Synthesis and characterization of multiphase bioactive glass-ceramics in the CaO–MgO–SiO2 system with B2O3 additive

2008 ◽  
Vol 23 (11) ◽  
pp. 2873-2879 ◽  
Author(s):  
Xianchun Chen ◽  
Yan Wei ◽  
Zhongbing Huang ◽  
Yunqing Kang ◽  
Guangfu Yin
Keyword(s):  
Bending Strength ◽  
Coefficient Of Thermal Expansion ◽  
Glass Ceramics ◽  
Nominal Composition ◽  
Apatite Formation ◽  
X Ray Diffraction ◽  
Cell Growth And Viability ◽  
Bonelike Apatite

A glass-ceramic (GC0) with nominal composition of 51.2% CaO–12.1% MgO–36.7% SiO2 (wt%) was synthesized. Then multiphase glass-ceramics of MGC1 and MGC2 were obtained by adding 1 and 2 wt% B2O3 to GC0 followed by thermal treatment. The bending strength of MGC1 was the highest, about 89.46 MPa, and the coefficient of thermal expansion was 10.67 × 10−6 °C−1, closer to that of Ti–6Al–4V alloy (10.03 × 10−6 °C−1). X-ray diffraction analysis confirmed that MGC1 was predominantly composed of akermanite, merwinite, and small amounts of dicalcium silicate crystalline phases. The bioactivity and cytocompatibility in vitro of MGC1 were detected by investigating the bonelike apatite-formation ability in simulated body fluid (SBF) and osteoblast morphology and viability. The results showed that MGC1 possessed bonelike apatite-formation ability in SBF and could release ionic products to significantly stimulate cell growth and viability. Furthermore, osteoblasts adhered and spread well on MGC1, indicating good bioactivity and potential cytocompatibility.

Structure Characterization of Sintered CaO-Al2O3-SiO2 Glass-Ceramic Reinforced with Spodumene

2013 ◽  
Vol 834-836 ◽  
pp. 309-314
Author(s):  
Zi Fan Xiao ◽  
Jin Shu Cheng ◽  
Jun Xie
Keyword(s):  
Glass Ceramic ◽  
Energy Dispersive Spectrometry ◽  
Crystal Size ◽  
Bending Strength ◽  
Glass Ceramics ◽  
Structure Characterization ◽  
X Ray Diffraction ◽  
Crystalline Phases ◽  
X Ray

A glass-ceramic belonging to the CaO-Al2O3-SiO2(CAS) system with different composition of spodumene and doping the Li2O with amount between 0~2.5 % (mass fraction) were prepared by onestage heat treatment, under sintering and crystallization temperature at 1120 °C for two hours. In this paper, differential thermal analysis, X-ray diffraction, scanning electron microscopy, energy dispersive spectrometry and bending strength test were employed to investigate the microstructure and properties of all samples. β-wollastonite crystals were identified as the major crystalline phases, and increasing Li2O was found to be benefit for the crystallization and tiny crystalline phases remelting, resulting in the content of major crystalline phases increased first and then decreased with increasing the expense of spodumene. Meanwhile, the crystal size can be positively related with the content of Li2O. The preferable admixed dosage of spodumene can be obtained, besides the strength of glass-ceramics can be more than 90 MPa.

scholarly journals Morphology andIn VitroBehavior of Electrospun Fibrous Poly(D,L-lactic acid) for Biomedical Applications

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Toshihiro Inami ◽  
Yasuhiro Tanimoto ◽  
Masayuki Ueda ◽  
Yo Shibata ◽  
Satoshi Hirayama ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Biomedical Applications ◽  
Polymer Concentration ◽  
The Body ◽  
Solution Flow Rate ◽  
Apatite Formation ◽  
X Ray Diffraction ◽  
Solution Flow

This work describes the fabrication, optimization, and characterization of electrospun fibrous poly(D,L-lactic acid) (PDLLA) for biomedical applications. The influences of the polymer concentration of the electrospinning solution (5, 10, or 15 wt%) and the solution flow rate (0.1, 0.5, 1.0, or 2.0 mL/h) on the morphology of the obtained fibrous PDLLA were evaluated. Thein vitrobiocompatibility of two types of PDLLA, ester terminated PDLLA (PDLLA-R) and carboxyl terminated PDLLA (PDLLA-COOH), was evaluated by monitoring apatite formation on samples immersed in Hanks’ balanced salt (HBS) solution. 15 wt% polymer solution was the most beneficial for preparing a fibrous PDLLA structure. Meanwhile, no differences in morphology were observed for PDLLA prepared at various flow rates. Apatite precipitate is formed on both types of PDLLA only 1 day after immersion in HBS solution. After 7 days of immersion, PDLLA-COOH showed greater apatite formation ability compared with that of PDLLA-R, as measured by thin-film X-ray diffraction. The results indicated that the carboxyl group is effective for apatite precipitation in the body environment.

