Effect of Simulated Body Fluid on the Microstructure of Ferrimagnetic Bioglass-Ceramics

2004 ◽  
Vol 839 ◽  
Author(s):  
N. I. Papanearchou ◽  
Th. Leventouri ◽  
A. C. Kis ◽  
A. Hotiu ◽  
I. M. Anderson
Keyword(s):  
Electron Microscopy ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Processing Parameters ◽  
X Ray Diffraction ◽  
X Ray ◽  
In Series ◽  
Structure And Microstructure ◽  
Scanning Electron

ABSTRACTThe effect of simulated body fluid (SBF) on the structure and microstructure of ferrimagnetic bioglass ceramics (FBC) was investigated in series of samples in the system of the oxides [0.45(CaO, P2O5) (0.52-x)SiO2 xFe2O3 0.03Na2O], with X = 0.05, 0.10, 0.15, 0.20. Physical properties of the materials were studied as a function of processing parameters and time of immersion in SBF by x-ray diffraction (XRD) and scanning electron microscopy (SEM) with energy dispersive x-ray spectroscopy (EDS). The in vitro experiment showed that bioactivity of the FBC varies with the composition of the oxides, heat treatment, and time of exposure in SBF in a non-systematic way. A surface layer of Si, P, Ca partially covers the Fe, O dendrites, while formation and size of pores is determined by the specific processing parameters of the materials.

Bioactive Composite Materials for Bone Tissue Applications

2006 ◽  
Vol 514-516 ◽  
pp. 985-989
Author(s):  
B.J.M. Leite Ferreira ◽  
M.G.G.M. Duarte ◽  
M. Helena Gil ◽  
Rui N. Correia ◽  
J. Román ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Bone Tissue ◽  
Tissue Repair ◽  
Body Fluid ◽  
In Vitro Bioactivity ◽  
X Ray Diffraction ◽  
X Ray ◽  
Biodegradable Composite ◽  
Scanning Electron

Two materials with potential application in bone tissue repair have been developed: 1) a non-biodegradable composite based in a new methacrylic-co-acrylic matrix; and 2) a biodegradable composite based in a chitosan (Ch) matrix. Both matrices were reinforced with glass-ceramic particles of composition (mol%) 70 SiO2 – 30 CaO. The in vitro bioactivity of composites was assessed by soaking in simulated body fluid (SBF) for periods of up to 7 days at 37º C. X-ray diffraction (XRD) and scanning electron microscopy coupled with X-ray energy dispersive spectroscopy (SEM-EDS) were used for deposit identification after different soaking periods. Calcium phosphate particulate deposits were detected after 3 days of immersion, followed by growth and maturation towards apatite.

scholarly journals Development of an Oxcarbazepine Solid Dispersion Using Skimmed Milk to Improve the Solubility and Dissolution Profile

2019 ◽  
Vol 11 (05) ◽  
Author(s):  
M. Shah ◽  
D. Patel
Keyword(s):  
Electron Microscopy ◽  
Solid Dispersion ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Infra Red ◽  
Crystalline Nature ◽  
Skimmed Milk ◽  
Scanning Electron

Oxcarbazepine has low solubility and low oral bioavailability, so it’s a challenge to formulate suitable dosage form. In this present investigation, to improve the dissolution rate and solubility, skimmed milk is used as a carrier. Physical mixers were prepared using various drugs to carrier ratio and spray drying technology was used to develop solid dispersion with the carrier. Various techniques were used to characterize the solid dispersion immediately after they were made which includes differential scanning calorimetry, scanning electron microscopy, fourier transform infra- red spectroscopy, X-ray diffraction and in-vitro dissolution profiles. The differential scanning calorimetry thermograms of raw drug indicated of its anhydrous crystalline nature. In thermograms of solid dispersion, the characteristic peak was absent suggesting the change from crystalline nature to amorphous form. X-ray diffraction confirmed those results. X-ray diffraction results of raw drug showed highly intense peak characteristic of its crystalline nature where solid dispersion showed less intense, more diffused peak indicating the change in crystalline form. Fourier transforms infra-red spectroscopy studies showed there was no interaction between drug and carrier. Scanning electron microscopy support the amorphous nature of mixer. The whole formulation showed distinct enhancement in the drug release behavior and solubility. The optimum oxcarbazepine to skimmed milk ratio 1:3 enhances the in-vitro drug release by 3.5 fold and also show distinct increase in solubility. It was concluded that for improvement of solubility of poorly water soluble oxcarbazepine, skimmed milk powder as a carrier can be utilize very well.

