scholarly journals Relationship between montelukast and behavioral problems in preschool children with asthma

2022 ◽  
Vol 50 (1) ◽  
pp. 85-91
Author(s):  
Eda Özata ◽  
Zülfikar Akelma ◽  
Sacit Günbey
Keyword(s):  
Preschool Children ◽  
Behavioral Problems ◽  
Inhaled Corticosteroids ◽  
Controlled Study ◽  
Control Group ◽  
Healthy Children ◽  
Significant Difference ◽  
Children With Asthma ◽  
Healthy Control ◽  
Asthma Group

Background: There is insufficient clarity regarding whether or not drugs used in asthma cause behavioral problems in children.Methods: A total of 155 individuals, categorized into an asthma group (n = 95) and a control group (n = 60), were enrolled in the current prospective controlled study. The asthma group consisted of patients receiving treatment (inhaled corticosteroids [ICS] or montelukast) for at least 1 month. Check Behavior Checklist (CBCL) for ages 1.5–5 scores for the asthma and controls were compared. The asthma group was divided into two subgroups based on prophylactic therapy received, ICS and montelukast, and these groups’ CBCL scores were also compared. Results: The asthma group consisted of 95 children (ICS subgroup 45, montelukast subgroup 50) and the healthy control group of 60 cases. The mean total CBCL score was higher in the asthma group than in the control group (42 vs 32, respectively, P = 0.001). Internalization and externalization scores were also higher in the asthma group compared to the control group (P = 0.004 and P = 0.005, respectively). No significant difference was determined in terms of CBCL scores between the ICS and montelukast groups (P = 0.3). Montelukast was discontinued in one asthmatic child due to hallucination.Conclusion: This study determined a higher rate of behavioral problems in preschool children with asthma compared to healthy children. In contrast to other studies in the literature, we determined no difference in terms of total CBCL, and internalization and externalization scores of children with asthma who received ICS and montelukast. Nevertheless, it should be kept in mind that montelukast may cause serious neuropsychiatric events such as hallucination.

scholarly journals Quality of Life in Children with Asthma versus Healthy Children

2018 ◽  
Vol 6 (8) ◽  
pp. 1413-1418 ◽  
Author(s):  
Samaneh Kouzegaran ◽  
Parisa Samimi ◽  
Hamid Ahanchian ◽  
Maryam Khoshkhui ◽  
Fatemeh Behmanesh
Keyword(s):  
Quality Of Life ◽  
Physical Performance ◽  
Control Group ◽  
P Value ◽  
Healthy Children ◽  
Significant Difference ◽  
Children With Asthma ◽  
And Performance ◽  
Asthma Group

BACKGROUND: Asthma is the most prevalent chronic disease in the pediatric age group. The disease affects different aspects of the children's lives, such as physical, emotional, social and educational aspects. Thus, more focus has been on the quality of life in these patients rather than the duration of their illness in recent years.AIM: This study examined the different aspects of quality of life in asthmatic children for the first time in this geographic area.METHODS: The study was cross-sectional conducted in 2015-2016. The asthmatic group was 100 patients aged 8 to 12 admitted to the Asthma and Allergy Clinic of Ghaem Hospital (as) in Mashhad with the control group composed of 100 healthy children of the same age and gender. The standard questionnaire pedsQLTM was used for comparing the quality of life of children in the two groups. Statistical analysis was SPSS23 with P-value less than 0.05, which was statistically significant.RESULTS: In each group, 58 patients were boys, and 42 were girls. In a comparison of the quality of life of children, the asthma group with a mean total score of Peds QL 20.99 ± 12.54 compared to the healthy children with a mean total score of Peds QL of 8.8 ± 5.41 had a lower quality of life (P < 0.001). Moreover, regarding various aspects of quality of life asthma group had a lower quality of life in physical performance, emotional performance and performance in school (P < 0.001). Nonetheless, there was no significant difference between the two groups considering social function (P = 0.267). Examining the relationship between Peds QL score of patients with asthma with various variables was indicative of the fact that Peds QL scores were significantly correlated with the gender of the patients, showing better quality of life in the girls (P = 0.001).CONCLUSION: The results indicated that children with asthma have a significantly lower quality of life compared with healthy children of the same age. Also, in examining the different aspects of quality of life, these children had a lower quality of life in physical performance, emotional performance, and performance at school, and were at the level as that of healthy children only in social performance.

