HORMONE ASSAYS DURING RECURRENT EXCESSIVE HAIRGROWTH IN PREGNANCY

1964 ◽  
Vol 45 (3) ◽  
pp. 447-456 ◽  
Author(s):  
Aarno Turunen ◽  
Sykkö Pesonen ◽  
Harry Zilliacus
Keyword(s):  
Placental Tissue ◽  
Normal Subjects ◽  
First Trimester ◽  
Control Group ◽  
Steroid Synthesis ◽  
Incubation Experiments ◽  
Before And After ◽  
Stimulation Tests ◽  
First Trimester Of Pregnancy ◽  
Hormone Excretion

ABSTRACT Three cases of recurrent excessive hairgrowth during pregnancy are described. The hormone excretion of two of these women was studied before and after stimulation tests. The patients received 40 IU of corticotrophin as an intravenous infusion and in addition a total of 3 mg fluorocortisone to produce suppression of the adrenals. Urinary steroids were determined before and during the stimulation tests. Four patients who were in the first trimester of pregnancy served as controls. After the legal termination of pregnancy incubation experiments with placental tissue were carried out to determine the ability of the placenta to convert the 17-OH-group of testosterone to the 17-keto-group. The results of these experiments were compared with those in normal subjects. In one case pregnancy had been legally terminated, and in the other the placenta was full-term. In both patients an increased 17-OH-progesterone secretion and some block in steroid synthesis were responsible for dysfunction. The excretion of total 17-ketosteroids, epiandrosterone and androsterone were higher in these patients than in the control group. In incubation experiments of placental tissue it was confirmed that the 17β-dehydrogenase activity of the patients was lower than in the control placenta. Hence, the inactivating capacity of testosterone was less than that of the control group. This phenomenon may be responsible for an increased level of testosterone in the plasma of the patients and of excessive hairgrowth during pregnancy. Of the six children born to the three mothers with recurrent excessive hairgrowth during pregnancy, three had severe congenital malformations, in one case of the heart and in two cases of the extremities.

FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

1962 ◽  
Vol 41 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Pentti A. Järvinen ◽  
Sykkö Pesonen ◽  
Pirkko Väänänen
Keyword(s):  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Control Group ◽  
Before And After ◽  
Daily Urine ◽  
First Trimester Of Pregnancy ◽  
The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

The relation to pregnancy, the child, motherhood of women in IVF situation

2015 ◽  
Vol 6 (4) ◽  
pp. 97-104
Author(s):  
Arina Yurevna Malenova ◽  
Irina Gennadevna Kytkova
Keyword(s):  
Family Relations ◽  
First Trimester ◽  
Family Education ◽  
In Vitro Fertilisation ◽  
Control Group ◽  
The Family ◽  
Before And After ◽  
Group 2 ◽  
High Level

Research objective - studying of features of the relation to pregnancy, the child, motherhood of women in IVF situation. Selection: 100 married pregnant women aged from 28 till 42 years (the first pregnancy of the first trimester, complications in the anamnesis isn't present) representing two groups on 50 people: 1) after artificial insemination (empirical group); 2) in a situation natural pregnancy (control group). The leading motives of pregnancy, types of the attitude towards themselves, pregnancies, to the child, people around, the prevailing installations in the sphere of the family relations, features of representation of future mothers about themselves and "the ideal parent" are defined by testing. Distinctions in all respects with women from control group are found. It is established that in vitro fertilisation the high level of readiness for motherhood according to its motivational characteristics is observed. Prevalence of constructive motives of pregnancy against concern in the health and aspirations to meet social expectations is revealed. The leading types of a gestational dominant are optimum and euphoric, the hypertrophied positive emotional background of pregnancy is observed. In the future of a bike probability the dependent relations with the child, preference of the sponsoring or authoritative style of family education. Revaluation of own parental qualities when comparing with image of ideal mother is observed. Results allow to carry women to the group of risk demanding psychological maintenance before and after the childbirth.

