scholarly journals BENEFITS OF VOLUMETRIC COMPRESSION OSCILLOMETRY FOR THE ASSESSMENT OF HEMODYNAMIC PARAMETERS IN PATIENTS WITH ARTERIAL HYPERTENSION

2013 ◽  
Vol 12 (2) ◽  
pp. 10-17
Author(s):  
L. V. Shpak ◽  
E. S. Galoshina
Keyword(s):  
Arterial Hypertension ◽  
Vascular Wall ◽  
Healthy People ◽  
Control Group ◽  
Hemodynamic Parameters ◽  
Simultaneous Reduction ◽  
Non Invasive ◽  
Wide Range ◽  
The Status ◽  
Stage 1

Aim. To compare the parameters of central and peripheral hemodynamics in healthy people and patients with Stage 1–3 arterial hypertension (AH).Material and methods. In total, 105 individuals were examined. The control group (CG) included 50 healthy people (25 women and 25 men; mean age 27,8±0,8 years) with optimal and normal levels of blood pressure (BP) (mean levels 118,5±1,6/71,82±1,2 mm Hg). The main group (MG) included 55 patients (41 women and 14 men; mean age 62,9±1,6 years) with systolo-diastolic AH: Stage 1 in 25 (mean BP levels 146,1±0,9/84,9±1,6 mm Hg), Stage 2 in 20 (164,4±1,8/95±2,1 mm Hg), and Stage 3 in 10 (189,6±10,6/92,6±6,3 mm Hg). The method of volumetric compression oscillometry (VCO) was used to assess a wide range of myocardial and hemodynamic parameters.Results. In AH patients, all AH phenotypes, vascular and cardiac parameters were increasing, with a simultaneous reduction in vascular wall distensibility, in parallel with the AH progression from Stage 1 to Stage 3. This indicated an increase in myocardial contractility, tone strain of arterial wall, and peripheral vascular resistance. From Stage 1 to Stage 3, the prevalence of hyper- and eukinetic cardiac hemodynamic types was decreasing, while the prevalence of mixed and hypokinetic types was increasing. The mixed hemodynamic type (a combination of hyper-, eu-, and particularly hypokinetic type characteristics) was considered as an incompletely developed disadaptive hypokinetic type.Conclusion. The VCO method is an effective, non-invasive way to simultaneously assess the status of multiple hemodynamic parameters in both healthy people and AH patients. A specific benefit of this method is the registration of lateral BP levels and identification of mixed (additional) hemodynamic type. 

RISK FACTORS FOR REDUCING VITAMIN D SUPPLY IN ADOLESCENTS WITH ARTERIAL HYPERTENSION AND OBESITY

2021 ◽  
Vol 100 (2) ◽  
pp. 187-191
Author(s):  
S.S.K. Zeid ◽  
◽  
L.V. Yakovleva ◽  
Keyword(s):  
Vitamin D ◽  
Arterial Hypertension ◽  
Comparison Group ◽  
Vitamin D Insufficiency ◽  
Test System ◽  
White Coat Hypertension ◽  
Control Group ◽  
Internal Factors ◽  
Wide Range ◽  
Normal Body Weight

The aim of the study is to determine the contribution of external and internal factors, such as the season, body mass index (BMI), age, sex, degree of AH, the formation of insufficiency and/or deficiency of 25 (OH)D in adolescents with arterial hypertension (AH). Materials and methods: the core group consisted of 87 adolescents with primary AH, which then were divided into two subgroups depending on BMI (Subgroup 1 – overweight and obese, Subgroup 2 – with normal body weight). The control group consisted of 23 adolescents with the phenomenon of «white coat hypertension» (WHT). The level of 25(OH)D in the blood serum was determined by immunoextraction with further with further quantitative determination by enzyme immunoassay using StarFax 2100 analyzer (USA). A DIA source Immuno assays S.A. test system. (Belgium) was used. All calculations were carried out according to the instruction in which the norm was 25(OH)D>/=30–100 ng/ml; insufficiency – 10–29 ng/ml; deficiency – > 10 ng/ml. Results: the level of 25(OH)D in peripheral blood fluctuated in a wide range – from 5,1 to 50,2 ng/ml, the median level of 25(OH)D was 17,8 ng/ml [12,2; 23,5]. According to the results of the study, only 4 (3,6%) children had a normal vitamin D level, 95 (86,4%) had vitamin D insufficiency and 11 (10%) had a deficiency. The median values of 25(OH)D in children of the comparison group were statistically significantly higher than in children with AH of the 1st and 2nd subgroups – 23,3 ng/ml [20,8; 26,0], 14,9 ng/ml [10,8; 19,5] and 17,1 ng/ml [11,8; 23,7], respectively, p=0,001. Conclusion: according to the results of the multivariate analysis, 25(OH)D in the observed adolescents depends on many factors, such as age (6,7%), gender differences (5,7%), etc. The seasons have the greatest influence on its level (62,3%) and BMI (21,4%), the least – AH (3,9%).

