scholarly journals Apatite Formation on Electrochemically Treated Titanium

1999 ◽  
Vol 599 ◽  
Author(s):  
K. Tsuru ◽  
S. Takemoto ◽  
S. Hayakawa ◽  
A. Osaka
Keyword(s):  
Calcium Ions ◽  
Body Fluid ◽  
Cathodic Polarization ◽  
Apatite Formation ◽  
Hydrated Silica ◽  
Spontaneous Deposition ◽  
Artificial Materials ◽  
Titania Gel ◽  
A Cell ◽  
Harmful Effects

AbstractApatite formation on artificial materials in a body environment is the prerequisite condition for showing bioactivity i.e. bone-bonding ability. A specific hydrated silica or titania gel has the ability of apatite deposition in body environment. We electrochemically prepared such a bioactive titanium oxide layer on titanium(Ti) with a cell consisting of Ti as the working electrode, Pt as the counter one, Ag/AgCl as the reference one, and an aqueous solution of 0.1 mol/L Ca(NO3)2 as the electrolyte solution. Ti was kept at 9.5V for 1 hour for oxidation(denoted as Ca9.5). Ti was subject to cathodic polarization at −3.0V for 10 min(Ca-3.0).: calcium ions were expected to be adsorbed on its surface. On treatment Ca9.5–3.0 Ti was first oxidated at 9.5V for 1 hour and subsequently kept at −3.0V for 10 min. The specimens of Ca9.5–3.0 and Ca-3.0 were found so bioactive as to deposit apatite within 12 hours and 1 day, respectively, in a simulated body fluid(Kokubo solution) whereas those due to Ca9.5 could not deposit apatite within 7 days. Calcium hydroxide and calcium carbonate detected on the bioactive surface caused no harmful effects on spontaneous deposition of apatite in the fluid.

Comparison of Apatite Formation on Polyamide Films Containing Carboxyl and Sulfonic Groups in a Solution Mimicking Body Fluid

2006 ◽  
Vol 309-311 ◽  
pp. 477-480
Author(s):  
Chikara Ohtsuki ◽  
Takahiro Kawai ◽  
Masanobu Kamitakahara ◽  
Masao Tanihara ◽  
Toshiki Miyazaki ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Crystal Growth ◽  
Simulated Body Fluid ◽  
Calcium Ions ◽  
Body Fluid ◽  
Functional Group ◽  
Carboxyl Groups ◽  
Apatite Formation ◽  
Ion Concentrations ◽  
Polyamide Film

Apatite formation on polyamide films containing either carboxyl or sulfonic groups was compared in 1.5SBF, whose ion concentrations are 1.5 times those of a simulated body fluid (SBF). The sulfonic groups induced the apatite nucleation earlier than the carboxyl groups. In contrast, the rate of crystal growth depended not on the kind of functional group, but on the degree of supersaturation of the surrounding solution. The more ready association of sulfonic groups with calcium ions may lead to earlier apatite nucleation than that of carboxyl groups. Adhesive strength of the apatite layer to polyamide film containing sulfonic groups was significantly lower than that with carboxyl groups depending on the chemical interactions as well as on the mechanical properties of the polyamide film.

scholarly journals Apatite-Forming Ability of Flowable vs. Putty Formulations of Newly Developed Bioactive Glass-Containing Endodontic Cement

2021 ◽  
Vol 11 (19) ◽  
pp. 8969
Author(s):  
Naoki Edanami ◽  
Razi Saifullah Ibn Belal ◽  
Shoji Takenaka ◽  
Kunihiko Yoshiba ◽  
Nagako Yoshiba ◽  
...  
Keyword(s):  
Calcium Ions ◽  
Calcium Ion ◽  
Body Fluid ◽  
Apatite Formation ◽  
Ion Release ◽  
Phosphate Ion ◽  
Phosphate Ions ◽  
Ability Levels ◽  
Consumption Rates ◽  
The Media

This study compared the apatite-forming ability (AFA) levels of flowable and putty formulations of Nishika Canal Sealer BG Multi (F-NBG and P-NBG, respectively) and attempted to clarify the cause of differences in the AFA levels of F-NBG and P-NBG. NBG samples were aged in simulated body fluid (SBF) or 1-, 5-, or 10-g/L bovine serum albumin-containing SBF (BSA-SBF) and analyzed in terms of their ultrastructures, elemental compositions, and Raman spectra to identify apatite formation. The phosphate ion consumption rates of NBG samples in the media were evaluated as an indicator of apatite growth. The original elemental composition, calcium ion release, and alkalizing ability levels of F-NBG and P-NBG were also evaluated. Apparent apatite formation was detected on all NBG samples except F-NBG aged in 10-g/L BSA-SBF. P-NBG consumed phosphate ions faster than F-NBG. As-prepared P-NBG showed more silicon elements on its surface than as-prepared F-NBG. P-NBG released more calcium ions than F-NBG, although their alkalizing ability levels did not differ statistically. In conclusion, the AFA of P-NBG was greater than that of F-NBG, probably because of the greater ability of P-NBG to expose silanol groups on the surface and release calcium ions.

