scholarly journals Ethical Dimensions of Human Organoids Research

2021 ◽  
Vol 83 (9) ◽  
pp. 575-578
Author(s):  
Tashaé Gomez-Jones ◽  
Robert M. Kao
Keyword(s):  
Stem Cells ◽  
Mammalian Cell ◽  
Three Dimensional ◽  
Review Article ◽  
Cross Cultural ◽  
Ethical Framework ◽  
The Past ◽  
Cell Organization ◽  
The Cross

Over the past decade, the development of three-dimensional mammalian cell organization—called human organoids—from stem cells has provided a framework for future clinical therapies. As human organoid research progresses, we also need to keep in mind the cross-cultural and ethical dimensions of human organoids research. Our review article aims to examine the ethical dimensions of cerebral human organoids and provide an ethical framework guide within human organoids research.

Missionary Women as Models in the Cross-Cultural Context

1982 ◽  
Vol 10 (4) ◽  
pp. 455-460 ◽  
Author(s):  
Frances Hiebert
Keyword(s):  
Cultural Context ◽  
Cross Cultural ◽  
Women Missionaries ◽  
Past Century ◽  
The Past ◽  
Success Stories ◽  
Mission Agencies ◽  
The Cross ◽  
Missionary Women ◽  
The Church

Long neglected in missionary histories, women missionaries are the unsung heroes of the past century, and well may be the source of much of this century's missionary success stories, says Fran Hiebert in this provocative article. Instead of claiming to be the champions of women, Western mission agencies may need to repent and look for some ashcloth if they are not going to lose their credibility vis-à-vis the church in the Two-Thirds World.

Curatorial Work

2016 ◽  
Author(s):  
Tarek Elhaik
Keyword(s):  
Contemporary Art ◽  
Cross Cultural ◽  
National Museum ◽  
Cultural Approach ◽  
The Past ◽  
Total Destruction ◽  
The Media ◽  
The Cross

This chapter examines the dominant concepts that form the so-called ethnographic turn in contemporary art, including the cross-cultural approach. It first provides an overview of the notions of montage and animation that have been added to the media anthropological repertoire before discussing post-Mexican assemblages. It then looks at Roger Bartra's notion of a ‘post-Mexican condition’, Silvia Gruner's archaeophobic video Don't Fuck with the Past, You Might Get Pregnant and Eduardo Abaroa's iconoclastic installation The Total Destruction of the National Museum of Anthropology, highlighting the lessons that can be learned from this assemblage of seemingly nihilistic gestures and post-anthropological attitudes. It also introduces the contemporary anthropologist's mode of curatorial work and argues that the stakes behind this ‘assemblage-work’ are nothing less than the differential futures brewing in the contemporariness of contemporary anthropology and contemporary curation.

scholarly journals Cross-Cultural Communication of Regional Images Based on Multimodal Discourse Analysis and Network Security

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Qing Xu ◽  
Guangming Wang
Keyword(s):  
Network Security ◽  
Information Overload ◽  
Three Dimensional ◽  
Indicator System ◽  
Cross Cultural ◽  
Cultural Communication ◽  
Location Service ◽  
Cross Cultural Communication ◽  
Multimodal Discourse ◽  
The Cross

Numerous evaluation methods are used as effective indicators for the cross-cultural communication of a regional image. However, because these indicators are primarily in a foreign cultural situation, it is challenging to measure their attitudes and cognitions across geographic distances and cultural differences. This challenge motivated us to combine cultural communication methods and modern location service technology to carry out regional image communication research. First, this article examines the basic process of cross-cultural communication and the generation of regional images from an information transmission and network security perspective. It combines multimodal discourse to analyze influencing factors and establishes a hierarchical model of the cross-cultural communication indicator system. Secondly, based on the location-based service (LBS), this article adds scene information to develop a user tendency model. This model effectively handles the conversion between two-dimensional scoring space and three-dimensional tendency space and can adapt to the short-term changes of users' tendency. The experimental results verify that the location-based e-commerce recommendation algorithm proposed in this paper can better solve information overload and obtain a significant recommendation effect.

