SOMATOMEDIN A AND B IN SERUM FROM NEONATES, THEIR MOTHERS AND CORD BLOOD

1977 ◽  
Vol 85 (3) ◽  
pp. 636-643 ◽  
Author(s):  
H. Svan ◽  
K. Hall ◽  
M. Ritzén ◽  
K. Takano ◽  
A. Skottner
Keyword(s):  
Birth Weight ◽  
Cord Blood ◽  
Pregnant Women ◽  
Reference Group ◽  
B Value ◽  
Mean Value ◽  
Radioreceptor Assay ◽  
B Values ◽  
Positive Correlation ◽  
The Mean

ABSTRACT Somatomedin A by radioreceptor assay and somatomedin B by radioimmunoassay were measured in serum from women immediately after parturition and from their newborns. The mean levels of somatomedin A in both mothers (0.54 U/ml) and infants (0.50 U/ml) were significantly decreased compared to a reference group consisting of 21 non-pregnant women (0.91 U/ml). There was no difference between the mothers and their children. The mean somatomedin B value in serum from the mothers (63.9 μg/ml) was above that found in non-pregnant women (19.2 μg/ml) and the mean value in cord blood and serum from the infants (7.1 μg/ml) was below it. A positive correlation was noted between somatomedin A and B in cord blood; r = 0.78. The combined somatomedin A and B values in cord blood were positively correlated to birth weight (r = 0.51, P < 0.05).

scholarly journals Maternal Serum and Cord Blood Leptin Concentrations at Delivery in Normal Pregnancies and in Pregnancies Complicated by Intrauterine Growth Restriction

Obesity Facts ◽  
2021 ◽  
pp. 1-8
Author(s):  
Małgorzata Stefaniak ◽  
Ewa Dmoch-Gajzlerska
Keyword(s):  
Birth Weight ◽  
Cord Blood ◽  
Pregnant Women ◽  
Fetal Growth ◽  
Intrauterine Growth Restriction ◽  
Maternal Serum ◽  
Serum Leptin ◽  
Intrauterine Growth ◽  
The Mean ◽  
Maternal Bmi

<b><i>Introduction:</i></b> Leptin is a polypeptide hormone, and in pregnancy, it is secreted by the placenta and maternal and fetal adipose tissues. Normal leptin production is a factor responsible for uncomplicated gestation, embryo development, and fetal growth. The study compared maternal serum and cord blood leptin concentrations at delivery in normal pregnancies and in pregnancies complicated by intrauterine growth restriction (IUGR). <b><i>Methods:</i></b> The study was performed in 25 pregnant women with isolated IUGR and in 194 pregnant women without any complications. Leptin concentrations in maternal serum and in cord blood samples collected at delivery were measured by ELISA and subsequently analyzed by maternal body mass index (BMI), mode of delivery, and infant gender and birth weight. For comparative analyses of normally distributed variables, parametric tests were used, that is, the Student <i>t</i> test and a one-way ANOVA. The nonparametric Mann-Whitney test was used when the distribution was not normal. The Pearson correlation coefficient was calculated to assess the correlation between normally distributed variables (<i>p</i> &#x3c; 0.05). <b><i>Results:</i></b> In pregnancies complicated by IUGR, the mean maternal serum leptin concentration at delivery was significantly higher (52.73 ± 30.49 ng/mL) than in normal pregnancies (37.17 ± 28.07 ng/mL) (<i>p</i> = 0.01). The mean cord blood leptin concentration in pregnancies complicated by IUGR was 7.97 ± 4.46 ng/mL and significantly lower than in normal pregnancies (14.78 ± 15.97 ng/mL) (<i>p</i> = 0.04). In normal pregnancies, but not in pregnancies complicated by IUGR, a statistically significant correlation was established between maternal serum leptin concentrations and maternal BMI at delivery (<i>r</i> = 0.22; <i>p</i> = 0.00). No statistically significant correlation was found between cord blood leptin concentrations and maternal BMI in either study subjects or controls. In normal pregnancies, but not in pregnancies complicated by IUGR, a strong correlation was observed between cord blood leptin concentrations and birth weight (<i>r</i> = 0.23; <i>p</i> = 0.00). <b><i>Conclusions:</i></b> Elevated maternal blood leptin concentrations in pregnancies complicated by IUGR may indicate a significant adverse effect of elevated leptin on fetal growth. The differences in leptin concentrations, measured in maternal serum and in cord blood, between the study subjects and controls suggest that deregulated leptin levels may increase the risk of obstetric complications associated with placental insufficiency.