Biomimetic Coating on Zirconia Composites Induced by Chemical Treatment

2007 ◽  
Vol 560 ◽  
pp. 127-132 ◽  
Author(s):  
S. Ortega-Chavarría ◽  
Dora A. Cortés-Hernández ◽  
Akemi A. Nogiwa-Valdez
Keyword(s):  
Calcium Ions ◽  
Chemical Treatment ◽  
Body Fluid ◽  
Apatite Formation ◽  
Biomimetic Coating ◽  
Zirconia Composites ◽  
Alumina Composites ◽  
Simulated Body Fluids ◽  
Biomimetic Method ◽  
Bonelike Apatite

The effect of the chemical treatment of zirconia/alumina composites followed by a biomimetic treatment has been studied. The composites are prepared from a powder mixture of Mg- PSZ and Al2O3. The powders are ball-milled in acetone and uniaxially pressed after drying. The specimens are sintered at 1550 °C in air. After sintering, chemical treatment is performed by immersing the samples in a 5M aqueous solution of phosphoric acid at 95 °C for 4 days. The biomimetic method consists of immersing the chemically-treated samples in simulated body fluid at 36.5 °C. In some cases a wollastonite bed is used as a supplier of calcium ions, resulting in the formation of a bonelike apatite layer. The presence of this bioactive system during the biomimetic process has a positive significant effect on the bioactivation of the composites for either short or long times of immersion of the composites in simulated body fluids. The chemical treatment increases also the rate of apatite formation at short immersion periods.

Study of Bio-Mineralization of BCP with Compensation of Calcium and Phosphate Ions

2009 ◽  
Vol 610-613 ◽  
pp. 1391-1394
Author(s):  
Hua De Zheng ◽  
Ying Jun Wang ◽  
Qiang Ma ◽  
Cheng Yun Ning ◽  
Xiao Feng Chen
Keyword(s):  
Free Energy ◽  
Calcium Phosphate ◽  
Calcium Ions ◽  
Biphasic Calcium Phosphate ◽  
Porous Ceramic ◽  
Apatite Layer ◽  
Apatite Formation ◽  
Phosphate Ions

In the present study, an Intelligent Multi-parameter Simulated Evaluation in vitro （IMSE system） was used to study the deposition properties of apatite formation on the surface of biphasic calcium phosphate porous ceramic (BCP) from static and dynamic r-SBF. Results showed that apatite formed on the surface of BCP from static and dynamic r-SBF differed between each other. In static r-SBF, ions were transferred by diffusion, which could not compensate the consuming of calcium ions, and mist apatite layer was formed on the surface of samples. But in the dynamic r-SBF, simulated fluid was adjusted precisely and flowed forcedly, the concentrations of ions were homogeneous; with the compensation of ions, calcium and phosphate were supersaturated, and the free energy of apatite formation was negative, bone-like apatite sheets were formed on the surface of samples.

Surface Modification Of Polymers With Grafting And Coating Of Silane Hybrids And Their Bioactivity

1999 ◽  
Vol 576 ◽  
Author(s):  
Masaaki Kubo ◽  
Seisuke Takashima ◽  
Kanji Tsuru ◽  
Satoshi Hayakawa ◽  
Akiyoshi Osaka ◽  
...  
Keyword(s):  
Contact Angle ◽  
High Density Polyethylene ◽  
Body Fluid ◽  
Chemical Species ◽  
Hydrated Silica ◽  
Bioactive Materials ◽  
Poly Vinyl Chloride ◽  
Essential Chemical ◽  
Surface Modified

ABSTRACTHydrated silica rich Si-OH and Si-0- groups serve in a body environment as sites for nucleation of apatite, and are known as an essential chemical species for bioactive materials. Organic polymers having surface modified with the hydrated silica will show bioactivity: bone tissues grow toward the apatite layer and bond to materials. Thus MOPS-M (3-methacryloxypropyltrimethoxysilane) was grafted under emulsion polymerization procedure to high density polyethylene (HDPE), poly (vinyl chloride) (PVC) and polyamide (PA) substrates to examine in vitro deposition of apatite (bioactivity) after soaking in a simulated body fluid (Kokubo solution). Bioactivity was confirmed for the grafted PVC and PA substrates and discussed in terms of contact angle and relative amount of grafted silane molecules.

