scholarly journals Reference values for IGF-I serum concentration in an adult population: use of the VARIETE cohort for two new immunoassays

2021 ◽  
Author(s):  
Nadia Sabbah ◽  
Peter Wolf ◽  
Céline Piedvache ◽  
Séverine Trabado ◽  
Tristan Verdelet ◽  
...  
Keyword(s):  
Normative Data ◽  
Adult Population ◽  
Weighted Kappa ◽  
Reference Intervals ◽  
Healthy Population ◽  
Upper Limits ◽  
Igf I ◽  
General Adult Population ◽  
Large Random Sample ◽  
Lower Limits

Context: Measurement of IGF-I is important in the management of patients with growth hormone disorders. Here we aim to establish normative data for two new IGF-I assay kits based on a large random sample of the French general adult population. Subjects and Methods: We measured IGF-I in 911 healthy adults (18–90 years) with two immunoassays (ROCHE Elecsys® and IMMULITE-2000 calibrated against the new IS 02/2547). We compared the data with those of the six immunoassays (iSYS, LIAISON XL, IMMULITE-2000 calibrated against the first IS 87/518, IGFI RIACT, Mediagnost ELISA, and Mediagnost RIA) that we reported previously. The pairwise concordance among the eight assays was assessed with Bland-Altman plots for both the IGF-1 raw data and the standard deviation scores (SDS), as well as with the percentage of observed agreement and the weighted Kappa coefficient for categorizing IGF-I SDS (ClinicalTrials.gov Identifier: NCT01831648). Results: The normative data included the range of values (2.5–97.5 percentiles) given by the two new IGF-I assays according to age group and sex. A formula for the SDS calculation is provided. For the previous six assays, the lower limits of the reference intervals of the two new assays were similar, but the upper limits varied markedly. The pairwise concordances were only moderate (kappa 0.57). Conclusions: Data obtained for these two new IGF-I immunoassays confirm that despite being obtained in the same large healthy population, the reference intervals of the eight commercial IGF-1 assay kits showed noteworthy differences. The agreement among the various methods was moderate to good.

scholarly journals Reference Values for IGF-I Serum Concentrations: Comparison of Six Immunoassays

2016 ◽  
Vol 101 (9) ◽  
pp. 3450-3458 ◽  
Author(s):  
Philippe Chanson ◽  
Armelle Arnoux ◽  
Maria Mavromati ◽  
Sylvie Brailly-Tabard ◽  
Catherine Massart ◽  
...  
Keyword(s):  
Normative Data ◽  
Adult Population ◽  
Weighted Kappa ◽  
Reference Intervals ◽  
Healthy Population ◽  
Multicenter Cohort Study ◽  
Cross Sectional ◽  
Somatotropic Axis ◽  
Igf I ◽  
General Adult Population

Abstract Context: Measurement of IGF-I is essential for diagnosis and management of patients with disorders affecting the somatotropic axis. However, even when IGF-I kit manufacturers follow recent consensus guidelines, different kits can give very different results for a given sample. Objectives: We sought to establish normative data for six IGF-I assay kits based on a large random sample of the French general adult population. Subjects and Methods: In a cross-sectional multicenter cohort study, we measured IGF-I in 911 healthy adults (18–90 years) with six immunoassays (iSYS, LIAISON XL, IMMULITE, IGFI RIACT, Mediagnost ELISA, and Mediagnost RIA). Pairwise concordance between assays was assessed with Bland-Altman plots for both IGF-1 raw data and standard deviation scores (SDS), as well as with the percentage of observed agreement and the weighted Kappa coefficient for categorized IGF-I SDS. Results: Normative data included the range of values (2.5–97.5 percentiles) given by the six IGF-I assays according to age group and sex. A formula for SDS calculation is provided. Although the lower limits of the reference intervals of the six assays were similar, the upper limits varied markedly. Pairwise concordances were moderate to good (0.38–0.70). Conclusion: Despite being obtained in the same healthy population, the reference intervals of the six commercial IGF-1 assay kits showed noteworthy differences. Agreement between methods was moderate to good.