Organoids: Three-Dimensional ‘blobs’ that are Reshaping the Future of Medicine

2021 ◽  
Author(s):  
Nicole Min Qian Pek
Keyword(s):  
Stem Cells ◽  
Developmental Disorders ◽  
Metabolic Diseases ◽  
Three Dimensional ◽  
Human Diseases ◽  
Disease Phenotypes ◽  
The Past ◽  
Model Complex ◽  
Dimensional Cell

Over the past decade, new advancements in stem cell and three-dimensional cell culture technologies have reignited interests in organoid research. The unassuming ‘blobs’ of cells made to mimic organs are revolutionizing human medicine. By utilizing stem cells such as human pluripotent stem cells (hPSCs), a wide variety of organoids can be generated in the lab. hPSC-derived organoids have proven to be powerful tools to model complex human diseases including but not limited to developmental disorders, degenerative diseases, infectious diseases, metabolic diseases, and cancers. Due to their complexities and multi-cellularity, these organoids can better recapitulate sophisticated disease phenotypes when compared to monolayered cells. Diseased organoids can then be easily expanded in vitro for drug discovery or high-throughput therapeutic screening. Organoid transplantation is also currently explored in the field of regenerative medicine. Researchers are now looking towards the generation of ‘next-gen’ organoids that reflect even higher degrees of organ complexities to achieve greater levels of cellular maturity and functionality while still maintaining its relatively simple form. Organoids, undoubtedly, hold tremendous promise in helping us understand and treat a wide array of human diseases.

scholarly journals Role of Three-Dimensional Visualization Modalities in Medical Education

2021 ◽  
Vol 9 ◽  
Author(s):  
Ivy Bui ◽  
Arunabh Bhattacharya ◽  
Si Hui Wong ◽  
Harinder R. Singh ◽  
Arpit Agarwal
Keyword(s):  
Medical Education ◽  
3D Visualization ◽  
Three Dimensional ◽  
Content Delivery ◽  
Review Article ◽  
Anatomical Models ◽  
The Past ◽  
Education Experience ◽  
3D Printed

For the past two decades, slide-based presentation has been the method of content delivery in medical education. In recent years, other teaching modalities involving three-dimensional (3D) visualization such as 3D printed anatomical models, virtual reality (VR), and augmented reality (AR) have been explored to augment the education experience. This review article will analyze the use of slide-based presentation, 3D printed anatomical models, AR, and VR technologies in medical education, including their benefits and limitations.

scholarly journals The Progress and Prospects of Putative Biomarkers for Liver Cancer Stem Cells in Hepatocellular Carcinoma

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Yan Xiang ◽  
Ting Yang ◽  
Bing-yao Pang ◽  
Ying Zhu ◽  
Yong-ning Liu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Review Article ◽  
Curative Effect ◽  
The Past ◽  
Liver Cancer Stem Cells

Accumulating evidence suggests that hepatocellular carcinoma (HCC) is organized by liver cancer stem cells (LCSCs), which are a subset of cells with “stem-like” characteristics. Identification of the LCSCs is a fundamental and important problem in HCC research. LCSCs have been investigated by various stem cell biomarkers. There is still lack of consensus regarding the existence of a “global” marker for LCSCs in HCC. In this review article, we summarize the progress and prospects of putative biomarkers for LCSCs in the past decades, which is essential to develop future therapies targeting CSCs and to predict prognosis and curative effect of these therapies.