Synthesis of Glasses and Glass-Ceramics of the System Diopside - Fluorapatite and Characterization of Their in Vitro Bioactivity

MRS Advances ◽  
2017 ◽  
Vol 2 (61) ◽  
pp. 3845-3850
Author(s):  
Jorge López-Cuevas ◽  
Juan C. Rendón-Angeles ◽  
José L. Rodríguez-Galicia ◽  
Carlos A. Gutiérrez-Chavarría
Keyword(s):  
Structural Changes ◽  
Glass Ceramics ◽  
Inhibitory Effect ◽  
Molar Ratio ◽  
Isothermal Treatment ◽  
In Vitro Bioactivity ◽  
X Ray Diffraction ◽  
D 20

AbstractGlasses and glass-ceramics of the system Diopside [D, CaMgSi2O6] - Fluorapatite [FAp, Ca5(PO4)3F] were synthesized and characterized. The studied theoretical phase compositions were (wt%): 1) 70% D-30% FAp, 2) 60% D-40% FAp and 3) 80% D-20% FAp. The glass-ceramics were synthesized by isothermal treatment of the corresponding parent glasses at either 800, 900 or 1000 °C, with holding times of either 30 min, 2 h or 5 h at high temperature. The in vitro bioactivities of all materials were tested in Kokubo’s Simulated Body Fluid (SBF), for 21 days at pH = 7.4 and 37 °C. All materials were characterized by X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM/EDS). In all cases, the in vitro bioactivity increased with decreasing crystallization degree in the materials, which was likely due to an inhibitory effect of the structural changes occurring during thermal treatment of the glasses. This was more accentuated for long thermal treatments. After 21 days of soaking in the SBF, an apatite-like surface layer, with a Ca/P molar ratio close to 1.67, was formed in the case of the parent glass of composition 2. This was attributed to an enhancing effect of so-called “phase separation” phenomenon that took place during the synthesis of that particular glass. Lastly, the MgO content of the glasses made no clear difference on their in vitro bioactivity.

In-Vitro Bioactivity Characterization of Sodium-Potassium Mica and Fluorapatite Containing Glass Ceramics

2007 ◽  
Vol 330-332 ◽  
pp. 185-188
Author(s):  
Gultekin Goller ◽  
Can Cekli ◽  
Ipek Akin ◽  
Erdem Demirkesen
Keyword(s):  
Glass Ceramics ◽  
Xrd Analysis ◽  
In Vitro Bioactivity ◽  
X Ray Diffraction ◽  
Sodium Potassium ◽  
X Ray ◽  
Ftir Technique ◽  
Molecular Bonding

The aim of this study is to find out the crystallization behaviour and in-vitro bioactivity character of machinable glass ceramics having different ratios of Na/K mica and apatite phases, to ascertain the best machinable composition. In order to investigate the bioactivity behavior of the samples the simulated body fluid (SBF) was prepared. Samples were removed from the solution after 1 hour, 1 day, 1, 2, 3 and 4 weeks. FEG-SEM was used to characterize the morphology of precipitation HCA layer on the surface depending on time. Molecular bonding characterization of HCA layers were carried out by using Fourier Transform Infrared Spectroscopy (FTIR) technique. The thin film X-ray diffraction (TF-XRD) analysis was used to characterize the variation of chemical composition on precipitated layer by time. Optimum results were obtained by the composition, containing 70wt% Na/K mica and 30wt% fluorapatite which had an average mica size of 3-4 microns.

Extraction and Characterization of Natural Hydroxyapatite from Goat Bone for Biomedical Applications

2020 ◽  
Vol 1010 ◽  
pp. 573-578
Author(s):  
Sarfa Azian Ismail ◽  
Hasan Zuhudi Abdullah
Keyword(s):  
Calcination Temperature ◽  
Biomedical Applications ◽  
Extraction Process ◽  
Apatite Formation ◽  
X Ray Diffraction ◽  
X Ray ◽  
Shape Structure ◽  
Micron Size