The Source of Serum Ferritin during Infection. Studies with Concanavalin A–Sepharose Absorption

1980 ◽  
Vol 59 (5) ◽  
pp. 385-387 ◽  
Author(s):  
G. Birgegård
Keyword(s):  
Serum Ferritin ◽  
Concanavalin A ◽  
Normal Subjects ◽  
Normal Serum ◽  
Control Group ◽  
Serum Samples ◽  
Tissue Samples ◽  
Group Of Seven ◽  
Acute Infections ◽  
Before And After

1. Serum samples were collected from ten patients hospitalized for acute infections and from a control group of seven normal subjects. Tissue ferritin was obtained by purification of ferritin from normal human liver and from the ferritin standard of a commercially available assay kit. 2. The serum and tissue samples were incubated with concanavalin A-Sepharose, which has the ability to bind normal serum ferritin. 3. Concanavalin A, a plant lectin which binds to glucose, can be coupled to Sepharose particles and by incubation and centrifugation ferritin in normal serum can be absorbed to about 70%. The serum and tissue samples were incubated with concanavalin A-Sepharose and the ferritin content was measured before and after. 4. It was found that ferritin in the serum of patients with acute infections was absorbed to the same extent as in normal serum (about 80%), irrespective of the initial value. Only about 20% of the tissue ferritin was absorbed. 5. It is concluded that the ferritin in serum during infection is of the same glucosylated type as the ferritin normally present in serum, whereas intracellular ferritin is not glycosylated. This indicates that the elevation of serum ferritin during infection is caused by a release along the normal pathways, i.e. an augmented synthesis, not by leakage from damaged cells.

scholarly journals Could molecular assessment of calcium metabolism be a useful tool to early screen patients at risk for pre-eclampsia complicated pregnancy? Proposal and rationale

2015 ◽  
Vol 53 (7) ◽  
Author(s):  
Salvatore Gizzo ◽  
Marco Noventa ◽  
Stefania Di Gangi ◽  
Carlo Saccardi ◽  
Erich Cosmi ◽  
...  
Keyword(s):  
Calcium Intake ◽  
Calcium Metabolism ◽  
Large Scale ◽  
Calcium Supplementation ◽  
English Literature ◽  
First Trimester ◽  
Control Group ◽  
Hypertensive Disorders ◽  
Increased Risk ◽  
First Trimester Of Pregnancy

AbstractOne of the most frequent causes of maternal and perinatal morbidity is represented by hypertensive disorders during pregnancy. Women at high risk must be subjected to a more intensive antenatal surveillance and prophylactic treatments. Many genetic risk factors, clinical features and biomarkers have been proposed but none of these seems able to prevent pre-eclampsia onset. English literature review of manuscripts focused on calcium intake and hypertensive disorders during pregnancy was performed. We performed a critical analysis of evidences about maternal calcium metabolism pattern in pregnancy analyzing all possible bias affecting studies. Calcium supplementation seems to give beneficial effects on women with low calcium intake. Some evidence reported that calcium supplementation may drastically reduce the percentage of pre-eclampsia onset consequently improving the neonatal outcome. Starting from this evidence, it is intuitive that investigations on maternal calcium metabolism pattern in first trimester of pregnancy could represent a low cost, large scale tool to screen pregnant women and to identify those at increased risk of pre-eclampsia onset. We propose a biochemical screening of maternal calcium metabolism pattern in first trimester of pregnancy to discriminate patients who potentially may benefit from calcium supplementation. In a second step we propose to randomly allocate the sub-cohort of patients with calcium metabolism disorders in a treatment group (calcium supplementation) or in a control group (placebo) to define if calcium supplementation may represent a dietary mean to reduce pre-eclampsia onset and to improve pregnancy outcome.

scholarly journals Exposure to Propylthiouracil in the First Trimester of Pregnancy and Birth Defects: A Study at a Single Institution