Mitochondrial Reconstructions Based on Serial Thick Sections and HVEM

1975 ◽  
Vol 33 ◽  
pp. 286-287
Author(s):  
Jerome J. Paulin
Keyword(s):  
Imaging Techniques ◽  
Three Dimensional ◽  
Posterior Pole ◽  
Dimensional Structure ◽  
Stereo Imaging ◽  
Thin Sections ◽  
Anatomical Features ◽  
The Past ◽  
Cellular Components ◽  
Mitochondrial Reticulum

Within the past decade it has become apparent that HVEM offers the biologist a means to explore the three-dimensional structure of cells and/or organelles. Stereo-imaging of thick sections (e.g. 0.25-10 μm) not only reveals anatomical features of cellular components, but also reduces errors of interpretation associated with overlap of structures seen in thick sections. Concomitant with stereo-imaging techniques conventional serial Sectioning methods developed with thin sections have been adopted to serial thick sections (≥ 0.25 μm). Three-dimensional reconstructions of the chondriome of several species of trypanosomatid flagellates have been made from tracings of mitochondrial profiles on cellulose acetate sheets. The sheets are flooded with acetone, gluing them together, and the model sawed from the composite and redrawn.The extensive mitochondrial reticulum can be seen in consecutive thick sections of (0.25 μm thick) Crithidia fasciculata (Figs. 1-2). Profiles of the mitochondrion are distinguishable from the anterior apex of the cell (small arrow, Fig. 1) to the posterior pole (small arrow, Fig. 2).

Three-dimensional image analysis and visualization in confocal light microscopy

1993 ◽  
Vol 51 ◽  
pp. 158-159
Author(s):  
J. K. Samarabandu ◽  
R. Acharya ◽  
D. R. Pareddy ◽  
P. C. Cheng
Keyword(s):  
Depth Perception ◽  
Computer Graphic ◽  
Three Dimensional ◽  
Cellular Organization ◽  
Data Set ◽  
Computational Burden ◽  
Interactive Operation ◽  
Cell Organization ◽  
Confocal Images ◽  
3D Digitization

In the study of cell organization in a maize meristem, direct viewing of confocal optical sections in 3D (by means of 3D projection of the volumetric data set, Figure 1) becomes very difficult and confusing because of the large number of nucleus involved. Numerical description of the cellular organization (e.g. position, size and orientation of each structure) and computer graphic presentation are some of the solutions to effectively study the structure of such a complex system. An attempt at data-reduction by means of manually contouring cell nucleus in 3D was reported (Summers et al., 1990). Apart from being labour intensive, this 3D digitization technique suffers from the inaccuracies of manual 3D tracing related to the depth perception of the operator. However, it does demonstrate that reducing stack of confocal images to a 3D graphic representation helps to visualize and analyze complex tissues (Figure 2). This procedure also significantly reduce computational burden in an interactive operation.

The Cross-Cultural Equivalence of Parental Rearing Measure: EMBU-C

2006 ◽  
Vol 22 (2) ◽  
pp. 85-91 ◽  
Author(s):  
Maja Deković ◽  
Margreet ten Have ◽  
Wilma A.M. Vollebergh ◽  
Trees Pels ◽  
Annerieke Oosterwegel ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Cultural Differences ◽  
Cross Cultural ◽  
Child Rearing ◽  
Latent Factors ◽  
Immigrant Adolescents ◽  
Confirmatory Factor ◽  
Parental Rearing ◽  
The Cross ◽  
Multigroup Confirmatory Factor Analysis

We examined the cross-cultural equivalence of a widely used instrument that assesses perceived parental rearing, the EMBU-C, among native Dutch and immigrant adolescents living in The Netherlands. The results of a multigroup confirmatory factor analysis indicated that the factor structure of the EMBU-C, consisting of three latent factors (Warmth, Rejection, and Overprotection), and reliabilities of these scales are similar in both samples. These findings lend further support for the factorial and construct validity of this instrument. The comparison of perceived child rearing between native Dutch and immigrant adolescents showed cultural differences in only one of the assessed dimensions: Immigrant adolescents perceive their parents as more overprotective than do Dutch adolescents.

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