Ectopic cutaneous schistosomiasis - Case report

Schistosomiasis mansoni is a systemic disease caused by a helminth of the schistosoma genus. The disease is generally asymptomatic or gastrointestinal symptoms may predominate. Skin lesions related to the disease are rarely diagnosed, even in endemic areas. The authors report the case of a young girl diagnosed with cutaneous schistosomiasis with involvement of the abdomen, back and scapular region. Schistosoma eggs were found in the lesions by histopathologic exam. There was no evidence of systemic involvement. Schistosomiasis must be included in the list of differential diagnosis of skin damage, especially in endemic areas, due to the potential consequences, in case of late diagnosis and treatment.

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Dermatological Manifestations of COVID-19 in Children

Journal of Skin and Stem Cell ◽

10.5812/jssc.106890 ◽

2020 ◽

Vol 7 (2) ◽

Author(s):

Vivek Athwani ◽

Sunil Gothwal

Keyword(s):

Toxic Shock Syndrome ◽

Gastrointestinal Symptoms ◽

Skin Lesions ◽

Skin Involvement ◽

Toxic Shock ◽

Cutaneous Manifestations ◽

Systemic Involvement ◽

Atypical Kawasaki Disease ◽

Coronavirus Infection ◽

Inflammatory Syndrome

: Coronavirus infection 2019 (COVID-19) primarily has a respiratory system and multi-systemic involvement. Respiratory and gastrointestinal symptoms are predominantly seen in children. In adults, few COVID-19 cases are reported with cutaneous manifestations. Although children are less severely affected by COVID-19, there is increasing evidence for skin involvement, which is in the form of chilblain (e.g., lesions, vesicular, and maculopapular) and erythema multiforme (e.g., rash). Also, few COVID-19 cases are presented with a clinical picture of atypical Kawasaki disease and toxic shock syndrome, later defined as pediatric multisystem inflammatory syndrome (PMIS). The present study aims to summarize various skin lesions with COVID-19.

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First Clinical Cases of Spirometrosis in Two Cats in Korea

The Korean Journal of Parasitology ◽

10.3347/kjp.2021.59.2.153 ◽

2021 ◽

Vol 59 (2) ◽

pp. 153-157

Author(s):

Joohyung Kim ◽

Younsung Ock ◽

Kihwan Yang ◽

Seongjun Choe ◽

Kyung-Mee Park ◽

...

Keyword(s):

Differential Diagnosis ◽

Companion Animals ◽

Gastrointestinal Symptoms ◽

Molecular Analyses ◽

Main Symptom ◽

Regular Monitoring ◽

Preventive Medication ◽

Endemic Areas ◽

Clinical Cases

This study reports the first two clinical cases of spirometrosis caused by Spirometra sp. in cats in Korea. In these two cases, the cats vomited, and long proglottids of tapeworm were recovered. The sick cats presented with anorexia and lethargy. However, they unexpectedly showed no diarrhea, which is the main symptom of spirometrosis. Based on a fecal floatation test as well as morphological and molecular analyses, the parasite was diagnosed as Spirometra sp. The 2 cases were treated with praziquantel. This study suggests regular monitoring of health and deworming in companion animals, even when animals are well cared for, with regular preventive medication. Additionally, spirometrosis should be considered in the differential diagnosis in cases of gastrointestinal symptoms in Spirometra endemic areas.

