scholarly journals Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties

MRS Advances ◽  
2018 ◽  
Vol 3 (30) ◽  
pp. 1703-1709
Author(s):  
Xuefei Zhang ◽  
Yuan Zhang ◽  
Matthew Z. Yates
Keyword(s):  
Titanium Dioxide ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Antibacterial Property ◽  
Composite Coatings ◽  
Antibacterial Properties ◽  
Release Profile ◽  
Titanium Dioxide Nanotubes ◽  
Model Drug ◽  
Drug Compound

ABSTRACTHydroxyapatite (HA)/nanotubular titanium dioxide (TiO2) composite coatings loaded with antibiotics were developed to combine biocompatibility and antibacterial property. TiO2 nanotubes were first fabricated on Ti plates using anodization techniques. Then HA nanocrystals were synthesized on the TiO2 nanotubes by electrochemical deposition, followed by loading of a model drug compound, streptomycin. The streptomycin release profile of the composite coating was investigated. Bacterial tests demonstrate that the streptomycin-loaded composite coatings were highly effective in inhibiting bacterial growth. Simulated body fluid (SBF) experiments indicated that the composite coatings possessed good osseointegration capability.

scholarly journals Electrophoretic Deposition and Characteristics of Chitosan–Nanosilver Composite Coatings on a Nanotubular TiO2 Layer

Coatings ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 245
Author(s):  
Michał Bartmański ◽  
Łukasz Pawłowski ◽  
Andrzej Zieliński ◽  
Aleksandra Mielewczyk-Gryń ◽  
Gabriel Strugała ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Active Substance ◽  
Body Fluid ◽  
Composite Coatings ◽  
Antibacterial Properties ◽  
Titanium Implants ◽  
Surface Active Substance ◽  
Tio2 Layer ◽  
Surface Active ◽  
Silver Dissolution

The surface treatment of titanium implants has been applied mainly to increase surface bioactivity and, more recently, to introduce antibacterial properties. To this end, composite coatings have been investigated, particularly those based on hydroxyapatite. The present research was aimed at the development of another coating type, chitosan–nanosilver, deposited on a Ti13Zr13Nb alloy. The research comprised characterization of the coating’s microstructure and morphology, time-dependent nanosilver dissolution in simulated body fluid, and investigation of the nanomechanical properties of surface coatings composed of chitosan and nanosilver, with or without a surface-active substance, deposited at different voltages for 1 min on a nanotubular TiO2 layer. The microstructure, morphology, topography, and phase composition were examined, and the silver dissolution rate in simulated body fluid, nanoscale mechanical properties, and water contact angle were measured. The voltage value significantly influenced surface roughness. All specimens possessed high biocompatibility. The highest and best adhesion of the coatings was observed in the absence of a surface-active substance. Silver dissolution caused the appearance of silver ions in solution at levels effective against bacteria and below the upper safe limit value.

scholarly journals Preparation and Degradation Characteristics of MAO/APS Composite Bio-Coating in Simulated Body Fluid

Coatings ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 667
Author(s):  
Zexin Wang ◽  
Fei Ye ◽  
Liangyu Chen ◽  
Weigang Lv ◽  
Zhengyi Zhang ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Composite Coating ◽  
Body Fluid ◽  
Composite Coatings ◽  
Degradation Process ◽  
Ceramic Coatings ◽  
Immersion Test ◽  
Substrate Material ◽  
Atmospheric Plasma

In this work, ZK60 magnesium alloy was employed as a substrate material to produce ceramic coatings, containing Ca and P, by micro-arc oxidation (MAO). Atmospheric plasma spraying (APS) was used to prepare the hydroxyapatite layer (HA) on the MAO coating to obtain a composite coating for better biological activity. The coatings were examined by various means including an X-ray diffractometer, a scanning electron microscope and an energy spectrometer. Meanwhile, an electrochemical examination, immersion test and tensile test were used to evaluate the in vitro performance of the composite coatings. The results showed that the composite coating has a better corrosion resistance. In addition, this work proposed a degradation model of the composite coating in the simulated body fluid immersion test. This model explains the degradation process of the MAO/APS coating in SBF.

