scholarly journals Plasma soluble α-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters

2012 ◽  
Vol 167 (3) ◽  
pp. 433-440 ◽  
Author(s):  
Tania Siahanidou ◽  
Maria Garatzioti ◽  
Christina Lazaropoulou ◽  
Georgia Kourlaba ◽  
Ioannis Papassotiriou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Full Term ◽  
Metabolic Parameters ◽  
Model Assessment ◽  
Metabolic Disturbances ◽  
Term Infants ◽  
Vitamin D Metabolism ◽  
Term Neonates ◽  
And Oxidative Stress

Objectiveα-Klotho (α-KL), a protein with antiaging properties, regulates phosphate, calcium, and bone metabolism, induces resistance to oxidative stress, and may participate in insulin signaling. The role of α-KL in neonates, known to be prone to metabolic disturbances and oxidative stress, is not known. The aim of this study was to evaluate circulating soluble α-KL concentrations in preterm and full-term neonates and unravel possible correlations with growth, metabolism, and indices of oxidative stress.DesignProspective study.MethodsPlasma-soluble α-KL levels were determined by specific ELISA in 50 healthy neonates (25 preterm, mean (s.d.) gestational age (GA) 33.7 (1.1) weeks, and 25 full-term infants) at days 14 and 28 of life. Associations of α-KL with anthropometric, metabolic parameters, and indices of oxidative stress were examined.Resultsα-KL levels were significantly higher in full-term than in preterm infants at both days 14 (1099 (480) pg/ml vs 884 (239) pg/ml respectively; P<0.05) and 28 (1277 (444) pg/ml vs 983 (264) pg/ml respectively; P<0.01). In both preterm and full-term infants, α-KL levels increased significantly from day 14 to 28 of life (P<0.001). Circulating α-KL concentrations correlated with GA (β=0.32, P=0.001), body weight (β=0.34, P=0.001), body length (β=0.33, P=0.001), 1,25-dihydroxy-vitamin D level (β=0.24, P<0.05), and malondialdehyde level (β=0.20, P<0.05) but not with glucose, insulin, or homeostasis model assessment index of insulin resistance values.ConclusionsSoluble α-KL levels rise as GA and postnatal age advance in neonates and may have an impact on vitamin D metabolism and oxidative stress. Whether α-KL may have a role in the regulation of infants' growth should be further studied.

scholarly journals Επίπεδα της πρωτεΐνης klotho σε πρόωρα νεογνά

2012 ◽  
Author(s):  
Μαρία Γαρατζιώτη
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Body Weight ◽  
Gestational Age ◽  
Full Term ◽  
Model Assessment ◽  
Metabolic Disturbances ◽  
Term Infants ◽  
Vitamin D Metabolism ◽  
Assessment Index

Klotho, a protein with anti-aging properties, regulates phosphate, calcium and bonemetabolism, induces resistance against oxidative stress and may participate in insulinsignalling. Neonates, especially preterm ones, are prone to metabolic disturbances andoxidative stress. The role of kltho in neonates is not known.The objective of this prospective study was to evaluate circulating klothoconcentrations in preterm and full-term neonates and unravel possible correlationswith growth, metabolism and indices of oxidative stress.Plasma Klotho levels were determined by specific ELISA in 50 healthy neonates (25preterm, mean [SD] gestational age 33.7 [1.1] weeks and 25 full-term infants) at days14 and 28 of life. Associations of Klotho with anthropometric (body weight andlength) and metabolic parameters (serum calcium, phosphate, 1,25-dihydroxy-vitaminD, parathormone, FGF23, glucose, insulin, homeostasis model assessment index ofinsulin resistance [HOMA-IR]), and indices of oxidative stress (malonyldialdehyde[MDA] concentration and superoxide dismutase activity) were examined.Statistical analysis led to the following results:1. Plasma Klotho levels are significantly higher in full-term than preterm infantsat both days 14 (1099 [480] pg/mL vs. 884 [239] pg/mL, respectively; P<0.05) and 28(1277 [444] pg/mL vs. 983 [264] pg/mL, respectively; P<0.01).2. In both preterm and full-term infants, Klotho levels increase significantly fromday 14 to 28 of life (P<0.001).3. Circulating -Klotho concentrations correlate with gestational age (r=0.32,P=0.001), body weight (r=0.34, p=0.001), body length (r=0.33, P=0.001), 1,25-dihydroxy-vitamin D level (r=0.24, P<0.05) and MDA level (r=0.20, P<0.05), but notwith glucose, insulin, or HOMA-IR values.In conclusion, plasma klotho levels rise as gestational and postnatal age advance inneonates and may have an impact on vitamin D metabolism and oxidative stress.Whether klotho may have a role in the regulation of infants’ growth needs to befurther studied.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

