scholarly journals Pattern of Indirect Immunofluorescence Assay Antinuclear Antibody in Pediatric Lupus Nephritis

2020 ◽  
Vol 8 (1) ◽  
pp. 38-42
Author(s):  
Fadhila Novianti ◽  
Reni Ghrahani ◽  
Noormarina Indraswari
Keyword(s):  
Lupus Erythematosus ◽  
Medical Records ◽  
Renal Involvement ◽  
Cross Sectional Study ◽  
Immunofluorescence Assay ◽  
Chi Square ◽  
Cross Sectional ◽  
Pediatric Systemic Lupus Erythematosus ◽  
Pediatric Lupus ◽  
Using Data

Objective: To determine the association between Anti-Nuclear Antibody (ANA) pattern in pediatric Systemic Lupus Erythematosus (SLE) patients and proteinuria as a sign of renal involvement in SLE. Methods: This was a cross-sectional study, using data from medical records involving 89 newly diagnosed with SLE (aged ≤ 18 years) in Department of Child Health Dr. Hasan Sadikin General Hospital, Bandung, from January 1st 2018 to June 30th 2019. Data of ANA pattern and proteinuria were collected from medical record. ANA pattern was examined by Immunofluorescence Assay (IFA) method. Chi-square was used to analyze the association between ANA pattern and proteinuria as a sign of renal involvement in pediatric SLE patients. Results: There were 89 patients, consisting of 7 male (7.9%) and 82 female (92.%) with median age of 14 (IQR=12-16). There were only 44 pattern of ANA as follow: homogenous 56.8%, speckled 36.4%, and nucleolar 6.8%. However, there is no significant association between homogenous pattern with proteinuria events (p=0.831). Conclusions: Homogenous pattern was the most frequent ANA pattern in children with SLE, and the pattern has no association with proteinuria events.

scholarly journals 33. Concerning Trends of Pediatric Leprosy in Minas Gerais, Brazil and Associations with Number of Municipality Medical Facilities

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S17-S17
Author(s):  
Taylor Landay ◽  
Julie A Clennon ◽  
José A Ferreira ◽  
Lucia A Fraga ◽  
Maria Aparecida F Grossi ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Minas Gerais ◽  
Chi Square ◽  
Cross Sectional ◽  
Period 2 ◽  
Time Period ◽  
Medical Facilities ◽  
Age Of Diagnosis ◽  
Using Data ◽  
Incident Cases

Abstract Background Leprosy in children under 15 years of age, and in particular, the presence of leprosy grade 2 disability (G2D) in children, signifies ongoing transmission and the need for improved surveillance. Our objective was to describe the epidemiology of pediatric leprosy in Minas Gerais, Brazil and to explore associations with access to medical facilities. Methods A cross-sectional study was conducted using data from the Brazilian Notifiable Diseases Surveillance System (SINAN) from 2002–2017. Incident cases were included if they resided in a municipality with both adult and pediatric cases. Municipalities were divided by the number of medical facilities per municipality: < 5, 5–17, and 18 or higher. Analyses compared pediatric cases across two time periods (2002–2009 and 2010–2017) and number of medical facilities / municipality using chi-square, t-tests, and logistic regression. Results A total of 27,725 cases were reported with 1,611 under 15 years of age. Overall incidence declined from 34.8 per 100,000 to 13.6 per 100,000 during the study period with pediatric incidence declining from 2.6 per 100,000 to 0.8 per 100,000. Time period 2 (TP2) showed an increase in the proportion of pediatric G2D (2.58% vs 1.91%, p < 0.0001) when compared to time period 1 (TP1). Mean age of diagnosis in children was younger in TP2 then in TP1 (10.06 vs 10.43, p=0.02). In 2017, the pediatric incidence in municipalities with the fewest medical facilities was 0.95 per 100,000 compared to 0.23 per 100,000 in municipalities with > 5 facilities (p=0.009). There was significantly higher odds of disability at diagnosis (grades 1 and 2) in pediatric cases residing in municipalities with < 5 medical facilities (aOR 1.88; 95% CI 1.37–2.59), adjusted for age and sex. See map (Fig 1). Figure 1. Cases of Pediatric Disability By Number of Municipality Medical Facilities from 2002–2017 (White areas without reported pediatric leprosy) Conclusion The increasing proportion of G2D in children in the second half of the study period despite declining incidence suggest occult infections among children and adults alike in Minas Gerais. Furthermore, the average age of diagnosis in children should increase, not decrease, if M. leprae transmission was truly declining. Lastly, the association between fewer municipality health facilities and increased disability suggest barriers to timely diagnosis and a critical area of focus for research into access to healthcare and leprosy risk. Disclosures All Authors: No reported disclosures

scholarly journals PREDICTORS OF INSOMNIA IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S464-S464
Author(s):  
Meghan Mattos ◽  
Eric M Davis ◽  
Carol Manning
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Total Sample ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Data Set ◽  
Specialized Care ◽  
Using Data ◽  
Cognitive Problems