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Cutaneous Cryptococcosis Mimicking Basal Cell Carcinoma in a Patient with AIDS

Journal of Cutaneous Medicine and Surgery ◽

10.1177/120347549800300112 ◽

1998 ◽

Vol 3 (1) ◽

pp. 43-45 ◽

Cited By ~ 7

Author(s):

Rosemarie Ingleton ◽

Evelyn Koestenblatt ◽

Philip Don ◽

Howard Levy ◽

Wojciech Szaniawski ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Systemic Disease ◽

Immune Deficiency Syndrome ◽

Skin Lesions ◽

Deficiency Syndrome ◽

Cutaneous Manifestations ◽

Systemic Involvement ◽

Cutaneous Cryptococcosis

Background: Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans. This ubiquitous organism has emerged as a frequent finding in immunosuppressed patients, especially those with underlying malignancies, organ transplants, and the acquired immune deficiency syndrome (AIDS). Cutaneous manifestations of cryptococcosis occur in 10 to 15% of patients having systemic involvement. These skin lesions may simulate a variety of different disease entities. Methods: A case of crytococcosis mimicking a basal cell carcinoma is the subject of a case report presentation. Results: A case of cutaneous cryptococcosis mimicking basal cell carcinoma occurred in a patient with AIDS, who did not appear to have dissemination, but was treated aggressively to stem possible occult systemic disease. Conclusion: Cutaneous crytococcosis may mimic other dermatologic disorders.

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The Differential Diagnosis of Sterile Pyuria in Pediatric Patients: A Review

Global Pediatric Health ◽

10.1177/2333794x21993712 ◽

2021 ◽

Vol 8 ◽

pp. 2333794X2199371

Author(s):

Donald W. Bendig

Keyword(s):

Differential Diagnosis ◽

Pediatric Patients ◽

Systemic Disease ◽

Common Finding ◽

Extensive Literature ◽

Sexually Transmitted ◽

Persistent Symptoms ◽

Sterile Pyuria ◽

Extensive Literature Search ◽

Definition Of

Sterile pyuria is a common finding in pediatric patients. Literature describing the diagnoses as well as clinical characteristics of children with sterile pyuria is lacking. This review was performed to establish an evidence-based approach to the differential diagnosis by way of an extensive literature search. The definition of pyuria is inconsistent. The various causes of pediatric sterile pyuria identified were classified as either Infectious or Non-Infectious. Sub-categories of Infectious causes include: Viral Infection, Bacterial Infection, Other Infections (tuberculosis, fungal, parasitic), Sexually Transmitted Infections, Recent Antibiotic Therapy. Non-Infectious causes include: Systemic Disease, Renal Disease, Drug Related, Inflammation adjacent to Genitourinary Tract. Clinicians that encounter pediatric patients with sterile pyuria and persistent symptoms should consider the substantial differential diagnosis described in this study.

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POS0826 SKIN LIMITED IGA VASCULITIS IN ADULTS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.1383 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 666.1-666

Author(s):

A. Hočevar ◽

J. Ostrovrsnik ◽

K. Perdan-Pirkmajer ◽

M. Tomsic ◽

Z. Rotar

Keyword(s):

