Microfluidic Biomaterials

MRS Bulletin ◽  
2006 ◽  
Vol 31 (2) ◽  
pp. 114-119 ◽  
Author(s):  
Abraham D. Stroock ◽  
Mario Cabodi
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Mass Transfer ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Wound Dressings ◽  
Living Systems ◽  
Living Tissue ◽  
Hydrodynamic Stresses

Biomedical applications—prostheses, tissue engineering, drug delivery, and wound healing—demand increasingly sophisticated characteristics from the materials that come into contact with living systems in the laboratory and the clinic. With the development of microfluidics, there is an opportunity to create active biomaterials based on embedded microfluidic structures. These structures allow for control of the concentrations of soluble chemicals and hydrodynamic stresses within the material and at its interfaces, and thus allow one to tailor the environment experienced by the living tissue. In this article, we review initial efforts to develop these microfluidic biomaterials and present considerations regarding the required characteristics of the materials and of the microfluidic-mediated mass transfer. As specific examples, we present work toward microfluidic control of mass transfer in scaffolds for tissue engineering and in wound dressings.

scholarly journals Antibacterial cellulose-based aerogels for wound healing application: A review

2020 ◽  
Vol 7 (10) ◽  
pp. 4032-4040
Author(s):  
Esam Bashir Yahya ◽  
Marwa Mohammed Alzalouk ◽  
Khalifa A. Alfallous ◽  
Abdullah F. Abogmaza
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Medical Applications ◽  
Tissue Engineering Scaffolds

Aerogels have been steadily developed since its first invention to become one of the most promising materials for various medical and non-medical applications. It has been prepared from organic and inorganic materials, in pure forms or composites. Cellulose-based aerogels are considered one of the promising materials in biomedical applications due to their availability, degradability, biocompatibility and non-cytotoxicity compared to conventional silica or metal-based aerogels. The unique properties of such materials permit their utilization in drug delivery, biosensing, tissue engineering scaffolds, and wound dressing. This review presents a summary of aerogel development as well as the properties and applications of aerogels. Herein, we further discuss the recent works pertaining to utilization of cellulose-based aerogels for antibacterial delivery.

Recent advances of self-assembling peptide-based hydrogels for biomedical applications

Soft Matter ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. 1704-1715 ◽  
Author(s):  
Jieling Li ◽  
Ruirui Xing ◽  
Shuo Bai ◽  
Xuehai Yan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
3D Bioprinting ◽  
Biological Applications ◽  
Antitumor Therapy ◽  
Self Assembling ◽  
Recent Advances

The review introduces several methods for fabrication of robust peptide-based hydrogels and their biological applications in the fields of drug delivery and antitumor therapy, antimicrobial and wound healing materials, and 3D bioprinting and tissue engineering.

scholarly journals Multifunctional Hydrogel Nanocomposites for Biomedical Applications

2021 ◽  
Author(s):  
Emma Barrett-Catton ◽  
Murial L. Ross ◽  
Prashanth Asuri
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Wound Healing ◽  
Physical Properties ◽  
Biomedical Applications ◽  
Biochemical Properties ◽  
Broad Applicability ◽  
Hydrogel Nanocomposites

Hydrogels are used for various biomedical applications due to their biocompatibility, capacity to mimic the extracellular matrix, and ability to encapsulate and deliver cells and therapeutics. However, traditional hydrogels have a few shortcomings, especially regarding their physical properties, thereby limiting their broad applicability. Recently, researchers have investigated the incorporation of nanoparticles (NPs) into hydrogels to improve and add to the physical and biochemical properties of hydrogels. This brief review focuses on papers that describe the use of nanoparticles to improve more than one property of hydrogels. Such multifunctional hydrogel nanocomposites have enhanced potential for various applications, including tissue engineering, drug delivery, wound healing, bioprinting and biowearable devices.

scholarly journals Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Saurav Das ◽  
Debapratim Das
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Rational Design ◽  
Soft Materials ◽  
Biological Molecules ◽  
3D Bioprinting ◽  
Significant Progress ◽  
Mechanical Stiffness