scholarly journals The increasing of arterial vascular resistance is a primary factor of development isolated systolic hypertensions

2007 ◽  
Vol 13 (1) ◽  
pp. 7-13
Author(s):  
A. A. Sokolov ◽  
M. V. Soldatenko
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Arterial Hypertension ◽  
Vascular Resistance ◽  
Vascular Tone ◽  
Arterial Wall ◽  
Pulse Wave ◽  
Vascular Wall ◽  
Non Invasive ◽  
Modern Methods

In the submitted review value of increase of vascular resistance and a vascular tone in development of an isolated arterial hypertension has been shown. Parameters of elasticity of the arteries, used for the characteristic of properties of a vascular wall are discussed. In the review modern methods non invasive study of the properties of the arterial wall was described. The special attention has been given study of the pulse wave velocity, value of parameters of resistance and arterial stiffness for an estimation of the forecast was shown.

scholarly journals The hardness of the vessel wall in patients with arterial hypertension

2015 ◽  
Vol 12 (2) ◽  
pp. 43-48
Author(s):  
O D Ostroumova ◽  
A I Kochetkov ◽  
I I Kopchenov ◽  
T F Guseva ◽  
O V Bondarec
Keyword(s):  
Arterial Hypertension ◽  
Vessel Wall ◽  
Antihypertensive Drugs ◽  
Blood Pressure Level ◽  
Vascular Wall ◽  
Cardiovascular Complications ◽  
Increased Risk ◽  
The Status ◽  
The Difference

The article deals with the role of the hardness of the vessel wall in the pathogenesis of arterial hypertension and its complications and cardiovascular mortality. We discussed the factors increasing the hardness of the vessel wall, such as age, blood pressure level, atherosclerosis, smoking and diabetes mellitus. We showed the indicators reflecting the status of the vascular wall and which could play a role of markers of increased risk of cardiovascular complications. We reviewed the data concerning the improvement of the parameters of the hardness of the vessel wall under the influence of antihypertensive therapy using the angiotensin II type 1 receptor blocker - candesartan. We discussed the possible mechanisms of the candesartan influence on the elastic properties of the vessels. We stressed that the effect on the hardness of the arteries on using antihypertensive drugs, even within the same class, was different, which, apparently, was associated with the difference in the pharmacokinetic properties.

scholarly journals 408 The relationship between right ventricle-arterial coupling and cardiac metabolism in pulmonary arterial hypertension - multimodal study

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
R Kazimierczyk ◽  
P Szumowski ◽  
P Blaszczak ◽  
E Kazimierczyk ◽  
K Ptaszynska-Kopczynska ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Control Group ◽  
Hemodynamic Parameters ◽  
Metabolic Demand ◽  
Pulmonary Arterial ◽  
The Relationship ◽  
Rv Function ◽  
Worse Prognosis

Abstract Background Right ventricular (RV) function is a major determinant of survival in patients with pulmonary arterial hypertension (PAH). The concept of coupling mainly refers to the relationship between ventricular contractility and afterload. In advanced PAH, to maintain cardiac output, RV dilates and the uncoupling occurs with wall stress and increased metabolic demand. We previously confirmed that impaired RV function is associated with increased glucose uptake of RV myocytes estimated by PET, which marks patients with worse prognosis. Purpose Whether echocardiographic approach of coupling parameters in PAH patients has relationship with RV metabolic alterations. Methods Twenty-six stable PAH patients (mean age 49.92 ± 15.94 years) and sixteen healthy subjects (control group) were enrolled into the study. The TAPSE, reflecting RV contractility, was obtained by mono-dimensional echo in standard technique. The echo estimation of the sPAP was reflecting RV afterload. Ventricular-arterial coupling was evaluated by the ratio between those two parameters. All PAH patients had also right heart catheterization (RHC) and PET performed during baseline visit. Heart glucose metabolism was assessed with fluorodeoxyglucose (FDG) as a tracer in PET. Its uptake was quantified as mean standardized uptake value (SUV) for both left ventricle (LV) and RV. Mean follow-up time of this study was 16.6 ± 7.5 months and the clinical end-point (CEP) was defined as death or clinical deterioration. Results Most of enrolled patients were in the WHO functional Class III (61%, 16). There were significant correlations between echo-derived hemodynamic parameters and RHC-derived values e.g. emPAP vs mPAP (RHC), r = 0.86, p < 0.001. Echo-estimated RV ventricular-arterial coupling parameter (TAPSE/sPAP) was 0.35 ± 0.20 in PAH group and 1.51 ± 0.22 in control group, p < 0.001. Mean SUV RV/LV ratio was 1.03 ± 0.68 in PAH group and 0.19 ± 0.08 in controls, p < 0.005. Echo-derived TAPSE/sPAP significantly correlated with hemodynamic parameters from RHC – cardiac output and pulmonary vascular resistance. Interestingly, we also observed significant correlations of TAPSE/sPAP with glucose uptake in PET - SUV RV as well as with SUV RV/LV (r=-0.63, p = 0.0006; r=-0.50, p = 0.0009), confirming higher metabolic demand in uncoupled heart in case of PAH. Furthermore, patients who reached CEP (n = 15, 57%) had a significantly lower TAPSE/esPAP ratio (0.29 ± 0.17 vs 0.43 ± 0.21, p = 0.04) and higher SUV RV/LV (1.39 ± 0.79 vs 0.55 ± 0.45, p = 0.01). ROC analysis revealed significant cut-off value of TAPSE/esPAP in predicting CEP (AUC 0.72 (95% CI 0.52-0.92), p = 0.03). Patients with TAPSE/esPAP lower than 0.25 mm/mmHg had worse prognosis, log-rank test, p = 0.001 (Figure 1). Conclusions Simple echocardiographic parameter reflecting RV coupling (TAPSE/esPAP) related to altered myocardium metabolism in PAH may predict outcome in patients with PAH. Abstract 408 Figure 1