Clinical Characteristics ◽

Systemic Disease ◽

Elevated Serum ◽

Skin Lesions ◽

Current Smoker ◽

P Value ◽

Symptom Duration ◽

Iga Vasculitis ◽

Reactive Protein

Background:IgA vasculitis (IgAV) could be limited to skin or evolve into a systemic disease, affecting characteristically joints, gastrointestinal tract and/or kidneys.Objectives:We aimed to look for differences between adult IgAV patients with disease limited to skin compared to systemic IgAV.Methods:Medical records of histologically proven adult IgAV cases, diagnosed between January 2010 and December 2020 at our secondary/tertiary rheumatology centre were analyzed.Results:During the 132-month observation period we identified 328 new IgAV cases (59.5% males, median (IQR) age 64.3 (45.1; 76.1) years). Ninety-four (40.2%) patients had skin limited disease, and the rest systemic IgAV.Clinical differences between skin limited and systemic adult IgAV are presented in table 1. Adults with IgAV limited to skin were significantly older, had less commonly skin lesions above the waistline and a lower level of C reactive protein compared to patients with a systemic disease. There were no differences in the frequency of skin necroses between the compared IgAV subgroups. The frequency of potential vasculitis triggers (prior infections, new medications, malignancy) was similar between the compared subgroups.Table 1.Clinical characteristics of IgA vasculitis patients with skin limited and systemic diseaseClinical characteristicsSkin limited IgAV (94)Systemic IgAV (234)P valueMale gender (%)54.361.50.263Age (years)*68.0 (55.0-80.5)61.5 (41.7-75.8)0.007Current smoker (%)13.821.80.123Antecedent infection (%)28.733.80.434New medication23.423.51.0History of cancer12.810.70.569Symptom duration (days)*7 (5-21)8 (5-14)0.756Purpura above waistline36.255.60.002Skin necroses (%)52.145.70.329ESR /mm/h) *32 (18-52)34 (17-53)0.873CRP (g/l) *13.5 (1-32)30 (11-68)<0.001Elevated serum IgA (%)50.649.10.892Legend: * median and IQR;Follow up data were available for 250 (76.2%) patients. During the follow up of median (IQR) 12.5 (6.8 – 22.4) months 35 patients relapsed (13/70 (18.6%) with skin limited IgAV and 22/180 (12.2%) with systemic IgAV, p= 0.224).Conclusion:Skin limited IgAV was associated with older age and less extensive skin puprura in adults. However, relapses of purpura were as common as in systemic IgAV.Disclosure of Interests:None declared

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Cystic fibrosis in disguise – the wolf in sheep’s clothing, a case report

BMC Pediatrics ◽

10.1186/s12887-021-02636-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Friederike Wilbert ◽

Sarah C. Grünert ◽

Andrea Heinzmann ◽

Sebastian F. N. Bode

Keyword(s):

Cystic Fibrosis ◽

Systemic Disease ◽

Gastrointestinal Symptoms ◽

Chloride Concentration ◽

Failure To Thrive ◽

Sweat Test ◽

Upper Airways ◽

Inborn Errors ◽

Hepatic Involvement ◽

Number Of Patients

Abstract Background Childhood hypoglycemia in combination with hepatomegaly is suspicious for inborn errors of metabolism. Cystic fibrosis typically presents with failure to thrive, pulmonary and gastrointestinal symptoms. Hepatic involvement and hypoglycemia can occur in a significant number of patients, although hepatomegaly is uncommon. Case presentation A 28 months old boy was presented with recurrent upper airways infections, progressive lethargy and weight loss. Clinically hepatomegaly was the main presenting feature and hypoglycemia (minimum 1.4 mmol/l) was noted as were elevated transaminases. The patient did not produce enough sweat to analyze it. Infectious causes for hepatitis were excluded and a broad metabolic work-up initiated. A therapy with starch was initiated to control hypoglycemia. In further course loose stools were reported and pancreatic elastase was found to be reduced. A further sweat test yielded pathological chloride concentration and genetic testing confirmed the diagnosis of cystic fibrosis. Conclusions Cystic fibrosis is a systemic disease and less common presentations need to be considered. Even in the age of CF-newborn screening in many countries CF needs to be ruled out in typical and atypical clinical presentations and diagnostics need to be repeated if inconclusive.

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Skin lesions, differential diagnosis and practical approach to potential survivors of torture

Journal of the European Academy of Dermatology and Venereology ◽

10.1111/jdv.15439 ◽

2019 ◽

Vol 33 (7) ◽

pp. 1232-1240 ◽

Cited By ~ 10

Author(s):

K. Clarysse ◽

M. Grosber ◽

J. Ring ◽

J. Gutermuth ◽

C. Kivlahan

Keyword(s):

Differential Diagnosis ◽

Skin Lesions ◽

Practical Approach ◽

Survivors Of Torture

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Systemic Diseases Associated with Nasal Symptoms

American Journal of Rhinology ◽

10.2500/105065887781390390 ◽

1987 ◽

Vol 1 (1) ◽

pp. 33-44 ◽

Cited By ~ 2

Author(s):

Guy A. Settipane

Keyword(s):