Abstract Insomnia is a common disorder that affects up to 40% of people age 65 and older. Untreated insomnia can decrease quality of life, increase healthcare use, and exacerbate cognitive problems. Individuals with cognitive impairment experience more sleep disorders than those without cognitive concerns, yet little is known about insomnia and mild cognitive impairment (MCI). Our objective was to examine predictors of insomnia in persons with MCI (PwMCI). Using data from the National Alzheimer’s Coordinating Center Uniform Data Set, a cross-sectional study of older PwMCI was conducted. Independent sample t-tests and contingency tables with chi-square tests of independence were used to examine differences between PwMCI with and without insomnia. Multivariate binary logistic modeling was performed. The total sample (N=1543) was comprised of 234 (15.1%) with clinician-reported insomnia and 1309 (84.9%) without insomnia. PwMCI and insomnia were more likely to be younger, take more medications, and smoke cigarettes (p.05). Three variables significantly predicted insomnia in PwMCI subjects in a multivariate model: active depression (OR 1.66, 95%CI 1.21, 2.27), active anxiety (OR 2.16, 95%CI 1.57, 2.99) and arthritis (OR 1.78, 95%CI 1.33, 2.39). Differences in predictors of insomnia in PwMCI highlight the need for geriatric and mental health specialists to provide specialized care to this population. Future studies should examine conversion of PwMCI with insomnia to dementia and the compounding effects of insomnia on cognition.

scholarly journals A Cross Sectional Study on Serological Prevalence of Ehrlichia canis and Rickettsia conorii in Different Canine Population of Sicily (South-Italy) during 2017–2019

Animals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2444
Author(s):  
Sergio Migliore ◽  
Valeria Gargano ◽  
Claudia De Maria ◽  
Delia Gambino ◽  
Antonino Gentile ◽  
...  
Keyword(s):  
Rhipicephalus Sanguineus ◽  
Wide Distribution ◽  
Cross Sectional Study ◽  
Immunofluorescence Assay ◽  
Rickettsia Conorii ◽  
Chi Square ◽  
Cross Sectional ◽  
South Italy ◽  
Significant Difference ◽  
Canine Population

Vector-borne pathogens such as Erlichia canis and Rickettsia conorii are widespread in the Mediterranean basin. Rhipicephalus sanguineus, is considered the main vector in Mediterranean climatic areas. Seroprevalence in dogs is variable in relation to environmental factors, presence of vectors, and dogs’ management. We investigated the seroprevalence in Sicilian dogs during 2017–2019, considering temporal as well as spatial variations, and different canine population. A total of 11,009 sera were analyzed: 7568 and 3441 sera were tested to detect antibodies to E. canis and to R. conorii, respectively, by immunofluorescence assay. The rainfall average in the sampling sites during the three-year period was also considered. Statistical analyses were performed using chi-square tests for association between two or more variables. We reported a prevalence of 29.6% and 53.6% for E. canis and R. conorii, respectively. Significant temporal variation was found in R. conorii, while significant difference was found considering canine population and spatial variation regarding both pathogens. Our study updates the previous results of E. canis and R. conorii seroprevalence in dogs in Sicily, and confirms the wide distribution of these pathogens. In addition, we considered, for the first time, three different variables to identify the areas and the canine populations most exposed to risk.

scholarly journals Factors associated with pericardial effusion in pediatric systemic lupus erythematosus

2018 ◽  
Vol 58 (5) ◽  
pp. 227-32
Author(s):  
Pediana Rachmawati ◽  
Indah K. Murni ◽  
Sasmito Nugroho ◽  
Noormanto Noormanto ◽  
Sumadiono Sumadiono
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Pericardial Effusion ◽  
Hemolytic Anemia ◽  
Lupus Erythematosus ◽  
Medical Records ◽  
Multivariate Logistic Regression Analysis ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Pediatric Systemic Lupus Erythematosus ◽  
Factors Associated

