Effects of endurance training on hormonal responses to prolonged physical exercise in males

1993 ◽  
Vol 129 (2) ◽  
pp. 109-113 ◽  
Author(s):  
Tommi J Vasankari ◽  
Urho M Kujala ◽  
Olli J Heinonen ◽  
Ilpo T Huhtaniemi
Keyword(s):  
Physical Exercise ◽  
Endurance Training ◽  
Venous Blood ◽  
Serum Testosterone ◽  
Hormonal Changes ◽  
Significant Trial ◽  
Significant Group ◽  
Prolonged Physical Exercise ◽  
Before And After ◽  
On The Road

The effect of several years' endurance training on hormonal changes during acute prolonged physical exercise was studied. In trial I, 13 cross-country skiers were studied before and after a 75-km ski race and 3 weeks later on a control day. In trial II, 10 trained and 8 untrained subjects bicycled for 4 h on the road with as high a performance level as possible. Venous blood samples were taken in both trials before and after the exercise. In trial I, serum concentrations of luteinizing hormone (p<0.01) and follicle-stimulating hormone (FSH, p <0.001) decreased more from morning to afternoon samples, and cortisol (p <0.001) and growth hormone (GH, p <0.001) increased more during the ski race when compared to the control day. Serum testosterone decreased during the ski race (p <0.01) but not on the control day. In trial II, a group difference was seen in serum FSH levels which was higher in the trained than untrained subjects at all three time points (F =4.66, p=0.046). A significant trial-group interaction (p =0.020) was seen in GH, the GH being lower before exercise and higher 2 h after exercise in the untrained subjects. There was a significant group contrast between pre- and post-exercise samples in testosterone (p = 0.021) and cortisol (p = 0.022). In conclusion, the higher basal FSH concentration in the trained versus untrained subjects may be a sign of compensated hypogonadism due to intensive chronic training or it may be due to dysfunction of Sertoli cells. Signs of adaptation to resist the hormonal changes caused by acute physical exercise can be seen in the trained subjects when compared to the untrained subjects.

Biochemical Variables in Plasma and Urine before and after Prolonged Physical Exercise

Enzyme ◽  
1985 ◽  
Vol 33 (3) ◽  
pp. 134-142 ◽  
Author(s):  
P. (a) Hespel ◽  
E. (b) Vanden Eynde ◽  
A. (a) Amery ◽  
P. (a) Lijnen
Keyword(s):  
Physical Exercise ◽  
Biochemical Variables ◽  
Prolonged Physical Exercise ◽  
Before And After

Pituitary-gonadal response to gonadotropin-releasing hormone stimulation is enhanced in men after strenuous physical exercise

1993 ◽  
Vol 129 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Tommi J Vasankari ◽  
Urho M Kujala ◽  
Simo Taimela ◽  
Ilpo T Huhtaniemi
Keyword(s):  
Growth Hormone ◽  
Physical Exercise ◽  
Gonadotropin Releasing Hormone ◽  
Adult Males ◽  
Response Curves ◽  
Releasing Hormone ◽  
The Road ◽  
Strenuous Physical Exercise ◽  
Before And After ◽  
On The Road

The effects of strenuous physical exercise were studied on the pituitary-testicular response to gonadotropin-releasing hormone (GnRH) stimulation and on growth hormone (GH) and cortisol secretion. Eight healthy adult males were injected twice intravenously with 0.1 mg of GnRH at intervals of 21 days. At the time of the first injection (exercise trial) the subjects had been bicycling for 4 h on the road, and at the time of the second injection (rest trial) they had been resting in a sitting position for 4 h. Blood samples were taken before and after the 4-h period and 30, 60 and 120 min after the GnRH injection. Both testosterone and luteinizing hormone (LH) decreased during the exercise by 18% (p=0.037) and 29% (p=0.0028), respectively, but increased after the GnRH injection by 1.4- and 12.9-fold (p=0.0001 for both). The areas under the testosterone and LH response curves after GnRH were significantly larger in the exercise trial than in the rest trial, threefold (p = 0.013) and 1.3-fold (p=0.0007), respectively. Growth hormone and cortisol increased during the exercise trial. In the rest trial, the GnRH injection increased serum GH concentrations (p = 0.02 7). In conclusion, the diminished hypothalamic GnRH secretion seems to be the major cause of the post-exercise decrease in LH and testosterone, but altered sensitivity of the pituitary to GnRH also may be involved. Apparently, the build-up of pituitary LH stores during exercise explains the enhanced LH and testosterone response to GnRH challenge after exercise in comparison to control GnRH challenge.

