Systemic Diseases Associated with Nasal Symptoms

1987 ◽  
Vol 1 (1) ◽  
pp. 33-44 ◽  
Author(s):  
Guy A. Settipane
Keyword(s):  
Differential Diagnosis ◽  
Fungal Infections ◽  
Systemic Disease ◽  
Systemic Diseases ◽  
Proper Treatment ◽  
Csf Rhinorrhea ◽  
Nasal Symptoms ◽  
Appropriate Treatment ◽  
Life Threatening ◽  
Careful History

Many systemic diseases are associated with nasal symptoms, Rhinitis associated with asthma is probably the most common with leprosy and fungal infections being the rarest. A careful history and nasal examination in a patient with rhinitis may lead to the discovery of more significant systemic diseases. Proper treatment of systemic disease will often cure or improve the associated rhinitis. Similarly, appropriate treatment of the rhinitis/sinusitis may reduce systemic complaints such as asthma. At times, identification of the cause of rhinitis as in CSF rhinorrhea, Wegeners’ syndrome, etc., alerts one to a life-threatening entity. Thus, it is apparent that the nose is an excellent mirror of some systemic diseases and identifying and understanding the differential diagnosis of nasal symptoms may be a tremendous help in diagnosing the disease and treating the whole patient.

scholarly journals Characteristics of Systemic Diseases in the Breast: Clinical, Imaging and Pathologic Features

2012 ◽  
Vol 8 (5) ◽  
pp. 593-599
Author(s):  
Shahla Masood
Keyword(s):  
Systemic Disease ◽  
Evaluation Process ◽  
Breast Disease ◽  
Breast Diseases ◽  
Systemic Diseases ◽  
Benign Condition ◽  
Condition Versus ◽  
Appropriate Treatment ◽  
Pathologic Features ◽  
The Impact

Despite tremendous efforts placed on advances in diagnosis and treatment of the spectrum of breast disease, the impact of systemic diseases on the breast has remained under recognized. Distinction between a variety of benign breast diseases versus those that are manifestations of a systemic disease is critically important for appropriate treatment planning and follow-up of patients. This article is designed to provide an overview of different systemic diseases that can present as a breast lesion. Attempts are made to highlight the significance of the distinction between benign breast disease versus benign conditions that present as the result of a systemic disease. Naturally, distinction between any benign condition versus breast carcinoma is a part of the evaluation process.

Lung aspergilloma with pituitary invasive aspergillosis presenting as headache and hyponatraemia

2021 ◽  
Vol 14 (1) ◽  
pp. e238721
Author(s):  
Eunho Choi ◽  
Sun Bean Kim ◽  
Jong Hun Kim ◽  
Young Kyung Yoon
Keyword(s):  
Diabetes Mellitus ◽  
Differential Diagnosis ◽  
Mortality Rate ◽  
Invasive Aspergillosis ◽  
Fungal Infections ◽  
Imaging Study ◽  
Lung Mass ◽  
Tissue Invasion ◽  
Life Threatening ◽  
The Brain

Fungal infections involving the pituitary gland are rare and can be life threatening. A 75-year-old man with hypertension and diabetes mellitus presented with headache and hyponatraemia. Imaging study showed right upper lung mass, and mass resection showed aspergilloma without tissue invasion on histology. The patient developed visual impairment a few weeks later, and MRI of the brain revealed bilateral sphenoid sinusitis and pituitary invasion. The trans-sphenoidal biopsy confirmed invasive Aspergillus infection. His sphenoidal sinuses were endoscopically debrided, and he was treated with oral voriconazole. Pituitary aspergillosis should be considered in the differential diagnosis in patients with lung aspergilloma with headache and sinusitis. Prompt biopsy and antifungal treatment are important due to the high mortality rate of the infection.

scholarly journals Differential Diagnosis of Hypoglycemia

2021 ◽  
Vol 96 (6) ◽  
pp. 484-492
Author(s):  
Young Sang Lyu ◽  
Jin Hwa Kim ◽  
Sang Yong Kim
Keyword(s):  
Differential Diagnosis ◽  
Treatment Strategy ◽  
Accurate Diagnosis ◽  
Diagnostic Approach ◽  
Hypoglycemic Agents ◽  
Blood Testing ◽  
Appropriate Treatment ◽  
Life Threatening

Hypoglycemia is common but can lead to life-threatening consequences. Accurate diagnosis is important to establish the appropriate treatment strategy. Most cases of hypoglycemia are caused by hypoglycemic agents, although it can occur in individuals without diabetes. A systemic and comprehensive diagnostic approach is required to diagnose hypoglycemia in patients without diabetes. It is important to perform appropriate blood testing during an episode of hypoglycemia. This review will focus on the definition, differential diagnosis, causes, and treatment of hypoglycemia, particularly in people without diabetes.