Background Cardiovascular involvement in systemic lupus erythematosus (SLE) has been reported to range from 4-78%. Complications can affect all structures of the heart, including the endocardium, myocardium, pericardium, and valves. Pericarditis is the most common manifestation, with an incidence of 11-54% in SLE patients. Pericardial effusion is often observed in patients with pericarditis, and can be confirmed by echocardiography. Objective To determine factors associated with pericardial effusion in children with SLE. Methods We conducted a restrospective cross-sectional study by reviewing medical records of children with SLE aged less than 18 years who underwent echocardiography at the Dr. Sardjito Hospital. Yogyakarta, from January 2011 to March 2018. Patients with congenital heart disease or incomplete medical records were excluded. A multivariate logistic regression analysis was done to determine factors that independetly associated with pericardial effusion. Results Among 165 children with SLE, 73 fulfilled the inclusion criteria. The prevalence of pericardial effusion was 54.8%. Median age was 13 (range 5-17) years and the female-to-male ratio was 8:1. Hemolytic anemia (OR=4.135; 95%CI 1.039 to 16.453; P=0.044) was significantly associated with pericardial effusion. Conclusion Hemolytic anemia is significantly associated with pericardial effusion in children with SLE.

scholarly journals Early symptoms of systemic lupus erythematosus (SLE) recalled by 339 SLE patients

Lupus ◽  
2018 ◽  
Vol 27 (9) ◽  
pp. 1431-1436 ◽  
Author(s):  
N Leuchten ◽  
B Milke ◽  
B Winkler-Rohlfing ◽  
D Daikh ◽  
T Dörner ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Renal Involvement ◽  
Cross Sectional Study ◽  
Classification Criteria ◽  
Self Report ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Delphi Approach ◽  
Number Of Patients

Objective The European League Against Rheumatism and the American College of Rheumatology jointly embarked on a new classification criteria for systemic lupus erythematosus (SLE) project. Its first phase involved generation of a broad set of items potentially useful for classification of SLE. This study was undertaken to add the patient perspective to an expert Delphi approach and an early patient cohort study. Methods A national cross-sectional study was conducted. A self-report questionnaire was published in the “Schmetterling” (Butterfly), the quarterly journal of the German SLE patient association. Individuals with SLE were asked to anonymously complete the questionnaire, which asked for demographic details, organ manifestations, autoantibodies and symptoms. Results A total of 339 completed questionnaires out of 2498 were returned, a response rate of 13.6%; 83.2% reported they were ANA positive and 81.7% reported joint, 66.1% skin and 33.0% renal involvement. For the time before and in the first year after their SLE diagnosis, the majority reported fatigue (89.4%), joint pain (86.7%), photosensitivity (79.4%) and myalgia (76.1%). Of interest, more than half of the patients reported fever as an early symptom (53.7%). Conclusion For a Caucasian European SLE patient population, the overall characteristics suggest meaningful representation. While many symptoms were reported as expected, the high percentage of patients reporting fever and the significant number of patients with unexpected gastrointestinal complaints are of particular interest. These data add to the information on early SLE symptoms informing the development process of new SLE classification criteria.

A Cross Sectional Study of Antiphospholipid-protein Antibodies in Patients with Venous Thromboembolism

2001 ◽  
Vol 86 (08) ◽  
pp. 538-542 ◽  
Author(s):  
Jean Amiral ◽  
Luc de Saint Martin ◽  
Dominique Mottier ◽  
Elisabeth Pasquier
Keyword(s):  
Risk Factor ◽  
Venous Thromboembolism ◽  
Lupus Erythematosus ◽  
Annexin V ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Qualitative Comparison ◽  
Cross Sectional ◽  
Systematic Screening ◽  
Prolonged Immobilization

