Characteristics of ultradistal radius bone density during childhood: results from the Bone Mineral Density in Childhood Study

2019 ◽  
Author(s):  
Joseph Kindler ◽  
Jonathan Mitchell ◽  
Shana McCormack ◽  
Diana Cousminer ◽  
Alessandra Chesi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Ultradistal Radius

scholarly journals Bone Mineral Density Measurements: Are they Worth While?

1996 ◽  
Vol 89 (8) ◽  
pp. 457-461 ◽  
Author(s):  
D J Torgerson ◽  
C Donaldson ◽  
D M Reid
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Bone Mineral ◽  
Diagnostic Tool ◽  
Screening Tool ◽  
Density Measurement ◽  
Bone Density Measurement ◽  
Mineral Density ◽  
Density Measurements ◽  
Bone Mineral Measurements

Bone mineral density measurements have been criticized on the grounds that they are not a worth-while screening tool. In this paper we argue that bone mineral measurements can be an efficient diagnostic tool even if they are not of proven value for screening. There is complex relationship between the costs of a measurement, the intervention and the predictive value of the test all of which must be accounted for when assessing the value of a bone density measurement. For bone density measurements to be used for screening, a wider evaluation needs to be undertaken compared with that for their use as a diagnostic tool. We address some common objections, for example, that low compliance with screening would undermine efficiency, and show that these are not relevant. Evaluations of screening need to address issues that are likely to affect efficiency.

Decreased Bone Density in Adolescent Girls With Anorexia Nervosa

PEDIATRICS ◽  
1990 ◽  
Vol 86 (3) ◽  
pp. 440-447 ◽  
Author(s):  
Laura K. Bachrach ◽  
David Guido ◽  
Debra Katzman ◽  
Iris F. Litt ◽  
Robert Marcus
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Anorexia Nervosa ◽  
Bone Density ◽  
Bone Mass ◽  
Body Mass ◽  
Bone Mineral ◽  
Whole Body ◽  
Mineral Density ◽  
Control Subjects

Osteoporosis develops in women with chronic anorexia nervosa. To determine whether bone mass is reduced in younger patients as well, bone density was studied in a group of adolescent patients with anorexia nervosa. With single- and dual-photon absorptiometry, a comparison was made of bone mineral density of midradius, lumbar spine, and whole body in 18 girls (12 to 20 years of age) with anorexia nervosa and 25 healthy control subjects of comparable age. Patients had significantly lower lumbar vertebral bone density than did control subjects (0.830 ± 0.140 vs 1.054 ± 0.139 g/cm2) and significantly lower whole body bone mass (0.700 ± 0.130 vs 0.955 ± 0.130 g/cm2). Midradius bone density was not significantly reduced. Of 18 patients, 12 had bone density greater than 2 standard deviations less than normal values for age. The diagnosis of anorexia nervosa had been made less than 1 year earlier for half of these girls. Body mass index correlated significantly with bone mass in girls who were not anorexic (P < .05, .005, and .0001 for lumbar, radius, and whole body, respectively). Bone mineral correlated significantly with body mass index in patients with anorexia nervosa as well. In addition, age at onset and duration of anorexia nervosa, but not calcium intake, activity level, or duration of amenorrhea correlated significantly with bone mineral density. It was concluded that important deficits of bone mass occur as a frequent and often early complication of anorexia nervosa in adolescence. Whole body is considerably more sensitive than midradius bone density as a measure of cortical bone loss in this illness. Low body mass index is an important predictor of this reduction in bone mass.

scholarly journals Protective effect ofGlycyrrhiza glabraroots extract on bone mineral density of ovariectomized rats

BioMedicine ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 8 ◽  
Author(s):  
Dimitrios Galanis ◽  
Konstantinos Soultanis ◽  
Pavlos Lelovas ◽  
Alexandros Zervas ◽  
Panagiotis Papadopoulos ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Protective Effect ◽  
Bone Mineral ◽  
Proximal Tibia ◽  
Glycyrrhiza Glabra ◽  
Ovariectomized Rats ◽  
Mineral Density ◽  
Three Point Bending ◽  
Significant Difference

