Incidence and mortality by larynx cancer in Central and South America

ABSTRACT Objective: To describe how the incidence and mortality trends for laryngeal cancer in South and Central American countries. Methods: Time series study, with incidence data from the International Agency for Research on Cancer, from 1990 to 2012 and mortality data from 17 countries of the World Health Organization, from 1995 to 2013. The trend was analyzed by Joinpoint regression. Results: The highest incidence rate for laryngeal cancer was in Brazil, with 5.9 new cases per 100,000 men, and the highest mortality rate in Uruguay with 4.2 deaths per 100,000 men. The incidence ratio between genders ranged from 4: 1 (Colombia) to 12: 1 (Ecuador). The mortality ratio between the sexes ranged from 4: 1 (Peru) to 14: 1 (Uruguay). Conclusion: Most countries had low incidence rates and reduced mortality in Latin America.

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P087 Mortality trends from systemic lupus erythematosus in Cuba: 2001-2014

Rheumatology ◽

10.1093/rheumatology/keab247.085 ◽

2021 ◽

Vol 60 (Supplement_1) ◽

Author(s):

Halbert Hernández Negrín

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Health Problem ◽

Time Trends ◽

Reference Population ◽

World Health ◽

Mortality Data ◽

Systemic Lupus ◽

Mortality Trends ◽

Health Organization

Abstract Background/Aims There is little research on the mortality of Cuban patients with systemic lupus erythematosus (SLE), with not enough impact to recognize SLE as a health problem in the country. Our aim was to identify time trends and geographic variability in the mortality of Cuban patients with SLE. Methods Mortality data of decedents over 15 years old were retrieved from the Cuban Ministry of Public Health mortality database, based on International Classification of Disease (ICD), Tenth Revision (ICD-10, code M32). We computed age-standardized mortality rate (ASMR) for each year and province as the estimated number of deaths per million inhabitants and its 95% confidence interval (95% CI) using World Health Organization reference population. The 2001-2014 time trends were analyzed using Jointpoint software. Results Between 2001 and 2014, 1,054 deaths from SLE were found, mostly women (89.0%), white (54.4%) with a median age of 43 years (interquartile range: 34-53). In 2014 the ASMR caused by SLE per million inhabitants was 14.4 (95% CI: 10.9 to 18.4) in women and 1.3 (95% CI: 0.5 to 3.2) in men. A growing time trend was identified in the ASMR by SLE throughout the period (average annual percentage change [AAPC]: 1.6; 95% CI: 0.6 to 2.6), highest in males (AAPC: 5.6; 95% CI: 1.7 to 9.7) than in females (AAPC: 1.2; 95% CI: 0.3 to 2.0). The highest mortality in women was concentrated in the provinces of Camagüey, Las Tunas and Granma, and in the case of men, in Havana and Ciego de Ávila. Conclusion The variation in the magnitude of the risk of dying from SLE over time and geographic areas indicates the possible influence of biological, environmental, socioeconomic and health systems factors. The growing trend in SLE mortality in Cuba demands its recognition as an important health problem and immediate actions that help mitigate it. Disclosure H. Hernández Negrín: None.

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Thyroid cancer incidence and mortality in Latin America

10.1101/487249 ◽

2018 ◽

Author(s):

Fábia Cheyenne Gomes de Morais Fernandes ◽

Dyego Leandro Bezerra de Souza ◽

Maria Paula Curado ◽

Isabelle Ribeiro Barbosa

Keyword(s):