scholarly journals Effects of antioxidant supplementation on oxidative stress balance in young footballers– a randomized double-blind trial

2021 ◽  
Author(s):  
Błażej Stankiewicz ◽  
Mirosława Cieślicka ◽  
Sławomir Kujawski ◽  
Elżbieta Piskorska ◽  
Tomasz Kowalik ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Antioxidant Capacity ◽  
Venous Blood ◽  
Thiobarbituric Acid ◽  
Double Blind ◽  
Before And After ◽  
Total Antioxidant ◽  
Double Blinded ◽  
And Control ◽  
Chokeberry Juice

Abstract Background: The intensive physical exercise in which athletes take part in competitive sports can negatively affect the pro-oxidative–antioxidant balance. The use of compounds with high antioxidant potential, which certainly should include chokeberry, can prevent these adverse changes. Methods: The study was conducted as a double blinded randomized trial on a group of football players (mean age=15.8), who underwent 7 weeks of supplementation with 200 ml chokeberry juice per day. The players were randomly assigned to the experimental (supplemented, FP-S; n = 12) and control (placebo, FB-C; n = 8) groups. Before and after the supplementation period, participants performed an beep test . Venous blood was taken for serum isolation before, immediately after, 3 h, 24 h after the test Level of thiobarbituric acid reactive products (TBARS), hydroxy-2'-deoxyguanosine (8-OHdG), total antioxidant capacity (TAC), iron (Fe), hepcidin, ferritin, myoglobin, albumin and morphological parameters (RBC, HGB, HCT, MCV, MCH, MCHC and lactic acid) were measured.Results: There were no significant impact of the supplementation intervention in response to the physical exercise test in the studied groups.. The post-hoc test showed no effect of chokeberry juice supply on any of the morphological, biochemical or performance parameters analysed.Conclusions: The supplementation of Chokeberry juice shows no effects on measured parameters in studied populations. It may indicate Such results may indicate insufficient antioxidant capacity of the supplemented juice.

scholarly journals BIOMEDICINE ON HORMONE MEDIATION OF SPORTS IN ADOLESCENT HEIGHT DEVELOPMENT

2022 ◽  
Vol 28 (1) ◽  
pp. 23-26
Author(s):  
Lulu Gao ◽  
Jian Tian
Keyword(s):  
Physical Exercise ◽  
Serum Testosterone ◽  
High Volume ◽  
Free Testosterone ◽  
Hormonal Changes ◽  
Load Prediction ◽  
Quiet Time ◽  
Young Athletes ◽  
Level Of Evidence ◽  
Exercise Load

ABSTRACT Introduction: Physical exercise is an important factor in regulating energy balance and body composition. Exercise itself is a kind of body stress. It involves the central nervous system, cardiovascular, respiratory, endocrine, and other systems. Sports have various effects on the hormones in adolescent height development. Objective: This article analyzes the effects of different time and load exercise training on the levels of serum testosterone, free testosterone, and cortisol in young athletes. Methods: The athletes’ blood samples were collected at the quiet time in the morning before each experiment, immediately after exercise, and at three time intervals the next morning. Then blood testosterone (T), free testosterone (FT), and corticosteroids (C) were measured. Results: One-time and one-day high-volume training can cause a decrease in serum testosterone and free testosterone levels and an increase in cortisol hormones in young athletes. The testosterone level of young athletes rises immediately after exercise. Conclusion: Hormonal changes after physical exercise provide a scientific basis for athlete exercise load prediction and exercise plan formulation. Level of evidence II; Therapeutic studies - investigation of treatment results.

Serum Testosterone Is Not Related to Peak V̇O2 and Submaximal Blood Lactate Responses in 12- to 16-Year-Old Males

1994 ◽  
Vol 6 (2) ◽  
pp. 120-127 ◽  
Author(s):  
Joanne R. Welsman ◽  
Neil Armstrong ◽  
Brian J. Kirby
Keyword(s):  
Blood Lactate ◽  
Venous Blood ◽  
Objective Measure ◽  
Correlation Coefficients ◽  
Serum Testosterone ◽  
Treadmill Running ◽  
Hormonal Changes ◽  
Testosterone Levels ◽  
Explained Variance ◽  
Lactate Levels

This study was designed to investigate the influence of sexual maturity on peak V̇O2 and blood lactate responses to exercise using serum testosterone levels as an objective measure of maturity. Testosterone levels were determined in venous blood samples obtained from 12- to 16-year-old males (n = 50). Peak V̇O2 and percentage of peak V̇O2 at blood lactate levels of 2.5 and 4.0 mmol·L−1 were determined during incremental treadmill running. Standard multiple regression revealed that body mass, age, and height explained 74% of the variance in peak V̇O2 scores. The addition of serum testosterone to the equation failed to produce a significant increase in the explained variance. Correlation coefficients between testosterone and the lactate variables were not significant (p > .05). These findings do not support the hypothesis that hormonal changes per se during sexual maturation play an important role in the development of peak V̇O2 and blood lactate responses to exercise.