Objective: The aim of this study was to evaluate the potential effect of the methanolic extract of plantGlycyrrhiza glabraroots on bone mineral density and femoral bone strength of ovariectomized rats.Methods: Thirty 10-month-old Wistar rats were randomly separated into three groups of ten, Control, Ovariectomy and Ovariectomy-plus-Glycyrrhiza in their drinking water. Total and proximal tibial bone mineral density was measured in all groups before ovariectomy (baseline) and after 3 and 6 months post ovariectomy. Three-point-bending of the femurs and uterine weight and histology were examined at the end of the study.Results: No significant difference was noted in bone density percentage change of total tibia from baseline to 3 months between Control and Ovariectomy-plus-Glycyrrhiza groups (+5.31% ± 4.75 and +3.30% ± 6.31 respectively,P = non significant), and of proximal tibia accordingly (+5.58% ± 6.92 and +2.61% ± 13.62,P = non significant) demonstrating a strong osteoprotective effect. There was notable difference in percentage change of total tibia from baseline to 6 months between groups Ovariectomy and Ovariectomy-plus-Glycyrrhiza (−13.03% ± 5.11 and −0.84% ± 7.63 respectively,P < 0.005), and of proximal tibia accordingly (−27.9% ± 3.69 and −0.81% ± 14.85 respectively,P < 0.001), confirming the protective effect ofGlycyrrhiza glabraextract in preserving bone density of the Ovariectomy-plus-Glycyrrhiza group. Three-point-bending did not reveal any statistically significant difference between Ovariectomy and Ovariectomy-plus-Glycyrrhiza groups. Uterine weights of the Ovariectomy-plus-Glycyrrhiza group ranged between the other two groups with no statistically significant difference to each.Conclusions:Glycyrrhiza glabraroot extract notably protected tibial bone mineral density loss in Ovariectomy-plus-Glycyrrhiza rats in comparison with ovariectomized rats, but did not improve biomechanical strength.

The state of bone mineral density in the prolapse of the pelvic organs

GYNECOLOGY ◽  
2021 ◽  
Vol 23 (2) ◽  
pp. 173-176
Author(s):  
Il’nur I. Musin ◽  
Timur B. Minasov ◽  
Raisa A. Naftulovich ◽  
Elena M. Popova ◽  
Karina N. Mingareeva ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Roc Analysis ◽  
Genital Prolapse ◽  
Outpatient Basis ◽  
Mineral Density ◽  
Severe Osteoporosis ◽  
Experimental Group

Background. Plausible predictions of future mortality and disability are useful aids in making decisions about priorities for medical research. Recent advances in medicine have led to the fact that some countries, such as Japan, have the highest life expectancy in the world. Osteoporotic fractures make a significant contribution to the development of morbidity and mortality in the aging population. Despite an active study of the mechanisms of the development of pelvic organ prolapse and disorders of bone mineral density separately, the general background of these diseases has previously been little studied. Aim. To study bone density according to densitometry data in peri- and postmenopausal women. Materials and methods. To carry out this study, 2 groups of women were formed. The first (experimental) group included 76 women admitted for routine surgical treatment of genital prolapse, the second group (control) 68 women without clinical manifestations of pelvic floor descent, who underwent a medical examination by a gynecologist on an outpatient basis. Results. Analysis of extragenital diseases in women included in the study showed a high prevalence in the experimental group of hypertension (p=0.028), osteochondrosis (p=0.001), scoliosis (p=0.028), hemorrhoids (p=0.013). Also, women in this group more often noted stretch marks on the skin (p=0.002) and were more often operated on for other diseases (p=0.043), which indicates the association of genital prolapse with undifferentiated connective tissue dysplasia and hypertension. The diagnosed severe osteoporosis (according to 1 or more densitometry indicators, where the T-score is less than -2.5) had a direct correlation with the duration of menopause. For a detailed analysis of the factors influencing severe osteoporosis in peri- and postmenopausal women, logistic regression analysis and ROC analysis were performed. The independent variable was the presence of severe osteoporosis, and the dependent variables were: stage according to POP-Q, the presence of hypertension, the presence of diabetes mellitus in history. Conclusion. This study confirms the presence of a comorbidity decrease in bone density according to densitometry and the presence of hypertension (p=0.028) and genital prolapse. According to the ROC analysis, an increase in the stage of genital prolapse according to the POP-Q classification increases the risk of developing severe osteoporosis.

