Including Individuals with Memory Impairment in the Research Process: The Importance of Scales and Response Categories Used in Surveys

2012 ◽  
Vol 7 (2) ◽  
pp. 70-79 ◽  
Author(s):  
Maura L. Krestar ◽  
Wendy Looman ◽  
Sara Powers ◽  
Nicole Dawson ◽  
Katherine S. Judge
Keyword(s):  
Memory Impairment ◽  
Research Process ◽  
With Memory

scholarly journals Early stages of tau pathology and its associations with functional connectivity, atrophy and memory

Brain ◽  
2021 ◽  
Author(s):  
David Berron ◽  
Jacob W Vogel ◽  
Philip S Insel ◽  
Joana B Pereira ◽  
Long Xie ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Entorhinal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Impairment ◽  
Memory Performance ◽  
Hippocampal Atrophy ◽  
Tau Pathology ◽  
Β Amyloid ◽  
With Memory

Abstract In Alzheimer’s disease, postmortem studies have shown that the first cortical site where neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial temporal lobe that largely overlaps with area 35, and the entorhinal cortex. Here we used tau-PET imaging to investigate the sequence of tau pathology progression within the human medial temporal lobe and across regions in the posterior-medial system. Our objective was to study how medial temporal tau is related to functional connectivity, regional atrophy, and memory performance. We included 215 β-amyloid negative cognitively unimpaired, 81 β-amyloid positive cognitively unimpaired and 87 β-amyloid positive individuals with mild cognitive impairment, who each underwent [18]F-RO948 tau and [18]F-flutemetamol amyloid PET imaging, structural T1-MRI and memory assessments as part of the Swedish BioFINDER-2 study. First, event-based modelling revealed that the entorhinal cortex and area 35 show the earliest signs of tau accumulation followed by the anterior and posterior hippocampus, area 36 and the parahippocampal cortex. In later stages, tau accumulation became abnormal in neocortical temporal and finally parietal brain regions. Second, in cognitively unimpaired individuals, increased tau load was related to local atrophy in the entorhinal cortex, area 35 and the anterior hippocampus and tau load in several anterior medial temporal lobe subregions was associated with distant atrophy of the posterior hippocampus. Tau load, but not atrophy, in these regions was associated with lower memory performance. Further, tau-related reductions in functional connectivity in critical networks between the medial temporal lobe and regions in the posterior-medial system were associated with this early memory impairment. Finally, in patients with mild cognitive impairment, the association of tau load in the hippocampus with memory performance was partially mediated by posterior hippocampal atrophy. In summary, our findings highlight the progression of tau pathology across medial temporal lobe subregions and its disease-stage specific association with memory performance. While tau pathology might affect memory performance in cognitively unimpaired individuals via reduced functional connectivity in critical medial temporal lobe-cortical networks, memory impairment in mild cognitively impaired patients is associated with posterior hippocampal atrophy.

A CSF biomarker of intrathecal B cells activation correlates with memory impairment in multiple sclerosis

2021 ◽  
Vol 429 ◽  
pp. 117772
Author(s):  
Lorenzo Gaetani ◽  
Giovanni Brachelente ◽  
Nicola Salvadori ◽  
Elena Chipi ◽  
Elena Di Sabatino ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
B Cells ◽  
Memory Impairment ◽  
Csf Biomarker ◽  
With Memory

scholarly journals Delayed recall memory impairment in patients with Parkinson's disease

2016 ◽  
Vol 10 (3) ◽  
pp. 204-209 ◽  
Author(s):  
Arthur Oscar Schelp ◽  
Cristiane Lara Mendes-Chiloff ◽  
Vanessa Cristina Paduan ◽  
José Eduardo Corrente ◽  
Fabrício Diniz de Lima ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Episodic Memory ◽  
Memory Impairment ◽  
Rating Scale ◽  
Demographic Variables ◽  
Delayed Recall ◽  
Recall Memory ◽  
Significant Difference ◽  
With Memory

ABSTRACT Age is one of the risk factors for dementia in patients with Parkinson's disease (PDD). Distinct cognitive syndromes of Parkinson's disease (PD) have been identified in previous studies. Questions about the role of such cognitive disorders in PD outcomes, especially memory dysfunction, in patients with PD remain unanswered. Objective: To establish possible correlations between delayed recall memory (episodic memory), age, and other demographic variables in patients with PD. Methods: A two-stage protocol was applied. Patients with delayed recall memory compromise, selected based on a brief battery of tests (BBRC-Edu), were classified as dementia cases and submitted to the Mattis Dementia Rating Scale (MDRS). Data from patients with memory disturbances were compared against individuals without episodic memory impairment, and correlated with age and demographic variables. Results: Except for identification and naming, all subtests in the screening battery showed a significant difference (p≤0.0001) between the memory-compromised group (case) and the group without memory impairment (no case). The results also correlated negatively with age (p≤0.0001) and positively with level of education (p=0.0874) in patients with PD. Conclusion: The analysis showed a significant relationship between age and dementia characterized by impaired episodic memory. The findings support reports of a wide spectrum of neuropsychological performance impairment in PD with age, particularly dementia associated with memory deterioration. No correlations between disease duration and cognitive dysfunction were evident.

