scholarly journals Correction of cicatricial changes in subacute stage of myocardial infarction with using of dispersed allogenic biomaterial

2019 ◽  
pp. 68-74
Author(s):  
A. I. Lebedeva ◽  
S. A. Afanasyev ◽  
D. S. Kondratyeva ◽  
E. M. Gareev ◽  
S. A. Muslimov ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Keratan Sulfate ◽  
Physiological Saline ◽  
Male Rats ◽  
Control Group ◽  
Subacute Stage ◽  
Decay Products ◽  
Experimental Group ◽  
Inflammatory Effect

Aim. To identify the features of myocardial remodeling after implantation of a dispersed allogenic biomaterial (DAB) in the subacute stage of experimental infarction and determine the role of decay products in the formation of regenerate.Material and methods. Male rats in the control group (n=30) 5 days after coronary occlusion received physiological saline (intramyocardially), in the experimental group (n=30) — 3 mg of DAB. Myocardial tissues were examined after 7 14, 50 days from the beginning of the experiment using histological, immunohistochemical and statistical methods.Results. In the experimental group, the cicatrix area was reduced by 1,66 times. The products of DAB biodegradation were collagen, sulfated (dermatan- and keratan sulfate), as well as non-sulfated (hyaluronic acid) glycosaminoglycans. Used DAB served as a promoter of the early proliferative phase of inflammation and had an anti-inflammatory effect. DAB particles were a chemoattractant of stem and progenitor myocardial cells in the subacute stage of myocardial infarction. It contributed to their differentiation and integration into the tissue.Conclusion. The products of biodegradation of allogeneic biomaterial, administered intramyocardially in the subacute stage of infarction, contribute to the formation of muscular-connective tissue regenerate and effectively prevent its cicatricial devolution.

scholarly journals The Role of Pineal Gland and Exogenous Melatonin on the Irradiation Stress Response of Suprarenal Gland

2006 ◽  
Vol 6 (4) ◽  
pp. 18-21 ◽  
Author(s):  
Selma Aličelebić ◽  
Zakira Mornjaković ◽  
Irfan Šuško ◽  
Esad Ćosović ◽  
Amira Beganović-Petrović
Keyword(s):  
Pineal Gland ◽  
Protective Role ◽  
Male Rats ◽  
Control Group ◽  
Exogenous Melatonin ◽  
Suprarenal Gland ◽  
Irradiation Stress ◽  
Experimental Group ◽  
Qualitative And Quantitative Characteristics

Pineal gland has and antistressogenic role. Its main hormone, melatonin, has radio protective effect on endocrine and other dynamic tissues. In our previous study, we have shown that pinealectomy changes the behavior of suprarenal gland in totally irradiated rats. The aim of this study is to evaluate the effect of exogenous melatonin on suprarenal gland of rats with or without pineal gland. Four months after pinealectomy (experimental group) or shampinealectomy (control group), adult Wistar male rats were daily treated with 0,2 mg of melatoninintraperitoneally, during two weeks. Thereafter, all animals were totally irradiated with 8 Gy of Gamma rays produced from Cobalt 60. Animals who survived were sacrificed on the 17(th) post irradiation day. Qualitative and quantitative characteristics of the suprarenal gland were studied using histological methods. The results show that exogenous melatonin had protective role on suprarenal gland in totally irradiated rats and that those effects were more pronounced in the presence of pineal gland.

Role of Nutrition Counseling and Lifestyle Modification in Managing Prediabetes

2021 ◽  
pp. 037957212110254
Author(s):  
Harleen Kaur ◽  
Neerja Singla ◽  
Rohini Jain
Keyword(s):  
Hemoglobin A1c ◽  
Lifestyle Modification ◽  
Fasting Blood Glucose ◽  
Nutrition Intervention ◽  
Control Group ◽  
Population Prevalence ◽  
Significant Difference ◽  
And Control ◽  
Experimental Group