The Impact of Training Load on Bone Mineral Density of Adolescent Swimmers: A Structural Equation Modeling Approach

2017 ◽  
Vol 29 (4) ◽  
pp. 520-528 ◽  
Author(s):  
Ricardo Ribeiro Agostinete ◽  
Santiago Maillane-Vanegas ◽  
Kyle R. Lynch ◽  
Bruna Turi-Lynch ◽  
Manuel J. Coelho-e-Silva ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Soft Tissue ◽  
Bone Density ◽  
Muscle Mass ◽  
Bone Mineral ◽  
Training Load ◽  
Mediating Effect ◽  
Lower Limbs ◽  
Whole Body ◽  
Mineral Density

Purpose:To investigate the mediating effect of muscle mass on the relationship between training load and bone density in adolescent swimmers.Methods:A cross-sectional study involving 87 control and 22 swimmers aged 10–19 years (overall sample:n = 109). Swimmers had a minimum of 1 year of competition in regional and national championships, and control adolescents reported 1 year without any organized sport. Bone density was the main outcome (dual-energy X-ray absorptiometry), which was measured in upper limbs, lower limbs, spine, and whole body. Monthly training load was the independent variable, while the mediation effect of lean soft tissue was assessed. Maturity offset, age, inflammation, and vitamin D intake were treated as covariates.Results:Swimmers had lower bone density than controls; there was a significant and positive relationship between training load and muscle mass. In boys, training load presented a negative correlation with bone density in lower limbs [r = −.293; 95% confidence interval (CI), −.553 to −.034]. In girls, training load was negatively related to bone mineral density in lower limbs (r = .563; 95% CI, −.770 to −.356) and whole body (r = −.409; 95% CI, −.609 to −.209).Conclusion:Training load had a negative relationship on bone density of swimmers of both sexes, independently of the positive effect of lean soft tissue on bone density.

scholarly journals Tracking of Bone Mass and Density during Childhood and Adolescence

2010 ◽  
Vol 95 (4) ◽  
pp. 1690-1698 ◽  
Author(s):  
Heidi J. Kalkwarf ◽  
Vicente Gilsanz ◽  
Joan M. Lappe ◽  
Sharon Oberfield ◽  
John A. Shepherd ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Bone Mineral ◽  
Sexual Maturation ◽  
Childhood And Adolescence ◽  
Z Score ◽  
Mineral Density ◽  
Growth Status ◽  
Low Bone Density ◽  
Z Scores

Abstract Context: Whether a child with low bone mineral density (BMD) at one point in time will continue to have low BMD, despite continued growth and maturation, is important clinically. The stability of a characteristic during growth is referred to as “tracking.” Objective: We examined the degree of tracking in bone mineral content (BMC) and BMD during childhood and adolescence and investigated whether tracking varied according to age, sexual maturation, and changes in growth status. Design: We conducted a longitudinal study with measurements at baseline and annually for 3 yr. Setting: The Bone Mineral Density in Childhood Study was conducted at five clinical centers in the United States. Study Participants: A total of 1554 girls and boys, ages 6–16 yr at baseline, participated in the study. Main Outcome Measures: Whole body, spine, hip, and forearm BMC and BMD were measured by dual-energy x-ray absorptiometry, and age-, sex-, and race-specific Z-scores were calculated. Deviation from tracking was calculated as the Z-score at yr 3 minus baseline. Results: Correlations between Z-scores at baseline and yr 3 ranged from 0.76–0.88. Among children with a Z-score below −1.5 at baseline, 72–87% still had a Z-score below −1 after 3 yr. Age, sexual maturation, and deviations in growth status (P &lt; 0.01) were associated with deviation from tracking; however, tracking was strongly evident even after adjusting for the effects of age, maturation, and growth. Conclusions: Bone density showed a high degree of tracking over 3 yr in children and adolescents. Healthy children with low bone density will likely continue to have low bone density unless effective interventions are instituted.

scholarly journals Relationship Between Mechanical Properties and Bone Mineral Density of Human Femoral Bone Retrieved from Patients with Osteoarthritis