scholarly journals Evaluation of oral functions of the stomatognathic system according to the levels of asthma severity

2012 ◽  
Vol 24 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Mariana San Jorge de Castro ◽  
Adyléia Aparecida Dalbo Contrera Toro ◽  
Eulália Sakano ◽  
José Dirceu Ribeiro
Keyword(s):  
Persistent Asthma ◽  
Asthma Severity ◽  
Control Group ◽  
Healthy Children ◽  
Structural Part ◽  
Assessment Protocol ◽  
Group I ◽  
Study Results ◽  
Children With Asthma ◽  
Asthma Group

PURPOSE: To compare the orofacial functions (chewing, swallowing and speech) in children with asthma and healthy children. METHODS: A cross sectional study including 54 children of both genders with ages between 7 and 10 years was conducted. Twenty-seven of these subjects composed the experimental group, and were subdivided into two severity levels of asthma: Group I - mild intermittent and persistent asthma; Group II - persistent moderate to severe asthma. Twenty-seven healthy children were included in the control group (Group III). Speech-language pathology evaluation used the adapted Orofacial Myofunctional Assessment Protocol. Adaptation consisted in the exclusion of the structural part of the test, since this was not the aim of the study. The structural part was excluded because it was not the aim of this study. RESULTS: It was found alterations in oral functions, with significant differences between the three groups. These alterations showed no correlation with asthma severity, since the highest rate of alterations was found in Group I (mild asthma). CONCLUSION: Regardless of the severity level, children with asthma have altered patterns of chewing, swallowing and speech.

scholarly journals Factors Associated with Poor Asthma Control in Children Aged Five to 13 years

2006 ◽  
Vol 13 (1) ◽  
pp. 23-29 ◽  
Author(s):  
SL Mcghan ◽  
C MacDonald ◽  
DE James ◽  
P Naidu ◽  
E Wong ◽  
...  
Keyword(s):  
Asthma Control ◽  
Tobacco Smoke ◽  
Inhaled Corticosteroids ◽  
Psychosocial Impact ◽  
Control Group ◽  
Action Plans ◽  
Poor Control ◽  
The Poor ◽  
Significant Difference ◽  
Children With Asthma

BACKGROUND: Most children with asthma should be able to achieve acceptable control. However, are there differences between those with acceptable and poor control, and if so, how can health care approaches be modified accordingly?OBJECTIVE: To examine the characteristics of elementary school children aged five to 13 years with acceptable and poor levels of asthma control.METHODS: The present cross-sectional study of children with asthma used five indicators of control, as outlined by the Canadian Asthma Consensus Report, to categorize acceptable and poor asthma control.RESULTS: Of 153 children, 115 (75%) were rated as having poorly controlled asthma. Of those with poor control, 65 (64%) children were currently using inhaled corticosteroids, and 65% of those reported using inhaled corticosteroids daily versus as needed. Fifty-one per cent of the children with poorly controlled asthma had exposure to tobacco smoke, whereas 79% of the children with asthma under acceptable control were from households with no smokers (P=0.002). The poor control group also had significantly worse parental perceptions of the psychosocial impact of asthma on their child. No significant difference was found in the percentage of those who had written action plans in the poor control group (28%) compared with the acceptable control group (26%), and similar percentages in each group stated that they used the plans.CONCLUSIONS: Despite the high use of inhaled corticosteroids, the majority of children had poorly controlled asthma. The poor control group had more exposure to tobacco smoke and a worse psychosocial impact due to asthma. Few children had past asthma education and action plans, suggesting that there is a need to improve access to and tools for education.