Objective: India is the second country after China having the highest population prevalence of diabetes. Several research studies investigating diabetes have been done, but not much work has been done on prediabetes. The purpose of this study was to investigate the effect of nutrition and lifestyle modification on prediabetic females. Methods: A total of 120 prediabetic females from Ludhiana city were divided into 2 matched groups: control group (n = 60) and experimental group (n = 60). Impact of nutrition intervention for dietary and lifestyle modification (for 3 months) was assessed on the anthropometric, dietary, biochemical parameters, and diabetes risk score of the experimental group and control group (no intervention). Results: All the selected 120 subjects completed the study (experimental group = 60; control group = 60). There was significant difference in the changes between the 2 groups throughout the study. The fasting blood glucose and glycated hemoglobin A1c levels of the experimental group subjects reduced significantly ( P ≤ .01). However, no change was observed among the control group subjects. The lipid profile of the experimental group showed a significant improvement ( P ≤ .01). Conclusion: Nutrition counselling of the prediabetics regarding dietary and lifestyle modification is recommended so as to improve their metabolic control, thus preventing them from being diabetics.

scholarly journals Induced Empathy Moderates Emotional Responses to Expressive Qualities in Music

2020 ◽  
pp. 102986492097472
Author(s):  
Katherine O’Neill ◽  
Hauke Egermann
Keyword(s):  
Ecological Validity ◽  
Emotional Responses ◽  
Control Group ◽  
Causal Mechanism ◽  
Music Listening ◽  
Psychological Mechanisms ◽  
Priming Paradigm ◽  
Valence And Arousal ◽  
Experimental Group

Recent research has explored the role of empathy in the context of music listening. Here, through an empathy priming paradigm, situational empathy was shown to act as a causal mechanism in inducing emotion, although the way empathy was primed had low levels of ecological validity. We therefore conducted an online experiment to explore the extent to which information about a composer’s expressive intentions when writing a piece of music would significantly affect the degree to which participants reportedly empathise with the composer and in turn influence emotional responses to expressive music. A total of 229 participants were randomly assigned to three groups. The experimental group read short texts describing the emotions felt by the composer during the process of composition. To control for the effect of text regardless of its content, one control group read texts describing the characteristics of the music they were to hear, and a second control group was not given any textual information. Participants listened to 30-second excerpts of four pieces of music, selected to express emotions from the four quadrants of the circumplex theory of emotion. Having heard each music excerpt, participants rated the valence and arousal they experienced and completed a measure of situational empathy. Results show that situational empathy in response to music is significantly associated with trait empathy. As opposed to those in the control conditions, participants in the experimental group responded with significantly higher levels of situational empathy. Receiving this text significantly moderated the effect of the expressiveness of stimuli on induced emotion, indicating that it induced empathy. We conclude that empathy can be induced during music listening through the provision of information about the specific emotions of a person relating to the music. These findings contribute to an understanding of the psychological mechanisms that underlie emotional responses to music.

Delivery of CD151 by Ultrasound Microbubbles in Rabbit Myocardial Infarction

Cardiology ◽  
2016 ◽  
Vol 135 (4) ◽  
pp. 221-227 ◽  
Author(s):  
Shao-Ling Yang ◽  
Ke-Qiang Tang ◽  
Jun-Jia Tao ◽  
Ai-Hong Wan ◽  
Yan-Duan Lin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Function ◽  
Rabbit Model ◽  
Physiological Saline ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Control Group ◽  
Therapeutic Effects ◽  
Ventricular Ejection Fraction ◽  
Cluster Of Differentiation

Objectives: We aimed to evaluate whether ultrasound (US) and microbubble-mediated delivery of Cluster of Differentiation 151 (CD151) could enhance the therapeutic effects of CD151 on myocardial infarction (MI). Methods: A rabbit model of MI was established by a modified Fujita method. Then, 50 MI rabbits were randomly divided into 5 groups, including G1 (CD151 plasmid and physiological saline in the presence of US); G2 (CD151 and Sonovue in the presence of US); G3 (CD151 and Sonovue in the absence of US); G4 (Sonovue in the absence of US), and a control group (physiological saline in the absence of US). After 14 days of treatment, the expression of CD151 was detected by Western blot. Besides, vessel density of peri-infarcted myocardium was measured by immunohistochemistry, and cardiac function was analyzed by echocardiography. Results: The rabbit model of MI was established successfully. CD151 injection increased the expression of CD151 and microvessel density in the myocardium of MI rabbits. Heart function was significantly improved by CD151, which exhibited increased left ventricular ejection fraction, left ventricular fractional shortening and a reduced Tei index. Besides, US Sonovue significantly increased the expression efficiency of CD151. Conclusion: US microbubble was an effective vector for CD151 delivery. CD151 might be an effective therapeutic target for MI.

