scholarly journals Járvány, vírus, Virológiai Nemzeti Laboratórium

2021 ◽  
Vol 2 (1) ◽  
pp. 62-67
Author(s):  
Ferenc Jakab

Összefoglaló. A fertőző betegségek világméretű fenyegetettsége és terjedése komoly társadalmi, egészségügyi kockázatot jelent minden nemzet számára. A lokális problémák megoldása mellett minden esetben közös nemzeti és nemzetközi összefogás szükséges. Az elmúlt években hazánkban is egyre nagyobb számban jelentek, illetve erősödtek meg új fertőző betegségek, amelyek szignifikáns társadalmi fenyegetést jelentenek. Éppen ezért a Virológiai Nemzeti Laboratórium (VNL) létrehozásának célja a Pécsi Tudományegyetem, Szentágothai János Kutatóközpont (PTE SzKK) kötelékén belül működő komplex virológiai laboratóriumi egység kutatási teljesítményének és kutatás-fejlesztési tevékenységének növelése, és ezzel párhuzamosan részvétel a hazai és nemzetközi szintű kutatási hálózatok munkájában. A VNL-hez tartozó komplex virológiai kutatási egység egyedüli hazánkban, hiszen minden biológiai biztonsági szintű laboratóriumi facilitással rendelkezik. Ennek megfelelően lehetőség van a 2-es (BSL-2), 3-as (BSL-3) és egyetlen egyetemi fenntartású laboratóriumként 4-es biológiai biztonsági szintű (BSL-4) laboratóriumi tevékenység elvégzésére. Ezzel egyedülálló lehetőséget nyit hazánkban is a fertőző betegségek leküzdésében vívott harcban. Hazánkban a PTE rendelkezik az egyetlen ilyen komplex virológiai kutatólaboratóriummal, amelyet tisztán kutatási és nem járványügyi feladatok elvégzésére hoztak létre. Ennek megfelelően az itt munkát végző fiatal kollégák az egyetemi prioritásoknak megfelelően a nemzetközileg elismert, kimagasló tudományos eredmények elérését tűzték ki célul. Mivel a laboratóriumi egység egyedülálló hazánkban, így a virológia területén nemcsak a kutatást, de az oktatást is kiválóan szolgálja. A PTE SzKK Virológia Kutatócsoportjának elsődleges kutatási területe az állatokról emberekre terjedő, úgynevezett virális zoonózisok vizsgálata. Ezen kórokozók a legtöbb esetben súlyos, akár halálos kimenetelű fertőzéseket is képesek okozni, éppen ezért a vizsgálatok igen magas szakmai kompetenciát és megfelelő laboratóriumi infrastruktúrát igényelnek. Mindazonáltal az ilyen irányú vizsgálatok száma nemzetközi szinten is igen megnőtt, hiszen az új betegségek megjelenése is gyakoribbá vált, amit elsősorban a környezeti és emberi tényezők együttes hatása eredményezhet. A kutatócsoport az alapkutatásokon kívül számos alkalmazott kutatási projektben is részt vesz, amelyek célja a humán diagnosztikában, betegellátási gyakorlatban is alkalmazható tesztek, potenciálisan antivirális hatóanyagok fejlesztése, tesztelése. Mivel a laboratórium egyedülálló biológiai biztonsági szinttel rendelkezik az ilyen irányú alkalmazott kutatásokban, kutatás-fejlesztési és innovációs (K+F+I) tevékenységekben is részt tud venni, ezzel emelve a hazai kutatás-fejlesztési irányokat a mikrobiológia területén. A virológiai laboratórium nemcsak alap- és alkalmazott kutatásokat folytat, de szükség esetén részt tud venni a hazai védelmi, biztonsági szervek munkájában is. A VNL fő célja egy hazai, magas színvonalú nemzeti virológiai kutatási centrum létrehozása, amely elősegíti a hazai virológiai kutatások tudományos fejlesztését, valamint a szakterület K+F+I tevékenységének növelését. Summary. Today, the global threat and spread of infectious diseases pose serious social and health risks for every nation of the world. In addition to local challenges, there is a sustained need for national and international collaborations. In recent years, numerous new infectious diseases have emerged and grown into significant social threats also in Hungary. Therefore, in collaboration with national and international research networks, the ultimate goal of the National Laboratory of Virology (NLV) is to boost the performance and R&D activities of the Virology Laboratory complex of the Szentágothai János Research Centre (PTE-SzKK) at the University of Pécs. Due to its specific, high level facilities, our virology research unit has a unique asset in Hungary. Accordingly, it is capable of conducting experiments requiring Biosafety Level 2 (BSL-2), Biosafety Level 3 (BSL-3) and as the only academically supported unit in Hungary, it is also capable of covering Biosafety Level 4 (BSL-4) standards to uniquely combat infectious diseases in the area. Our laboratory is a distinctive research facility not only nationally, but internationally as well. Currently, the University of Pécs possesses the only virological research laboratory in Hungary that was established purely for research purposes and not for performing epidemiological tasks. Accordingly, aligned with their academic priorities, our young investigators set their horizons towards achieving internationally recognized, outstanding scientific results. Notably, because our renowned laboratory unit is unparalleled throughout the country, colleagues are wishing to pursue research and training in the field of virology. The primary research field of the PTE-SzKK Virology Research Group is studying the so-called viral zoonoses; infectious transmissions from animals to humans. In most cases, these pathogens may cause serious, or even fatal infections requiring high level professional competence and corresponding laboratory infrastructure. Nevertheless, the number of international studies has recently surged as new diseases evolve and become more common due to the combined effects of environmental and human factors. In addition to basic science, our team is also conducting a number of applied research projects such as development of potential antiviral agents and tests for human diagnostics and medical care. Since our laboratory possesses a particularly high level of biosafety, it may be equally utilized in clinical practice and by providing novel directions for the national microbiology research and R&D field. Moreover, NLV not only implements basic and applied research, but also collaborates with various organizations of the Homeland Security of Hungary. The primary goal to establish an NLV was to utilize a National research facility in the field of virology in Hungary in order to increase both research and R&D activity in the country.