Apatite-Forming Ability of Organic-Inorganic Hybrids Prepared from Calcium Silicate and Glucomannan

2007 ◽  
Vol 361-363 ◽  
pp. 567-570
Author(s):  
Yasuyuki Morita ◽  
Toshiki Miyazaki ◽  
Eiichi Ishida ◽  
Chikara Ohtsuki
Keyword(s):  
Calcium Silicate ◽  
Body Fluid ◽  
Organic Polymer ◽  
Apatite Formation ◽  
X Ray Diffraction ◽  
Electron Microscopic ◽  
Living Body ◽  
Bioactive Ceramics ◽  
Previously Treated

So-called bioactive ceramics are used for bone-repairing owing to attractive features such as direct bone-bonding in living body. However, there is limitation on clinical applications due to their inappropriate mechanical properties performances such as higher brittleness and lower fracture toughness than natural bone. To overcome this problem, hybrid materials have been developed by modification of calcium silicate, that is basic component of bioactive ceramics, with organic polymer. It is known that bioactive ceramics bond to bone through bone-like apatite layer which is formed on their surfaces by chemical reaction with body fluid. We attempted preparation of bioactive organic-inorganic hybrids from Glucomannan that is a kind of complex polysaccharide, and calcium silicate. Hybrids were prepared from glucomannan and tetraethoxysilane (TEOS). They were treated with 1M (=mol·m-3) CaCl2 aqueous solution for 24 hours. Then ability of apatite formation on the hybrids was examined in vitro using simulated body fluid (SBF, Kokubo solution). Surface structure of the specimens was examined by thin-film X-ray diffraction (TF-XRD), scanning electron microscopic (SEM) observation. The hybrids with TEOS:Glucomannan= 1:1 to 4:1 in mass ratio formed the apatite in SBF within 3 or 7 d, when they were previously treated with CaCl2 solution.

scholarly journals Tri-Functional Calcium-Deficient Calcium Titanate Coating on Titanium Metal by Chemical and Heat Treatment

Coatings ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 561 ◽  
Author(s):  
Seiji Yamaguchi ◽  
Phuc Thi Minh Le ◽  
Morihiro Ito ◽  
Seine A. Shintani ◽  
Hiroaki Takadama
Keyword(s):  
Antibacterial Activity ◽  
Body Fluid ◽  
Bone Growth ◽  
Solution Treatment ◽  
Calcium Titanate ◽  
The Other ◽  
Apatite Formation ◽  
Clinical Use ◽  
Ion Release ◽  
High Bone

The main problem of orthopedic and dental titanium (Ti) implants has been poor bone-bonding to the metal. Various coatings to improve the bone-bonding, including the hydroxyapatite and titania, have been developed, and some of them have been to successfully applied clinical use. On the other hand, there are still challenges to provide antibacterial activity and promotion of bone growth on Ti. It was shown that a calcium-deficient calcium titanate coating on Ti and its alloys exhibits high bone-bonding owing to its apatite formation. In this study, Sr and Ag ions, known for their promotion of bone growth and antibacterial activity, were introduced into the calcium-deficient calcium titanate by a three-step aqueous solution treatment combined with heat. The treated metal formed apatite within 3 days in a simulated body fluid and exhibited antibacterial activity to Escherichia coli without showing any cytotoxicity in MC3T3-E1 preosteoblast cells. Furthermore, the metal slowly released 1.29 ppm of Sr ions. The Ti with calcium-deficient calcium titanate doped with Sr and Ag will be useful for orthopedic and dental implants, since it should bond to bone because of its apatite formation, promote bone growth due to Sr ion release, and prevent infection owing to its antibacterial activity.

Bone Formation in Non-Osseous Tissues of Biphasic HA/β-TCP Bioceramics Sintered by Different Ways

2007 ◽  
Vol 336-338 ◽  
pp. 1666-1669 ◽  
Author(s):  
Jun Guo Ran ◽  
Li Gou ◽  
Bao Hui Su ◽  
Fang Hu Wang ◽  
Lu Wei Sun ◽  
...  
Keyword(s):  
Bone Formation ◽  
Body Fluid ◽  
Microwave Plasma ◽  
Microwave Sintering ◽  
Apatite Formation ◽  
Conventional Furnace ◽  
Plasma Sintering ◽  
Higher Temperature ◽  
Healthy Dogs ◽  
Lower Temperature

In order to improve the bioactivity of calcium phosphate bioceramics, biphasic HA/β-TCP (BCP) bioceramics were prepared by the microwave sintering and the microwave plasma sintering. Bone-like apatite formation of the resulting samples was investigated in simulated body fluid (SBF). The samples were also implanted in dorsal muscles of healthy dogs for 1.5and 3 months. All samples after taking out were examined by histological observation. Bone formation in different sintering ways and temperatures was investigated in details. Better osteoinductivity was found in samples sintered by the microwave and microwave plasma instead of the conventional furnace, as well as by lower temperature (1050 oC) instead of higher temperature (1150 oC). It accounts for that the increase in degradability of materials sintered by microwave and microwave plasma or lower temperature leads to the better of bone-like apatite formation and bone formation due to fine grains and lower crystallinity.

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