Effective Role of Emotions in Teaching

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Sujit Dhanraj Kumavat
Keyword(s):  
Teaching Methods ◽  
Teaching Method ◽  
Negative Emotion ◽  
Junior College ◽  
Control Group ◽  
Neutral Group ◽  
Group I ◽  
Group Control Group ◽  
Experimental Group

The objective of the present study was to find out the role of emotion in effective teaching of junior college students. The sample for the present research selected from the grantable junior college in Ahmednagar. For the research 11th class 90 students of Commerce faculty was selected. Among them 30 student selected for the positive emotion teaching group (Experimental group I). 30 students selected for the negative emotion (Experimental group II). And 30 students were selected for the neutral group (Control group III). The age range of the students were 17 to 18 years (M=35.00 SD=7.38). In the research Simple random method was used. The first hypothesis of the research was positive emotional teaching method high in English retention than negative and neutral teaching methods. Tolls 11th class English syllabus selected for the study. Result first result was showed that positive emotional teaching had significantly high English retention than the negative and neutral emotional teaching methods.

scholarly journals Enhancing ESL Learners’ Vocabulary Learning of Metaphorically-used Words

2017 ◽  
Vol 8 (5) ◽  
pp. 835 ◽  
Author(s):  
Leonardo Veliz
Keyword(s):  
Small Groups ◽  
Control Group ◽  
Esl Students ◽  
English As Second Language ◽  
Lexical Learning ◽  
Study Participants ◽  
Esl Learners ◽  
Journal Entries ◽  
Experimental Group

The present study examined the role of awareness of metaphor in learners’ lexical learning. A total of 35 intermediate English as second language (ESL) students participated in this study. Participants were randomly divided into two small groups. One (N = 17) served as the control group and the other (N = 18) as the experimental group. Both groups were taught several metaphorically-used expressions over a period of six weeks. The groups differed in that the experimental group received systematic and explicit explanations of the source and target relationships that underlie metaphor, while the control group did not receive such instruction. Pre-tests and Post-tests were administered in order to measure lexical understanding of metaphorical items. Two journal entries were given out to students at two different intervals throughout the teaching period in order to tap into their views of how their lexical understanding of metaphor was changing, or not changing, over time. Results revealed that those students who received systematic and explicit explanations on the concrete experiential basis of metaphor showed greater understanding of metaphorical meanings, and seemed more inclined to unpacking their metaphoricity by looking at what lies behind them.

PROLONGED BAKTERIOPHAGAL INFECTION OF GUT MICROBIOTA REDUCES THE EXPRESSION OF ALPHA-SYNUCLEIN IN THE RAT PANETH CELLS

2020 ◽  
pp. 60-65
Author(s):  
Татьяна Николаевна Сергеева ◽  
Владимир Николаевич Николенко ◽  
Юлия Николаевна Кузнецова ◽  
Валерий Георгиевич Сергеев
Keyword(s):  
Gut Microbiota ◽  
Experimental Studies ◽  
Physiological Saline ◽  
Alpha Synuclein ◽  
Paneth Cells ◽  
Male Rats ◽  
Control Group ◽  
Human Pathogens ◽  
Bacteriophage Infection ◽  
Intestinal Dysbiosis