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Ai Yoshihara ◽  
Jaeduk Yoshimura Noh ◽  
Natsuko Watanabe ◽  
Miho Fukushita ◽  
Masako Matsumoto ◽  
...  
Keyword(s):  
Medical Treatment ◽  
Birth Defects ◽  
Antithyroid Drug ◽  
First Trimester ◽  
Control Group ◽  
Graves Disease ◽  
Increased Risk ◽  
Group A ◽  
First Trimester Of Pregnancy ◽  
Maternal Thyroid

Abstract Context Medical treatment of Graves disease during the first trimester has been the subject of controversy ever since treatment with an antithyroid drug during the first trimester was reported to possibly be associated with an increased risk of birth defects in newborns. Objective We investigated whether the incidence of birth defects among newborns born to mothers with Graves disease (GD) treated with propylthiouracil (PTU) during the first trimester of pregnancy was higher than in a control group that was not exposed to any medication. Methods We reviewed the cases of 1913 women with GD who gave birth between January 1, 2015, and May 31, 2019. Detailed information concerning the outcome of pregnancy and the presence of birth defects was collected at the first visit after the delivery and again 1 year after delivery. We classified the mothers and infants into 3 groups according to the treatment the mother had received for GD in the first trimester of pregnancy: a group in which the mothers had been treated with PTU alone (PTU group), a group in which the mothers had not been treated with any medication (control group), and a group in which the mothers had received some other medical treatment, such as thiamazole, potassium iodide, or 2 or more drugs (other treatment group). Results The incidence of malformed infant births was 5.5% (30/541 infants) in the PTU group and 5.7% (27/ 475 infants) in the control group. There were no specific birth defects in the PTU group, and there were no significant differences between PTU dosages or maternal thyroid function according to whether mothers had delivered a child with a birth defect. Conclusion The results of our retrospective study showed that treatment with PTU during the first trimester of pregnancy did not increase the incidence of birth defects among newborns.

scholarly journals LABOR COURSE AND CONDITION OF NEWBORNS IN WOMEN WITH PLACENTAL DYSFUNCTION DUE TO GESTATIONAL ENDOTHELIOPATHY

World Science ◽  
2019 ◽  
Vol 2 (9(49)) ◽  
pp. 4-8
Author(s):  
V. V. Lazurenko ◽  
I. B. Borzenko ◽  
D. Yu. Tertyshnik
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Caesarean Section ◽  
Fetal Growth ◽  
Fetal Distress ◽  
First Trimester ◽  
Control Group ◽  
Perinatal Complications ◽  
Placental Dysfunction ◽  
First Trimester Of Pregnancy

The purpose of the study is to evaluate the effect of placental dysfunction caused by gestational endotheliopathy on the course of labor and the condition of the newborn. The first group consisted of 70 patients with placental dysfunction with gestational endotheliopathy confirmed by laboratory-instrumental findings in the first trimester of pregnancy. The control group included 30 pregnant women with physiological gestational course. PD secondary to GE leads to preterm birth, fetal distress, increases the percentage of caesarean section, contributes to the delay of fetal growth and birth weight, poor infant status and perinatal complications.

Correction of vaginal dysbiosis with cavitated solution of chlorhexidine in the 1st trimester of pregnancy: effectiveness and safety

2014 ◽  
Vol 63 (5) ◽  
pp. 29-37
Author(s):  
Ekaterina Sergeevna Voroshilina ◽  
Danila Leonidovich Zornikov ◽  
Evgeniy Eduardovich Plotko
Keyword(s):  
Bacterial Load ◽  
Invasive Procedure ◽  
First Trimester ◽  
Optimal Level ◽  
Vacuum Aspiration ◽  
Before And After ◽  
Primary Composition ◽  
First Trimester Of Pregnancy ◽  
Surgical Abortion ◽  
Lactobacillus Spp