The relation between second-trimester placental elasticity and poor obstetric outcomes in low-risk pregnancies

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Murat Akbas ◽  
Faik Mumtaz Koyuncu ◽  
Burcu Artunç-Ülkümen ◽  
Gökce Akbas
Keyword(s):  
Birth Weight ◽  
Pregnant Women ◽  
Value Added ◽  
Shear Wave Elastography ◽  
Multiple Regression Model ◽  
Low Risk ◽  
Obstetric Outcomes ◽  
Second Trimester ◽  
The Mean ◽  
Random Measurements

AbstractObjectivesIncreased placental stiffness is associated with various pathological conditions. Our objective was to evaluate the relation between the second-trimester placental elasticity value in low-risk pregnant women and poor obstetric outcomes.MethodsA total of 143 pregnant women were enrolled. Placental elasticity values were measured using the transabdominal point shear wave elastography method. 10 random measurements were obtained from different areas of the placenta. The mean was accepted as the mean placental elasticity value. Logistic regression analyses were performed to identify independent variables associated with obstetric outcomes.ResultsSecond-trimester placental elasticity value was significantly and positively associated with the poor obstetric outcomes (p=0.038). We could predict a poor outcome with 69.2% sensitivity and 60.7% specificity if we defined the placental elasticity cut-off as 3.19 kPa. Furthermore, in the multiple regression model, the placental elasticity value added significantly to the prediction of birth weight (p=0.043).ConclusionsOur results showed that the pregnancies with a stiffer placenta in the second trimester were associated with an increased likelihood of exhibiting poor obstetric outcomes. Also, placental elasticity was independently associated with birth weight.

scholarly journals Maternal obesity influences birth weight more than gestational diabetes

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Eman M Alfadhli
Keyword(s):  
Birth Weight ◽  
Gestational Diabetes ◽  
Pregnancy Outcomes ◽  
Maternal Obesity ◽  
Reference Group ◽  
Adverse Pregnancy Outcomes ◽  
Antenatal Visit ◽  
Oral Glucose ◽  
The Mean ◽  
Adverse Pregnancy

Abstract Background Maternal obesity and gestational diabetes (GDM) are commonly encountered during pregnancy. Both conditions are independently associated with unfavorable pregnancy consequences. The objective of this study was to compare the effects of obesity and GDM on birth weight, macrosomia, and other adverse pregnancy outcomes. Methods This cohort study involved 531 women with a singleton pregnancy attending the Maternity and Children’s Hospital, Medina, Saudi Arabia, between June 2014 and June 2015. Participants underwent a 75-g oral glucose tolerance test between 24 and 28 weeks. The International Association of Diabetes and Pregnancy Study Groups criteria were used for GDM diagnosis. BMI was assessed at the first antenatal visit, and obesity was defined as a BMI ≥30.0 kg/m2. All women were followed up until delivery. Women were divided into 4 groups: non-GDM nonobese (reference group), GDM nonobese, obese non-GDM, and obese GDM. Clinical characteristics and adverse pregnancy outcomes were compared. Results The mean age and BMI of the participants were 30.5 years and 29.3 kg/m2, respectively. GDM was diagnosed in 50.2% of the participants, and obesity was diagnosed in 47.8% of the participants. Obese women with GDM were the oldest and heaviest among all women. The mean birth weight increased in order among the four groups; it was highest in the infants in the obese GDM group, followed by those in the obese non-GDM, GDM nonobese and reference groups. Obesity and GDM alone or in combination were associated with higher rates of macrosomia and cesarean deliveries than the reference group. Neonatal intensive care unit (NICU) admission was higher in infants in the GDM nonobese and obese GDM groups. The frequency of low Apgar score was significantly higher in infants in the obese GDM group than in infants in the reference group. Conclusions Maternal obesity seems to influence birth weight more than GDM, while GDM is associated with a greater risk of admission to the NICU. The combination of both conditions is associated with the greatest risk of adverse pregnancy outcomes.

scholarly journals Factors influencing the dental caries in pregnant women: a cross-sectional study