Bioactive apatite, which is hydroxyapatite (HAP) with the chemical formula of Ca10(PO4)6(OH)2 have been extensively investigated for biomedical applications in bone and teeth implants due to its biocompatibility characteristics has similar physical-chemical characteristics with human bone. The issues to be highlighted here is to explore the potential of using food waste from goat bone to produce useful natural HAP. This study is to extract natural HAP powder from goat bone waste. The extraction process involved cleaning and boiling process, drying process, crushing, grinding and milling to obtain micron size powder of goat bone and joint. The sample then underwent a calcination process with 900°C, 1000°C, and 1100°C for goat bone and 900°C for goat joint with 3 hours holding time. The characteristic of produced HAP powder was characterised with Scanning Electron Microscope (SEM), Energy Dispersive X-ray Spectroscopy (EDS), X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). The in vitro testing of HAP completed by using Simulated Body Fluid (SBF) and SEM to observe the microstructure of apatite formation. The XRD and EDS results show the HAP crystallinity and Ca/P ratio increase with the increasing of calcination temperature for bone. The bone-like apatite formation appeared in the goat bone and joint sample with calcination temperature 900°C, 1000°C, and 1100°C. The optimum hydroxyapatite is from goat bone sample with calcination temperature 1100°C due to the apatite growth fully cover the surface of the sample with a needle shape structure of the cauliflower structure.

Iron-Rich Glass-Ceramics Obtained from Mill Scale

2015 ◽  
Vol 820 ◽  
pp. 411-416
Author(s):  
Indiara Tereza Alves ◽  
Cristian Faller ◽  
Diógenes Honorato Piva ◽  
Roger Honorato Piva ◽  
Fernando Marco Bertan ◽  
...  
Keyword(s):  
Bending Strength ◽  
Coefficient Of Thermal Expansion ◽  
Glass Ceramics ◽  
Lithium Oxide ◽  
Differential Analysis ◽  
X Ray Diffraction ◽  
Mill Scale ◽  
X Ray ◽  
Heat Treated ◽  
Wet Ground

Mill scale contains high amounts of iron and it is classified as residue Class 2 – Not Inert (ABNT NBR 10.004:2004). Considering its availability, this study aimed to investigate glass-ceramics from this residue focused on its valorization. The influence of lithium oxide and zirconia was also evaluated. Six formulations were melted at 1350 °C and obtained frits were wet ground, dried and characterized: X-ray fluorescence, X-ray diffraction, thermal differential analysis and dilatometry. Pressed bodies were dried and heat treated at 950 °C. After, crystallized samples were characterized by different techniques: X-ray diffraction, apparent and theoretical density, coefficient of thermal expansion, hardness and bending strength. Results showed that lithium oxide and zirconia significantly influenced the thermal and structural behavior of obtained glass-ceramics.

scholarly journals Characterization of ferrite nanoparticles for preparation of biocomposites

2017 ◽  
Vol 8 ◽  
pp. 1257-1265 ◽  
Author(s):  
Urszula Klekotka ◽  
Magdalena Rogowska ◽  
Dariusz Satuła ◽  
Beata Kalska-Szostko
Keyword(s):  
Chemical Method ◽  
Ferrite Nanoparticles ◽  
Chemical Activity ◽  
Nominal Composition ◽  
X Ray Diffraction ◽  
Wet Chemical Method ◽  
X Ray ◽  
Transmission Electron ◽  
Wet Chemical

Ferrite nanoparticles with nominal composition Me0.5Fe2.5O4 (Me = Co, Fe, Ni or Mn) have been successfully prepared by the wet chemical method. The obtained particles have a mean diameter of 11–16 ± 2 nm and were modified to improve their magnetic properties and chemical activity. The surface of the pristine nanoparticles was functionalized afterwards with –COOH and –NH2 groups to obtain a bioactive layer. To achieve our goal, two different modification approaches were realized. In the first one, glutaraldehyde was attached to the nanoparticles as a linker. In the second one, direct bonding of such nanoparticles with a bioparticle was studied. In subsequent steps, the nanoparticles were immobilized with enzymes such as albumin, glucose oxidase, lipase and trypsin as a test bioparticles. The characterization of the nanoparticles was acheived by transmission electron microscopy, X-ray diffraction, energy dispersive X-ray and Mössbauer spectroscopy. The effect of the obtained biocomposites was monitored by Fourier transform infrared spectroscopy. The obtained results show that in some cases the use of glutaraldehyde was crucial (albumin).

scholarly journals A GREEN APPROACH FOR THE SYNTHESIS OF DRUG DELIVERY SYSTEM, MESOPOROUS SILICA GRAFTED ACRYLAMIDE –β- CYCLODEXTRIN COMPOSITE, FOR THE CONTROLLED RELEASE OF CURCUMIN

2018 ◽  
Vol 11 (9) ◽  
pp. 372
Author(s):  
Manohar D Mullassery ◽  
Noeline B Fernandez ◽  
Surya R ◽  
Diana Thomas
Keyword(s):  
Drug Delivery ◽  
Controlled Delivery ◽  
X Ray Diffraction ◽  
In Vitro Biocompatibility ◽  
Green Approach ◽  
Solvent Free Conditions ◽  
Good Biocompatibility ◽  
Biocompatibility Study