In Vitro Study of Microplasma Sprayed Hydroxyapatite Coatings in Simulated Body Fluid

2009 ◽  
Vol 79-82 ◽  
pp. 815-818 ◽  
Author(s):  
Qiu Ying Zhao ◽  
Ding Yong He ◽  
Xiao Yan Li ◽  
Jian Min Jiang
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Carbonate Apatite ◽  
In Vitro Test ◽  
X Ray Diffraction ◽  
X Ray ◽  
Amorphous Phases ◽  
Hydroxyapatite Coatings ◽  
Vitro Test

Hydroxyapatite (HA) coatings were deposited onto Ti6Al4V substrate by microplasma spraying (MPS) in the current research. The morphology, phase compositions, and percentage of crystallinity of the coatings were characterized by means of scanning electron microscopy (SEM) and X-ray diffraction. An in vitro evaluation by soaking the coatings in simulated body fluid (SBF) for up to 14 days was conducted aiming at the evaluation of their bioactivity. Results from the present investigation suggest that microplasma sprayed HA coatings exhibited certain roughness, pores, and microcracks. Thermal decomposition existed in the coatings where HA, α-TCP，β-TCP, amorphous phases, and CaO-exclusive impurities were observed. The in vitro test indicated that HA coatings deposited by MPS possessed better bioactivity and stability. A layer of carbonate-apatite covered most of the coating surface, which did not exhibit significant spalling after incubation in SBF.

scholarly journals The Atomic-Scale Interaction of Bioactive Glasses with Simulated Body Fluid

2005 ◽  
Vol 480-481 ◽  
pp. 21-26 ◽  
Author(s):  
L.J. Skipper ◽  
F.E. Sowrey ◽  
D.M. Pickup ◽  
R.J. Newport ◽  
K.O. Drake ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Sol Gel ◽  
Atomic Scale ◽  
X Ray Diffraction ◽  
Bioactive Glasses ◽  
Edge Structure ◽  
X Ray ◽  
X Ray Absorption

The formation of a carbonate-containing hydroxyapatite, HCAp, layer on bioactive calcium silicate sol-gel glass of the formula (CaO)0.3(SiO2)0.7 has been studied in-vitro in Simulated Body Fluid (SBF). Extended X-ray Absorption Fine Structure (EXAFS), X-ray Absorption Near Edge Structure (XANES), X-ray diffraction (XRD), and solid state nuclear magnetic resonance (NMR) measurements have been performed with results showing the formation of a significantly amorphous HCAp layer after less than 5 hours in solution.

scholarly journals Preparation and Biocompatibility of Poly Methyl Methacrylate (PMMA)-Mesoporous Bioactive Glass (MBG) Composite Scaffolds

Gels ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 180
Author(s):  
Irina Atkinson ◽  
Ana Maria Seciu-Grama ◽  
Oana Catalina Mocioiu ◽  
Ana Maria Mocioiu ◽  
Luminita Predoana ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Composite Scaffold ◽  
Bone Diseases ◽  
X Ray Diffraction ◽  
Composite Scaffolds ◽  
X Ray ◽  
In Vitro Biocompatibility ◽  
Mesoporous Bioactive Glass ◽  
Scanning Electron

In recent years, the rising number of bone diseases which affect millions of people worldwide has led to an increased demand for materials with restoring and augmentation properties that can be used in therapies for bone pathologies. In this work, PMMA- MBG composite scaffolds containing ceria (0, 1, 3 mol%) were obtained by the phase separation method. The obtained composite scaffolds were characterized by X-ray diffraction, infrared spectroscopy, and scanning electron microscopy. UV–Vis measurement and EDX analysis confirmed the presence of cerium ions in the composite scaffolds. Evaluation of the in-vitro biocompatibility using MTT assay showed that composite scaffold containing 1 mol% of ceria presented higher viability than control cells (100%) for concentrations ranging between 5 and 50% after 96 h of incubation.

Fast Synthesis of Rutile/Apatite Core/Shell Structured Photocatalyst in Simulated Body Fluid

2012 ◽  
Vol 465 ◽  
pp. 66-71 ◽  
Author(s):  
Fu Zhi Shi ◽  
Yao Gang Li ◽  
Hong Zhi Wang ◽  
Qing Hong Zhang
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Core Shell ◽  
X Ray Diffraction ◽  
Soaking Time ◽  
X Ray ◽  
Transmission Electron ◽  
Tio2 Microspheres

The core/shell structured rutile/apatite was prepared by soaking rutile TiO2 (R-TiO2) microspheres into a simulated body fluid (SBF) only for 1 day. The as-prepared samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), energy dispersive X-ray (EDX) and N2 adsorption measurements. XRD showed that the apatite content increased with prolonging the soaking time or increasing the SBF concentration. TEM and EDX demonstrated that apatite had been coated on the surface of R-TiO2 microspheres successfully. HRTEM indicated that the lattice spacings of 0.27 nm and 0.32 nm were assigned to (211) plane of apatite and (101) plane of R-TiO2, respectively.