2014 ◽  
Vol 9 (5) ◽  
pp. 818-822
Author(s):  
Hideaki Higashi ◽  
◽  
Hiroshi Kida

The Hokkaido University Research Center for Zoonosis Control (CZC) established the Hokudai Center for Zoonosis Control in Zambia (HUCZCZ) at the School of Veterinary Medicine, the University of Zambia, in 2007 to control zoonotic diseases in the areas of South Africa, where various emerging infectious diseases have occurred. The CZC promotes epidemiological studies and basic researches of infectious diseases caused by viruses, protozoa, and bacteria by using the biosafety level 3 facility in the HUCZCZ. This article introduces research activities of the HUCZCZ in Zambia.


2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
R Arnone ◽  
G Romano ◽  
J Skinner ◽  
S Watt ◽  
C Poenicke ◽  
...  

Abstract In December 2013 the European Commission approved the project promoted by CEFPAS, The Centre for Training and Research in Public Health within the programme PROGRESS, “Improving the operational skills of health personnel working in the emergency departments. A useful tool to give concrete answers to EU policies on patients’ safety and to create new working opportunities”. This project aimed to combine the need to find innovative solutions in the field of healthcare with the objective of increasing the safety of patients in emergency departments, while also covering the need to promote worker mobility within the European Union. The key tool for implementing this goal is the exchange of experience and best practices. The project partners included: the Edinburgh University of Medicine, the Napier University (again in Edinburgh), the Dresden University of Technology, the Herlev Hospital (in Copenhagen) through the DIMS or the Danish Institute for Medical Simulation at the University of Copenhagen, as well as ISMETT and CREAM (the Research Centre of the University of Medicine) in Palermo. Every partner, during the planning, has provided the know how developed in the area of emergency. Specifically it has been analyzed the possibility to compare and visit the simulation Centres of Edinburgh, Dresden and Palermo, and to study the use, in each country, of innovative methodology during the training of the health personnel. The partner, during the planning of the project, studied also how to help people to find easier jobs opportunities in the health sector (so they thought to create a specific data base of the emergency departments operating in Italy, Scotland and Germany where to find a job or a chance for an internship). The project has lasted for one year and has provided research activities and the exchange of experience and best practices. Key messages There is a huge difference regarding the way in which the emergency system is organized within single countries around Europe. Comparing high-level organisations we have benefited in terms of ideas, projects and potential objectives to be set in order to improve our work and to improve results for patients.


Author(s):  
Salvatore Ameduri ◽  
Antonio Concilio ◽  
Ignazio Dimino ◽  
Rosario Pecora ◽  
Sergio Ricci

By introducing the progresses on Morphing currently achieved within the European Project “AIRGREEN2”, in Clean-Sky 2 GRA platform, this work presents a review of the research step forwards accomplished in the last decade by three Italian Partners largely active in the field: the Italian Aerospace Research Centre, the University of Naples “Federico II” and the Politecnico of Milano. A chronologic overview is at first presented, revisiting the research programs and the achieved results; an organic development path has been then built, starting from low TRL achievements up to arrive at the most complete technical accomplishments, characterized by a high level of integration and targeting specific aerospace applications.


