scholarly journals Waist circumference increased risk of benign prostatic hyperplasia through an increase in the level of interleukin-6 and insulin resistance in abdominal obesity patients

2017 ◽  
Vol 6 (1) ◽  
pp. 204
Author(s):  
Wira Gotera ◽  
Wira Mahadita ◽  
I Made Bakta ◽  
AA. Gde Oka ◽  
AAG. Budiartha ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Benign Prostatic Hyperplasia ◽  
Waist Circumference ◽  
Abdominal Obesity ◽  
Interleukin 6 ◽  
Prostatic Hyperplasia ◽  
Increased Risk

scholarly journals Association of Androgenetic Alopecia with Benign Prostatic Hyperplasia: A Case Control Study

2018 ◽  
Vol 16 (1) ◽  
pp. 17-23
Author(s):  
Manoj Kumar Chaudhary ◽  
Sudha Agrawal ◽  
Chandra Shekhar Agrawal
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Family History ◽  
Early Onset ◽  
Positive Family History ◽  
Prostatic Hyperplasia ◽  
Androgenetic Alopecia ◽  
Pelvic Ultrasonography ◽  
Increased Risk ◽  
History Of ◽  
Common Pathogenesis

Introduction: Androgenetic alopecia (AGA) is associated with increased risk of several systemic diseases and some environmental factors, however, controversies exist. Since AGA and Benign Prostatic Hyperplasia (BPH) share common pathogenesis and AGA manifests some decades before BPH onset, it may serve as an early marker of BPH.Objective: This study was conducted to know AGA and its association with BPH in men ≥20 years of age.Materials and Methods: Clinically diagnosed cases of AGA (n=176) and 117 age matched healthy controls were enrolled. All cases and controls were subjected for abdomino-pelvic ultrasonography, urinary flowmetry, fasting lipid profiles, glycemic index and body mass index. International Prostate Symptom Score (IPSS) was also assessed.Results: Among 176 patients, 120 (68.18%) had Hamilton-Norwood grade III AGA and 56 (31.82%) had grade IV-VII AGA. In both groups, 140 (79.55%) cases and 93 (79.49%) controls were aged <35 years respectively. Family history of AGA was present in 108 (61.36%) cases and 2 (1.71%) controls. This observation was statistically significant with OR= 89.61 (95%CI 23.67-339.29). Three (1.7%) cases and none of the controls had prostate volume >30ml. Seventeen(9.66%) cases and 4 (3.42%) controls were graded as moderately/severely symptomatic IPSS. Statistically significant association was seen between family history and early onset of hair loss (<35 years) in a male sibling or parent.Conclusion: Although positive family history was associated with early onset of AGA, no association between AGA and BPH could be elicited in our study.

scholarly journals Rhodesian Ridgebacks have an increased risk to develop benign prostatic hyperplasia

2020 ◽  
Vol 55 (3) ◽  
pp. 283-292 ◽  
Author(s):  
Franziska Werhahn Beining ◽  
Carola Urhausen ◽  
Karola Wolf ◽  
Marion Schmicke ◽  
Karl Rohn ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Increased Risk

scholarly journals Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Xin Gu ◽  
Tao Huang ◽  
Ding Xu ◽  
Liujian Duan ◽  
Yang Jiao ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Chinese Population ◽  
Prostatic Hyperplasia ◽  
Free Psa ◽  
Reductase Inhibitors ◽  
Increased Risk ◽  
Chinese Descent ◽  
Adrenergic Blockers ◽  
Total Psa ◽  
The Relationship

Recent studies reported that rs2252004 at 10q26 was significantly associated with prostate cancer (PCa) risk in a Japanese population and was subsequently confirmed in a Chinese population. We aimed to assess the relationship between this locus and risk/aggressiveness of benign prostatic hyperplasia (BPH). The current study included 426 BPH cases and 1,008 controls from Xinhua Hospital in Shanghai, China. All BPH patients were treated withα-adrenergic blockers and 5α-reductase inhibitors for at least 9 months. Associations between rs2252004 and BPH risk/aggressiveness were tested using logistic regression. Associations between rs2252004 and clinical parameters including International Prostate Symptom Score (IPSS), total prostate volume (TPV), total PSA (tPSA), and free PSA (fPSA) were evaluated by linear regression. Allele “A” in rs2252004 was significantly associated with increased risk for aggressiveness of BPH in a Chinese population (OR = 1.42, 95% CI: 1.04–1.96,P=0.03). Patients with the genotype “A/A” (homozygous minor allele) had an increase of IPSS and TPV after treatment (P=0.045and 0.024, resp.). No association was observed between rs2252004, BPH risk, and baseline clinicopathological traits (AllP>0.05). Our study is the first to show that rs2252004 at 10q26 was associated with BPH aggressiveness and efficacy of BPH treatment.

