scholarly journals Brazilian legislation on genetic heritage harms Biodiversity Convention goals and threatens basic biology research and education

2018 ◽  
Vol 90 (2) ◽  
pp. 1279-1284 ◽  
Author(s):  
RUY JOSÉ V. ALVES ◽  
MARCELO WEKSLER ◽  
JOÃO A. OLIVEIRA ◽  
PAULO A. BUCKUP ◽  
JOSÉ P. POMBAL JR. ◽  
...  
Keyword(s):  
Brazilian Legislation ◽  
Basic Biology ◽  
Research And Education ◽  
Biodiversity Convention ◽  
Biology Research

scholarly journals Perspectives on an alternative career path in regulatory science

2013 ◽  
Vol 24 (14) ◽  
pp. 2157-2159 ◽  
Author(s):  
F. Owen Fields
Keyword(s):  
Career Path ◽  
Basic Research ◽  
Regulatory Science ◽  
Basic Biology ◽  
Biology Research

Perspectives are provided on an alternative career path in regulatory science for those currently involved in basic biology research. This path is compared and contrasted with basic research, and factors to be examined if one is considering such a path are discussed.

Bridging Darwin's Origin of Species & Wegener's Origin of Continents and Oceans:

2016 ◽  
Vol 78 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Cristina Sousa
Keyword(s):  
Evolutionary History ◽  
Charles Darwin ◽  
Common Ancestor ◽  
Teaching Strategy ◽  
Origin Of Species ◽  
History Of ◽  
The Common ◽  
Research And Education ◽  
Evolution By Natural Selection ◽  
Biology Research

The common ancestor and evolution by natural selection, concepts introduced by Charles Darwin, constitute the central core of biology research and education. However, students generally struggle to understand these concepts and commonly form misconceptions about them. To help teachers select the most revelant portions of Darwin's work, I suggest some sentences from On the Origin of Species and briefly discuss their implications. I also suggest a teaching strategy that uses history of science and curriculum crosscutting concepts (cause and effect) that constitute the framework to explain the evolutionary history of ratites (flightless birds) as described by Darwin, starting in the Jurassic, with the breakup of Gondwanaland, as first described by Alfred Wegener in The Origin of Continents and Oceans.

scholarly journals A Novel Single Cell Culture Chip Based on One-Step Method

2018 ◽  
Vol 36 (1) ◽  
pp. 132-138
Author(s):  
Fang Ye ◽  
Meiying He ◽  
Jin Xie ◽  
Li Xie ◽  
Honglong Chang ◽  
...  
Keyword(s):  
Cell Culture ◽  
Single Cell ◽  
Research Focus ◽  
Step Method ◽  
One Step ◽  
Basic Biology ◽  
Single Cell Culture ◽  
Micromolding In Capillaries ◽  
Biology Research

More and more basic biology research focus on the single cell level. However, the way to fabricate a chemically patterned surface exist some questions such as complex fabrication process, graphic quality puzzle and so on. In this paper, we present a One-Step method based on Poly 2-hydroxyethyl methacrylate (PolyHEMA) and micromolding in capillaries (MIMIC) technology to fabricate single cell culture chip. Experimental evidence indicates that the integrity and stability of the PolyHEMA pattern can perfectly satisfy the need of long-term cell culture.

scholarly journals Why we need more basic biology research, not less

2012 ◽  
Vol 23 (21) ◽  
pp. 4160-4161 ◽  
Author(s):  
David Botstein
Keyword(s):  
Translational Research ◽  
Human Health ◽  
Medical Diagnosis ◽  
Basic Science ◽  
Direct Consequence ◽  
Biomedical Science ◽  
Half Century ◽  
Living Things ◽  
Basic Biology ◽  
Biology Research

Much of the spectacular progress in biomedical science over the last half-century is the direct consequence of the work of thousands of basic scientists whose primary goal was understanding of the fundamental working of living things. Despite this, many politicians, funders, and even scientists have come to believe that the pace of successful applications to medical diagnosis and therapy is limited by our willingness to focus directly on human health, rather than a continuing deficit of understanding. By this theory, curiosity-driven research, aimed at understanding, is no longer important or even useful. What is advocated instead is “translational” research aimed directly at treating disease. I believe this idea to be deeply mistaken. Recent history suggests instead that what we have learned in the last 50 years is only the beginning. The way forward is to invest more in basic science, not less.

scholarly journals Studying Liver Regeneration by Means of Molecular Biology: How Far We Are in Interpreting the Findings?