Aim. The aim of this study was to evaluate changes of vaginal microbiocenosis composition of pregnant women in first trimester after irrigation of the vagina with cavitated 0.05% solution of chlorhexidine and to find out if the following dotation of Lactobacillus spp. was needed. Materials and methods. 104 women planning induced termination of pregnancy in first trimester by vacuum aspiration were examined in order to estimate efficiency of vaginal microbiocenosis correction using irrigation of the vagina with cavitated 0.05% solution of chlorhexidine and to find out if the following dotation of Lactobacillus spp. was needed. All women had undergown irrigation of vagina and exocervix with 0.05% solution of chlorhexidine in order to prepare them for surgical abortion. Vaginal microbiocenosis before and after this procedure was evaluated by microscopy and real-time PCR (test Femoflor-16, DNA-Technology LLC, Moscow). Results. It was established that in patients with normocenosis the amount of Lactobacillus spp. decreased accordingly to the decrease of general bacterial load in the vagina at that the proportion of Lactobacillus spp. in microbiota stayed almost the same and was more than 90% in all examined women. In women with dysbiosis the decrease of general bacterial load in the vagina after irrigation with cavitated 0.05% solution of chlorhexidine happens mostly due to absolute and relative content of opportunistic microflora in microbiome. However initially low level of Lactobacillus does not allow reaching their optimal level after the first treatment stage. In these cases, the necessity of dotation of Lactobacillus spp. on the second stage of treatment is practically assured. Conclusions. The data demonstrated safety of use cavitated 0.05% solution of chlorhexidine for irrigation of the vagina in first trimester of pregnancy, that allow apply the method for prevention of infected complications before invasive procedure independently of primary composition of vaginal microbiota. Also this method demonstrated high effectiveness as approach for treatment of vaginal dysbiosis. However the continuing deficiency of lactobacilli requires their dotation on following stage.

First trimester erythropoietin (EPO) serum concentration as a potential marker for abnormal placentation disorders. Reference values for erythropoietin (EPO) concentration at 11–13+6 weeks of gestation

2016 ◽  
Vol 44 (2) ◽  
Author(s):  
Przemysław Kosiński ◽  
Dorota A. Bomba-Opoń ◽  
Mirosław Wielgoś
Keyword(s):  
Serum Concentration ◽  
Intrauterine Growth Restriction ◽  
First Trimester ◽  
Control Group ◽  
Abnormal Placentation ◽  
Intrauterine Growth ◽  
Potential Marker ◽  
First Trimester Of Pregnancy ◽  
A Prospective Study ◽  
And Control

AbstractTo investigate the possible effect of abnormal placentation disorders such as preeclampsia (PE), pregnancy induced hypertension (PIH) and intrauterine growth restriction (IUGR) on erythropoietin (EPO) serum concentration in women in the first trimester of pregnancy.A prospective study was performed in a group of pregnant women between 11 and 13A group of 198 analyzed patients was divided into three groups depending on pregnancy outcome: abnormal placentation group (n=30), macrosomia (n=13) and control group (n=155). EPO concentrations between the three groups of patients revealed that they differ significantly (F=15.172, P<0.001). EPO concentration is significantly higher in abnormal placentation patients compared to the control group (P<0.001) and macrosomia group (P=0.004). The most significant increase in EPO concentration was detected within patients with PIH. Also the uterine artery pulsatility index was positively correlated with EPO concentration (P<0.01).First-trimester maternal EPO concentration might be considered as a possible marker of abnormal placentation disorders and should be given more attention in future prospective studies.

