scholarly journals Do gender and puberty influence allergic diseases?

2021 ◽  
Vol 49 (2) ◽  
pp. 122-125
Author(s):  
Cristine Secco Rosário ◽  
Cristina Alves Cardozo ◽  
Herberto José Chong Neto ◽  
Nelson Augusto Rosário Filho
Keyword(s):  
Molecular Genetic ◽  
Allergic Diseases ◽  
Sex And Gender ◽  
Sexual Hormones ◽  
Biological Sex ◽  
Female Predominance ◽  
Different Populations ◽  
And Gender ◽  
Epigenetic Patterns ◽  
Gender Specific

Differences between biological sex, gender identity, and their impact on health may have significant implications for the prevention, screening, diagnosis, and treatment of several diseases, including allergies. Asthma, allergic rhinitis (AR), atopic dermatitis (AD), and allergic conjunctivitis (AC) have different prevalences and different risk factors in infancy. Although boys present allergies more often in childhood, it quickly changes during girls’ sexual development, leading to lifelong female predominance of allergic diseases. This can be explained by the influence of sexual hormones, different lifestyles adopted by men and women, microbiota diversity, diet distinctions, professional options, and adherence to treatment, among others. Gender-related aspects should become essential parameters in allergology to diagnostic and therapeutic stratification, associated with molecular, genetic, and epigenetic patterns. Longitudinal studies would be interesting to evaluate possible mechanisms underlying these differences in prevalence. Sex- and gender-specific observations beyond 14 years of age are scarce and further allergic multimorbidity studies in different populations, especially in adults, are necessary.

Sex and Gender Differences in Rilpivirine based ART - Data from the HIVCENTER Frankfurt

2019 ◽  
Vol 17 (5) ◽  
pp. 368-374
Author(s):  
G. Schüttfort ◽  
K. Philipp ◽  
P. de Leuw ◽  
E. Herrmann ◽  
G. Kann ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Virologic Failure ◽  
Response Rates ◽  
Virologic Response ◽  
Close Monitoring ◽  
Sex And Gender ◽  
Overall Response ◽  
Number Of Patients ◽  
And Gender ◽  
Gender Specific

Objectives: While Rilpivirine has shown high overall response rates in treatment-naïve patients without sex and gender specific differences in clinical trials, Sex and gender specific data in treatment experienced patients receiving rilpivirine are still limited. We conducted a 48 week efficacy and safety analysis in naïve and treatment experienced men and women using retrospective data from the HIVCENTER Frankfurt. Materials and methods: In this retrospective observational study data of all patients who received a rilpivirine based regimen at the HIVCENTER between March 2011 and December 2015 were analyzed. Primary endpoint was the proportion of patients with any discontinuation until week 48. Virologic response rates (FDA snapshot analysis; HIV-1 RNA <50 copies/mL) were assessed at week 48. Results: 194 patients (34% female) were included in the analysis. 74% were treatment-experienced and 26% naïve, respectively. Discontinuations were observed in 31 (15.9%) patients. Regarding sex differences, the proportion of discontinuations was significantly higher in women than in men (24.2% vs. 11.7%; p=0.024; ODDS-Ratio = 2.41; CI 1.12 – 5.18). Virologic failure occurred in 8 PLWHIV (4.1%). Conclusions: While virologic overall response rates to rilpivirine based ART were high for both treatment-experienced and -naïve patients the proportion of discontinuations was significantly higher in women (24.2% vs. 11.7%; p = 0.024; ODDS-Ratio = 2.41; CI 1.12 – 5.18). Although the total number of patients with virologic failure was low (4.1%), the higher rate of ART discontinuations in female patients receiving RPV require close monitoring in the first months of treatment addressing special needs of women living with HIV.

scholarly journals Breaking the Binary

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Lucy Mercer-Mapstone ◽  
Sarah Bajan ◽  
Kasia Banas ◽  
Arthur Morphett ◽  
Kristine McGrath
Keyword(s):  
Minority Group ◽  
First Year ◽  
Sex And Gender ◽  
Biological Sex ◽  
Positive Attitudes ◽  
Student Cohorts ◽  
The Difference ◽  
Students Attitudes ◽  
And Gender ◽  
Partnership Approach

The need to make higher education curricula gender-inclusive is increasingly pressing as student cohorts diversify. We adopted a student-staff partnership approach to design, integrate, and evaluate a module that taught first-year science students the difference between biological sex, gender identity, gender expression, and sexual orientation in the context of genetics concepts at an Australian university. This module aimed to break the binary in misconceptions of both sex and gender, emphasising that both exist on separate spectra. Data triangulation was used to evaluate students’ attitudes towards the module and their learning of module concepts. Students’ attitudes were positive overall, and evaluation of students’ learning indicated that the majority of students understood and retained key concepts, while also identifying common misconceptions. Perhaps the most important finding was that students who identified as belonging to a minority group had significantly more positive attitudes towards the module than non-minority students. This finding supports previous research that has found inclusive curricula have greater benefit for students from minority backgrounds, indicating the importance of making such curriculum enhancements. Our results speak to both the co-creation process and students’ learning outcomes, providing valuable insights for practitioners both within science and beyond.

Sex- and Gender-Specific Aspects of Migraine Treatment

2019 ◽  
pp. 31-43 ◽  
Author(s):  
Daphne S. van Casteren ◽  
Emile G. M. Couturier ◽  
Antoinette Maassen van den Brink
Keyword(s):  
Migraine Treatment ◽  
Sex And Gender ◽  
And Gender ◽  
Gender Specific

scholarly journals Sex/Gender-Specific Imbalance in CVD: Could Physical Activity Help to Improve Clinical Outcome Targeting CVD Molecular Mechanisms in Women?