Repetitive behavior among autistic children 3–10 years old and a control group in Albania

2017 ◽  
Vol 41 (S1) ◽  
pp. S451-S452
Author(s):  
Anita Pilika ◽  
Pasho Maksuti ◽  
Deana Rama ◽  
Endri Murati ◽  
Greta Guga ◽  
...  
Keyword(s):  
Behavioral Problems ◽  
Repetitive Behavior ◽  
Children With Autism ◽  
Control Group ◽  
Healthy Children ◽  
Autistic Children ◽  
Significant Difference ◽  
The Mean ◽  
Behavior Scale ◽  
Competing Interest

IntroductionAutism is a lifelong disability that impairs 3 main areas; communication skills, social interaction and behavioral patterns.ObjectivesTo investigate the repetitive behavior in autistic children 3–10 years old.AimsComparison of repetitive behavior between autistic children with a control group of clinically healthy children matched for age and sex.MethodsRepetitive Behavior Scale (RBS-R) questionnaire was translated, validated and provided to examine children (n = 70) in each group.ResultsChildren with autism show significant behavioral problems as compared to healthy children in all subscales and the full RBS-R. Results of the t-test for independent samples indicated a significant difference in mean score for the children with autism of age 3–6 year old (M = 53.1) and for control group (M = 11.9), t = −13.3, P < 0.01. Also, the mean score of children with autism of age 7–10 year old (M = 54.9) is significantly higher, compared to control group (M = 13.7), t = −12.2, P < 0.01.ConclusionThis comparison provides information on particular forms of repetitive behavior to further our understanding on these important symptoms.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals The effects of maternal anxiety and attitudes on the adherence to inhaled corticosteroids in children with asthma

2021 ◽  
Vol 49 (3) ◽  
pp. 138-145
Author(s):  
Ozlem Sancakli ◽  
Asli Akin Aslan
Keyword(s):  
Treatment Adherence ◽  
Patient Group ◽  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
Maternal Anxiety ◽  
Control Group ◽  
Healthy Children ◽  
Asthma Control Test ◽  
Parent Attitude ◽  
Children With Asthma

Objective: Long-term inhaled corticosteroid (ICS) use in children with asthma causes serious concerns in parents, leading to treatment non-adherence. This study aimed to investigate the effect of maternal anxiety and attitudes on adherence to ICS therapy in children with asthma. Method: The patient group included the children with mild to moderate persistent asthma, aged 6–11 years. Healthy children in a similar age range were included as a control group. The patient group was divided into two categories (treatment adherent and non-adherent) accord-ing to the regularity of ICS use. All patients were assessed with Childhood-Asthma Control Test (C-ACT), and their mothers were assessed using Parent Attitude Research Instrument (PARI) and Beck’s Anxiety Inventory (BAI).Results: A total of 156 children (age: 7.4 ± 1.4 years, F/M: 71/85) with persistent asthma and 60 healthy children (age: 7.5 ± 1.3 years, F/M:25/35) were included in the study. The rate of adher-ence in children with asthma was 52.6%. Mothers of non-adherent patients had significantly higher BAI scores than those of the adherent patients and controls (p < 0.001 and p < 0.001, respectively). The number of mothers who indicated that they did not have enough informa-tion about asthma and treatment was also higher in the non-adherent group. PARI subtest scores were not different between the adherent and non-adherent groups.Conclusions: In our study, it was found that mothers’ anxiety levels and their knowledge about asthma and medications were associated with treatment adherence in children with asthma. Psychological and educational support to the families of children with asthma would improve their treatment adherence and efficacy.

scholarly journals Oral health related habits, knowledge and attittude in children with asthma

2017 ◽  
Vol 64 (3) ◽  
pp. 121-130
Author(s):  
Bojana Davidović ◽  
Mirjana Ivanović ◽  
Dejan Bokonjić ◽  
Svjetlana Janković ◽  
Igor Radović ◽  
...  
Keyword(s):  
Oral Health ◽  
Oral Hygiene ◽  
Control Group ◽  
Healthy Children ◽  
Pediatric Dentist ◽  
Dental Procedures ◽  
Significant Difference ◽  
Children With Asthma ◽  
Health Related ◽  
And Behavior