Latin America ◽

Thyroid Cancer ◽

Costa Rica ◽

Cancer Incidence ◽

World Health ◽

International Agency ◽

Mortality Data ◽

Incidence Trends ◽

Incidence And Mortality ◽

Thyroid Cancer Incidence

This study analyzed trends in thyroid cancer incidence and mortality in countries of Latin America. Ecological study of time series, with incidence data extracted from the International Agency for Research on Cancer (IARC), in the 1990-2012 period and mortality data obtained from 16 countries of the World Health Organization (WHO), in the 1995-2013 period. The trend of incidence rate was analyzed by the Joinpoint regression. The average annual percentage change (AAPC) and the 95% confidence interval (CI 95%) were calculated for incidence and mortality. The average rate of thyroid cancer incidence was higher in Quito (Ecuador) between the ages of 40 to 59 years old, 42.2 new cases per 100,000 inhabitants, as well as mortality 4.8 deaths per 100,000 women inhabitants above 60 years old. There was an increase in thyroid cancer incidence trends in women, for all age groups, in Cali, Costa Rica and Quito and men in Costa Rica; there was stability above the age of 60 years old in Cali, Goiania, Quito and Valdivia in men, as well as women in Goiania and Valdivia. There was a trend of increasing mortality for females in three countries: Ecuador (AAPC= 3,28 CI 95% 1,36;5,24), Guatemala (AAPC= 6,14 CI 95% 2,81;9,58) and Mexico (AAPC= 0,67 CI 95% 0,16;1,18). Thyroid cancer in Latin America showed a high incidence, with increased incidence in women. Stability in mortality was observed for most countries of Latin America.

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Leukemia mortality in children from Latin America: Trends and predictions to 2030

10.21203/rs.3.rs-64774/v2 ◽

2020 ◽

Author(s):

J. Smith Torres-Roman ◽

Bryan Valcarcel ◽

Pedro Guerra-Canchari ◽

Camila Alves Dos Santos ◽

Isabelle Ribeiro Barbosa ◽

...

Keyword(s):

Latin American ◽

Mortality Rates ◽

World Health ◽

Mortality Data ◽

Mortality Trends ◽

Annual Percent Change ◽

Universal Healthcare ◽

The World ◽

Health Organization ◽

Universal Healthcare Coverage

Abstract Background: Reports suggest that Latin American and Caribbean (LAC) countries have not reduced in leukemia mortality compared to high-income countries. However, updated trends remain largely unknown in the region. Given that leukemia is the leading cause of cancer-related death in LAC children, we evaluated mortality trends in children (0-14y) from 15 LAC countries for the period 2000-2017 and predicted mortality to 2030.Methods: We retrieved cancer mortality data using the World Health Organization Mortality Database. Mortality rates (standardized to the world standard SEGI population) were analyzed for 15 LAC countries. We evaluated the average mortality rates for the last 5 years (2013-2017). Joinpoint regression analysis was used to evaluate leukemia mortality trends and provide an estimated annual percent change (EAPC). Nordpred was utilized for the calculation of predictions until 2030.Results: Between 2013 and 2017, the highest mortality rates were reported in Venezuela, Ecuador, Nicaragua, Mexico, and Peru. Upward mortality trends were reported in Nicaragua (EAPC by 2.9% in boys, and EAPC by 2.0% in girls), and Peru (EAPC by 1.4% in both sexes). Puerto Rico experienced large declines in mortality among both boys (EAPC by −9.7%), and girls (EAPC by −6.0%). Leukemia mortality will increase in Argentina, Ecuador, Guatemala, Panama, Peru, and Uruguay by 2030.Conclusion: Leukemia mortality is predicted to increase in some LAC countries by 2030. Interventions to prevent this outcome should be tailor to reduce the socioeconomic inequalities and ensure universal healthcare coverage.

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Prediction of Cancer Incidence and Mortality in Korea, 2020

Cancer Research and Treatment ◽

10.4143/crt.2020.203 ◽

2020 ◽

Vol 52 (2) ◽

pp. 351-358 ◽

Cited By ~ 9

Author(s):

Kyu-Won Jung ◽

Young-Joo Won ◽

Seri Hong ◽

Hyun-Joo Kong ◽

Eun Sook Lee

Keyword(s):

Regression Model ◽

Cancer Incidence ◽

Linear Trend ◽

Cancer Control ◽

Incidence Rates ◽

Cancer Site ◽

Mortality Data ◽

Control Programs ◽

Incidence Data ◽

Incidence And Mortality

PurposeThis study aimed to report the projected cancer incidence and mortality for the year 2020 to estimate Korea’s current cancer burden.Materials and MethodsCancer incidence data from 1999 to 2017 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2018 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against observed years and then by multiplying the projected age-specific rates by the age-specific population. A <i>Joinpoint</i> regression model was used to determine the year in which the linear trend changed significantly; we only used the data of the latest trend.ResultsIn total, 243,263 new cancer cases and 80,546 cancer deaths are expected to occur in Korea in 2020. The most common cancer site is expected to be the lung, followed by the stomach, thyroid, colon/rectum, and breast. These five cancers types are expected to represent half of the overall burden of cancer in Korea. The most common type of cancer among people who die is expected to be lung cancer, followed by liver, colon/rectal, pancreatic, and stomach cancers.ConclusionThe incidence rates for all types of cancer in Korea are estimated to decrease gradually. These up-to-date estimates of the cancer burden in Korea could be an important resource for planning and evaluating cancer-control programs.