Цель - исследовать интенсивность экспрессии белка альфа-синуклеина клетками Панета у крыс в норме и условиях длительного бактериофагального инфицирования микробиоты. Материал и методы. Экспериментальные исследования проведены на 12 половозрелых крысах-самцах линии Вистар массой 280-320 г. Крысам основной группы (n=7) еженедельно на протяжении 12 нед ректально вводили 0,5 мл раствора, содержащего смесь бактериофагов против 14 патогенов человека (Microgen, Россия). Однократная доза вводимой бактериофагальной смеси содержала 0,5×10ед./мл каждого фага. Животные контрольной группы (n=5) получали по аналогичной схеме 0,5 мл стерильного изотонического раствора натрия хлорида. После интракардиальной перфузии отбирали фрагменты проксимального отдела подвздошной кишки на уровне 1-3 см выше илеоцекального соединения. Серийные криостатные срезы кишечника использовали для окрашивания гематоксилином - эозином и выявления иммунопозитивного альфа-синуклеина при помощи моноклональных мышиных антител (Sigma-Aldrich, USA) и коммерческого набора, содержащего авидин-биотин-пероксидазный комплекс (АBC Elite; Vector Laboratories, Burlingame, CA). Результаты. Длительное бактериофагальное инфицирование приводило к значимому снижению относительно контроля количества клеток, иммунопозитивных к альфа-синуклеину. В клетках Панета значимо снижались площади, занимаемые иммунореактивным продуктом к альфа-синуклеину и ацидофильными гранулами. Выводы. В апикальных частях клеток Панета, в области локализации ацидофильных гранул детектируется иммунопозитивный альфа-синуклеин. Дисбиоз кишечника, вызываемый бактериофагальным инфицированием микробиоты, приводит к гранулярному истощению клеток Панета и снижению экспрессии в них иммунореактивного альфа-синуклеина, что свидетельствует о его вовлеченности в механизмы экскреции. Objective - to investigate the intensity of the alpha - synuclein expression by Paneth cells of rat in normal conditions and prolonged bacteriophagal infection of gut microbiota. Material and methods. Experimental studies were performed on 12 adult Wistar male rats weighting 280-320 g. The rats of the main group (n=7) received rectally a 0,5 ml of solution containing a mixture of bacteriophages directed against 14 human pathogens (Microgen, Russia). The solution was introduced weekly for a period of 12 weeks. Each dose of bacteriophagal mixture contained 0,5×10 units/ml of each phage. Animals of the control group (n=5) received 0,5 ml of sterile physiological saline according to the same scheme. After transcardial perfusion, specimens of proximal portion of ileum 1-2 cm upstream the ileocecal junction were obtained. Serial cryostat sections were used for hematoxylin and eosin staining and for detection of immunopositive alpha-synuclein by monoclonal mouse antibodies (Sigma-Aldrich, USA) and commercially available kit containing avidin-biotin-peroxidase complex (АBC Elite; Vector Laboratories, Burlingame, CA). Results. Prolonged bacteriophage infection led to a significant decrease in the number of alpha-synuclein immunopositive cells compared with control. The area of Paneth cells occupied by the alpha synuclein-immunoreactive product and acidophilic granules significantly reduced. Conclusions. Immunopositive alpha-synuclein was detected in the apical parts of Paneth cells, in the area of acidophilic granules localization. The intestinal dysbiosis caused by bacteriophage infection of microbiota led to granular depletion of Paneth cells and a decrease in the expression of immunoreactive alphasynuclein in them, which indicates its involvement in excretion mechanisms.

Abstract 452: Effect of Exercise Training on Sleep Quality and Quality of Life in Post Myocardial Infarction Patients

2016 ◽  
Vol 119 (suppl_1) ◽  
Author(s):  
Jayati Vohra ◽  
Kushal Madan ◽  
Manish Sharma ◽  
J.P.S Sawhney
Keyword(s):  
Quality Of Life ◽  
Myocardial Infarction ◽  
Exercise Training ◽  
Sleep Quality ◽  
Physical Functioning ◽  
Exercise Program ◽  
Exercise Group ◽  
Control Group ◽  
Experimental Group

Objectives: To study the effect of four weeks of aerobic exercise training, on sleep quality and quality of life parameters like anxiety, depression and physical functioning in Post Myocardial Infarction (MI) patients. Methods: ST elevated MI patients (n=21, <65years age) were voluntarily divided into 2 groups, control group (n=11) and exercising group (n=10). The patients in experimental group followed an exercise program of 3 sessions per week for 4 weeks. The subjective quality of life, anxiety and depression levels were assessed by the SF 36 questionnaire and Hospital Anxiety & Depression Scale (HAD scale) and the sleep quality was assessed using Pittsburgh Sleep Quality Index (PSQI). Poor sleep quality and short sleep duration was defined as PSQI > 5 and total sleep time <6hrs. respectively. After 4 weeks of the program the questionnaires were repeated for all 21 patients. Wilcoxon rank order test and Student T test were used. P<0.05 was considered statistically significant Results: Intergroup analysis showed statically significant reduction in anxiety score (9vs0.5) and depression score (3vs0) in exercise group as compared to control group respectively. As compared to control group, exercise group also showed statistically significant improvement in the quality of life parameter score [physical functioning (750vs1000), role functioning physical (0vs400) & emotional (0vs300), energy level (215vs400), emotional well-being (400vs500), social functioning (120vs200), general health (230vs462.5) & health changes (50vs100)]. Intra group analysis also showed significant changes only in exercise group. After 4 weeks of exercise training, PSQI score improved in the experimental group from 9.5±4.11 to 1.13±0.35 (p=0.00029) indicating better sleep quality and duration. While it remained comparable to the baseline values in the control group i.e. from 9.9±4.70 to 10.33±3.87 (p value= 0.514). Conclusion: Four weeks of exercise program improves the quality & duration of sleep and quality of life in MI patients after 2 weeks of index event.