Establishment of reference intervals for immunoassay analytes of adult population in Saudi Arabia

2020 ◽  
Vol 58 (8) ◽  
pp. 1302-1313 ◽  
Author(s):  
Anwar Borai ◽  
Kiyoshi Ichihara ◽  
Abdulaziz Masaud ◽  
Waleed Tamimi ◽  
Suhad Bahijri ◽  
...  
Keyword(s):  
Vitamin D ◽  
Saudi Arabia ◽  
Adult Population ◽  
Reference Intervals ◽  
Careful Consideration ◽  
Upper Limits ◽  
Sources Of Variation ◽  
Vitamin D Supplements ◽  
Saudi Arabians ◽  
Abbott Architect

AbstractBackgroundThis is a second part of report on the IFCC global multicenter study conducted in Saudi Arabia to derive reference intervals (RIs) for 20 immunoassay analytes including five tumor makers, five reproductive, seven other hormones and three vitamins.MethodsA total of 826 apparently healthy individuals aged ≥18 years were recruited in three clinical laboratories located in western, central and eastern Saudi Arabia using the protocol specified for the global study. All serum specimens were measured using Abbott, Architect analyzers. Multiple regression analysis (MRA) was performed to explore sources of variation of each analyte: age, body mass index (BMI), physical exercise and smoking. The magnitude of variation of reference values (RVs) attributable to sex, age and region was calculated by ANOVA as a standard deviation ratio (SDR). RIs were derived by the parametric (P) method.ResultsMRA revealed that region, smoking and exercise were not relevant sources of variation for any analyte. Based on SDR and actual between-sex differences in upper limits (ULs), we chose to partition RIs by sex for all analytes except for α-fetoprotein and parathyroid hormone (PTH). Age-specific RIs were required in females for ferritin, estradiol, progesterone, testosterone, follitropin, luteotropin and prolactin (PRL). With prominent BMI-related increase, RIs for insulin and C-peptide were derived after excluding individuals with BMI > 32 kg/m2. Individuals taking vitamin D supplements were excluded in deriving RIs for vitamin D and PTH.ConclusionsRIs of major immunoassay analytes specific for Saudi Arabians were established in careful consideration of various biological sources of variation.

Establishment of reference intervals of clinical chemistry analytes for the adult population in Saudi Arabia: a study conducted as a part of the IFCC global study on reference values

2016 ◽  
Vol 54 (5) ◽  
Author(s):  
Anwar Borai ◽  
Kiyoshi Ichihara ◽  
Abdulaziz Al Masaud ◽  
Waleed Tamimi ◽  
Suhad Bahijri ◽  
...  
Keyword(s):  
Reference Values ◽  
Clinical Chemistry ◽  
Adult Population ◽  
Parametric Method ◽  
Reference Intervals ◽  
Test Results ◽  
Upper Limits ◽  
High Prevalence ◽  
Global Study ◽  
Non Parametric

AbstractBackground:This study is a part of the IFCC-global study to derive reference intervals (RIs) for 28 chemistry analytes in Saudis.Method:Healthy individuals (n=826) aged ≥18 years were recruited using the global study protocol. All specimens were measured using an Architect analyzer. RIs were derived by both parametric and non-parametric methods for comparative purpose. The need for secondary exclusion of reference values based on latent abnormal values exclusion (LAVE) method was examined. The magnitude of variation attributable to gender, ages and regions was calculated by the standard deviation ratio (SDR). Sources of variations: age, BMI, physical exercise and smoking levels were investigated by using the multiple regression analysis.Results:SDRs for gender, age and regional differences were significant for 14, 8 and 2 analytes, respectively. BMI-related changes in test results were noted conspicuously for CRP. For some metabolic related parameters the ranges of RIs by non-parametric method were wider than by the parametric method and RIs derived using the LAVE method were significantly different than those without it. RIs were derived with and without gender partition (BMI, drugs and supplements were considered).Conclusions:RIs applicable to Saudis were established for the majority of chemistry analytes, whereas gender, regional and age RI partitioning was required for some analytes. The elevated upper limits of metabolic analytes reflects the existence of high prevalence of metabolic syndrome in Saudi population.