In Vitro Bioactivity of Composite of Nanophase Titania/Bioactive Glass-Ceramic in Simulated Body Fluid

2005 ◽  
Vol 288-289 ◽  
pp. 171-174
Author(s):  
Hui Wang ◽  
Bang Cheng Yang ◽  
Qi Feng Yu ◽  
Dayi Wu ◽  
Xing Dong Zhang
Keyword(s):  
Simulated Body Fluid ◽  
Bioactive Glass ◽  
Glass Ceramic ◽  
Body Fluid ◽  
Mechanical Analysis ◽  
Apatite Formation ◽  
X Ray Diffraction ◽  
X Ray ◽  
Biomechanical Compatibility

Titania ceramics is lack of bone-bonding ability even if it has excellent biocompatibility. Recently, it is even found that the nanophase titania ceramics could enhance the proliferation of osteoblasts. If the bone-bonding ability of this material is improved, it would be a potential bone replacement material. Bioactive glass-ceramic (BGC) is provided with the best bioactivity in biomaterials. In this study, the apatite formation ability and the mechanic properties of titania ceramic were investigated by the accession of BGC. Four samples: TiO2 ceramic, TiO2 +10%BGC, TiO2 +20%BGC and BGC were prepared respectively. These ceramics were exposed to a simulated body fluid (SBF) for 7, 14 and 21d. Scanning electron microscopy (SEM), energy dispersive X-ray detector (EDX) and thin film X-ray diffraction (TF-XRD) results showed that the apatite formation of the ceramics was improved by adding BGC into nanophase titania ceramic. The mechanical analysis showed the biomechanical compatibility was also improved by adding BGC into nanophase titania ceramic.

The Oxidation Resistance of Cu-Ag Alloy Nanopowders Prepared by Induction Plasma Technology

2012 ◽  
Vol 151 ◽  
pp. 28-31 ◽  
Author(s):  
Min Ming Zou ◽  
Mi Yan ◽  
Fu Jun Shang ◽  
Wei Huang ◽  
Yong Liu ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Oxidation Resistance ◽  
Average Diameter ◽  
Processing Parameters ◽  
X Ray Diffraction ◽  
Plasma Technology ◽  
Induction Plasma ◽  
X Ray ◽  
Suitable Processing ◽  
Scanning Electron

The Cu-30wt%Ag alloy nanopowders are prepared by induction plasma technology, and the nanopowder is successfully coated by terpineol (C10H18O). The morphology, phase composition and oxidation resistance of nanopowders are characterized by scanning electron microscopy (SEM), X-ray diffraction and thermogravimetric (TG) analysis. When the suitable processing parameters of induction plasma are chosen, the spherical morphology and average diameter about 89 nm of Cu-30wt%Ag nanopowders are obtained. Meanwhile, the Cu-Ag alloy nanopowders which are coated by terpineol are free from oxidation when temperature is below 280°C.

Characterization of Hydroxyapatite-Titanium Oxide Scaffolds Made by the Polymeric Sponge Method

2012 ◽  
Vol 727-728 ◽  
pp. 1113-1118 ◽  
Author(s):  
A.G.S. Galdino ◽  
Cecília A.C. Zavaglia
Keyword(s):  
Electron Microscopy ◽  
Titanium Oxide ◽  
Bone Reconstruction ◽  
X Ray Diffraction ◽  
Technical Literature ◽  
X Ray ◽  
Polyurethane Sponge ◽  
Scanning Electron

Along decades, bioceramics have been used as materials for bone reconstruction, where hydroxyapatite is one of the most used bioceramics. But hydroxyapatite mechanical strength is not so high when compared with another bioceramics. This research aimed to characterize hydroxyapatite-titanium oxide scaffolds with different compositions. Samples were made using a polyurethane sponge with compositions of 70%-30% wt., 60%-40% wt. and 50%-50% wt. of hydroxyapatite-titanium oxide, calcined at 550°C for burning the polymeric sponge and sintered at 1250°C, 1300°C and 1350°C. Samples were characterized by scanning electron microscopy (SEM), x-ray diffraction (XRD) and energy dispersive x-ray spectroscopy (EDS). Results showed that all compositions maintained the polymeric sponge pores structure without any residual traces of the polymeric sponge. Those results are in accordance with technical literature and it is indicated to do in vitro essays to study the scaffolds biocompatibility for using as bone reconstruction materials.

Sign in / Sign up

Export Citation Format

Share Document