scholarly journals The protective role of CsNPs and CurNPs against DNA damage, oxidative stress, and histopathological and immunohistochemical alterations induced by hydroxyapatite nanoparticles in male rat kidney

2019 ◽  
Vol 8 (5) ◽  
pp. 741-753 ◽  
Author(s):  
Israa F. Mosa ◽  
Mokhtar I. Yousef ◽  
Maher Kamel ◽  
Osama F. Mosa ◽  
Yasser Helmy
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Biological Effects ◽  
Male Rats ◽  
Nuclear Antigen ◽  
Male Rat ◽  
Control Group ◽  
Renal Tubules ◽  
Hydroxyapatite Nanoparticles

Abstract Hydroxyapatite nanoparticles (HAP-NPs) are an inorganic component of natural bone and are mainly used in the tissue engineering field due to their bioactivity, osteoconductivity, biocompatibility, non-inflammatory, and non-toxicity properties. However, the current toxicity data for HAP-NPs regarding human health are limited, and only a few results from basic studies have been published. Therefore, the present study was designed to investigate the beneficial role of chitosan nanoparticles (CsNPs) and curcumin nanoparticles (CurNPs) in alleviating nephrotoxicity induced by HAP-NPs in male rats. The results showed that HAP-NPs caused a reduction in antioxidant enzymes and induced lipid peroxidation, nitric oxide production and DNA oxidation. Moreover, HAP-NP administration was associated with intense histologic changes in kidney architecture and immunoreactivity to proliferating cell nuclear antigen (PCNA). However, the presence of CsNPs and/or CurNPs along with HAP-NPs reduced the levels of oxidative stress through improving the activities of antioxidant enzymes. Also, the rats administered the nanoparticles showed a moderate improvement in glomerular damage which matched that of the control group and showed mild positive reactions to PCNA–ir in glomeruli and renal tubules in the cortical and medullary portions. These novel insights confirm that the presence of chitosan and curcumin in nanoforms has powerful biological effects with enhanced bioactivity and bioavailability phenomena compared to their microphase counterparts. Also, they were able to ameliorate the nephrotoxicity induced by HAP-NPs.

Stepping into the Role of Professional Writer

2011 ◽  
pp. 250-260
Author(s):  
Christine Aikens Wolfe ◽  
Cheryl North-Coleman ◽  
Shari Wallis Williams ◽  
Denise Amos ◽  
Glorianne Bradshaw ◽  
...  
Keyword(s):  
Qualitative Research ◽  
Annual Meeting ◽  
National Writing Project ◽  
Professional Writing ◽  
Control Group ◽  
Santa Fe ◽  
Writing Project ◽  
Professional Writers ◽  
Experimental Group

A group of National Writing Project teachers from around the nation attended a Professional Writing Retreat in Santa Fe in 2004 and continued their collaboration. This chapter examines the progress of the group’s commitment to communicate by electronic means about writing about teaching. Teachers from the experimental group, those who answered the call to examine their continued involvement with the group, provide qualitative research narratives about how each responds as they help one another to step into the role of professional writer. Statistics gathered from both the experimental and a control group of teachers (who attended the same retreat but did not answer the survey) allow the reader to chart the teachers’ success in: (a) presenting together about being professional writers, (b) writing together as professional writers, (c) writing individually about teacher-practice, and (d) meeting at the National Writing Project’s Annual Meeting in order to continue to support each other’s work.

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