The role of sex hormones in the mechanism of inhibited LH release in female patients with anorexia nervosa

1982 ◽  
Vol 99 (3) ◽  
pp. 334-338 ◽  
Author(s):  
B. Baranowska ◽  
S. Zgliczyński
Keyword(s):  
Anorexia Nervosa ◽  
Serum Testosterone ◽  
Sex Hormone Binding Globulin ◽  
Control Group ◽  
Hormonal Changes ◽  
Female Patients ◽  
Serum Lh ◽  
Before And After ◽  
Lh Release ◽  
Lh Secretion

Abstract. In order to elucidate the mechanism of impaired LH secretion, 60 female patients with anorexia nervosa were investigated. A control group consisted of 14 women of the same age, examined in the follicular phase of the menstrual cycle. The serum LH, FSH, prolactin, TSH, testosterone, dihydrotestosterone, dehydroepiandrosterone, Δ 4-androstenedione, oestrone, oestradiol, oestriol, progesterone, thyroxine, triiodothyronine, reverse T3 and serum sex hormone binding globulin (SHBG) concentrations were measured. The results showed a significant increase in serum dehydroepiandrosterone, testosterone, oestriol and reverse T3 concentrations. However, oestrone, oestradiol, progesterone, SHBG and triiodothyronine levels were significantly lower than those of the control group. The mean serum LH concentration in patients with anorexia nervosa before and after LRH stimulation was significantly lower than that in the control group, but FSH secretion in response to LRH was normal. All hormonal changes in anorexia nervosa disappeared after weight gain during cyproheptadine treatment. Dramatically increased dehydroepiandrosterone levels suggest that the high testosterone in women with anorexia nervosa is derived from adrenal rather than from gonadal steroids. There was no correlation between serum testosterone, dehydroepiandrosterone, oestriol and LH concentrations indicating that steroid hormone disturbances do not cause impaired LH release in anorexia nervosa.

Exercise-Induced Hemostatic Alterations Are Detectable by Rotation Thrombelastography (ROTEM): A Marathon Study

2009 ◽  
Vol 16 (5) ◽  
pp. 543-548 ◽  
Author(s):  
Christoph Sucker ◽  
Rainer B. Zotz ◽  
Beate Senft ◽  
Rudiger E. Scharf ◽  
Knut Kröger ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Venous Blood ◽  
Single Step ◽  
Whole Blood Assay ◽  
Paired Samples ◽  
Step Procedure ◽  
Before And After ◽  
The Mean ◽  
Exercise Induced ◽  
Comparison Of The Results

Rotation thrombelastography (ROTEM) provides a whole blood assay that allows the assessment of plasmic- and platelet-related hemostasis in a single-step procedure. In our current study, we focused on the capability of the method to detect hemostatic alterations induced by physical exercise, enrolling 33 healthy participants of the Dusseldorf Marathon 2006. Venous blood drawn immediately before and after finishing the marathon was analyzed by a rotational thrombelastograph (Pentapharm, Munich, Germany). On initiation of blood coagulation by recalcification, standard ROTEM parameters were determined. Comparison of the results obtained before and after the physical exercise was performed using the Student t test for paired samples. As a result, the mean clotting time (CT) determined from blood samples obtained immediately after the marathon was significantly shorter (662.9 ± 67.8 seconds vs 505.6 ± 97.3 seconds, P = .002) and the mean maximal clot firmness was significantly broader (48.4 ± 6.6 mm vs 51.5 ± 4.5 mm, P = .0004) when compared to results obtained before the physical exercise. Differences between mean clot formation times (CFTs; 280.6 + 96 seconds vs 270.4 ± 73.8 seconds) and mean α angles (45.9° ± 8° vs 47.8° ± 5.8°) before and after the marathon were not statistically significant. Remarkably, some participants showed opposed results, particularly prolongation of CT and narrowing of maximum clot firmness (MCF). Our study demonstrates that ROTEM is sensitive to exercise-induced hemostatic alterations. The method appears to be capable of detecting even distinct changes in hemostasis in a single-step procedure. Further analyses are needed to clarify which hemostasis parameters influence ROTEM results and which ROTEM results are independent predictors of exercise-induced alterations of plasmic and platelet function. This might help to explain interindividual differences in exercise-induced alterations of hemostasis.