Unilateral ECT: Advantages and Efficacy in the Treatment of Depression

1985 ◽  
Vol 30 (2) ◽  
pp. 142-147 ◽  
Author(s):  
Réjean Fontaine ◽  
Trevor Young
Keyword(s):  
Electroconvulsive Therapy ◽  
Recovery Time ◽  
Memory Impairment ◽  
Technical Aspect ◽  
Drug Resistant ◽  
Dominant Hemisphere ◽  
Several Variables ◽  
Treatment Of Depression ◽  
Efficacious Treatment ◽  
With Memory

Electroconvulsive therapy is an efficacious treatment for some acute or drug resistant psychiatric disorders. However, there is some concern with memory impairment and brain damage and in order to decrease these complications, some changes to the technical aspect of electroconvulsive therapy were implemented during the last few decades. One of the major changes is the use of unilateral electrical stimulation on the non-dominant hemisphere which leads to less memory impairment and faster recovery time of cognitive functions. However, for optimal efficacy several variables have to be understood and integrated: electrodes placement, interelectrodes distance, waveform stimuli.

A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment

Neurology ◽  
1996 ◽  
Vol 46 (1) ◽  
pp. 149-154 ◽  
Author(s):  
M. C. Tierney ◽  
J. P. Szalai ◽  
W. G. Snow ◽  
R. H. Fisher ◽  
T. Tsuda ◽  
...  
Keyword(s):  
Prospective Study ◽  
Memory Impairment ◽  
Clinical Utility ◽  
Apoe Genotype ◽  
Prediction Of Outcome ◽  
A Prospective Study ◽  
With Memory

scholarly journals Vgkc Encephalitis With Low-Titer Antibodies: Case Report

2020 ◽  
pp. 1-3
Author(s):  
Sena Aksoy ◽  
◽  
Mina Uzülmez ◽  
Aysun Soysal ◽  
◽  
...  
Keyword(s):  
Case Report ◽  
Potassium Channel ◽  
Memory Impairment ◽  
Psychiatric Symptoms ◽  
Autoimmune Encephalitis ◽  
Voltage Gated ◽  
With Memory

Voltage-gated potassium channel (VGKC) encephalitis is a type of autoimmune encephalitis, that presents with memory impairment, headache, psychiatric symptoms and seizures. Although contactin-associated protein 2 (CASPR2) and leucine-rich glioma inactivated 1 (LGI1) are clearly identifed as components of the VGKC complex, additional subtypes are known to exist. In this report, we present a case of 64-year-old patient with VGKC antibodies, negative for CASPR2 and LGI1

scholarly journals Communicating through music: creating accessible songs for Individuals with memory loss

2021 ◽  
Author(s):  
Hallie Anthony
Keyword(s):  
Verbal Memory ◽  
Memory Loss ◽  
Research Process ◽  
Future Research ◽  
Human Communication ◽  
Information Retention ◽  
Scholarly Literature ◽  
Musical Compositions ◽  
Original Musical ◽  
With Memory

This Major Research Paper (MRP) is a research-­creation project that explores the role, impact and influence of music n human communication. More specifically, this MRP investigates the way that music can assist in cognitive comprehension and information retention in individuals with varied forms of memory loss and considers the ways that music can be used to assist in aiding verbal memory and communicating emotion. It also offers insight on methods that could be utilized to further study this area of research. As a research-­creation project, this MRP includes three original musical compositions (Composition A1, Composition B2, and Composition C3) that were developed in response to the scholarly literature on this topic. The three musical compositions that have been produced for this project aim to communicate emotion, create aesthetic satisfaction, and aid in reinforcing the production of memories based on the information presented in the compositions. The composition creation process was informed by information gathered throughout the research process that addresses topics such as: the influence of music on individual listeners, emotion in music, and musical techniques that can be used to successfully communicate ideas. Beyond the scope of this MRP/research-­creation project, these compositions aim to serve as a basis for testing cognitive function in individuals with varied forms of memory loss. Detailed discussion of the design of the musical compositions, including information related to the composition influences, and a breakdown of each composition are included alongside the MRP’s focus on scholarly literature and research. Furthermore, the potential implications of these compositions, including the ways they could assist in future research, is discussed.

The Experience of Dementia Communication

2020 ◽  
pp. 83-106
Author(s):  
Alison Wray
Keyword(s):  
Individual Differences ◽  
Memory Impairment ◽  
Emotional Experience ◽  
Communication Problems ◽  
Personal Resilience ◽  
The Many ◽  
With Memory

Communication is an early casualty of dementia symptoms on account of the loss of confidence and agency arising from reduced expressive ability, plus the challenges to identity associated with memory impairment. Drawing on first-hand accounts, this chapter explores how people living with a dementia and their carers perceive the role of communication problems in shaping their experiences, and what they say they need for their lives to be easier. The emotional experience of being a family or professional carer is considered. The concept of emotional reserve is introduced, as a means of accounting for individual differences in personal resilience to the many challenges associated with living with a dementia or caring for someone who is.

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