Motricidade ◽  
2016 ◽  
Vol 12 (2) ◽  
pp. 1
Author(s):  
Nuno Domingos Garrido

<p>The Journal Motricidade has always been walking in parallel with the scientific communities.</p><p>We found that the affiliation of most authors has, nearly always, a University (Uni) or a Research Center (RC). In fact it is almost impossible to conduct research outside these two universes. In this sense, Uni and RC feed the most, if not all, of scientific journals worldwide. By this I mean that is in the interest of Motricidade to be associated with high-quality RC and Uni equally recognized.</p><p>With regard to RC, Motricidade will publish this year a supplement of the International Congress of Research Centre in Sports Sciences, Health Sciences and Human Development (CIDESD). This RC has conducted research in a variety of areas within the Sport Sciences and Health and always with high recognition and associated publications. It was not by chance that this RC was evaluated with ‘very good’ by the Portuguese Foundation for Science and Technology (FCT) panel and has been granted funding.</p><p>This Congress, which takes place every two years, targets to converge research and high level practices within these three areas: Sports, Health and Human Development. The 2016 CIDESD edition is dedicated to "Exercise and Health, Sports and Human Development" and will be held at the University of Évora, between 11 and 12 November of 2016. The readers can check the program in the following link <a href="http://gdoc.uevora.pt/450120" target="_blank">http://gdoc.uevora.pt/450120</a> and get more information in the Congress Site available at <a href="http://www.cidesd2016.uevora.pt/">http://www.cidesd2016.uevora.pt/</a>.</p><p>With regard to Uni, Motricidade signed a cooperation protocol with the University of Beira Interior (UBI) in May of 2016, involving the development and dissemination of scientific knowledge in Sports Sciences, Psychology, Human Development and Health.</p><p>At the present, UBI hosts more than 6,000 students spread across five faculties - Arts &amp; Letters, Sciences, Health Sciences, Humanities and Social Sciences and Engineering.</p><p>When looking at the rankings, for instance the Times Higher Education (THE), v.2016-17 (<a href="https://www.timeshighereducation.com/world-university-rankings/universidade-da-beira-interior#ranking-dataset/589595">https://www.timeshighereducation.com/world-university-rankings/universidade-da-beira-interior#ranking-dataset/589595</a>), we can see that UBI is growing, mostly in Research publications, in other words, on the number of research publications, where at least one author is affiliated to the university (<a href="http://www.umultirank.org/#!/home?trackType=home&amp;sightMode=undefined">http://www.umultirank.org/#!/home?trackType=home&amp;sightMode=undefined</a>).</p><p>We hope to contribute to maintain or increase this number of publications, since among the various clauses drawn up, in order to encourage research with publication in peer review journals, it was agreed that any manuscript submitted and accepted for publication, whose author or collaborators are affiliated with UBI is due half the rate of publication.</p><p>Union makes us stronger.</p>


Author(s):  
Oliver Brownbridge ◽  
Matthew Sully ◽  
Joshua Noons ◽  
Ibrahim Albayati

Abstract Commercial food outlets in the UK are responsible for 3% of the UK total energy consumption, with refrigeration systems account for 29% of this total. This highlights the potential and importance of huge energy saving within commercial refrigeration systems. In this paper, a validated model that simulates a commercial refrigeration system installed over 2000 sqft to mimic a real express store installed at Riseholme Refrigeration Research Centre at the University of Lincoln, UK, is developed and presented. The detailed modelling of the display case using a temperature model comprising of three states include air inside the display case, products, and the evaporator. Additionally, the model presents a holistic view of the whole system with each subsystem cohesively linked together. Further focus has been given on the high temperature (HT) system due to the high level of installations of this system found in retail commercial refrigeration stores as well as low temperature (LT) systems featuring doors which decrease the heat transfer from the store into the cases. It is concluded that the trends of the simulation results for the display case temperatures, expansion valve opening degree, suction line pressures, and compressors power consumption, all have high resemblance to the trends of collected data obtained from Riseholme Refrigeration Research Centre. This supports the validation of the developed model.