Investigation of Ag Oxidation and Ion Adsorption on Small Intestinal Submucosa in Simulated Body Fluid through Simultaneous Electrochemical and SPR Measurements

2015 ◽  
Vol 1119 ◽  
pp. 438-443
Author(s):  
Claudiu Constantin Manole ◽  
Ioana Demetrescu
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Electrochemical Techniques ◽  
Antibacterial Properties ◽  
Small Intestinal Submucosa ◽  
Human Blood Plasma ◽  
Ion Adsorption ◽  
Electrochemical Approach ◽  
Small Intestinal ◽  
Intestinal Submucosa

Small Intestinal Submucosa (SIS) is a material used from ancient times in foods, and more recently as a biomaterial. To ensure antibacterial properties, the presence of ionic Ag+is benefic and brings a minimum of toxicity to the SIS. In this paper, the electrochemical oxidation of Ag is considered to obtain the ionic Ag+. The simultaneous use of Surface Plasmon Resonance (SPR) and Electrochemical techniques opens an insight on Ag oxidation. The study is undertaken in a Simulated Body Fluid (SBF) with ions concentration that closely resembles the concentrations of the human blood plasma for a simulation of the Ag+ions behavior in physiological conditions. The simultaneous SPR and Electrochemical approach highlighted aspects of the ion adsorption into the SIS membrane.

scholarly journals Bioactivity Behavior Evaluation of PCL-Chitosan-Nanobaghdadite Coating on AZ91 Magnesium Alloy in Simulated Body Fluid

Coatings ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 231
Author(s):  
Farzad Soleymani ◽  
Rahmatollah Emadi ◽  
Sorour Sadeghzade ◽  
Fariborz Tavangarian
Keyword(s):  
Simulated Body Fluid ◽  
Corrosion Rate ◽  
Composite Coating ◽  
Body Fluid ◽  
Composite Coatings ◽  
Phosphate Buffer Solution ◽  
Az91 Alloy ◽  
Apatite Formation ◽  
Az91 Magnesium Alloy ◽  
Sbf Solution

Polymer–ceramic composite coatings on magnesium-based alloys have attracted lots of attention in recent years, to control the speed of degradability and to enhance bioactivity and biocompatibility. In this study, to decrease the corrosion rate in a simulated body fluid (SBF) solution for long periods, to control degradability, and to enhance bioactivity, polycaprolactone–chitosan composite coatings with different percentages of baghdadite (0 wt.%, 3 wt.%, and 5 wt.%) were applied to an anodized AZ91 alloy. According to the results of the immersion test of the composite coating containing 3 wt.% baghdadite in a phosphate buffer solution (PBS), the corrosion rate decreased from 0.45 (for the AZ91 sample) to 0.11 mg/cm2·h after seven days of immersion. To evaluate the apatite formation capability of specimens, samples were immersed in an SBF solution. The results showed that the samples were bioactive as apatite layers formed on the surface of specimens. The composite coating containing 3 wt.% baghdadite showed the highest apatite-formation capability, with a controlled release of ions, and the lowest corrosion rate in the SBF.

Synthesis of Ag-Containing CaO-SiO2 Gel and its Apatite Forming Ability in Simulated Body Fluid

2013 ◽  
Vol 587 ◽  
pp. 56-59 ◽  
Author(s):  
S.B. Cho ◽  
G.J. Yoon ◽  
E.M. An ◽  
Y.J. Kim ◽  
T.N. Kim ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Spherical Particle ◽  
Body Fluid ◽  
Antibacterial Property ◽  
Sol Gel ◽  
Spherical Particles ◽  
Silver Standard ◽  
Standard Solution ◽  
Gel Processing

We reported the apatite-forming ability of CaO-SiO2 spherical particles obtained through a sol-gel processing. In this study, we synthesized the CaO-SiO2 containing silver (Ag) ions using silver standard solution to induce antibacterial property and evaluated the effects of Ag on their apatite forming ability in a simulated body fluid (SBF). The particles with 30CaO·70SiO2 starting composition in Ag standard solution with range 0 to 500 ppm Ag content were synthesized through the sol-gel processing. The prepared 30CaO·70SiO2 could be obtained as spherical particles with regardless of Ag contents. The prepared Ag-contained 30CaO·70SiO2 particles formed apatite on their surfaces after soaking in SBF regardless of Ag contents. Consequently, Ag-contained 30CaO·70SiO2 spherical particle could be obtained without decrease of its apatite forming ability.