Peptide-based hydrogels have captivated remarkable attention in recent times and serve as an excellent platform for biomedical applications owing to the impressive amalgamation of unique properties such as biocompatibility, biodegradability, easily tunable hydrophilicity/hydrophobicity, modular incorporation of stimuli sensitivity and other functionalities, adjustable mechanical stiffness/rigidity and close mimicry to biological molecules. Putting all these on the same plate offers smart soft materials that can be used for tissue engineering, drug delivery, 3D bioprinting, wound healing to name a few. A plethora of work has been accomplished and a significant progress has been realized using these peptide-based platforms. However, designing hydrogelators with the desired functionalities and their self-assembled nanostructures is still highly serendipitous in nature and thus a roadmap providing guidelines toward designing and preparing these soft-materials and applying them for a desired goal is a pressing need of the hour. This review aims to provide a concise outline for that purpose and the design principles of peptide-based hydrogels along with their potential for biomedical applications are discussed with the help of selected recent reports.

scholarly journals Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

2021 ◽  
Vol 17 ◽  
pp. 2553-2569
Author(s):  
Luke O Jones ◽  
Leah Williams ◽  
Tasmin Boam ◽  
Martin Kalmet ◽  
Chidubem Oguike ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Freezing Temperature ◽  
Wound Dressings ◽  
3D Bioprinting ◽  
Surgical Incision ◽  
Comprehensive Review ◽  
Highly Effective ◽  
Polymeric Structures

Cryogels are macroporous polymeric structures formed from the cryogelation of monomers/polymers in a solvent below freezing temperature. Due to their inherent interconnected macroporosity, ease of preparation, and biocompatibility, they are increasingly being investigated for use in biomedical applications such as 3D-bioprinting, drug delivery, wound healing, and as injectable therapeutics. This review highlights the fundamentals of macroporous cryogel preparation, cryogel properties that can be useful in the highlighted biomedical applications, followed by a comprehensive review of recent studies in these areas. Research evaluated includes the use of cryogels to combat various types of cancer, for implantation without surgical incision, and use as highly effective wound dressings. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable macroporous cryogels.

scholarly journals Nanocellulose in Biotechnology and Medicine: Focus on Skin Tissue Engineering and Wound Healing

2018 ◽  
Author(s):  
Lucie Bacakova ◽  
Julia Pajorova ◽  
Marketa Bacakova ◽  
Anne Skogberg ◽  
Pasi Kallio ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Contact Lenses ◽  
Heart Defects ◽  
Cellulose Nanofibers ◽  
Wound Dressings ◽  
Skin Tissue ◽  
Skin Tissue Engineering ◽  
Wide Range

Nanocellulose is cellulose in the form of nanostructures, i.e. features not exceeding 100 nm at least in one dimension. These nanostructures include nanofibrils, e.g. in bacterial cellulose; nanofibers, e.g. in electrospun matrices; nanowhiskers and nanocrystals. These structures can be further assembled into bigger 2D and 3D nano-, micro- and macro-structures, such as nanoplatelets, membranes, films, microparticles and porous macroscopic matrices. There are four main sources of nanocellulose: bacteria (Gluonacetobacter), plants (trees, shrubs, herbs), algae (Cladophora) and animals (Tunicata). Nanocellulose has emerged for a wide range of industrial, technology and biomedical applications, e.g. for adsorption, ultrafiltration, packaging, conservation of historical artifacts, thermal insulation and fire retardation, energy extraction and storage, acoustics, sensorics, controlled drug delivery, and particularly for tissue engineering. Nanocellulose is promising for use in scaffolds for engineering of blood vessels, neural tissue, bone, cartilage, liver, adipose tissue, urethra and dura mater, for repairing connective tissue and congenital heart defects, and for constructing contact lenses and protective barriers. This review is focused on applications of nanocellulose in skin tissue engineering and wound healing as a scaffold for cell growth, for delivering cells into wounds, and as a material for advanced wound dressings coupled with drug delivery, transparency and sensorics. Potential cytotoxicity and immunogenicity of nanocellulose are also discussed.

scholarly journals Multifunctional Hydrogel Nanocomposites for Biomedical Applications

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 856
Author(s):  
Emma Barrett-Catton ◽  
Murial L. Ross ◽  
Prashanth Asuri
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Wound Healing ◽  
Physical Properties ◽  
Biomedical Applications ◽  
Biochemical Properties ◽  
Broad Applicability ◽  
Hydrogel Nanocomposites

Hydrogels are used for various biomedical applications due to their biocompatibility, capacity to mimic the extracellular matrix, and ability to encapsulate and deliver cells and therapeutics. However, traditional hydrogels have a few shortcomings, especially regarding their physical properties, thereby limiting their broad applicability. Recently, researchers have investigated the incorporation of nanoparticles (NPs) into hydrogels to improve and add to the physical and biochemical properties of hydrogels. This brief review focuses on papers that describe the use of nanoparticles to improve more than one property of hydrogels. Such multifunctional hydrogel nanocomposites have enhanced potential for various applications including tissue engineering, drug delivery, wound healing, bioprinting, and biowearable devices.