2020 ◽  
Vol 21 (4) ◽  
pp. 1477
Author(s):  
Mauro Vaccarezza ◽  
Veronica Papa ◽  
Daniela Milani ◽  
Arianna Gonelli ◽  
Paola Secchiero ◽  
...  
Keyword(s):  
Physical Activity ◽  
Molecular Mechanisms ◽  
Population Aging ◽  
Sex And Gender ◽  
Cvd Risk ◽  
Men And Women ◽  
Positive Effects ◽  
And Gender ◽  
Underlying Mechanisms ◽  
Gender Specific

In the last two decades, new insights have been gained regarding sex/gender-related differences in cardiovascular disease (CVD). CVD represents the leading cause of death worldwide in both men and women, accounting for at least one-third of all deaths in women and half of deaths in women over 50 years in developing countries. Important sex-related differences in prevalence, presentation, management, and outcomes of different CVDs have been recently discovered, demonstrating sex/gender-specific pathophysiologic features in the presentation and prognosis of CVD in men and women. A large amount of evidence has highlighted the role of sex hormones in protecting women from CVDs, providing an advantage over men that is lost when women reach the menopause stage. This hormonal-dependent shift of sex-related CVD risk consequently affects the overall CVD epidemiology, particularly in light of the increasing trend of population aging. The benefits of physical activity have been recognized for a long time as a powerful preventive approach for both CVD prevention and aging-related morbidity control. Exercise training is indeed a potent physiological stimulus, which reduces primary and secondary cardiovascular events. However, the underlying mechanisms of these positive effects, including from a sex/gender perspective, still need to be fully elucidated. The aim of this work is to provide a review of the evidence linking sex/gender-related differences in CVD, including sex/gender-specific molecular mediators, to explore whether sex- and gender-tailored physical activity may be used as an effective tool to prevent CVD and improve clinical outcomes in women.

scholarly journals Field Test Results of Sex- and Gender-Specific Health Multimedia Case-Based Learning Modules

2019 ◽  
Vol 28 (12) ◽  
pp. 1755-1761
Author(s):  
Robert Casanova ◽  
Virginia Miller ◽  
Jongpil Cheon ◽  
Linda Gilmore ◽  
Rebecca Barron ◽  
...  
Keyword(s):  
Field Test ◽  
Sex And Gender ◽  
Test Results ◽  
Learning Modules ◽  
Case Based Learning ◽  
And Gender ◽  
Gender Specific ◽  
Case Based ◽  
Specific Health

scholarly journals Science Runs and the Debate Brakes: Somatic Gene-Editing as a New Tool for Gender-Specific Medicine in Alzheimer’s Disease

2020 ◽  
Vol 10 (7) ◽  
pp. 421 ◽  
Author(s):  
Pamela Tozzo ◽  
Silvia Zullo ◽  
Luciana Caenazzo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gender Equity ◽  
Gene Editing ◽  
Gender Diversity ◽  
Sex And Gender ◽  
Treatment And Prevention ◽  
Genetic Level ◽  
And Gender ◽  
Gender Specific

Gender-specific medicine is a discipline that studies the influence of sex and gender on physiology, pathophysiology, and diseases. One example in light of how a genetic-based disease among other diseases, that impact on sex, can be represented by the risk of developing dementia or Alzheimer’s disease. The question that comes into focus is whether gene-editing can represent a new line of investigation to be explored in the development of personalized, gender-specific medicine that guarantees gender equity in health policies. This article aims to discuss the relevance of adopting a gender-specific focus on gene-editing research, considered as a way of contributing to the advance of medicine’s understanding, treatment, and prevention of dementia, particularly Alzheimer’s disease. The development or improvement of cures could take advantage of the knowledge of the gender diversity in order to ascertain and develop differential interventions also at the genetic level between women and men, and this deserves special attention and deep ethical reflection.

In Favor of the 2019 Equality Act: A Comment on Burt

2021 ◽  
pp. 155708512199133
Author(s):  
Susan Gluck Mezey
Keyword(s):  
Gender Identity ◽  
Gender Equality ◽  
Legal Theory ◽  
Sex Discrimination ◽  
Theory And Practice ◽  
Sex And Gender ◽  
Federal Law ◽  
Biological Sex ◽  
And Gender

There are three reason why I disagree with the author’s premise that 2019 Equality Act disadvantages women by blurring the distinction between sex and gender identity. First, it ignores current legal theory and practice that sex discrimination encompasses gender identity discrimination in federal law; second, it has not made a sufficient case that the Act’s interpretation of sex would harm women; third, it incorrectly assumes gender equality in the workplace can be achieved while sex-segregated spaces remain segregated by biological sex. In sum, revising the Equality Act to exempt women’s spaces would sacrifice the principle of gender equality upon which the Act is based.

Subjectivity and Subjectivation

2015 ◽  
Author(s):  
Anna Marie Smith
Keyword(s):  
Social Relations ◽  
Judith Butler ◽  
Sex And Gender ◽  
Biological Sex ◽  
Angela Davis ◽  
Socialist Feminism ◽  
The Subject ◽  
And Gender ◽  
Foucauldian Theory ◽  
Theoretical Paradigms

A chapter addressing the formation of the subject, and the rejection of the assumption that gender and sex are simply given, in various feminist theory paradigms. The project of advancing gender justice requires close attention to the ways in which categories of biological sex and gender, in intersectional relations with race, ethnicity, nationality, class and so on, are historically constructed and deployed to bring subjects into being, even as these same categories are resisted and re-negotiated at the same time in an always agonistic field of social relations. Special reference is made to three pairs of theoretical paradigms and practitioners: liberal feminism and Nancy J. Hirschmann; antiracist socialist feminism and Angela Davis; Derridean-Foucauldian theory and Judith Butler.

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