scholarly journals Reference Intervals for Potassium, Sodium and Chloride among Libyan Healthy People

2020 ◽  
Vol 5 (3) ◽  
Keyword(s):  
Population Based ◽  
Reference Intervals ◽  
Healthy People ◽  
Sodium Potassium ◽  
Direct Potentiometry ◽  
Percentile Method ◽  
Upper Limits ◽  
Males And Females ◽  
Blood Specimens ◽  
Lower Limits

Background: In Libya, all laboratories use reference intervals (RIs) derived from other country’s populations, which differ from Libyan population in many aspects such as daily habits and race. Due to these differences, it is assumed that those RIs are not applicable to Libyans. Aim: The aim of this study was to establish RIs of sodium, potassium and chloride in serum of Libyan people. Materials and Methods: Two hundred and fifty-seven blood specimens of healthy people (males and females) were collected using venipuncture untreated tubes. The specimens were centrifuged for 15 minutes and the obtained sera were analyzed for their content of sodium, potassium and chloride using direct potentiometry method. Results and Discussion: The non-parametric percentile method was applied to establish the RIs of sodium, chloride and potassium, which were found to be: 135-143.3; 103-110; 3.7-5.2 mmol/L, respectively. There were no considerable differences in lower limits and/or upper limits of all established RIs between males and females, except that the upper limit of Cl− for females was slightly higher than that for males. Conclusion: As there are evident regional differences in RIs, the established RIs in this study will be more favorable in Libya than those listed in the manufacturer’s kit or those adopted from other population-based references.

Awareness of general adult population of Saudi Arabia toward Bell’s palsy

2020 ◽  
pp. 1191-1197
Author(s):  
Sultan Alamrani ◽  
Shahd Rummani ◽  
Zainab Khamdan ◽  
Aisha Alharbi ◽  
Ahmad Alshahrani ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Adult Population ◽  
General Adult Population

Unravelling the phenotypic tangle of autistic, schizotypal and social anxiety traits: A Network Analysis

2020 ◽  
Author(s):  
Orestis Zavlis ◽  
Myles Jones
Keyword(s):  
Network Analysis ◽  
Social Anxiety ◽  
Factor Structure ◽  
Adult Population ◽  
Autism Spectrum ◽  
Underlying Structure ◽  
Schizotypal Personality ◽  
The Social ◽  
Trait Level ◽  
General Adult Population

Substantial overlap exists between schizophrenia and autism spectrum disorders, with part of that overlap hypothesised to be due to comorbid social anxiety. The current paper investigates the interactions and factor structure of these disorders at a personality trait level, through the lens of a network model. The items of the Autism Quotient (AQ), Schizotypal Personality Questionnaire Brief-Revised (SPQ-BR), and the Liebowitz Social Anxiety Scale (L-SAS) were combined and completed by 345 members of the general adult population. An Exploratory Graph Analysis (EGA) on the AQ-SPQ-BR combined inventory revealed two communities (factors), which reflected the general autism and schizotypal phenotypes. An additional EGA on all inventories validated the AQ-SPQ-BR factor structure and revealed another community, Social Anxiety (L-SAS). A Network Analysis (NA) on all inventories revealed several moderately central subscales, which collectively reflected the social-interpersonal impairments of the three disorders. The current results suggest that a combination of recent network- and traditional factor-analytic techniques may present a fruitful approach to understanding the underlying structure as well as relation of different psychopathologies.