2021 ◽  
Vol 10 (1) ◽  
pp. e32810111226
Author(s):  
Gabriela Bohrer Bolsson ◽  
Jessica Klöckner Knorst ◽  
Marília Cunha Maroneze ◽  
Maísa Casarin ◽  
Patrícia Pasquali Dotto ◽  
...  
Keyword(s):  
Dental Caries ◽  
Pregnant Women ◽  
Basic Research ◽  
Cross Sectional Study ◽  
Mean Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mean ◽  
The City ◽  
Santa Maria

Objective: To assess factors associated with the average number of dental caries in pregnant women. Method: Basic research design: This cross-sectional study was performed between January 2017 and December 2018 in Santa Maria, Brazil. Clinical setting and participants: Multistage random sampling resulted in the recruitment of 256 pregnant women from public health centers across the city. Clinical exams and semi-structured questionnaires including demographic, socioeconomic and behavioral questions were performed by trained interviewers. Main outcome measure: The experience of dental caries was evaluated through the mean value of the Decay, Missing, and Filled Surface Index (DMFS) by 4 trained and calibrated examiners. Multilevel Poisson regression models were used to evaluate the influence of different variables on the average number of dental caries. Rate ratio (RR) and respective 95% confidence intervals were calculated (CI 95%). Results: The prevalence of untreated dental caries was 62.7% in the sample, while the mean DMFS index was 10.27 (± 10.92). Women who smoked during pregnancy had a higher mean DMFS (RR 1.41; 95% CI 1.25-1.57). Furthermore, pregnant women who had poor self-ratings of oral health had a higher average DMFS (RR 1.21; 95% CI 1.10-1.32). Conclusions: The results showed that older age, ethnicity, fewer years in education and the presence of dental plaque resulted in higher means of DMFS.

scholarly journals CORRELATION BETWEEN BODY MASS INDEX AND MICROALBUMINURIA IN ESSENTIAL HYPERTENSIVE ADULTS

2020 ◽  
pp. 54-56
Author(s):  
IRENGBAM SUSUPRIYA DEVI ◽  
GLADYS RAI ◽  
V. P. S PUNIA ◽  
MANOJ KUMAR NANDKEOLIAR
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Early Morning ◽  
Mean Value ◽  
Control Group ◽  
Inclusion Criteria ◽  
Hypertensive Patients ◽  
Positive Correlation ◽  
Arterial Blood ◽  
The Mean

Objective: This study aimed to find the correlation between body mass index (BMI) and microalbuminuria (MA) in essential hypertensive adults. Methods: This study included 35 essential hypertensive patients in the 18–65 years of age group, who satisfied the inclusion criteria. Arterial blood pressure was measured by a sphygmomanometer and the first voided early morning urine sample was collected for the estimation of microalbumin. Results: The mean age of the population studied was 49±11.08 in essential hypertensive patients and 46.89±11.10 in the control group. The mean value of BMI in the hypertensive group was found to be 27.59±5.45. In the present study, the mean value of microalbumin in essential hypertensive patients was 20.95±16.96. A significant positive correlation between BMI and MA was observed in the study with p<0.001. Conclusion: Our study shows a positive correlation between BMI and MA. Therefore, this study will help in the early detection of renal injury and prevents its progression to renal failure by lifestyle and diet modifications.

Lead Levels in Cord Blood

PEDIATRICS ◽  
1972 ◽  
Vol 49 (4) ◽  
pp. 606-608
Author(s):  
Paul Harris ◽  
Marshall R. Holley
Keyword(s):  
Cord Blood ◽  
Lead Poisoning ◽  
Whole Blood ◽  
Blood Lead ◽  
Mean Value ◽  
Diagnosis And Treatment ◽  
Normal Blood ◽  
Blood Lead Levels ◽  
Lead Levels ◽  
The Mean

Blood lead levels were determined on 24 mothers during labor and on the blood of their newborn offspring. The mean value for the mother's blood lead was 13.2 µg/100 gm (range 10 to 20) and for the cord blood 12.3 (range 10 to 20) µg/100 gm whole blood. These levels are lower than "normal" blood lead standards usually accepted in the diagnosis and treatment of childhood lead poisoning.