Body composition in psychotic disorders: a general population survey

2008 ◽  
Vol 39 (5) ◽  
pp. 801-810 ◽  
Author(s):  
S. E. Saarni ◽  
S. I. Saarni ◽  
M. Fogelholm ◽  
M. Heliövaara ◽  
J. Perälä ◽  
...  
Keyword(s):  
Body Composition ◽  
Waist Circumference ◽  
General Population ◽  
Muscle Mass ◽  
Abdominal Obesity ◽  
Psychotic Disorders ◽  
Large Population ◽  
Fat Free Mass ◽  
Fat Percentage ◽  
Increased Risk

BackgroundThe literature suggests an association between obesity and schizophrenia but fat mass and fat-free mass, which have been shown to be more predictive of all-cause mortality than only waist circumference and obesity [body mass index (BMI) ⩾30 kg/m2], have not been reported in psychotic disorders. We examined the detailed body composition of people with different psychotic disorders in a large population-based sample.MethodWe used a nationally representative sample of 8082 adult Finns aged ⩾30 years with measured anthropometrics (height, weight, waist circumference, fat percentage, fat-free mass and segmental muscle mass). Psychiatric diagnoses were based on a consensus procedure utilizing the Structured Clinical Interview for DSM-IV (SCID)-interview, case-notes and comprehensive register data.ResultsSchizophrenia (including schizo-affective disorder) was associated with obesity [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.5–3.6], abdominal obesity (waist circumference ⩾88 cm for women, ⩾102 cm for men) (OR 2.2, 95% CI 1.3–3.6) and with higher fat percentage (mean difference 3.8%, 95% CI 2.0–5.7%), adjusted for age and gender, than in the remaining sample. The associations between schizophrenia and low fat-free mass and decreased muscle mass on trunk and upper limbs became statistically significant after adjusting for BMI. After further adjusting for current antipsychotic medication, education, diet and smoking, schizophrenia remained associated with obesity (OR 1.9, 95% CI 1.1–3.6) and abdominal obesity (OR 3.8, 95% CI 1.5–9.4). Participants with affective psychoses did not differ from the general population.ConclusionsIndividuals with schizophrenia have metabolically unfavorable body composition, comprising abdominal obesity, high fat percentage and low muscle mass. This leads to increased risk of metabolic and cardiovascular diseases.

Abdominal obesity and risk for esophageal cancer: A nationwide population-based cohort study of South Korea.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 446-446
Author(s):  
Dong Ho Lee ◽  
Jae Ho Cho ◽  
Cheol Min Shin ◽  
Kyungdo Han ◽  
Hyuk Yoon ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cohort Study ◽  
Waist Circumference ◽  
South Korea ◽  
Abdominal Obesity ◽  
Population Based ◽  
Dependent Manner ◽  
Increased Risk ◽  
Chi Squared ◽  
The Relationship

446 Background: The relationship between overall obesity, as measured by body mass index (BMI), and risk of esophageal squamous cell carcinoma (ESCC) has been reported, and it has a negative correlation. However, the relationship with abdominal obesity, as measured by waist circumference, may be different. We investigated the association between abdominal obesity and ESCC. Methods: Retrospective cohort study with 22,809,722 individuals who had undergone regular health check-ups provided by the National Health Insurance Corporation between 2009 and 2012 (median follow-up period was 6.4 years) in South Korea. Abdominal obesity was defined as a waist circumference over 90 cm for men and 85 cm for women. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) using Chi-squared test and Cox proportional hazard model adjusted for confounding factors. Primary outcome was newly developed esophageal cancer. Results: After adjusting for BMI, abdominal obesity increased the risk of ESCC (HR 1.29, 95% CI 1.23–1.36). Waist circumference is associated with increased risk of ESCC in a dose-dependent manner ( P for trend < 0.0001). We analyzed individuals divided into five categories of BMI. Among individuals with overweight (BMI 23–24.9 kg/m2) and obese I (BMI 25–29.9 kg/m2), abdominal obesity was a risk factor associated with developing ESCC (HR 1.22, 95% CI 1.11–1.34; HR 1.28, 95% CI 1.18–1.39, respectively). Conclusions: Abdominal obesity, not BMI itself, is associated with an increased risk for ESCC. Therefore, reducing abdominal obesity may affect decreasing the development of ESCC.

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