Adrenal androgens and illness

1987 ◽  
Vol 116 (1) ◽  
pp. 155-160 ◽  
Author(s):  
C. G. Semple ◽  
C. E. Gray ◽  
G. H. Beastall
Keyword(s):  
Serum Cortisol ◽  
Control Group ◽  
Dehydroepiandrosterone Sulphate ◽  
Adrenal Androgen ◽  
Adrenal Androgens ◽  
Steroid Synthesis ◽  
Medically Ill ◽  
Before And After ◽  
Low Levels ◽  
Medically Ill Patients

Abstract. We have studied the adrenal androgen status of medically ill patients, patients before and after cholecystectomy and during recovery from burns injury. In patients ill for less than 2 weeks, serum androstenedione concentrations (mean ± sem) were raised (7.94 ± 0.98 nmol/l) as compared with a control group (4.83 ± 0.38 nmol/l, P < 0.005) or with patients ill for more than 2 weeks (5.21 ± 0.46 nmol/l, P < 0.02); serum dehydroepiandrosterone sulphate (DHAS) levels were lower in patients ill for more than 2 weeks (1.21 ± 0.42 μmol/l) than in either the acutely ill group (5.98 ± 1.06 μmol/l, P < 0.001) or the control ill group (5.56 ± 0.59 μmol/l, P < 0.001). In post-operative patients serum DHAS levels fell to below pre-operative levels reaching a nadir at day 8 (0.54 ± 0.19 vs 1.66 ± 0.56 μmol/l, P < 0.02). In burned patients serum cortisol levels were increased on admission (661 ± 91 vs 359 ± 30 nmol/l, P < 0.005) and remained high over the study period. Serum androstenedione concentrations were also high on admission (7.5 ± 1.0 vs 3.9 ± 0.3 nmol/l, P < 0.02). Serum DHAS concentrations were similar to control values on admission (6.8 ± 1.2 vs 5.2 ± 0.7 μmol/l), fell to low levels thereafter reaching a nadir during week 3 (1.6 ± 0.6 μmol/l, P < 0.001). Steroid synthesis in times of chronic illness may be diverted from adrenal androgen to corticosteroid pathways ensuring maintained secretion of cortisol, which is essential to the health of ill patients.

Aldosterone in panhypopitutarism: dynamic studies and therapeutic effects in Sheehan's syndrome

1986 ◽  
Vol 112 (3) ◽  
pp. 329-335 ◽  
Author(s):  
Fawzi Bakiri ◽  
Anne M. Riondel ◽  
Moulai Benmiloud ◽  
Michel B. Vallotton
Keyword(s):  
Thyroid Hormone ◽  
Control Group ◽  
Minor Role ◽  
Therapeutic Effects ◽  
Aldosterone Secretion ◽  
Before And After ◽  
Basal Plasma ◽  
Stimulation Tests ◽  
A Minor

Abstract. To appreciate the aldosterone secretion status in panhypopituitarism, the steroid response to stimulation was studied in a homogeneous group of 20 female patients presenting with global hypopituitarism. Specific effects of glucocorticoid and thyroid hormone deficiencies were also assessed by studying the same patients before and after cortisol (F) and cortisol plus thyroid hormone (F + T) substitution. The patients were submitted to two stimulation tests before and after each treatment: the orthostasis test (O-T) and the furosemide test (Furo-T). The results obtained in the 3 situations were compared, each patient serving as her own control. Comparison was also established with the results obtained in healthy women serving as control group. Basal plasma aldosterone levels in the untreated patients were not significantly different from those of the control group (5.43 ± 0.51 vs 7.16 ±0.80 ng/100 ml, mean ± sem). They were significantly lower after F (3.91 ± 0.42) and F + T substitution (3.31 ± 0.23) than those of untreated patients and controls. Response to both stimulations was blunted in the untreated patients (O-T: 14.10 ± 2.81; Furo-T: 9.78 ± 1.35) as compared to the control group (O-T: 26.46 ± 4.67; Furo-T: 23.96 ± 3.30). F treatment did not improve the response to either tests, (O-T: 11.42 ± 2.55; Furo-T: 10.32 ± 1.23). F + T treatment normalized the orthostasis response (20.83 ± 3.59) and increased the response to furosemide which remained, however, lower (15.28 ± 1.83) than in the control group. These results are in favour of a minor role of the pituitary in the regulation of aldosterone secretion. They emphasize the role of thyroid hormones which may act partly directly, partly through their effect on renin secretion.

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