Wireless nanotechnologies light up the next frontier in cell Calcium signalling

MRS Advances ◽  
2020 ◽  
Vol 5 (64) ◽  
pp. 3473-3489
Author(s):  
Ilaria Abdel Aziz ◽  
Maria Rosa Antognazza
Keyword(s):  
Calcium Signalling ◽  
Functional Materials ◽  
Signal Propagation ◽  
Long Distance ◽  
Non Invasive ◽  
Cellular Life ◽  
Physical Stimuli ◽  
Science Community ◽  
Material Science Community ◽  
Cell Calcium Signalling

AbstractCalcium ions impact nearly every aspect of cellular life, playing crucial roles as secondary messengers in regulation of neurotransmission, cell proliferation, migration and differentiation processes, intracellular homeostasis, long-distance signal propagation and stimuli physiological response. Despite its key-role, available techniques to study and selectively regulate Ca2+ signalling largely rely on chemical and electrical approaches, which often cannot ensure the necessary spatial and temporal resolution, specificity, modulation and reversal capability. In this context, Ca2+ modulation based on physical stimuli, such as magnetic, mechanical and optical tools, are emerging ass promising innovative solutions. Here, we focus our attention on a subclass of these approaches, namely wireless-activated techniques, and on functional materials able to act as non-invasive transduction elements. We present an overview of most recent outcomes in the field, and we critically evaluate their advantages and drawbacks. This work is mainly directed to the material science community, but hopefully it will provide a useful perspective also to the broader readership of biotechnologists, physiologists and clinicians.

scholarly journals Variation of Low-Frequency Time-Code Signal Field Strength during the Annular Solar Eclipse on 21 June 2020: Observation and Analysis

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1216
Author(s):  
Xin Wang ◽  
Bo Li ◽  
Fan Zhao ◽  
Xinyu Luo ◽  
Luxi Huang ◽  
...  
Keyword(s):  
Field Strength ◽  
Solar Eclipse ◽  
Low Frequency ◽  
Signal Propagation ◽  
Normal Operation ◽  
Time Code ◽  
Long Distance ◽  
Time Service ◽  
Annular Solar Eclipse ◽  
Signal Field

Due to the occlusion of the moon, an annular solar eclipse will have an effect on the ionosphere above the earth. The change of the ionosphere, for the low-frequency time-code signal that relies on it as a reflection medium for long-distance propagation, the signal field strength, and other parameters will also produce corresponding changes, which will affect the normal operation of the low-frequency time-code time service system. This paper selects the solar eclipse that occurred in China on 21 June 2020, and uses the existing measurement equipment to carry out experimental research on the low-frequency time-code signal. We measured and analyzed the signal field strength from 20 June 2020 to 23 June 2020, and combined solar activity data, ionospheric data, and geomagnetic data, and attempted to explore the reasons and rules of the change of signal parameters. The results showed that the field strength of the low-frequency time-code signal changed dramatically within a short time period, the max growth value can reach up to 17 dBμV/m and the variation trend yielded ‘three mutations’. This change in signal field strength is probably due to the occurrence of a solar eclipse that has an effect on the ionosphere. When the signal propagation conditions change, the signal strength will also change accordingly.

Long-distance wolf recolonization of France and Switzerland inferred from non-invasive genetic sampling over a period of 10 years

2003 ◽  
Vol 6 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Nathaniel Valière ◽  
Luca Fumagalli ◽  
Ludovic Gielly ◽  
Christian Miquel ◽  
Benoît Lequette ◽  
...  
Keyword(s):  
Long Distance ◽  
Non Invasive ◽  
Genetic Sampling

A Novel IoT-Based Method for Real-Time Detection of Spontaneous Leaks in Pipelines, Gathering Systems, and Offshore Risers

2021 ◽  
Author(s):  
Matthew Grimes ◽  
Nico Van Rensburg ◽  
Stuart Mitchell
Keyword(s):  
Signal Processing ◽  
Transmission Lines ◽  
Negative Pressure ◽  
Pressure Wave ◽  
Long Distance ◽  
Non Invasive ◽  
Long Distance Transmission ◽  
Offshore Production ◽  
Offshore Risers ◽  
Oil Gas

Abstract This paper presents on a non-invasive, IoT-based method for rapidly determining the presence and location of spontaneous leaks in pressurized lines transporting any type of product (e.g., oil, gas, water, etc.). Specific applications include long-distance transmission lines, gathering networks at well sites, and offshore production risers. The methodology combines proven negative pressure wave (NPW) sensing with advanced signal processing to minimize false positives and accurately identify the presence of small spontaneous leaks within seconds of their occurrence. In the case of long-distance transmission pipelines, the location of the leak can be localized to within 20-50 feet. The solution was commercialized in 2020 and has undergone extensive testing to verify its capabilities. It is currently in use by several operators, both onshore and offshore.