Summary Objective: To look for an association between venous thromboembolism (VTE) and antiphospholipid antibodies (aPL) in patients without Systemic Lupus Erythematosus (SLE) when implementing, beside conventional assays, new tests for aPL screening directed towards purified proteic targets. Methods: We conducted a cross-sectional, hospital-based study of consecutive unselected outpatients. We compared VTE+ patients to VTE- among 398 consecutive unselected outpatients referred for clinical suspicion of VTE. To detect aPL, the following ELISAs were performed : 1) a conventional standardized ELISA 2) an improved APA assay, 3) an anti-Beta2GPI ELISA, 4) an anti-Annexin V ELISA, 5) an anti-Prothrombin ELISA. We sought an association between VTE and aPL through a quantitative (t-test) and a qualitative comparison (chi-square test, according to the cut-off values set as the 95th percentile of aPL distribution). First we conducted an analysis of all patients. Then we stratified them into 2 subgroups, with or without a wellknown risk factor for VTE (prolonged immobilization >72h, surgery or trauma within the past three months, current malignancy). Results: 61% of patients were classified as VTE-positive. Before stratification, we did not find any significant association between the VTE status and aPL. However, after stratification, in the subgroup without risk factors for VTE, the frequency of positive values as regards the anti Prothrombin antibodies detection was significantly higher in VTE+ patients (p = 0,04). Conclusion: The presence of anti Prothrombin antibodies might be an independent risk factor of VTE. However systematic screening for aPL in non SLE patients referred for VTE suspicion at the time of the thromboembolic event has little clinical relevance.

Prevalence and treatment conditions for hypertension and dyslipidaemia complicated with systemic lupus erythematosus: A multi-centre cross-sectional study

Lupus ◽  
2021 ◽  
pp. 096120332110067
Author(s):  
Mayu Saito ◽  
Nobuyuki Yajima ◽  
Ryo Yanai ◽  
Yumi Tsubokura ◽  
Kunihiro Ichinose ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Blood Pressure ◽  
Lupus Erythematosus ◽  
Renal Involvement ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Treatment Conditions

Objective This study aimed to assess the prevalence and actual treatment conditions for hypertension and dyslipidaemia complicated with systemic lupus erythematosus (SLE). Methods This was a cross-sectional study. We established the lupus registry of nationwide institutions (LUNA), a multi-centre cohort of SLE patients in Japan. From February 2016 to July 2018, 597 SLE patients were registered in the LUNA. We evaluated the incidence of hypertension and dyslipidaemia and analysed the risk factors for hypertension and dyslipidaemia by logistic regression analysis. Results Overall, 597 patients were enrolled in the study. The median age was 44 years, and 88.0% of the patients were female. Among all the patients, 92.9% used prednisolone. The prevalence of hypertension and dyslipidaemia was 43.9% and 54.7%, respectively. Among the patients receiving medication for hypertension, 24.7% exhibited insufficient control (systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg), and among those receiving medication for hyperlipidaemia, 48.1% showed insufficient control (low-density lipoprotein cholesterol >140 mg/dL or triglyceride >150 mg/dL). The risk factors for hypertension were age, body mass index (BMI), disease duration, past maximum dose of prednisolone, and renal involvement, whereas those for dyslipidaemia were age and BMI. Conclusion About half of the patients had hypertension or dyslipidaemia, and a considerable number of cases were poorly controlled despite medication. Our data suggest that physicians should treat SLE activity as well as its complications, especially the common risk factors for atherosclerosis.

scholarly journals Resilience and Treatment Adhesion in Patients with Systemic Lupus Erythematosus

2014 ◽  
Vol 8 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Daniella Antunes Pousa Faria ◽  
Luciana Silva Revoredo ◽  
Maria José Vilar ◽  
Maia Eulália Maria Chaves
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Demographic Data ◽  
Working Hours ◽  
Cross Sectional Study ◽  
P Value ◽  
Systemic Lupus ◽  
Chi Square ◽  
Access To Treatment ◽  
Cross Sectional

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune, rheumatic inflammatory disease that can cause significant morbidity with evident psychological impacts and obvious harm to quality-of-life that require the patient to adapt treatment. Objective: Assessment of resilience and the self-reported treatment adhesion behaviors of patients with SLE, investigating which of these factors are associated to resilience. Method: Cross-sectional study of 40 women with SLE. A questionnaire with social demographic data, health history and the Wagnild Young Resilience Scale were used. Results: 62.5% followed the medical treatment properly but 55% found it difficult. 27.5% of the patients presented low resilience, 57.5% medium and 15% high resilience. Resilience was associated in the chi-square test (p-value < 0.05) with the variables work, understanding SLE, trying to find out about SLE, following the treatment correctly, difficulty in following the treatment and stopping some activity because of the disease. In the correlation analysis, resilience was associated with age (-0.3960), number of working hours (0.5533), specialized treatment duration (-0.8103) and disease duration from diagnosis (-0.8014). Conclusion: Patients with high resilience tended to follow treatment correctly, tried to understand the disease and adhered more to the treatment to avoid risks and promote protection factors. Therefore knowledge of resilience in patients with SLE is necessary. It is important that the state takes necessary actions to facilitate access to treatment, to educational programs and to medical support. Awareness and counselling sessions must be initiated to develop and promote individual capacities to learn how to tackle with the disease for which psychological support of family and doctors can play a significant role.

