The state of the immunity system in women with latent Papillomavirus infection of the cervix

2017 ◽  
pp. 135-138
Author(s):  
O.L. Dola ◽  
Keyword(s):  
Humoral Immunity ◽  
Significant Inhibition ◽  
The State ◽  
Simultaneous Increase ◽  
Functional Reserve ◽  
Urogenital Infection ◽  
Urogenital Infections ◽  
Papillomavirus Infection ◽  
Cellular And Humoral Immunity ◽  
Phagocytic Reaction

The article presents modern aspects of the state of immunity in women with latent papillomavirus infection (PVI) of the cervix. The objective: the study of the indicators characterizing the state of immunity in women with latent PVI of the cervix, often associated with urogenital infections (UGI), at the beginning of the survey and after 6 months of observation. Patients and methods. The study of cellular and humoral immunity was performed in 210 women with latent papillomavirus infection (PVI) and 15 healthy women at the beginning of the examination and 6 months later. 84 women were diagnosed with a monoinfection, 126 had a combined PVI and a urogenital infection (UGI). In 140 women transient PVI is established, in 70 – persistent. Results. In women with latent cervical pylori cervix, disorders of cellular immunity were observed (a slight decrease in the relative amount of CD3+, CD4+ lymphocytes and a simultaneous increase in the number of CD8+ lymphocytes, natural killers and B-lymphocytes) against the background of activation of the humoral immunity unit. Nonspecific protection of the female body with PVI was characterized by inhibition of the phagocytic reaction of neutrophils (Nf) and monocytes (Mg) against the background of an increase in oxygen-dependent metabolism, primarily HF, and a decrease in the functional reserve for both NF and MZ. The most pronounced disorders were found for patients with combined PVI and UGI. Conclusion. In women with transient PVI normalization of cellular and humoral immunity was observed, and the further persistence of the human papillomavirus in the genitals led to a more significant inhibition of phagocytic and HCT activity of phagocytes, as well as to a decrease in some parameters of the cellular and humoral immunity units. Key words: papillomavirus infection, cervix, cellular and humoral immunity.

scholarly journals THE STATE OF CELLULAR AND HUMORAL IMMUNITY IN INFANTS BORN WITH EXTREMELY LOW AND VERY LOW WEIGHT

2020 ◽  
Vol 18 (4) ◽  
pp. 396-401
Author(s):  
M. G. Devyaltovskaya ◽  
◽  
A. V. Simchenko ◽  
D. A. Kramko ◽  
◽  
...  
Keyword(s):  
Humoral Immunity ◽  
The State ◽  
Low Weight ◽  
Cellular And Humoral Immunity

Assessment of cellular immunity in oil production operators with an imbalance of lipid metabolism

2020 ◽  
Vol 60 (11) ◽  
pp. 717-719
Author(s):  
Inga N. Alikina ◽  
Olga A. Kazakova
Keyword(s):  
Lipid Metabolism ◽  
Humoral Immunity ◽  
Cellular Immunity ◽  
Comparison Group ◽  
Oil Production ◽  
Observation Group ◽  
Immunological Parameters ◽  
Production Factors ◽  
Cellular And Humoral Immunity ◽  
Atherosclerotic Process

Introduction. Studies indicate the high pathogenetic significance of the immune component in the development of atherosclerosis. The aim of the study is a comparative assessment of immunological parameters in workers of petrochemical production with varying degrees of imbalance in lipid metabolism and the development of the atherosclerotic process. Materials and methods. Men working at an oil production enterprise in the Perm Region were examined. The observation group consisted of oil production operators with a diagnosis of atherosclerosis, the comparison group - with dyslipidemia syndrome. To determine the parameters of lipid metabolism, the results of a biochemical blood test were used. CD-immunogram parameters were identified by flow cytometry. Specific antibodies to benzene were determined by the allergosorbent method. Results. The results of a comparative study of fat metabolism confirmed violations of the physiological ratio of lipids in the blood of oil production workers, which were expressed in a significant imbalance in the levels of lipidogram. There was an increased level of specific IgG antibodies to benzene in the observation group in relation to the comparison group. An imbalance of cellular immunity was found, which was characterized by signs of indicators activation of cellular differentiation clusters. Conclusions. Studies of immune system compartments demonstrate excessive activation of cellular and humoral immunity in oil production workers under the influence of a combination of harmful production factors. The simultaneously formed imbalance of lipid metabolism is associated with various degrees of clinical manifestation of atherosclerotic disorders, with the influence of harmful production factors, aggressiveness of cellular and humoral immunity, and smoking.

scholarly journals Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 298
Author(s):  
Daniele Focosi ◽  
Angelo Genoni ◽  
Ersilia Lucenteforte ◽  
Silvia Tillati ◽  
Antonio Tamborini ◽  
...  
Keyword(s):  
Humoral Immunity ◽  
Cross Reactivity ◽  
Clinical Severity ◽  
World Health ◽  
Laboratory Findings ◽  
Cellular And Humoral Immunity ◽  
Rate Ratios ◽  
Original Antigenic Sin

Antibody-dependent enhancement (ADE) of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) infection has been hypothesized. However, to date, there has been no in vitro or in vivo evidence supporting this. Cross-reactivity exists between SARS CoV-2 and other Coronaviridae for both cellular and humoral immunity. We show here that IgG against nucleocapsid protein of alphacoronavirus NL63 and 229E correlate with the World Health Organization’s (WHO) clinical severity score ≥ 5 (incidence rate ratios was 1.87 and 1.80, respectively, and 1.94 for the combination). These laboratory findings suggest possible ADE of SARS CoV-2 infection by previous alphacoronavirus immunity.