Magnesium, Total Calcium, Phosphorus, Copper, and Zinc in Plasma and Erythrocytes of Venous Cord Blood from Infants of Diabetic Mothers: Comparison with a Reference Group by Logistic Discriminant Analysis

1992 ◽  
Vol 38 (10) ◽  
pp. 2002-2007 ◽  
Author(s):  
M Speich ◽  
A Murat ◽  
J L Auget ◽  
B Bousquet ◽  
P Arnaud
Keyword(s):  
Cord Blood ◽  
Gestational Age ◽  
Comparison Group ◽  
Reference Group ◽  
Total Calcium ◽  
Infants Of Diabetic Mothers ◽  
Calcium Phosphorus ◽  
The Mean ◽  
Diabetic Mothers ◽  
Apparently Healthy

Abstract Concentrations of magnesium (Mg), total calcium (Ca), phosphorus (P), copper (Cu), and zinc (Zn) were investigated in plasma (Pl) and erythrocytes (Erc) of venous cord blood of 44 infants of diabetic mothers (IDMs). These same concentrations plus total glycohemoglobin and fructosamine were determined at delivery in a subset of 15 mothers of these infants. Mineral results for IDMs were compared with those for 66 apparently healthy newborns. The duration of gestation in the two groups was significantly different (P &lt; 0.001). After adjustment for gestational age, the mean (+/- SD) differences between groups were significant for birth weight, head circumference, Erc-Mg (1.71 +/- 0.17 for IDMs vs 1.76 +/- 0.15 mmol/L for control subjects), Pl-Ca (1.96 +/- 0.32 vs 2.48 +/- 0.22 mmol/L), Pl-P (1.99 +/- 0.40 vs 1.57 +/- 0.25 mmol/L), and Erc-Cu (10.9 +/- 2.41 vs 12.9 +/- 3.00 mumol/L), but not for Erc-Zn (33.0 +/- 18.3 vs 40.4 +/- 13.6 mumol/L). The variable that best discriminated between the two infant groups after adjustment for gestational age was Pl-Ca. In the 15 mothers, Pl-Mg (0.67 +/- 0.07 mmol/L) and Pl-Ca (1.66 +/- 0.21 mmol/L) concentrations were low, Pl-Zn (9.81 +/- 3.40 mumol/L) was normal, and Pl-Cu (33.5 +/- 10.7 mumol/L) was above normal. Correlations between total glycohemoglobin and mineral values of the mothers or paired IDM mineral values were not significant. The concentration of Pl-Ca was positively correlated with Erc-Cu (P &lt; 0.001) and Pl-Cu (P &lt; 0.05) in the comparison group newborns but not in the IDMs.

Determination Of Malondialdehyde In Normal And Diabetic Pregnancies

1981 ◽  
Author(s):  
I Rákóczi ◽  
Gy Geró ◽  
J Demeter ◽  
I Gáti
Keyword(s):  
Pregnant Women ◽  
Mean Value ◽  
Diabetic Pregnancy ◽  
Diabetic Patients ◽  
Third Trimester ◽  
The Mean ◽  
Platelet Hyperaggregation ◽  
Induced Aggregation ◽  
Increased Activity

It is known that platelet hyperaggregation observed in diabetic patients is, at least in part, due to an increased activity of the endoperoxide-thromboxane forming metabolic pathway. It was interesting to determine the platelet malondialdehyde /MDA/ production in normal and diabetic pregnancies. Following individuals have been studied: /I/ twenty-five healthy non-pregnant volunteers; /II/ thirty women in third trimester of non-complicated pregnancies; /III/ twenty two diabetic pregnant women without retinopathy; /IV/ fifteen diabetic pregnant women with retinopathy. Platelet MDA production following N-ethyl-maleimide induced aggregation was measured according to Stuart et al. The mean value of MDA production was similar in volunteers and normal pregnant women /SDM, 7.07±0.73 nmoles MDA per 109 platelets; 7.22±0.81/. The mean MDA production in diabetic women without retinopathy was slightly but nonsignificantly higher than that in normal pregnant women /7.57±1.02; p>0.05/. The corresponding value in diabetic women with retinopathy was significantly higher than the values in the other three groups /8.47±0.82; p<0.01/. These data suggest that the activation of prostaglandin synthetic pathway /measured by MDA/ is significantly increased in diabetic pregnancy complicated by retinopathy. The increase of platelet prostaglandin synthesis in diabetic pregnancy might play an important role in initiating and/or promoting the small-vessel complications of placenta.