Time derivatives in air temperature and enthalpy as non-invasive welfare indicators during long distance animal transport

2011 ◽  
Vol 110 (3) ◽  
pp. 253-260 ◽  
Author(s):  
Morris Villarroel ◽  
Pilar Barreiro ◽  
Peter Kettlewell ◽  
Marianne Farish ◽  
Malcolm Mitchell
Keyword(s):  
Air Temperature ◽  
Long Distance ◽  
Welfare Indicators ◽  
Non Invasive ◽  
Animal Transport

A Study of Characteristic Signal Propagation Buried Pipeline 2

2010 ◽  
Vol 36 ◽  
pp. 387-394
Author(s):  
Hisashi Oohira ◽  
Serikawa Seiichi
Keyword(s):  
Propagation Constant ◽  
Characteristic Impedance ◽  
Signal Propagation ◽  
Measuring System ◽  
Long Distance ◽  
Actual Measurement ◽  
Fault Resistance ◽  
System A ◽  
Characteristic Signal ◽  
Heavy Construction

It was reported in the previous report that the propagation constant measuring system for long distance pipelines was produced based upon the distribution constant theory for the purpose of maintenance and management of long distance pipelines buried underground and to have a system to directly measure the propagation constants and characteristic impedance of the pipeline buried underground. This time, a simulator for the signal propagation of a pipeline, referring to these actual measurement values, was constructed and various signal modes were simulated. On the prediction of accidents where heavy-construction equipment, such as backhoe or boring machine, has contact with a pipeline and damages the coating of pipeline, the damage simulations with a backhoe and boring machine were performed and the fault resistances of these heavy-construction pieces of equipment at the time of accidents were identified. As a result, it was revealed that the fault resistance generated by the metal-to-metal contact caused by the boring machine, which damages pipeline the most, was approximately 20-50Ω when water was used, and that caused by the backhoe was approximately 100Ω. In order to verify the detectable property of this system, a simulation was performed to determine how each distributed constant changed when this degree of grounding faults occurred in the monitoring section of the pipeline, and validated it with an actual pipeline.

Cell calcium signalling induced by endogenous lectin carbohydrate interaction in the Jurkat T cell line

1996 ◽  
Vol 13 (1) ◽  
pp. 99-105 ◽  
Author(s):  
Hermann Walzel ◽  
Jun Hirabayashi ◽  
Ken-Ichi Kasai ◽  
Josef Brock ◽  
Peter Neels
Keyword(s):  
T Cell ◽  
Cell Line ◽  
Calcium Signalling ◽  
Cell Calcium ◽  
Endogenous Lectin ◽  
Jurkat T Cell ◽  
Cell Calcium Signalling

scholarly journals Spatial characteristics to calcium signalling; the calcium wave as a basic unit in plant cell calcium signalling

1998 ◽  
Vol 353 (1374) ◽  
pp. 1463-1473 ◽  
Author(s):  
Rui Malhó ◽  
Ana Moutinho ◽  
Arnold van der Luit ◽  
Anthony J. Trewavas
Keyword(s):  
Plant Cell ◽  
Growth And Development ◽  
Calcium Signalling ◽  
Plant Cells ◽  
Basic Unit ◽  
Calcium Wave ◽  
Information Communication ◽  
Intercellular Movement ◽  
Mechanism Of Wave Propagation ◽  
Cell Calcium Signalling

Many signals that modify plant cell growth and development initiate changes in cytoplasmic Ca 2+ . The subsequent movement of Ca 2+ in the cytoplasm is thought to take place via waves of free Ca 2+ . These waves may be initiated at defined regions of the cell and movement requires release from a reticulated endoplasmic reticulum and the vacuole. The mechanism of wave propagation is outlined and the possible basis of repetitive reticulum wave formation, Ca 2+ oscillations and capacitative Ca 2+ signalling is discussed. Evidence for the presence of Ca 2+ waves in plant cells is outlined, and from studies on raphides it is suggested that the capabilities for capacitative Ca 2+ signalling are also present. The paper finishes with an outline of the possible interrelation between Ca 2+ waves and organelles and describes the intercellular movement of Ca 2+ waves and the relevance of such information communication to plant development.

scholarly journals Conservation of N-hydroxy-pipecolic acid-mediated systemic acquired resistance in crop plants

2019 ◽  
Author(s):  
Eric C. Holmes ◽  
Yun-Chu Chen ◽  
Elizabeth Sattely ◽  
Mary Beth Mudgett
Keyword(s):  
Systemic Acquired Resistance ◽  
Acquired Resistance ◽  
Signal Propagation ◽  
Crop Plants ◽  
Pipecolic Acid ◽  
List Type ◽  
In Planta ◽  
Long Distance ◽  
Plant Kingdom ◽  
Promising Strategy

SUMMARYSignal propagation and the coordination of whole-organism responses in plants rely heavily on small molecules. Systemic acquired resistance (SAR) is one such process in which long-distance signaling activates immune responses in uninfected tissue as a way to limit the spread of a primary, localized infection. Recently, N-hydroxy pipecolic acid (NHP) was discovered and shown to coordinate SAR in Arabidopsis. Here, we provide metabolic and biochemical evidence that NHP is conserved across the plant kingdom and demonstrate a role for NHP in mediating SAR responses in tomato and pepper. We reconstituted the NHP biosynthetic pathway in planta and show that transient expression of two NHP biosynthetic genes in tomato induces enhanced resistance to a bacterial pathogen in distal tissue. Our results suggest engineering strategies to induce NHP-mediated SAR are a promising route to improve broad-spectrum pathogen resistance in crops.IN BRIEFEngineering NHP production is a promising strategy to enhance disease resistance in crops.HIGHLIGHTSArabidopsis N-hydroxy-pipecolic acid (NHP) pathway is conserved across the plant kingdomApplication of NHP to tomato and pepper plants induces a robust SAR responseMetabolic engineering of the Arabidopsis NHP pathway in Solanum lycopersicum leads to enhanced NHP production and defense primingGenetic engineering for enhanced NHP production is a promising strategy to protect crop plants from multiple pathogens

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