EXPRESS: Method dependent variation in TSH and FT4 reference intervals in pregnancy: a systematic review

2021 ◽  
pp. 000456322110269
Author(s):  
O E Okosieme ◽  
Medha Agrawal ◽  
Danyal Usman ◽  
Carol Evans
Keyword(s):  
Systematic Review ◽  
Reference Interval ◽  
First Trimester ◽  
Reference Intervals ◽  
Assay Method ◽  
Specific Reference ◽  
Upper Limits ◽  
Wide Range ◽  
Assay Methods ◽  
In Pregnancy

Background: Gestational TSH and FT4 reference intervals may differ according to assay method but the extent of variation is unclear and has not been systematically evaluated. We conducted a systematic review of published studies on TSH and FT4 reference intervals in pregnancy. Our aim was to quantify method-related differences in gestation reference intervals, across four commonly used assay methods, Abbott, Beckman, Roche, and Siemens. Methods: We searched the literature for relevant studies, published between January 2000 and December 2020, in healthy pregnant women without thyroid antibodies or disease. For each study, we extracted trimester-specific reference intervals (2.5–97.5 percentiles) for TSH and FT4 as well as the manufacturer provided reference interval for the corresponding non-pregnant population. Results: TSH reference intervals showed a wide range of study-to-study differences with upper limits ranging from 2.33 to 8.30 mU/L. FT4 lower limits ranged from 4.40–13.93 pmol/L, with consistently lower reference intervals observed with the Beckman method. Differences between non-pregnant and first trimester reference intervals were highly variable, and for most studies the TSH upper limit in the first trimester could not be predicted or extrapolated from non-pregnant values. Conclusions: Our study confirms significant intra and inter-method disparities in gestational thyroid hormone reference intervals. The relationship between pregnant and non-pregnant values is inconsistent and does not support the existing practice in some laboratories of extrapolating gestation references from non-pregnant values. Laboratories should invest in deriving method-specific gestation reference intervals for their population.

scholarly journals Etiology of febrile respiratory infections in the general adult population in Singapore, 2007–2013

Heliyon ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. e06329
Author(s):  
Yihui Chen ◽  
Marcus G. Mah ◽  
Jenny G.H. Low ◽  
Eng Eong Ooi ◽  
Yvonne C.F. Su ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Adult Population ◽  
General Adult Population

scholarly journals Research Trends on Mobile Mental Health Application for General Population: A Scoping Review

2021 ◽  
Vol 18 (5) ◽  
pp. 2459
Author(s):  
Won Ju Hwang ◽  
Ji Sun Ha ◽  
Mi Jeong Kim
Keyword(s):  
Mental Health ◽  
Scoping Review ◽  
Mobile Apps ◽  
Rapid Development ◽  
Adult Population ◽  
Well Being ◽  
Stress Theory ◽  
Scoping Reviews ◽  
General Adult Population ◽  
Health Related

Background: Scoping reviews of the literature on the development and application of mental health apps based on theoretical suggestions are lacking. This study systematically examines studies on the effects and results of mental health mobile apps for the general adult population. Methods: Following PICOs (population, intervention, comparison, outcome, study design), a general form of scoping review was adopted. From January 2010 to December 2019, we selected the effects of mental health-related apps and intervention programs provided by mobile to the general adult population over the age of 18. Additionally, evaluation of methodological quality was assessed using the Scottish Intercollegiate Guidelines Network (SIGN) checklist. Results: Fourteen studies were analyzed of 1205 that were identified; duplicate and matching studies were excluded. One was a descriptive study and 13 were experimental, of which randomized control trials (RCTs) accounted for 71.4%. Four of the mobile apps were developed based on cognitive behavior theory, one based on stress theory, and one on ecological instant intervention theory. These apps included breathing training, meditation, and music therapy. Stress, depression, and anxiety decreased using these apps, and some were effective for well-being. Conclusion: With the rapid development of technology related to mental health, many mobile apps are developed, but apps based on theoretical knowledge and well-designed research are lacking. Further research and practices should be conducted to develop, test, and disseminate evidence-based mHealth for mental health promotion. RCT studies are needed to expand the application to mental health services to various populations.

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