Heat Treatment Effect on Biological Behavior of Polyetheretherketone Composites

2022 ◽  
Vol 54 ◽  
pp. 119-128
Author(s):  
Alaa A. Mohammed ◽  
Jawad K. Oleiwi
Keyword(s):  
Heat Treatment ◽  
Simulated Body Fluid ◽  
Mtt Assay ◽  
Body Fluid ◽  
Antibacterial Properties ◽  
Biological Behavior ◽  
Apatite Formation ◽  
Crystalline Polymers ◽  
Density Methods

Polyetheretherketone is a semi-crystalline thermoplastic polymer, that so with heat treatments, it is possible to get different properties which are very important for the material performance. Heat treatment is a broadly utilized to develop the semi-crystalline polymers properties. In the present investigation, annealing of polyetheretherketone (PEEK) was carried out at temperatures above its glass transition temperature (Tg) to study its effects upon the biological conduct of the control and PEEK ternary composites. The bioactivity of the specimens was evaluated by investigating the apatite formation after immersion for different periods in a simulated body fluid (SBF). The biocompatibility of specimens was assessed by MTT assay. Additionally, the antibacterial property of the specimens versus S. aureus was observed with the optical density methods. The results manifested that the formation of hydroxyapatite was obviously observed on specimens after immersion for (7 and 14 days) in the simulated body fluid (SBF). Otherwise, the results of MTT assay recorded the PEEK specimens that excited the activity of fibroblasts, and therefore a high cytocompatibility was noticed and the specimens revealed antibacterial properties against S. aureus. So, the results of the bioactivity, biocompatibility and antibacterial tests in vitro demonstrated that the heat treatment enhanced biological behavior.

scholarly journals Improvement of mechanical-antibacterial performances of AR/PMMA with TiO2 and HPQM treated by N-2(aminoethyl)-3-aminopropyl trimethoxysilane

2020 ◽  
pp. 073168442097519
Author(s):  
Paveena Tangudom ◽  
Ignacio Martín-Fabiani ◽  
Benjaphorn Prapagdee ◽  
Ekachai Wimolmala ◽  
Teerasak Markpin ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Mechanical Properties ◽  
Titanium Dioxide ◽  
Carboxylic Acid ◽  
Cell Growth ◽  
Antibacterial Property ◽  
Antibacterial Properties ◽  
Antibacterial Performance ◽  
Quinoline Carboxylic Acid ◽  
Antibacterial Material

The mechanical and antibacterial properties of acrylic rubber/poly(methyl methacrylate) (AR/PMMA) blend at 10 to 50 wt% of AR content with non-treated and treated titanium dioxide (TiO2) and 2-Hydroxypropyl-3-piperazinyl-quinoline carboxylic acid methacrylate (HPQM) by N-2(aminoethyl)-3-aminopropyl trimethoxysilane were studied. The antibacterial property against Escherichia coli was evaluated. The results found that the mechanical properties of ARt-TiO2/PMMA and ARt-HPQM/PMMA blend were higher than that of the ARTiO2/PMMA and ARHPQM/PMMA blend. For antibacterial property, the ARHPQM/PMMA and ARt-HPQM/PMMA blend could act as the antibacterial material, while the ARTiO2/PMMA blend did not show. However, the ARt-TiO2/PMMA blend could inhibit bacterial cell growth with 10 to 30 wt% of AR content. The recommended compositions of ARt-TiO2/PMMA blend, which improved both mechanical and antibacterial properties, were 10 to 30 wt% of AR and were 10 to 50 wt% of AR for ARt-HPQM/PMMA. Moreover, the UV radiation increased the antibacterial properties by the destruction of the interaction in treated TiO2 and HPQM and improved the antibacterial performance of ARt-TiO2/PMMA and ARt-HPQM/PMMA blend.

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