2012 ◽  
Vol 6 (1) ◽  
pp. 458-463 ◽  
Author(s):  
Yvonne Haba ◽  
Tobias Lindner ◽  
Andreas Fritsche ◽  
Ann-Kristin Schiebenhöfer ◽  
Robert Souffrant ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Mineral Density ◽  
Bone Density ◽  
Bone Mineral ◽  
Mechanical Load ◽  
Load Capacity ◽  
Quantitative Computed Tomography ◽  
Hip Osteoarthritis ◽  
Femoral Bone ◽  
Mineral Density

The objective of this study was to analyse retrieved human femoral bone samples using three different test methods, to elucidate the relationship between bone mineral density and mechanical properties. Human femoral heads were retrieved from 22 donors undergoing primary total hip replacement due to hip osteoarthritis and stored for a maximum of 24 hours postoperatively at + 6 °C to 8 °C. Analysis revealed an average structural modulus of 232±130 N/mm2 and ultimate compression strength of 6.1±3.3 N/mm2 with high standard deviations. Bone mineral densities of 385±133 mg/cm2 and 353±172 mg/cm3 were measured using thedual energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT), respectively. Ashing resulted in a bone mineral density of 323±97 mg/cm3. In particular, significant linear correlations were found between DXA and ashing with r = 0.89 (p < 0.01, n = 22) and between structural modulus and ashing with r = 0.76 (p < 0.01, n = 22). Thus, we demonstrated a significant relationship between mechanical properties and bone density. The correlations found can help to determine the mechanical load capacity of individual patients undergoing surgical treatments by means of noninvasive bone density measurements.

scholarly journals Bone Densitometry Indices of Humerus Bone in Patients with Partial Rupture of the Supraspinatus Tendon

2020 ◽  
pp. 71-77
Author(s):  
S.S. Strafun ◽  
S.V. Bohdan ◽  
S.M. Abbasov
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Bone Mineral ◽  
Humeral Head ◽  
Supraspinatus Tendon ◽  
X Rays ◽  
Partial Rupture ◽  
Mineral Density ◽  
Contralateral Limb ◽  
Partial Tear

Summary. Bone density is an important factor that affects the strength of the suture of the tendons of the rotator cuff. The higher the bone density is, the greater is the strength of fixation of the supraspinatus tendon to the bone, since the anchor is more securely fixed in the bone. Objective: to determine the bone mineral density of the proximal humeral epiphysis in patients with partial tear of the supraspinatus tendon. Materials and Methods. An X-ray examination of 48 shoulder joints (24 with partial tear of the supraspinatus tendon and 24 intact contralateral) was performed in 24 patients with partial tear of the supraspinatus tendon. On the electronic photographic prints of X-rays with the help of the specified software, 2 standard for all patients zones of determination of mineral density of bone tissue, both on the extremity with partial rupture of the supraspinatus tendon and on similar parts of the contralateral limb, were found. The bone mineral density (BMD) measurement zones were placed as follows: 1st zone - the greater tubercle of the humerus; 2nd zone - the middle of the humeral head. Each zone had a square shape and corresponded to 0.9±0.15 cm² of the area of the standard radiograph. Also, all patients underwent standard radiographic examination of the hip joints and lumbar spine. Conclusions: In zone 1 (the greater tubercle of the humerus), the bone mineral density of the limb with partial tear of the supraspinatus tendon reached 0.167±0.155 g/cm² and was slightly lower than that on the healthy limb 0.238±0.115 g/cm² (p<0.05). This indicates the effect of partial rupture of the supraspinatus tendon on the development of osteoporotic processes in the area of the greater tubercle of the humerus. In the 2nd zone (the middle of the humeral head), the average bone mineral density of the limb with partial rupture of the supraspinatus tendon reached 0.193±0.109 g/cm² and was also less than 0.245±0.159 g/cm² on the contralateral limb. In the 1st zone (the greater tubercle of the humerus), the dependence of changes in bone mineral density on the total changes in bone mineral density (r=0.62; p<0.01) was revealed. In zone 2 (r=0.14; p<0.01), bone mineral density was independent of overall changes in bone mineral density.

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