Mindfulness and insomnia at pregnancy

2016 ◽  
Vol 33 (S1) ◽  
pp. s269-s269
Author(s):  
M. Marques ◽  
A.T. Pereira ◽  
E. Bento ◽  
S. Xavier ◽  
J. Azevedo ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Pregnant Women ◽  
Mean Value ◽  
Inner Experience ◽  
The Mean ◽  
Competing Interest ◽  
Acting With Awareness ◽  
The Impact ◽  
Insomnia Symptoms ◽  
In Pregnancy

IntroductionThe impact of mindfulness in improving insomnia symptoms is documented in different samples (e.g. anxiety disorders; insomnia samples) and mindfulness based programs for pregnancy refer the association between mindfulness development and the reduction of insomnia symptoms/improvement of sleep.ObjectiveTo explore differences in the Facets Mindfulness Questionnaire-10 (FMQ-10; Azevedo et at. 2015), between sleep groups, in Portuguese pregnant women.MethodsFour hundred and nineteen pregnant women (mean age: 32.51 ± 4.759; weeks of gestation: 17.32 ± 4.803) answered the Facets Mindfulness Questionnaire-10 and the Insomnia Assessment Scale (IAS, Marques et al., 2015). Three sleep groups were created considering all the IAS items: good sleepers (no insomnia symptoms; no associated daily impairment); insomnia symptoms groups (one/more insomnia symptoms; no associated daily impairment; exclusion of other conditions/disorders explaining the symptoms); insomniacs (one/more insomnia symptoms; one/more daily associated impairment; exclusion of other conditions/disorders explaining the symptoms).ResultsThere were significant differences in the total FMQ-10 score, the F1/Nonjudging of inner experience and the F2/acting with awareness, between sleep groups [respectively, F (2.402) = 6,933; P = 0.001; F (2.406) = 10.243; P = 0.001; F (2.406) = 37.431; P = 0.002]. Tukey tests indicated that the mean total FMQ-10 and F1/Nonjudging of inner experience scores of good sleepers and insomnia symptoms group were significantly higher than of the insomniacs. The mean value of F2/acting with awareness in the good sleepers was significantly higher than of the insomniacs.ConclusionsIt seems important to develop mindfulness to improve sleep in pregnancy or reduce the impact of insomnia symptoms (common at pregnancy).Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Skinfold Thickness Measurement in Term Nigerian Neonates: Establishing Reference Values

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Olanike Abosede Olutekunbi ◽  
Adaobi Uzoamaka Solarin ◽  
Idowu Odunayo Senbanjo ◽  
Elizabeth Aruma Disu ◽  
Olisamedua Fidelis Njokanma
Keyword(s):  
Birth Weight ◽  
Reference Values ◽  
Reference Population ◽  
Skinfold Thickness ◽  
Thickness Measurement ◽  
Mean Value ◽  
Cross Sectional ◽  
Mean Values ◽  
The Mean ◽  
Thickness Measurements

Skin fold thickness (SFT) measurement is a reliable, cheap, simple, noninvasive method of body fat estimation at all ages including the neonatal period.Objective. To determine reference values of biceps, triceps, subscapular, and suprailiac skinfold thickness measurements in term Nigerian newborns.Method. A prospective cross-sectional study over a six-month period (Dec 2010–May 2011) was carried out on term and healthy neonates delivered between 37 and 41 weeks. The anthropometric measurements were taken within the first 48 hours of life including the skinfold thickness. The skinfold thickness measurements were taken at four sites, namely, triceps, biceps, subscapular, and suprailiac, using Harpenden skinfold calipers. The mean of two readings was recorded.Result. A total of one thousand one hundred and sixty-eight neonates were studied. The birth weight ranged between 2000 g and 5000 g with a mean birth weight of the neonates at3259±470 g. The mean birth weight of the males (3339±0.45) was significantly higher than that of females (3200±0.44) (p<0.0001). Female neonates had higher mean values of triceps, subscapular, and suprailiac skinfold thickness (p<0.001, resp.) while male neonates had higher mean value of biceps skinfold thickness (p=0.008). Females also had higher mean values of the sum of skinfold thicknesses at all four sites and the sum at the two truncal sites at every stratified gestational age.Conclusions. The sex specific percentile chart developed for skinfold thickness measurements can be used to detect deviation from the reference population such that infants who are at risk of nutritional or health problems are identified early, and intervention is instituted promptly.

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