2009 ◽  
Vol 52 (3) ◽  
pp. 91-99 ◽  
Author(s):  
David Rychtrmoc ◽  
Antonín Libra ◽  
Martin Bunček ◽  
Tomáš Garnol ◽  
Zuzana Červinková
Keyword(s):  
Molecular Biology ◽  
Liver Regeneration ◽  
Large Scale ◽  
Current Knowledge ◽  
Cell Cycle Control ◽  
Concise Review ◽  
Gene Expression Analyses ◽  
History Of ◽  
Basic Biology ◽  
Biology Research

Liver regeneration in mammals is a unique phenomenon attracting scientific interest for decades. It is a valuable model for basic biology research of cell cycle control as well as for clinically oriented studies of wide and heterogeneous group of liver diseases. This article provides a concise review of current knowledge about the liver regeneration, focusing mainly on rat partial hepatectomy model. The three main recognized phases of the regenerative response are described. The article also summarizes history of molecular biology approaches to the topic and finally comments on obstacles in interpreting the data obtained from large scale microarray-based gene expression analyses.

scholarly journals DeepATAC: A deep-learning method to predict regulatory factor binding activity from ATAC-seq signals

2017 ◽  
Author(s):  
Naozumi Hiranuma ◽  
Scott Lundberg ◽  
Su-In Lee
Keyword(s):  
Deep Learning ◽  
Dna Sequence ◽  
Chromatin Accessibility ◽  
Binding Activity ◽  
Sequence Motifs ◽  
Regulatory Factor ◽  
Genome Wide ◽  
Basic Biology ◽  
Dna Sequence Motifs ◽  
Biology Research

AbstractDetermining the binding locations of regulatory factors, such as transcription factors and histone modifications, is essential to both basic biology research and many clinical applications. Obtaining such genome-wide location maps directly is often invasive and resource-intensive, so it is common to impute binding locations from DNA sequence or measures of chromatin accessibility. We introduce DeepATAC, a deep-learning approach for imputing binding locations that uses both DNA sequence and chromatin accessibility as measured by ATAC-seq. DeepATAC significantly outperforms current approaches such as FIMO motif predictions overlapped with ATAC-seq peaks, and models based only on DNA sequence, such as DeepSEA. Visualizing the input importances for the DeepATAC model reveals DNA sequence motifs and ATAC-seq signal patterns that are important for predicting binding events. The Keras implementation and analysis pipelines of DeepATAC are available at https://github.com/hiranumn/deepatac.

scholarly journals Growth and mortality of Cachana (Cynopotamus atratoensis) in the cienaga Grande de Lorica, Colombia

2015 ◽  
pp. 5028-5036
Author(s):  
Charles Olaya-Nieto ◽  
Fredys Segura-Guevara ◽  
Antonio Vergara-Paternina
Keyword(s):  
Growth Rate ◽  
Total Mortality ◽  
Fishing Mortality ◽  
Total Length ◽  
Exploitation Rate ◽  
Basic Biology ◽  
Management And Conservation ◽  
Biology Research ◽  
Average Catch ◽  
Length Frequency Analysis

ABSTRACT Objective. Growth and mortality parameters of Cachana Cynopotamus atratoensis Eigenmann, 1907 in the cienaga Grande de Lorica, Sinu river basin, Colombia, were estimated. Materials and methods. The length frequency analysis to the information collected between January 2001 to December 2002, was applied. Results. The estimated values for asymptotic length, growth rate and age at zero length were 43.4 (±0.52) cm of total length, 0.29 (±0.02) year-1 and -0.53 years, respectively. Total mortality was estimated at 0.97 year-1, natural mortality at 0.72 year-1, fishing mortality at 0.25, the average catch size was 24.8 cm total length, being fully recruited to the fishery with 16.6 cm total length, with low exploitation rate (E: 0.26). Conclusions. Cachana is a fish with medium longevity and growth rate with low exploitation rate, suggesting that there is still no overfishing on the species. However, as it is an very important fish in the food security of fishermen and their families, its necessary to increase the basic biology research pointing to the management and conservation of the species in the cienaga and the Sinu basin.

Ultrastructural analysis of “Sensory” surface nerve endings and “putative” neurotransmitter sites in Schistosoma mansoni Miracidia

1989 ◽  
Vol 47 ◽  
pp. 962-963
Author(s):  
Betty Ruth Jones ◽  
Steve Chi-Tang Pan
Keyword(s):  
Nervous System ◽  
Life Cycle ◽  
Schistosoma Mansoni ◽  
Snail Host ◽  
Complex Life Cycle ◽  
Rational Approach ◽  
Effective Control ◽  
The Social ◽  
Social And Economic Development ◽  
Basic Biology

INTRODUCTION: Schistosomiasis has been described as “one of the most devastating diseases of mankind, second only to malaria in its deleterious effects on the social and economic development of populations in many warm areas of the world.” The disease is worldwide and is probably spreading faster and becoming more intense than the overall research efforts designed to provide the basis for countering it. Moreover, there are indications that the development of water resources and the demands for increasing cultivation and food in developing countries may prevent adequate control of the disease and thus the number of infections are increasing.Our knowledge of the basic biology of the parasites causing the disease is far from adequate. Such knowledge is essential if we are to develop a rational approach to the effective control of human schistosomiasis. The miracidium is the first infective stage in the complex life cycle of schistosomes. The future of the entire life cycle depends on the capacity and ability of this organism to locate and enter a suitable snail host for further development, Little is known about the nervous system of the miracidium of Schistosoma mansoni and of other trematodes. Studies indicate that miracidia contain a well developed and complex nervous system that may aid the larvae in locating and entering a susceptible snail host (Wilson, 1970; Brooker, 1972; Chernin, 1974; Pan, 1980; Mehlhorn, 1988; and Jones, 1987-1988).

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