Summary Introduction The aim of this research was to determine oral hygiene related habits, knowledge and behavior in children with asthma compared to healthy children. Methodology This study included 136 children, between 6 to 16 years of age, divided into the two groups. The first group included children with asthma (study group - SG), while the second included healthy children (control group - CG). A questionnaire containing three groups of questions related to oral-hygiene and dietery habits as well as oral health related behaviour in children was prepared. Results The percentage of children from SG that brush teeth several times a day was 60.2% compared to 77.2% of CG children (p<0.05). 19.1% of SG group children versus 38.2% of CG children brush their teeth longer than 2 minutes (p<0.05). There was no significant difference in the level of knowledge about plaque impact on oral health between the two groups (p>0.05). More than half (52.9%) of CG respondents regularly visit dentist, while 50.0% of SG goes regularly (p<0.01). 51.5% of CG children visit the pediatric dentist due to preventive reasons, while SG children goes mainly due to rehabilitation of teeth (42.6%). The fear of dental procedures is more pronounced in SG compared to CG children (p<0.001). Conclusion Oral hygiene related habits and oral health behavior were worse in children with asthma, while no difference was found in relation to the knowledge among the observed groups.

scholarly journals Evaluation of the Clinical and Laboratory Findings of Asthmatic Children with SARS-CoV-2 Infection

2021 ◽  
pp. 1-8
Author(s):  
Azize Pınar Metbulut ◽  
Özlem Mustafaoğlu ◽  
Gülşah Şen ◽  
Saliha Kanık Yüksek ◽  
İlknur Külhaş Çelik ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Clinical Findings ◽  
Control Group ◽  
Healthy Children ◽  
Retrospective Case ◽  
Laboratory Findings ◽  
Asthmatic Children ◽  
Significant Difference ◽  
Duration Of Hospitalization ◽  
Asthma Group

<b><i>Introduction:</i></b> There are a limited number of studies about the clinical findings of coronavirus infection in pediatric patients with asthma. We aimed to evaluate the clinical and laboratory characteristics of pediatric patients with asthma and healthy children without chronic disease who infected with SARS-CoV-2. <b><i>Methods:</i></b> This is a retrospective, case-control study comparing the asthma diagnosed and healthy children who were diagnosed as COVID-19 in our hospital between March 11 and November 10, 2020. <b><i>Results:</i></b> During the study period, 6,205 children were diagnosed with CO­VID-19 in our hospital. Only 54 (0.87%) patients had a diagnosis of asthma. The mean of the age was 10.5 years and 53.7% (<i>n</i>:29) of the patients with asthma were male. Cough, shortness of breath, emesis, and diarrhea were found to be significantly higher in asthma group than in the control group (respectively <i>p</i> = 0.002, 0.000, 0.002, 0.019, 0.015). Patients who were given SABA was significantly higher in asthma diagnosed patients (<i>p</i> = 0.000). Hospitalization was significantly higher in asthma group (<i>p</i> = 0.025), and the duration of hospitalization was significantly higher in control group (<i>p</i> = 0.034). There was no significant difference between the 2 groups in terms of requiring oxygen treatment and in laboratory findings between groups. <b><i>Conclusion:</i></b> This study revealed that pediatric patients diagnosed with asthma were in a mild clinic. According to these findings, asthma may not affect the course of the COVID-19 in children.

scholarly journals Comparison of nitric oxide and adrenomedullin levels of children with attention deficit hyperactivity disorder and anxiety disorder

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Yüksel Sümeyra Karagöz ◽  
Özlem Doğan ◽  
Serenay Elgün ◽  
Birim Günay Kılıç
Keyword(s):  
Nitric Oxide ◽  
Trait Anxiety ◽  
Rating Scale ◽  
Anxiety Symptoms ◽  
Control Group ◽  
Healthy Children ◽  
Children With Adhd ◽  
Significant Difference ◽  
Healthy Control ◽  
And Control