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Measles Elimination: Identifying Susceptible Sub-Populations to Tailor Immunization Strategies

Viruses ◽

10.3390/v11080765 ◽

2019 ◽

Vol 11 (8) ◽

pp. 765 ◽

Cited By ~ 1

Author(s):

Peter Kreidl ◽

David Ammerer ◽

Reinhard Würzner ◽

Anita Luckner Hornischer ◽

Dorothee von Laer ◽

...

Keyword(s):

Vaccine Coverage ◽

Incidence Rates ◽

World Health ◽

Sources Of Information ◽

Birth Cohorts ◽

Incidence Data ◽

Measles Elimination ◽

Seroprevalence Data ◽

Long Time ◽

Health Organization

Measles elimination has been identified as a public health priority in Europe for a long time but has not yet been achieved. The World Health Organization (WHO) recommends identification of susceptible sub-populations to target supplementary immunization activities. We used three different sources of information: retrospective samples investigated for measles IgG between 1997 and 2016, vaccine coverage data from the existing electronic registry for birth cohorts 2015 to 1999, and surveillance data from 2009 until 20 July 2019. We calculated susceptibility by birth cohort using seroprevalence data, adjusting vaccine coverage data with reported effectiveness (93% for the first and 97% for the second dose, respectively), and compared it with measles incidence data, aggregated by birth cohorts and districts. Susceptibility levels for persons 10–41 years (birth cohorts 2007–1976) were 10.4% and thus far above the recommended values of WHO (5%). Older birth cohorts were sufficiently protected. Districts with the highest susceptibility estimates corresponded with districts with the highest incidence rates. Birth cohorts with susceptibility levels > 10% showed a 4.7 increased relative risk of having had more than one measles case. We conclude that retrospective serosurveys are a cheap and useful approach in identifying susceptible sub-populations, especially for older birth cohorts whose coverage data remain scarce.

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Prostate cancer mortality trends in Argentina 1986-2006: an age-period-cohort and joinpoint analysis

Cadernos de Saúde Pública ◽

10.1590/s0102-311x2011000100013 ◽

2011 ◽

Vol 27 (1) ◽

pp. 123-130 ◽

Cited By ~ 19

Author(s):

Camila Niclis ◽

Sonia A. Pou ◽

Rubén H. Bengió ◽

Alberto R. Osella ◽

María del Pilar Díaz

Keyword(s):

Prostate Cancer ◽

Cancer Mortality ◽

Time Trends ◽

World Health ◽

Mortality Data ◽

Birth Cohorts ◽

Mortality Trends ◽

Prostate Cancer Mortality ◽

Increased Risk ◽

Health Organization

The aim of this study was to give an overview of the magnitude, variation by age and time trends in the rates of prostate cancer mortality in Córdoba province and in Argentina as a whole from 1986 to 2006. Mortality data were provided by the Córdoba Ministry of Health and the World Health Organization cancer mortality database. Prostate cancer mortality time trends were analyzed using joinpoint analysis and age-period-cohort models. In Argentina prostate cancer age-standardized mortality rates rose by 1% and 3.4% per year from 1986 to 1992 and from 1992 to 1998 respectively. There was a decreasing trend (-1.6%) for Argentina from 1998 and Córdoba (-1.9%) from 1995. Age-period-cohort models for the country and the province showed a strong age effect. In the country there was an increased risk in the 1996-2000 period, whereas there was decreased risk for birth cohorts since 1946, principally in Córdoba. A decreasing trend in prostate cancer mortality was found in Córdoba as well as in Argentina, which might be attributed to the improvement in treatment in this country.