scholarly journals The condition of parameters of memory, attention and thinking at men of young age officers under the contractwith arterial hypertension.

2009 ◽  
Vol 6 (4) ◽  
pp. 59-63
Author(s):  
Il'ya Mikhaylovich Davidovich ◽  
Oleg Vladimirovich Afonaskov ◽  
Yuliya Konstantinovna Staroverova
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Blood Pressure Monitoring ◽  
Control Group ◽  
Military Officers ◽  
Pressure Data ◽  
Pressure Profiles ◽  
Blood Pressure Data ◽  
Stage 1 ◽  
Made In

Aim: to evaluate memory, attention and thinking functions indices in young hired military officers depending on their 24-hours blood pressure profiles. Materials and methods. The study was made in 49 patients with stage 1-2 arterial hypertension, aged 39,3±0,8, who did not take hypotensive medicines or took them occasionally. 24-hours blood pressure monitoring was performed with assessment of cognitive functions (memory, attention) depending on the stage, degree and duration of the disease. The control group included 12 men with no signs of arterial hypertension. Results. Comparing with the controls the memory, attention and thinking indices in hypertonic patients were found to be lower .even in those who had the first degree of hypertension and duration of the disease less than 5 years. The hypertonic patients showed lowering of attention and semantic memory scopes irrespective of duration of the disease. There was a negative correlation between monitored blood pressure data and memory, attention and thinking indices. Conclusions. Light cognitive dysfunctions can be found in young hired military officers with initial arterial hypertension but they are more typical for stage 2 of the disease

scholarly journals Interleukin-6 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Yoshiaki Furuya ◽  
Toru Satoh ◽  
Masataka Kuwana
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Connective Tissue ◽  
Arterial Hypertension ◽  
Connective Tissue Disease ◽  
Interleukin 6 ◽  
Hemodynamic Parameters ◽  
Potential Therapeutic Target ◽  
Humanized Monoclonal Antibody ◽  
Wide Range ◽  
Pulmonary Arterial

Interleukin-6 (IL-6) is a pleiotropic cytokine with a wide range of biologic activities in immune regulation, hematopoiesis, inflammation, and oncogenesis. Recent accumulating evidence indicates a pathologic role for IL-6 in promoting proliferation of both smooth muscle and endothelial cells in the pulmonary arterioles, resulting in development of pulmonary arterial hypertension (PAH). Here, we describe a patient with mixed connective tissue disease and severe, refractory PAH. Her functional activity and hemodynamic parameters dramatically responded to tocilizumab, a humanized monoclonal antibody to human IL-6 receptor, which was aimed at treating multicentric Castleman's disease. It appears that IL-6 blockade may hold promise as an adjunct drug in treatment of PAH in idiopathic form as well as in association with connective tissue disease.

scholarly journals The research of neurohormonal biomarkers in arterial hypertension diagnosis in adolescents

2016 ◽  
Vol 63 (2) ◽  
pp. 140-147
Author(s):  
Victoria Grosu ◽  
◽  
Victoria Melnicov ◽  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Arterial Hypertension ◽  
Myocardial Hypertrophy ◽  
Myocardial Damage ◽  
Control Group ◽  
Hemodynamic Parameters ◽  
Biochemical Tests ◽  
Hypertension Diagnosis

