scholarly journals Controlling Nutritional Status is Useful for Predicting Postoperative Complications in very Elderly Patients with Colorectal Cancer: A Retrospective Study

2016 ◽  
Vol 28 (4) ◽  
pp. 317-325
Author(s):  
Akira SAITO ◽  
Masahiko MURAKAMI ◽  
Makoto WATANABE ◽  
Yoshiaki OZAWA ◽  
Kodai TOMIOKA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Study ◽  
Postoperative Complications ◽  
Nutritional Status ◽  
Elderly Patients ◽  
Very Elderly

scholarly journals Post-operative outcomes and predictors of mortality after colorectal cancer surgery in the very elderly patients

Heliyon ◽  
2019 ◽  
Vol 5 (8) ◽  
pp. e02363
Author(s):  
Matteo Novello ◽  
Francesco Vito Mandarino ◽  
Salomone Di Saverio ◽  
Davide Gori ◽  
Marialuisa Lugaresi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Elderly Patients ◽  
Cancer Surgery ◽  
Very Elderly ◽  
Colorectal Cancer Surgery ◽  
Predictors Of Mortality ◽  
Operative Outcomes

scholarly journals Association between Nutritional Status and Mortality after Aortic Valve Replacement Procedure in Elderly with Severe Aortic Stenosis

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 446 ◽  
Author(s):  
Edyta Wernio ◽  
Sylwia Małgorzewicz ◽  
Jolanta Anna Dardzińska ◽  
Dariusz Jagielak ◽  
Jan Rogowski ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Mortality Rate ◽  
Aortic Valve ◽  
Aortic Stenosis ◽  
Nutritional Status ◽  
Aortic Valve Replacement ◽  
Elderly Patients ◽  
Valve Replacement ◽  
Aortic Valve Area ◽  
One Year

Background: There is still a lack of data on the nutritional status of older people with aortic stenosis (AS) and the effect of poor nutrition on the occurrence of complications and mortality after an aortic valve replacement (AVR) procedure. The aim of this study was to assess the impact of selected nutritional status parameters in elderly patients with severe AS on the occurrence of postoperative complications and one-year mortality after the AVR procedure. Methods: 101 elderly patients with AS aged 74.6 ± 5.2 years who qualified for surgical treatment (aortic valve area [AVA] 0.73 ± 0.2 cm2) were enrolled in the study. A nutritional status assessment was performed before AVR surgery, and the frequency of postoperative complications occurring within 30 days of surgery was assessed. The one-year mortality rate was also captured. Results: Adverse events (both major and minor) up to 30 days occurred in 49.5% (n = 50) of the study population. Low Mini Nutritional Assessment (f-MNA) and Subjective Global Assessment (7-SGA) scores and low concentrations of total cholesterol, LDL-cholesterol, and prealbumin were associated with a higher risk of postoperative complications. The risk of complications increased 1.22 times (95% CI; 1.030–1.453; p = 0.019) with an impaired nutritional status. The annual mortality rate in the study group was 7.9%. Unintentional weight loss of >2.8% in the six months preceding surgery proved useful for predicting death within the first year after AVR surgery. Conclusions: The results indicate that poor nutritional status is an important factor affecting the adverse outcomes in elderly patients with severe aortic valve stenosis undergoing an AVR procedure.

scholarly journals Identification of the Risk Factors for Postoperative Complications in Elderly Patients with Colorectal Cancer

2016 ◽  
Vol 69 (4) ◽  
pp. 191-196
Author(s):  
Sho Sawazaki ◽  
Yasushi Rino ◽  
Hirohide Inoue ◽  
Norio Yukawa ◽  
Munetaka Masuda
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Postoperative Complications ◽  
Elderly Patients

scholarly journals Effect of Age on Laparoscopic Surgery and Postoperative Chemotherapy in Elderly Patients With Colorectal Cancer

2020 ◽  
Vol 36 (4) ◽  
pp. 229-242 ◽  
Author(s):  
Hyun Hee Kim ◽  
Myong Hoon Ihn ◽  
Yun Hee Lee ◽  
Jihyoun Lee ◽  
Sangchul Yun ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Laparoscopic Surgery ◽  
Postoperative Complications ◽  
Adverse Events ◽  
Elderly Patients ◽  
Chemotherapy Regimen ◽  
Postoperative Chemotherapy ◽  
Smoking History ◽  
Curative Intent ◽  
Physical Status Classification