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Incidence of Tetanus and Diphtheria in Relation to Adult Vaccination Schedules

Clinical Infectious Diseases ◽

10.1093/cid/ciaa017 ◽

2020 ◽

Cited By ~ 7

Author(s):

Ariel M Slifka ◽

Byung Park ◽

Lina Gao ◽

Mark K Slifka

Keyword(s):

Case Reports ◽

Booster Vaccination ◽

Incidence Rates ◽

Childhood Vaccination ◽

World Health ◽

Incidence Data ◽

Health Authorities ◽

Group 2 ◽

Health Organization ◽

Group 1

Abstract Background The World Health Organization (WHO) does not recommend routine adult booster vaccination for tetanus and diphtheria after completion of the childhood vaccination series. However, many countries continue to implement adult booster vaccinations, leading to the question of whether this is necessary to reduce the incidence of these 2 rare diseases. Methods We conducted an observational cohort study based on WHO case reports from 2001 through 2016. We compared the incidence of tetanus and diphtheria in 31 North American and European countries that either do or do not recommend adult booster vaccination. Results Countries that vaccinate adults every 5–20 years (group 1) were compared with countries that do not routinely vaccinate adults for tetanus or diphtheria (group 2). Comparison of group 1 vs group 2 revealed no significant decline in tetanus incidence rates among countries that vaccinate adults (P = .52; risk ratio [RR] = 0.78; 95% confidence interval [CI], .36 to 1.70). The risk of contracting diphtheria was increased among countries that vaccinate adults due to inclusion of Latvia, a country that had poor vaccination coverage (P < .001). However, if Latvia is excluded, there is no difference in diphtheria incidence between countries that do or do not routinely vaccinate adults (P = .26; RR = 2.46; 95% CI, .54 to 11.23). Conclusions Review of >11 billion person-years of incidence data revealed no benefit associated with performing adult booster vaccinations against tetanus or diphtheria. Similar to other vaccines, this analysis supports the WHO position on adult booster vaccination and, if approved by governing health authorities, this may allow more countries to focus healthcare resources on vulnerable and undervaccinated populations.

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SUN-302 Incidence Trends in Lung and Gastroenteropancreatic Neuroendocrine Neoplasms

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa046.309 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

Author(s):

Heba Alwan ◽

Stefano La Rosa ◽

Peter Kopp ◽

Simon Germann ◽

Manuela Maspoli-Conconi ◽

...

Keyword(s):

Cancer Registries ◽

Population Based ◽

Incidence Rates ◽

World Health ◽

International Agency ◽

Neuroendocrine Neoplasms ◽

Incidence Trends ◽

Time Period ◽

Well Differentiated ◽

Health Organization

Abstract Abstract Introduction The incidence of neuroendocrine neoplasms (NENs) seems to increase worldwide. However, long-term, population-based data that consider differentiation levels are sparse. Objective To evaluate the incidence trend of lung and gastroenteropancreatic (GEP) NENs according to the latest International Agency for Research on Cancer/World Health Organization classification over a 41-year time period in two Swiss regions. Methods All cases of lung and GEP NENs recorded in the Vaud and Neuchâtel Cancer Registries from 1976–2016 were included. NENs were stratified into well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Changes in annual age-standardized incidence rates were calculated for lung and GEP NETs and NECs by sex. Results There were 4141 patients diagnosed with NENs, of which 65% were men. The incidence of lung NETs did not reveal any statistically significant trend in men, but increased in women by 4.9%/year between 1976–2016. The incidence of lung NECs in men decreased significantly by 2.6%/year from 1985–2016 whereas the incidence of lung NECs in women increased significantly between 1976–1998 by 6%/year. For GEP NETs, a steady annual increase in incidence occurred between 1976–2016 with a magnitude of 1.7% in men and 1.3% in women. No trend in incidence of GEP NECs was found for both sexes. Conclusions The incidence trends of lung NECs in men and women parallel changes in smoking prevalence in the population whereas causes of the increase in incidence of GEP NETs are not fully understood. Our study supports the importance of evaluating the epidemiology of NENs by their differentiation level.