Differential Diagnosis ◽

Fungal Infections ◽

Systemic Disease ◽

Systemic Diseases ◽

Proper Treatment ◽

Csf Rhinorrhea ◽

Nasal Symptoms ◽

Appropriate Treatment ◽

Life Threatening ◽

Careful History

Many systemic diseases are associated with nasal symptoms, Rhinitis associated with asthma is probably the most common with leprosy and fungal infections being the rarest. A careful history and nasal examination in a patient with rhinitis may lead to the discovery of more significant systemic diseases. Proper treatment of systemic disease will often cure or improve the associated rhinitis. Similarly, appropriate treatment of the rhinitis/sinusitis may reduce systemic complaints such as asthma. At times, identification of the cause of rhinitis as in CSF rhinorrhea, Wegeners’ syndrome, etc., alerts one to a life-threatening entity. Thus, it is apparent that the nose is an excellent mirror of some systemic diseases and identifying and understanding the differential diagnosis of nasal symptoms may be a tremendous help in diagnosing the disease and treating the whole patient.

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Metastatic Melanoma Presenting as Intussusception in an 80-Year-Old Man: A Case Report

Case Reports in Pathology ◽

10.1155/2013/672816 ◽

2013 ◽

Vol 2013 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Sarah Alghamdi ◽

Yumna Omarzai

Keyword(s):

Differential Diagnosis ◽

Small Intestine ◽

Gastrointestinal Tract ◽

Metastatic Melanoma ◽

Clinical Presentation ◽

Gastrointestinal Symptoms ◽

Common Site ◽

Neoplastic Process ◽

History Of ◽

Uncommon Neoplasm

Malignant melanoma of the gastrointestinal tract is an uncommon neoplasm that could be primary or metastatic. Small intestine represents the most common site for the metastatic melanoma; however, it could be found anywhere in the gastrointestinal tract. Intussusception is a rare cause of intestinal obstruction in adults compared to children. In 90% of the cases, the underlying cause can be found, and in 65% of the cases, intussusception is caused by the neoplastic process. The majority of the neoplasms are benign, and about 15% are malignant. Metastatic melanoma is one of the most common metastatic malignancies to the gastrointestinal tract; however, the premortem diagnosis is rarely made. Here, we report an uncommon clinical presentation of metastatic melanoma causing intussusception in an 80-year-old man. This diagnosis should be considered in a differential diagnosis in any patient who presents with gastrointestinal symptoms and a history of melanoma.

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Focus on localized laryngeal amyloidosis: management of five cases

Open Medicine ◽

10.1515/med-2020-0400 ◽

2020 ◽

Vol 15 (1) ◽

pp. 327-332

Author(s):

Massimo Mesolella ◽

Gerardo Petruzzi ◽

Sarah Buono ◽

Grazia Salerno ◽

Francesco Antonio Salzano ◽

...

Keyword(s):

Systemic Disease ◽

Clinical Aspects ◽

Benign Tumors ◽

Local Form ◽

Systemic Involvement ◽

Clinical Syndromes ◽

Laryngeal Amyloidosis ◽

And Control ◽

Localized Laryngeal Amyloidosis

AbstractAmyloidosis is a group of idiopathic clinical syndromes caused by the deposition of insoluble fibrillar proteins (amyloid) in the extracellular matrix of organs and tissues. These deposits disrupt the function of the target organ. Amyloidosis can manifest as a systemic disease or a single-organ involvement (local form). Its etiology still remains unclear. Deposits of amyloid in the larynx are rare, accounting for between 0.2 and 1.2% of benign tumors of the larynx. In this retrospective study, we report the clinical aspects, diagnosis, treatment and follow-up of five female patients with localized laryngeal amyloidosis without systemic involvement. The patients were all treated successfully using microlaryngoscopy with CO2 laser or cold instruments. Prognosis is excellent; however, appropriate follow-up is an important part of the long-term management of this disease in order to prevent and control the possibility of local recurrence.

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