scholarly journals Perfil de idosos admitidos em serviço de fisioterapia frente à sazonalidade

2017 ◽  
Vol 27 (2) ◽  
pp. 24994
Author(s):  
Paulo Giusti Rossi ◽  
Ana Claudia Silva Farche ◽  
Juliana Hotta Ansai ◽  
Anielle Crtisthine de Medeiros Takahashi ◽  
Marcello Ávila Mascarenhas
Keyword(s):  
Physical Therapy ◽  
Elderly Patients ◽  
Medical Records ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Subtropical Zone ◽  
Significant Difference ◽  
Therapy Center

*** Profile of elderly admitted to a physical therapy center as a function of seasonality ***AIMS: To analyze the profile and the prevalence of diseases in elderly patients admitted to a physical therapy center in a medium-sized Brazilian city located in a subtropical zone in two different seasons of the year.METHODS: A cross-sectional study assessed the medical records of patients treated during summer and winter months in 2011. Medical records of male and female elderly patients (aged over 60 years) were included, and those without information on present medical diagnosis were excluded. Age and sex and both current and previous diagnostic records were analyzed. The chi-square test was used for the comparative analysis of the profile of the elderly patients for both seasons.RESULTS: Seventy-one medical records were analyzed. The mean age was 69.2±8.1 years and 48 (70.4%) patients were female. There was a higher prevalence of trauma-orthopedic diseases (60.6%). The greatest number of admissions was in winter (62.0%). At the time of referral, there were 17 cases (63.0%) of trauma-orthopaedic diseases in summer and 26 (59.1%) in winter; 3 cases (11.1%) of rheumatologic diseases in summer and 10 (22.7%) in winter; 5 cases (18.5%) of neurologic disorders in summer and 4 (9.1%) in winter; and 2 cases (7.4%) of postoperative complications in summer and 4 (9.1%) in winter (p=0.64).CONCLUSIONS: There was a greater demand for referrals of elderly patients to the physical therapy center in winter than in summer, with a predominance of female patients in both seasons. The most prevalent causes of referral were related to trauma-orthopaedic diseases, but there was no significant difference in the frequency of diagnoses according to season. Knowledge about the profile of the elderly admitted to physical therapy centers is important for targeting actions at this age group, conducting information, prevention, and health promotion campaigns.

scholarly journals Prevalence and risk of potentially adverse drug interactions in the treatment of acute alcohol poisoning

2016 ◽  
Vol 52 (1) ◽  
pp. 133-142 ◽  
Author(s):  
Joyce Dalline Silva Andrade ◽  
Chiara Erminia Rocha ◽  
Maria Amélia Vieira Maciel ◽  
Danielle Cristine Almeida Silva de Santana ◽  
Fernando José Malagueño de Santana
Keyword(s):  
Drug Interactions ◽  
Medical Care ◽  
Medical Records ◽  
Alcohol Misuse ◽  
Complete Recovery ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Alcohol Poisoning ◽  
Clinical Complications

ABSTRACT The aim of this paper is to determine the profile of acute alcohol poisoning and to estimate the risk of potentially adverse drug interactions (ADIs) in patients intoxicated by alcohol when attended in emergency care at hospital. A descriptive serial cross-sectional study was performed with 4,271 individuals intoxicated by alcohol, from January 2009 to July 2011. Possible correlations were measured by Pearson's chi-square test. The data show high consumption in the population, especially in males between 25 and 59 years. The main circumstances for poisoning were alcohol misuse (96.3%). After treatment complete recovery from the signs or symptoms of the poisoning was observed in 96.88% cases; and death in 0.70%. The demonstration of potential risk for ADIs in medical care included 300 medical records which contained a history of acute alcohol poisoning. Possible drug-drug interactions (44.2%) and drug-alcohol interactions (55.8%) were demonstrated in 60.60% of analyzed medical records. Among these cases, 3%, 92.4% and 4.6% were classified as mild, moderate and severe, respectively. The measurement of ADIs aims to prevent clinical complications in medical care for alcohol misuse disorders.

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