Arterial hypertension (AHT) is currently considered one of the most common pathologies of the cardiovascular system and one of the risk factors of atherosclerosis and chronic myocardial dysfunctions. Essential hypertension is accompanied by metabolic disorders, hypercatecholaminemia, hypertriglyceridemia, hyperinsulinemia, excessive fat storage in adipocytes in obese patients as well as other factors. To assess the degree and prognosis of arterial hypertension, it is important to use early diagnosis, first of all the signs of heart remodeling, metabolic and neurohormonal disorders, and changes in the arterial wall. Objectives of the study. Indices evaluation of neurohormonal biomarkers in arterial hypertension diagnosis in adolescents. Material and methods. The hemodynamic parameters of cardiac performance and neurohormonal biomarkers have been evaluated in this study of 113 children, divided in two groups. The first group included 52 patients, having chronic heart failure secondary to arterial hypertension and the second control group included 85 children. Obtained results. The EcoCG parameters in patients with arterial hypertension detected left myocardial hypertrophy and the septum myocardial hypertrophy, and the modification of the LVEF, LVSF. The determination of specific biochemical tests assessing myocardial damage biomarkers in patients with congestive heart failure secondary to arterial hypertension confirmed a statistically significant increase in serum content epinephrine in comparison with the control group (p<0.001), of the conclusive norepinephrine the control (p<0.05) and increase in urine content catecholamine in activity significance compared to the control group (p<0.001), with further increase concentration level in the dynamic therapy (p<0.001). Conclusions. The investigation performed shows that the patients with chronic heart failure develop hypoxic and ischemic processes, that lead to modified of hemodynamic parameters and metabolic and neurohormonal biomarkers.

Character of β-lymphocytes differentiation in women with hypertensive disorders during pregnancy

2021 ◽  
Vol 66 (8) ◽  
pp. 489-495
Author(s):  
I. A. Panova ◽  
A. V. Kudryashova ◽  
A. S. Panashchatenko ◽  
E. A. Rokotyanskaya ◽  
A. I. Malyshkina ◽  
...  
Keyword(s):  
B Cells ◽  
General Population ◽  
Arterial Hypertension ◽  
B Lymphocytes ◽  
Elastic Properties ◽  
Vascular Wall ◽  
Relative Content ◽  
Control Group ◽  
Hypertensive Disorders ◽  
B1 Cells

The aim of the work was to identify the features of B-lymphocyte differentiation in women with hypertensive disorders of various origins, to establish their relationship with indicators of the elastic properties of the vascular wall, and to develop additional diagnostic criteria for the severity of preeclampsia. We examined 193 women at 24-40 weeks of gestation. Of these, 39 women with chronic arterial hypertension, 35 women with preeclampsia that developed against the background of chronic arterial hypertension, 55 with preeclampsia. The control group consisted of 64 women without hypertensive disorders. To assess the elastic properties of the vascular wall, a sphygmographic attachment of the “Poly-Spectrum-8” hardware-software complex (“Neurosoft” Ivanovo) was used. The relative content of B-lymphocytes (CD19 + and CD20 +), regulatory B-cells (CD20 + IL-10 +), switched (CD19 + CD27 + IgD-) and non-switched (CD19 + CD27 + IgD +) memory cells, plasma cells (CD19 + CD20-CD38 +) in the general population of B-lymphocytes was assessed by flow cytometry on a FACSCantoII flow cytometer using the FACS Diva program. Statistical analysis was carried out using the programs “Statistica for Windows 6.0”, “Microsoft Excel 2010” and “MedCals”. All subjects with hypertensive disorders showed an increase in the stiffness of the arteries of the muscular and elastic types, the most pronounced in the groups of patients with PE, the maximum in women with CAH and associated PE. An increased level of B1-lymphocytes in the peripheral blood is also noted in all hypertensive disorders. There were revealed positive correlations of high strength between: the level of CD20 + cells and the velocity of pulse wave propagation through the arteries of the muscular type (PWVm) in all groups with hypertensive disorders; the content of B1 cells and PWVM in moderate preeclampsia; level emory B-cells and PWV in elastic-type arteries in women with CAH and associated PE. The ROC analysis of the relative content of B1 cells in the general population of B lymphocytes and the content of IL-10-producing cells in the population of CD20 + lymphocytes (Breg) in women with moderate and severe PE revealed criteria for the differential diagnosis of preeclampsia of varying severity. The presence of hypertensive disorders of various origins is accompanied by a decrease in the elasticity of the arterial vascular wall, which is most pronounced in patients with CAH and associated PE. These changes are largely correlated with the level of B cells. As additional criteria for determining the severity of PE, the relative content of B1 cells and IL-10-producing cells in the population of Breg CD20 + lymphocytes can be used.

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