scholarly journals Vitamin D status among preterm and full-term infants at birth

2013 ◽  
Vol 75 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Heather H. Burris ◽  
Linda J. Van Marter ◽  
Thomas F. McElrath ◽  
Patrik Tabatabai ◽  
Augusto A. Litonjua ◽  
...  
Keyword(s):  
Vitamin D ◽  
Full Term ◽  
Vitamin D Status ◽  
Term Infants

scholarly journals New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-21 ◽  
Author(s):  
José Pedraza-Chaverri ◽  
Laura G. Sánchez-Lozada ◽  
Horacio Osorio-Alonso ◽  
Edilia Tapia ◽  
Alexandra Scholze
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Cardiovascular Complications ◽  
Vitamin D Metabolism ◽  
Therapy Options ◽  
Mitochondrial Alterations ◽  
Inflammatory Processes ◽  
The Impact

In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals. In combination with a reduced antioxidant capacity this causes oxidative stress. This review focuses on current pathogenic concepts of oxidative stress for the decline of kidney function and development of cardiovascular complications. We discuss the impact of mitochondrial alterations and dysfunction, a pathogenic role for hyperuricemia, and disturbances of vitamin D metabolism and signal transduction. Recent antioxidant therapy options including the use of vitamin D and pharmacologic therapies for hyperuricemia are discussed. Finally, we review some new therapy options in diabetic nephropathy including antidiabetic agents (noninsulin dependent), plant antioxidants, and food components as alternative antioxidant therapies.

scholarly journals Effects of MP Polyethylene Microparticles on Microbiome and Inflammatory Response of Larval Zebrafish

Toxics ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 55
Author(s):  
Nicholas Kurchaba ◽  
Bryan J. Cassone ◽  
Caleb Northam ◽  
Bernadette F. Ardelli ◽  
Christophe M. R. LeMoine
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Markers ◽  
Production Cost ◽  
Resting Metabolic Rate ◽  
Metabolic Disturbances ◽  
Microbiome Composition ◽  
Larval Zebrafish ◽  
Living Organisms ◽  
Stress Mediator ◽  
And Oxidative Stress

Plastic polymers have quickly become one of the most abundant materials on Earth due to their low production cost and high versatility. Unfortunately, some of the discarded plastic can make its way into the environment and become fragmented into smaller microscopic particles, termed secondary microplastics (MP). In addition, primary MP, purposely manufactured microscopic plastic particles, can also make their way into our environment via various routes. Owing to their size and resilience, these MP can then be easily ingested by living organisms. The effect of MP particles on living organisms is suspected to have negative implications, especially during early development. In this study, we examined the effects of polyethylene MP ingestion for four and ten days of exposure starting at 5 days post-fertilization (dpf). In particular, we examined the effects of polyethylene MP exposure on resting metabolic rate, on gene expression of several inflammatory and oxidative stress linked genes, and on microbiome composition between treatments. Overall, we found no evidence of broad metabolic disturbances or inflammatory markers in MP-exposed fish for either period of time. However, there was a significant increase in the oxidative stress mediator L-FABP that occurred at 15 dpf. Furthermore, the microbiome was disrupted by MP exposure, with evidence of an increased abundance of Bacteroidetes in MP fish, a combination frequently found in intestinal pathologies. Thus, it appears that acute polyethylene MP exposure can increase oxidative stress and dysbiosis, which may render the animal more susceptible to diseases.

scholarly journals Vitamin D Metabolism-Related Gene Haplotypes and Their Association with Metabolic Disturbances Among African-American Urban Adults

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
May A. Beydoun ◽  
Sharmin Hossain ◽  
Salman M. Tajuddin ◽  
Jose A. Canas ◽  
Marie Kuczmarski ◽  
...  
Keyword(s):  
Vitamin D ◽  
African American ◽  
Related Gene ◽  
Metabolic Disturbances ◽  
Vitamin D Metabolism ◽  
Urban Adults

Vitamin D status and oxidative stress in diabetes mellitus

2018 ◽  
Vol 64 (7) ◽  
pp. 60 ◽  
Author(s):  
Wee Chee Lee ◽  
Siti Safiah Mokhtar ◽  
Seetha Munisamy ◽  
Sahran Yahaya ◽  
Aida Hanum Ghulam Rasool
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Vitamin D ◽  
Vitamin D Status ◽  
And Oxidative Stress
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