Abstract Objectives Many studies show that adrenomedullin (ADM) is associated with nitric oxide (NO) and various mechanisms and is involved in the etiopathogenesis of schizophrenia, bipolar disorder and autism by oxidative stress and HPA axis dsyregulation. The aim of this study comparison of nitric oxide and adrenomedullin levels in children with ADHD, AD and healthy control included in our study, especially due to their effect mechanisms as they may predict anxiety symptom, was to investigate the relationship between nitric oxide and adrenomedullin levels and anxiety symptoms in children with ADHD, AD and healthy control. Methods The study included 27 ADHD, 27 AD and 23 healthy children without any previous drug use, without comorbid disease. The semi-structured interview was conducted by the researcher in all the children attending the study. Sociodemographic information form, Conner’s Parent and Teacher Rating scale and State-Trait Anxiety Inventory (STAI) were evaluated. NO level measured by spectrophotometer, ADM levels were measured by ELISA. Results There was no statistically significant difference in the serum NO and ADM levels of the children included in the sampling group according to age and sex. There was no statistically significant difference between NO and ADM levels between ADHD, AD and control groups. There was no statistically significant relationship between serum NO and ADM levels and ADHD, AD and control group children of state-trait anxiety scores. Conclusions These findings may suggest that NO and ADM levels in children with ADHD, AD do not show these diseases and that these parameters are not associated with anxiety symptoms.

scholarly journals Investigation of TAGAP gene polymorphism (rs1738074) in Turkish pediatric celiac patients

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Melek Pehlivan ◽  
Tülay K. Ayna ◽  
Maşallah Baran ◽  
Mustafa Soyöz ◽  
Aslı Ö. Koçyiğit ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Disease Risk ◽  
Polymerase Chain Reaction Method ◽  
Control Group ◽  
Healthy Children ◽  
Single Nucleotide ◽  
Significant Difference ◽  
Allele Specific ◽  
And Control

Abstract Objectives There are several hypotheses on the effects of the rs1738074 T/C single nucleotide polymorphism in the TAGAP gene; however, there has been no study on Turkish pediatric patients. We aimed to investigate the association of celiac disease (CD) and type 1 diabetes mellitus (T1DM) comorbidity with the polymorphism in the TAGAP gene of Turkish pediatric patients. Methods Totally, 127 pediatric CD patients and 100 healthy children were included. We determined the polymorphism by the allele-specific polymerase chain reaction method. We used IBM SPSS Statistics version 25.0 and Arlequin 3.5.2 for the statistical analyses. The authors have no conflict of interest. Results It was determined that 72% (n=154) of only CD patients had C allele, whereas 28% (n=60) had T allele. Of the patients with celiac and T1DM, 42.5% (n=17) and 57.5% (n=23) had T and C alleles, respectively. Of the individuals in control group, 67% (n=134) had C allele, whereas 33% (n=66) had T allele. Conclusions There was no significant difference in the genotype and allele frequencies between the patient and control groups (p>0.05). There was no significant association between the disease risk and the polymorphism in our study group.

Thyroid Functions in Children on Levetiracetam or Valproic Acid Therapy

2020 ◽  
Author(s):  
Elif Karatoprak ◽  
Samet Paksoy
Keyword(s):  
Valproic Acid ◽  
Subclinical Hypothyroidism ◽  
Control Group ◽  
Thyroid Function Tests ◽  
Healthy Children ◽  
Control Groups ◽  
Acid Therapy ◽  
Significant Difference ◽  
And Control ◽  
Tsh Levels

AbstractThe aim of this study was to investigate the thyroid functions in children receiving levetiracetam or valproate monotherapy. We retrospectively reviewed the records of children with controlled epilepsy receiving valproic acid (VPA group) or levetiracetam monotherapy (LEV group) for at least 6 months. Free thyroxine 4 levels (fT4) and thyroid stimulating hormone (TSH) levels were compared between VPA group, LEV group, and age- and gender-matched healthy children (control group). A total of 190 children were included in the study: 63 were in the VPA, 60 in the LEV, and 67 in the control group. Although there was no significant difference regarding average fT4 levels, higher TSH levels were found in the VPA group when compared with the LEV and control groups (p < 0.001 and p < 0.001, respectively). There was no significant difference in terms of fT4 and TSH values in the LEV group when compared with the control group (p = 0.56 and p = 0.61, respectively). Subclinical hypothyroidism (defined as a TSH level above 5 uIU/mL with a normal fT4 level was detected in 16% of patients in the VPA group, none in the LEV and control groups. Our study found that VPA therapy is associated with an increased risk of subclinical hypothyroidism while LEV had no effect on thyroid function tests.

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