSF1 gene was hypermethylated during tumour evolution.In this report, we show the genetic alterations of a primary ccm and its recurrences to elucidate their relationships with the changes involved in the progression of this rare neoplasm.


1993 ◽  
Vol 264 (4) ◽  
pp. C995-C1002 ◽  
Author(s):  
W. T. Monacci ◽  
M. J. Merrill ◽  
E. H. Oldfield

Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) is a approximately 43-kDa secreted protein that has been shown in bioassays to induce endothelial proliferation, angiogenesis, and capillary hyperpermeability. VPF has been suggested to play an important role in the physiology of normal vasculature. To further elucidate the natural functions of VPF in vivo, the expression of VPF in normal tissues was examined using Northern blot analysis and in situ hybridization histochemistry. VPF mRNA is expressed in the brain, kidney, liver, lung, and spleen of the healthy adult rat. On Northern blots, the relative abundance of VPF mRNA observed in these tissues was highest in the lung and lowest in the spleen. As determined by in situ hybridization, the patterns of VPF expression are organ specific. Hybridization of an antisense VPF probe was concentrated in the cerebellar granule cell layer of the brain and in the glomeruli and tubules of the kidney. In the liver and lung, intense hybridization was observed homogeneously throughout both tissues, demonstrating that VPF mRNA is present in virtually every hepatocyte and pulmonary alveolar cell. Hybridization to the spleen was weaker and more diffuse. The widespread expression and organ-specific distribution of VPF mRNA in normal rat tissues supports the suggestion of an extensive role for this factor in the physiology of normal vasculature.


1978 ◽  
Vol 44 (4) ◽  
pp. 528-533 ◽  
Author(s):  
J. Seylaz ◽  
E. Pinard

A mass spectrograph technique has been developed for measurement of physiological gas partial pressures locally in the brain. The sampling cannula is implanted stereotaxically and remains in situ for several weeks. It is a thin cylinder in shape, and is covered with a thin polyethylene membrane across which gas molecules can be sampled continuously. The conductance of this membrane is well adapted to the limited rate of replacement of gas molecules afforded by the cerebral tissue, hence there is no depletion around the cannula; this depletion has until now been the major problem of this technology. The present technique provides a continuous measurement with fast response time, which is directly proportional to the partial pressures of the gases. The variations can be expressed as a percentage of the base-line value.


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