Objective: The scope of the present study was the preparation and characterization of a novel composite acrylamide β-cyclodextrin grafted 3-aminopropyltriethoxysilane bentonite (AMCD-g-APSB), for the controlled delivery of curcumin (CUR).Methods: AMCD-g-APSB, was synthesized by solvent-free conditions using microwave irradiation. The structure and surface morphology of the composite was established using Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, thermal analysis, etc.Results: The swelling percentage of the composite depends on both time and pH of the medium. The maximum swelling of the composite occurred at a pH of 7.4. The maximum drug encapsulation was occurring at a pH 3. About 96.5% of drug was loaded at pH 3. In vitro biocompatibility study was performed, and the result showed good biocompatibility of the composite in the concentration range 2.5–50 μg/ml.Conclusions: Drug delivery study of the composite proved that CUR could be successfully released in a controlled manner in the colon without much loses of the drug in the stomach.

Apatite-Forming Ability of Organic-Inorganic Hybrids Prepared from Calcium Silicate and Glucomannan

2007 ◽  
Vol 361-363 ◽  
pp. 567-570
Author(s):  
Yasuyuki Morita ◽  
Toshiki Miyazaki ◽  
Eiichi Ishida ◽  
Chikara Ohtsuki
Keyword(s):  
Calcium Silicate ◽  
Body Fluid ◽  
Organic Polymer ◽  
Apatite Formation ◽  
X Ray Diffraction ◽  
Electron Microscopic ◽  
Living Body ◽  
Bioactive Ceramics ◽  
Previously Treated

So-called bioactive ceramics are used for bone-repairing owing to attractive features such as direct bone-bonding in living body. However, there is limitation on clinical applications due to their inappropriate mechanical properties performances such as higher brittleness and lower fracture toughness than natural bone. To overcome this problem, hybrid materials have been developed by modification of calcium silicate, that is basic component of bioactive ceramics, with organic polymer. It is known that bioactive ceramics bond to bone through bone-like apatite layer which is formed on their surfaces by chemical reaction with body fluid. We attempted preparation of bioactive organic-inorganic hybrids from Glucomannan that is a kind of complex polysaccharide, and calcium silicate. Hybrids were prepared from glucomannan and tetraethoxysilane (TEOS). They were treated with 1M (=mol·m-3) CaCl2 aqueous solution for 24 hours. Then ability of apatite formation on the hybrids was examined in vitro using simulated body fluid (SBF, Kokubo solution). Surface structure of the specimens was examined by thin-film X-ray diffraction (TF-XRD), scanning electron microscopic (SEM) observation. The hybrids with TEOS:Glucomannan= 1:1 to 4:1 in mass ratio formed the apatite in SBF within 3 or 7 d, when they were previously treated with CaCl2 solution.

scholarly journals Synthesis and characterization of silver nanoparticle-decorated cobalt nanocomposites (Co@AgNPs) and their density-dependent antibacterial activity

2019 ◽  
Vol 6 (5) ◽  
pp. 182135 ◽  
Author(s):  
Zakia Kanwal ◽  
Muhammad Akram Raza ◽  
Saira Riaz ◽  
Saher Manzoor ◽  
Asima Tayyeb ◽  
...  
Keyword(s):  
Metallic Nanoparticles ◽  
Cobalt Acetate ◽  
X Ray Diffraction ◽  
Characteristic Analysis ◽  
Density Dependent ◽  
Antibacterial Performance ◽  
Magnetic Cores ◽  
Low Concentrations

Magnetic cores loaded with metallic nanoparticles can be promising nano-carriers for successful drug delivery at infectious sites. We report fabrication, characteristic analysis and in vitro antibacterial performance of nanocomposites comprising cobalt cores (Co-cores) functionalized with a varied concentration of silver nanoparticles (AgNPs). A two-step polyol process synchronized with the transmetalation reduction method was used. Co-cores were synthesized with cobalt acetate, and decoration of AgNPs was carried out with silver acetate. The density of AgNPs was varied by changing the amount of silver content as 0.01, 0.1 and 0.2 g in the synthesis solution. Both AgNPs and Co-cores were spherical having a size range of 30–80 nm and 200 nm to more than 1 µm, respectively, as determined by scanning electron microscopy. The metallic nature and face-centred cubic crystalline phase of prepared nanocomposites were confirmed by X-ray diffraction. Biocompatibility analysis confirmed high cell viability of MCF7 at low concentrations of tested particles. The antibacterial performance of nanocomposites (Co@AgNPs) against Escherichia coli and Bacillus subtilis was found to be AgNPs density-dependent, and nanocomposites with the highest AgNPs density exhibited the maximum bactericidal efficacy. We therefore propose that Co@AgNPs as effective drug containers for various biomedical applications.

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