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Leukemia mortality in children from Latin America: Trends and predictions to 2030

10.21203/rs.3.rs-64774/v1 ◽

2020 ◽

Author(s):

J. Smith Torres-Roman ◽

Bryan Valcarcel ◽

Pedro Guerra-Canchari ◽

Camila Alves Dos Santos ◽

Isabelle Ribeiro Barbosa ◽

...

Keyword(s):

Latin American ◽

Mortality Rates ◽

World Health ◽

Mortality Data ◽

Mortality Trends ◽

Annual Percent Change ◽

Control Programs ◽

Standard Population ◽

Health Organization ◽

Treatment Abandonment

Abstract Background Reports suggest that Latin American and Caribbean (LAC) countries have not achieved the downward mortality trends in leukemia seen in other countries. However, updated trends remain largely unknown in the region. Given that leukemia is the leading cause of cancer-related death in LAC children, we aimed to evaluate mortality trends in children (0-14y) from 15 LAC countries for the period 2000–2017 and to predict mortality until 2030. Methods We retrieved cancer mortality data through the World Health Organization Mortality Database. Age-standardized (world standard population) rates were computed for LAC countries. Joinpoint regression analysis was used to examine trends in the mortality rates of leukemia and provide an estimated annual percent change (EAPC). Nordpred was utilized for the calculation of predictions until 2030. Results Between 2013 and 2017, the highest mortality rates were reported in Venezuela, Ecuador, Nicaragua, Mexico, and Peru. Upward mortality trends were reported in Nicaragua (EAPC by 1.2% in boys, and EAPC by 2.0% in girls), Panama (EAPC by 1.8% in boys, and by 2.7% in girls), and Peru (EAPC by 1.4% in both sexes). Puerto Rico experienced large declines in mortality among both boys (APC by − 9.7%), and girls (EAPC by − 6.0%). Forecasting models predicted that leukemia mortality between 2015 and 2030, will increase in Argentina, Ecuador, Guatemala, Panama, Peru, and Uruguay. Conclusion Leukemia mortality is predicted to increase unless efforts are made to intervene. Interventions include addressing the inequities in health care diagnosing cases earlier,, avoiding treatment abandonment, and proper supportive care such as infection control programs will reduce the mortality in a great proportion.

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Trends of HIV-Related Cancer Mortality between 2001 and 2018: An Observational Analysis

Tropical Medicine and Infectious Disease ◽

10.3390/tropicalmed6040213 ◽

2021 ◽

Vol 6 (4) ◽

pp. 213

Author(s):

Chinmay Jani ◽

Omar Al Omari ◽

Harpreet Singh ◽

Alexander Walker ◽

Kripa Patel ◽

...

Keyword(s):

Cancer Mortality ◽

Population Data ◽

Developed Countries ◽

World Health ◽

Mortality Data ◽

Female Mortality ◽

Mortality Trends ◽

Male Mortality ◽

The World ◽

Health Organization

The burden of AIDS-defining cancers has remained relatively steady for the past two decades, whilst the burden of non-AIDS-defining cancer has increased. Here, we conduct a study to describe mortality trends attributed to HIV-associated cancers in 31 countries. We extracted HIV-related cancer mortality data from 2001 to 2018 from the World Health Organization Mortality Database. We computed age-standardized death rates (ASDRs) per 100,000 population using the World Standard Population. Data were visualized using Locally Weighted Scatterplot Smoothing (LOWESS). Data for females were available for 25 countries. Overall, there has been a decrease in mortality attributed to HIV-associated cancers among most of the countries. In total, 18 out of 31 countries (58.0%) and 14 out of 25 countries (56.0%) showed decreases in male and female mortality, respectively. An increasing mortality trend was observed in many developing countries, such as Malaysia and Thailand, and some developed countries, such as the United Kingdom. Malaysia had the greatest increase in male mortality (+495.0%), and Canada had the greatest decrease (−88.5%). Thailand had the greatest increase in female mortality (+540.0%), and Germany had the greatest decrease (−86.0%). At the endpoint year, South Africa had the highest ASDRs for both males (16.8/100,000) and females (19.2/100,000). The lowest was in Japan for males (0.07/100,000) and Egypt for females (0.028/100,000).

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