2020 ◽  
pp. 116-120
Author(s):  
O. V. Marynchak

Abstract. Providing quality training for future medical specialists is an urgent problem of our time. The state program for reforming the medical sphere requires educational institutions to train specialists who possess not only a high level of theoretical knowledge, but also a qualified level of practical skills, communicative properties. The article analyzes in detail the experience of implementing an objective structured exam (OSСЕ) to assess the knowledge and skills of interns on the stage of final certification in the specialty "Infectious Diseases", which was held at the Department of Infectious Diseases and Epidemiology of Ivano-Frankivsk National Medical University in 2019 and 2020. In percentage terms, the exam performance was as follows: “excellent” - 11.1%, “good” - 88.8%. Criteria for the effectiveness and objectivity of the system for assessing practical and communicative skills in the OSСЕ system are determined. The role of OSСЕ in the assessment system in medical education is described. The technique of the exam at the Department of Infectious Diseases and Epidemiology is described in detail. The expediency of introducing OSСЕ for conducting state certification of specialists has been proved. To evaluate the results, a descriptive-analytical method was used. Conclusions are drawn and directions for further improving the methodology for conducting and preparing for OSСЕ and improving the methodology for its assessment are identified. According to the results of OSKI conducted by interns in the specialty "Infectious Diseases" at the Department of Infectious Diseases and Epidemiology, in order to optimize the examination at the preparation stage, it was decided: to form examination booklets with a sufficient database, start preparing for the exam already in the first year of training of interns paying more attention training communication skills, examination algorithms, treatment, emergency care; to evaluate the intermediate certification of interns after each thematic section using a structured exam technique; to improve the station assessment system for a more thorough differentiation of the result. It is worth noting that during the exam at one of the stations, most future specialists had low results of passing the skills, therefore, at a meeting of the department, it was decided to carefully review the tasks of this station and make appropriate adjustments. Тhe use of structured response algorithms by the examiner helps to increase the reliability of the assessment, and therefore, the impartiality and objectivity of the exam and it is the objectivity of the assessment of the exam that depends on its structure (number of stations, questions). So compared with the traditional version of clinical trials, OSKI has many positive advantages. OSKI is a reliable and impartial exam, the main purpose of which is to standardize the tasks for the examinees, which increases the commitment of the examinees because it completely eliminates the fact of the "unfortunate task". During the OSKI, not only the level of theoretical knowledge was evaluated, but also the competence of future specialists in the application of the knowledge and practice was tested. Without applying theoretical knowledge to analytical skills by interns, it is impossible to actually complete a practical task, interpret the results of the examination, establish a diagnosis, etc. A positive point is that due to the presence on the OSKI of question and answer algorithms, teachers adhere to established rules and assessment standards, can fairly evaluate the intern during a practical skill and minimize the subjective influence of the examiner on the evaluation process of the intern.  


Author(s):  
H. K. Birnbaum ◽  
I. M. Robertson

Studies of the effects of hydrogen environments on the deformation and fracture of fcc, bcc and hep metals and alloys have been carried out in a TEM environmental cell. The initial experiments were performed in the environmental cell of the HVEM facility at Argonne National Laboratory. More recently, a dedicated environmental cell facility has been constructed at the University of Illinois using a JEOL 4000EX and has been used for these studies. In the present paper we will describe the general design features of the JEOL environmental cell and some of the observations we have made on hydrogen effects on deformation and fracture.The JEOL environmental cell is designed to operate at 400 keV and below; in part because of the available accelerating voltage of the microscope and in part because the damage threshold of most materials is below 400 keV. The gas pressure at which chromatic aberration due to electron scattering from the gas molecules becomes excessive does not increase rapidly with with accelerating voltage making 400 keV a good choice from that point of view as well. A series of apertures were placed above and below the cell to control the pressures in various parts of the column.


Author(s):  
I. G. Zakharova ◽  
Yu. V. Boganyuk ◽  
M. S. Vorobyova ◽  
E. A. Pavlova

The article goal is to demonstrate the possibilities of the approach to diagnosing the level of IT graduates’ professional competence, based on the analysis of the student’s digital footprint and the content of the corresponding educational program. We describe methods for extracting student professional level indicators from digital footprint text data — courses’ descriptions and graduation qualification works. We show methods of comparing these indicators with the formalized requirements of employers, reflected in the texts of vacancies in the field of information technology. The proposed approach was applied at the Institute of Mathematics and Computer Science of the University of Tyumen. We performed diagnostics using a data set that included texts of courses’ descriptions for IT areas of undergraduate studies, 542 graduation qualification works in these areas, 879 descriptions of job requirements and information on graduate employment. The presented approach allows us to evaluate the relevance of the educational program as a whole and the level of professional competence of each student based on objective data. The results were used to update the content of some major courses and to include new elective courses in the curriculum.


The paper is a review on the textbook by A. V. Yeremin, «The History of the National Prosecutor’s office» and the anthology «The Prosecutor’s Office of the Russian Empire in the Documents of 1722–1917» (authors: V. V. Lavrov, A. V. Eremin, edited by N. M. Ivanov) published at the St. Petersburg Law Institute (branch) of the University of the Prosecutor’s office of the Russian Federation in 2018. The reviewers emphasize the high relevance and high level of research, their theoretical and practical significance. The textbook and the anthology will help the students increase their legal awareness, expand their horizons.


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