scholarly journals The HSP70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Hyundong Jo ◽  
Bong Yoon Kim ◽  
So Hui Park ◽  
Hyun Mi Kim ◽  
Sung Ho Shin ◽  
...  
Keyword(s):  
Humoral Immunity ◽  
Broad Spectrum ◽  
Protective Efficacy ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Host Defenses ◽  
Vaccination Site ◽  
Oil Emulsion ◽  
Foot And Mouth ◽  
Cellular And Humoral Immunity

AbstractCurrent foot-and-mouth disease (FMD) vaccines have significant limitations, including side effects due to oil emulsions at the vaccination site, a narrow spectrum of protective efficacy, and incomplete host defenses mediated by humoral immunity alone. To overcome these limitations, new FMD vaccines must ensure improved safety with non-oil-based adjuvants, a broad spectrum of host defenses within/between serotypes, and the simultaneous induction of cellular and humoral immunity. We designed a novel, immune-potent, recombinant protein rpHSP70-AD that induces robust cellular immunity and elicits a broad spectrum of host defenses against FMD virus (FMDV) infections. We demonstrated that an oil emulsion-free vaccine containing rpHSP70-AD mediates early, mid-term, and long-term immunity and drives potent host protection against FMDV type O and A, suggesting its potential as an FMD vaccine adjuvant in mice and pigs. These results suggest a key strategy for establishing next-generation FMD vaccines, including novel adjuvants.

IMMU-29. B-CELL-BASED VACCINE PRODUCES GLIOBLASTOMA-REACTIVE ANTIBODIES THAT CONTRIBUTE TO TUMOR CLEARANCE

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi98-vi98
Author(s):  
Brandyn Castro ◽  
Mark Dapash ◽  
David Hou ◽  
Aida Rashidi ◽  
Deepak Kanojia ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Humoral Immunity ◽  
Ex Vivo ◽  
Murine Models ◽  
Effector Functions ◽  
Tumor Bearing ◽  
Tumor Clearance ◽  
Cellular And Humoral Immunity

Abstract Glioblastomas (GBM) are characterized by a strong immunosuppressive environment, contributing to their poor prognosis and limited therapeutic response to immunotherapies. B-cells represent a unique opportunity to promote immunotherapy due to their potential to kill tumors by both cellular and humoral immunity. To generate our B-cell-based vaccine (BVax) platform, we activated 41BBL+ B cells from tumor bearing mice or GBM patient blood with BAFF, CD40, and IFNg. We have previously demonstrated that BVax potentiates radiation therapy, temozolomide and checkpoint blockade in murine models of GBM via enhancement of CD8+ T-cell based immunity. The aim of this current study is to evaluate the humoral effector functions of BVax. We examined the antibody (Ab) repertoire in vivo from serum of tumor-bearing B-cell knockout mice treated with BVax or by ex vivo stimulation of patient-derived BVax. Upon systemic administration, BVax infiltrates the tumor where it differentiates into plasmablasts. Murine BVax- and BNaive-derived serum immunoglobulin generated in vivo showed that the majority of murine BVax-derived Ab were IgG isotype, while BNaive mainly produced IgM isotype. Transfer of IgG from BVax treated mice directly into tumors of recipient animals significantly prolonged their survival, demonstrating anti-tumor cytotoxicity directly through humoral immunity. Patient-derived BVax activated ex vivo showed a plasmablast phenotype and the Ab repertoire supports the previous findings seen in our murine model. Our work suggests BVax-derived IgGs role in antibody-dependent cellular cytotoxicity and improved survival in murine models. This function, in addition to its role in cellular immunity against GBM, renders BVax a potentially effective alternative immunotherapeutic option for GBM patients.

Corticosterone transdermal application in toads (Rhinella icterica): Effects on cellular and humoral immunity and steroid plasma levels

2017 ◽  
Vol 327 (4) ◽  
pp. 200-213 ◽  
Author(s):  
Vania Regina Assis ◽  
Stefanny Christie Monteiro Titon ◽  
Nicolle Gilda Teixeira Queiroz-Hazarbassanov ◽  
Cristina de Oliveira Massoco ◽  
Fernando Ribeiro Gomes
Keyword(s):  
Humoral Immunity ◽  
Plasma Levels ◽  
Transdermal Application ◽  
Cellular And Humoral Immunity

Natural immunity factors in Polish mixed breed rabbits

2015 ◽  
Vol 18 (1) ◽  
pp. 19-28 ◽  
Author(s):  
B. Tokarz-Deptuła ◽  
P. Niedźwiedzka-Rystwej ◽  
M. Adamiak ◽  
B. Hukowska-Szematowicz ◽  
A. Trzeciak-Ryczek ◽  
...  
Keyword(s):  
Humoral Immunity ◽  
Peripheral Blood ◽  
Scientific Research ◽  
Natural Immunity ◽  
Immunological Status ◽  
Mixed Breed ◽  
Cellular And Humoral Immunity ◽  
The Impact

AbstractMixed-breed rabbits in Poland are widely used for diagnostic and scientific research and as utility animals, therefore there is a need to know their immunological status, as well as their haematological status. In this study natural immunity factors were analyzed in Polish mixed-breed rabbits and Polish mixed-breed rabbits with addition of blood of meet-breed, considering the impact of sex and season of the year (spring, summer, autumn, winter) using measurement of non-specific cellular and humoral immunity parameters in peripheral blood. The study has revealed that there is a variety between the two commonly used mixed-breed types of rabbits, especially when sex and season is concerned, which is crucial for using these animals in experiments.

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