Parathyroid gland before and after cisplatin treatment

1987 ◽  
Vol 45 ◽  
pp. 860-861
Author(s):  
S.K. Aggarwal ◽  
J.M. Fadool
Keyword(s):  
Parathyroid Gland ◽  
Wistar Rats ◽  
Antitumor Agent ◽  
The Body ◽  
Cross Linking ◽  
Limiting Factor ◽  
Hormonal Changes ◽  
Primary Mechanism ◽  
Before And After ◽  
Dna Strands

Cisplatin (CDDP) a potent antitumor agent suffers from severe toxic side effects with nephrotoxicity being the major dose-limiting factor, The primary mechanism of its action has been proposed to be through its cross-linking DNA strands. It has also been shown to inactivate various transport enzymes and induce hypocalcemia and hypomagnesemia that may be the underlying cause for some of its toxicities. The present is an effort to study its influence on the parathyroid gland for any hormonal changes that control calcium levels in the body.Male Swiss Wistar rats (Crl: (WI) BR) weighing 200-300 g and of 60 days in age were injected (ip) with cisplatin (7mg/kg in normal saline). The controls received saline injections only. The animals were injected (iv) with calcium (0.5 ml of 10% calcium gluconate/day) and were killed by decapitation on day 1 through 5. Trunk blood was collected in heparinized tubes.

Weekly Exercise Consistently Reinstates Positive Mood

1998 ◽  
Vol 3 (4) ◽  
pp. 271-280 ◽  
Author(s):  
Hannah Steinberg ◽  
Briony R. Nicholls ◽  
Elizabeth A. Sykes ◽  
N. LeBoutillier ◽  
Nerina Ramlakhan ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Negative Mood ◽  
Real Life ◽  
Positive Mood ◽  
Field Investigation ◽  
Single Bout ◽  
Before And After ◽  
Exercise Class ◽  
Negative Feelings ◽  
Over Time

Mood improvement immediately after a single bout of exercise is well documented, but less is known about successive and longer term effects. In a “real-life” field investigation, four kinds of exercise class (Beginners, Advanced, Body Funk and Callanetics) met once a week for up to 7 weeks. Before and after each class the members assessed how they felt by completing a questionnaire listing equal numbers of “positive” and “negative” mood words. Subjects who had attended at least five times were included in the analysis, which led to groups consisting of 18, 20, 16, and 16 subjects, respectively. All four kinds of exercise significantly increased positive and decreased negative feelings, and this result was surprisingly consistent in successive weeks. However, exercise seemed to have a much greater effect on positive than on negative moods. The favorable moods induced by each class seemed to have worn off by the following week, to be reinstated by the class itself. In the Callanetics class, positive mood also improved significantly over time. The Callanetics class involved “slower,” more demanding exercises, not always done to music. The Callanetics and Advanced classes also showed significantly greater preexercise negative moods in the first three sessions. However, these differences disappeared following exercise. Possibly, these two groups had become more “tolerant” to the mood-enhancing effects of physical exercise; this may be in part have been due to “exercise addiction.”

ADRENAL 17-HYDROXYCORTICOSTEROID SECRETION IN THE DOG IN RESPONSE TO ETHANOL

1972 ◽  
Vol 70 (4) ◽  
pp. 736-740 ◽  
Author(s):  
T. Suzuki ◽  
R. Higashi ◽  
T. Hirose ◽  
H. Ikeda ◽  
K. Tamura
Keyword(s):  
Venous Blood ◽  
Secretion Rate ◽  
Conscious Dogs ◽  
Blood Samples ◽  
Before And After

ABSTRACT Conscious dogs were infused intravenously with ethanol in doses of 0.7 and 1.0 g/kg. The adrenal venous blood samples were collected before and after the infusion of ethanol and analysed for 17-hydroxycorticosteroids (17-OHCS). After the infusion of 0.7 g/kg (subanaesthetic dose) of ethanol the adrenal 17-OHCS secretion rate showed either a slight increase or no change. After the infusion of 1.0 g/kg (anaesthetic dose) of ethanol the adrenal 17-OHCS secretion rate increased markedly and reached 1.21±0.15 (mean±sem) μg/kg/min, while it was 0.09±0.023 μg/kg/min before the infusion.

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