Recent Insights on Biomedical Applications of Bacterial Cellulose based Composite Hydrogels

2021 ◽  
Vol 28 ◽  
Author(s):  
Wei Liu ◽  
Haishun Du ◽  
Ting Zheng ◽  
Chuanling Si
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Bacterial Cellulose ◽  
High Purity ◽  
Biomedical Applications ◽  
3D Structure ◽  
Wound Dressings ◽  
Tissue Engineering Scaffolds ◽  
Composite Hydrogels ◽  
Good Biocompatibility

Background: Bacterial cellulose (BC) and its derivatives are a rich source of renewable natural ingredients, which are of great significance for biomedical and medical applications but have not yet been fully exploited. BC is a high-purity, biocompatible, and versatile biomaterial that can be used alone or in combination with other ingredients such as polymers and nanoparticles to provide different structural organization and function. This review briefly introduces the research status of BC hydrogels, focusing on the preparation of BC based composite hydrogels and their applications in the field of biomedicine, particularly the wound dressings, tissue engineering scaffolds, and drug delivery. Methods: By reviewing the most recent literature on this subject, we summarized recent advances in the preparation of BC based composite hydrogels and their advances in biomedical applications, including wound dressings, tissue engineering, and drug delivery. Results: BC composite hydrogels have broadened the field of application of BC and developed a variety of BC-based biomaterials with excellent properties. BC-based hydrogels have good biocompatibility and broad application prospects in the biomedical field. Conclusion: BC based composite hydrogels with the advantages of 3D structure, non-toxicity, high purity, and good biocompatibility, have great prospects in the development of sustainable and multifunctional biomaterials for biomedical applications.

A Review on Cellulose-based Materials for Biomedicine

2022 ◽  
Author(s):  
Hani Nasser Abdelhamid ◽  
Aji P. Mathew
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Antibacterial Agents ◽  
State Of The Art ◽  
Market Demand ◽  
Mechanical And Physical Properties ◽  
Research Findings

There are various biomaterials in nature, but none fulfills all the requirements. Cellulose, eco-friendly material-based biopolymers, have been advanced biomedicine to satisfy most market demand and circumvent many ecological concerns. This review aims to present an overview of the state of the art in cellulose's knowledge and technical biomedical applications. It included an extensive bibliography of recent research findings for fundamental and applied investigations. The chemical structure of cellulose allows modifications and simple conjugation with several materials, including nanoparticles, without tedious efforts. Cellulose-based materials were used for biomedicine applications such as antibacterial agents, antifouling, wound healing, drug delivery, tissue engineering, and bone regeneration. They advanced the applications to be cheap, biocompatible, biodegradable, easy for shaping and processing into different forms, with suitable chemical, mechanical and physical properties.

scholarly journals Application of polymer in biomedical implication

2021 ◽  
Vol 14 (2) ◽  
pp. 098-114
Author(s):  
Meheta Datta ◽  
Kazi Madina Maraz ◽  
Naziza Rahman ◽  
Ruhul A. Khan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Physical Properties ◽  
Biomedical Applications ◽  
Polymeric Materials ◽  
High Strength ◽  
Wound Dressings ◽  
Tissue Engineering Scaffolds ◽  
Great Demand ◽  
External Stimuli

Polymers are serving the mankind in various ways since long. Over the previous number of years, these polymers have found great demand in various domains. These materials are intensively studied over the years for a various range of applications Polymeric materials have found notable applications within the sphere of biomedical. This might ensue to their useful properties, such as: easy processing, lightweight and suppleness, high strength to weight, availability and recyclability. Polymeric materials also are able to alter their chemical or physical properties upon exposure to external stimuli. Thanks to these properties, they're widely applied for biomedical applications like drug delivery, tissue engineering scaffolds, wound dressings, and antibacterial coatings.

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