Purpose: We aimed to evaluate the postoperative complications of laparoscopic colorectal cancer (CRC) surgery and the adverse events of postoperative chemotherapy in elderly patients compared to younger patients and to identify the factors influencing the termination of postoperative chemotherapy.Methods: Between June 2015 and May 2018, 188 patients with CRC underwent laparoscopic surgery with curative intent. Patients aged ≥ 70 were defined as elderly. Postoperative complications and adverse events of chemotherapy were assessed by using the Clavien-Dindo classification and the Common Terminology Criteria for Adverse Events, respectively. The clinicopathological factors were analyzed retrospectively.Results: Seventy-eight patients were considered elderly with a mean age of 77.5 ± 5.5 years. Overall postoperative complications occurred in 68 patients (36.2%). Age and primary tumor location were independent predictors of overall postoperative complications. Smoking history was the only independent predictor of major postoperative complications. Of 113 patients who were recommended postoperative chemotherapy, 90 patients (79.6%) received postoperative chemotherapy. Overall adverse events occurred in 40 patients (44.4%). The American Society of Anesthesiologists physical status classification and chemotherapy regimen were significantly associated with overall adverse events. The chemotherapy regimen was the only factor significantly associated with severe adverse events. Of 90 patients, postoperative chemotherapy could not be completed in 11 (12.2%). Age was the only factor significantly associated with stopping postoperative chemotherapy (P = 0.003).Conclusion: This study shows that laparoscopic CRC surgery and postoperative chemotherapy were feasible in elderly patients. Further efforts are needed to ensure that elderly patients have the opportunity to make informed decisions regarding postoperative chemotherapy.

Impact of expression of SIRT1 and SIRT2 on outcome in the very elderly patients with colorectal cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15107-e15107
Author(s):  
In Sook Woo ◽  
Yun Hwa Jung ◽  
In Kyu Lee
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factor ◽  
Elderly Patients ◽  
Young Patients ◽  
High Expression ◽  
Very Elderly ◽  
Poor Prognostic Factor ◽  
Younger Patients ◽  
Sirt1 Expression ◽  
The Impact

e15107 Background: Surtuins(SIRTs), NAD+-dependent deacetylases, participate in cell metabolism and ageing associated diseases including cancer. The elderly has higher cancer incidence and mortality compared to the young. Many of patients with colorectal cancer are over the age of 80. The role of SIRT 1 and 2 in tumorigenesis remains debated and it has not been reported for the very elderly patients with cancer. We investigated the relationship of clinicopathologic parameters and expression of SIRT1 and 2 in colorectal cancer patients 80 years of age or older and the impact of ageing comparing with the younger patients. Methods: The expression of SIRT1 and 2 were evaluated in colorectal cancer tissues of 101 patients aged ≥80 years and 29 patients aged ≤40 years by immunohistochemistry. And correlations between expression of these proteins and clinicopathological features were analyzed. Results: High expression of SIRT1 was observed in 65/101 (64.4%) elderly patients and 11/29 (37.9%) young patients(p = 0.011). Similarly, high expression of SIRT2 was more commonly observed in 58/99 (58.6%) elderly patients than 8/29 (27.6%) young patients(p = 0.003). In all patients high SIRT2 expression was associated with comorbid DM, and stage of CRC were not associated with SIRT1 or SIRT2 expression status. Comparison of Kaplan-Meier survival curve using log rank test revealed that high expressions of SIRT1 and SIRT2 were significantly associated with worse prognosis (median OS 24.9ms vs 38.6ms, p = 0.027) and better prognosis (median OS 37.9ms vs 17.3ms, p = 0.006) respectively in elderly patients. No prognostic significances were observed in younger patients. In multivariate analysis, only high SIRT1 expression retained statistical significance as a poor prognostic factor in elderly patients with CRC. Conclusions: :High SIRT1 expression might become a significant poor prognostic factor for elderly CRC patients although further study is needed for younger patients to clarify the difference of expression according to the age between elderly and young patients with CRC. High SIRT2 expression showed association with comorbid DM, further studies are warranted to establish prognostic significance in CRC patients.

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