scholarly journals Role for IL-1 Family Cytokines in Fungal Infections

2021 ◽  
Vol 12 ◽  
Author(s):  
James S. Griffiths ◽  
Giorgio Camilli ◽  
Natalia K. Kotowicz ◽  
Jemima Ho ◽  
Jonathan P. Richardson ◽  
...  
Keyword(s):  
Fungal Pathogens ◽  
Fungal Infections ◽  
Systemic Disease ◽  
Severe Disease ◽  
Life Threatening ◽  
Current Therapies ◽  
Immunotherapy Target ◽  
Systemic Infections ◽  
Fungal Immunity ◽  
Anti Fungal

Fungal pathogens kill approximately 1.5 million individuals per year and represent a severe disease burden worldwide. It is estimated over 150 million people have serious fungal disease such as recurrent mucosal infections or life-threatening systemic infections. Disease can ensue from commensal fungi or new infection and involves different fungal morphologies and the expression of virulence factors. Therefore, anti-fungal immunity is complex and requires coordination between multiple facets of the immune system. IL-1 family cytokines are associated with acute and chronic inflammation and are essential for the innate response to infection. Recent research indicates IL-1 cytokines play a key role mediating immunity against different fungal infections. During mucosal disease, IL-1R and IL-36R are required for neutrophil recruitment and protective Th17 responses, but function through different mechanisms. During systemic disease, IL-18 drives protective Th1 responses, while IL-33 promotes Th2 and suppresses Th1 immunity. The IL-1 family represents an attractive anti-fungal immunotherapy target. There is a need for novel anti-fungal therapeutics, as current therapies are ineffective, toxic and encounter resistance, and no anti-fungal vaccine exists. Furthering our understanding of the IL-1 family cytokines and their complex role during fungal infection may aid the development of novel therapies. As such, this review will discuss the role for IL-1 family cytokines in fungal infections.

Apparent Proteinuria as a Consequence of Sodium Bicarbonate Ingestion

PEDIATRICS ◽  
1990 ◽  
Vol 86 (2) ◽  
pp. 318-319
Author(s):  
DAN WECHSLER ◽  
LAURA IBSEN ◽  
PATRICIA FOSARELLI
Keyword(s):  
Emergency Department ◽  
Differential Diagnosis ◽  
Correct Diagnosis ◽  
Difficult Problem ◽  
Screening Tests ◽  
History Taking ◽  
Laboratory Screening ◽  
Appropriate Treatment ◽  
Laboratory Results ◽  
Careful History

An infant who is brought to an emergency department with vague symptoms poses a difficult problem for the pediatrician. The presence of specific findings on laboratory screening tests often helps to narrow the differential diagnosis, enabling appropriate treatment. Unexpected laboratory results, however, may lead the physician astray in making the correct diagnosis. It is important to interpret laboratory results within the context of the entire clinical picture and to keep in mind the limitations of certain of these tests. We report a case of apparent proteinuria in a 7-week-old infant caused by the addition of baking soda to his formula, and point out that careful history-taking may help to avoid an extensive diagnostic workup.

scholarly journals Perawatan Periodontal pada Pasien Lupus Eritematosus Sistemik

2012 ◽  
Vol 19 (1) ◽  
pp. 72
Author(s):  
Nur Rahma Prihantini ◽  
Sri Lelyati C Masulili
Keyword(s):  
Periodontal Disease ◽  
Lupus Erythematosus ◽  
Dental Treatment ◽  
Systemic Disease ◽  
Oral Manifestations ◽  
Systemic Diseases ◽  
The Public ◽  
Public Purpose ◽  
Appropriate Treatment ◽  
Easy Bleeding

Background: Systematic disease is a risk factor in periodontal disease. In contrast, severe generalize periodontal disease may also contribute to the development of certain systemic diseases and has and adverse affect in controlling the systemic disease. The majority of systemic diseases manifest in the oral cavity, one of which is systemic Lupus Erythematosus (SLE)., anautoimmune chronic systemic diseases. To date, the etiology of Lupus Erythematosus is still not clear, but the prognosis can become good if the adequate theraphy is given. SLE have a fairly high incidence, but the dangers of this disease is still not widely understood by the public. Purpose: To demonstrate how to manage the oral manifestations of SLE, as it must be done carefully so that patients ca get appropriate treatment to be successful, and the patients with oral manifestations similar to SLE can have a more thorough axamination. Cases: Two patients with SLE and symptoms of easy bleeding gums, frequent stomatitis, dry mouth, and mobile teeth. In both cases, there is gingival hyperemia, edema, pockets of 3-6 mm (case 1) and 3-4 mm (case 2). Prior to dental treatment, both patients are consulted to an internist. Treatment: Periodontal initial treatment such as DHE, scaling, and tooth restorations. Gradual scaling done in multiple visits, followed by gingival curettage. Conclusion: A good periodontal treatment can reduce gingival inflammation, and relatively improve oral hygiene, so it can be expected to increase body immunity.

Pancytopenia: A Challenging Problem for Treating Physician

2018 ◽  
Vol 2 (01) ◽  
pp. 22-28
Author(s):  
Md. Rezaul Karim Chowdhury ◽  
Amina Begum ◽  
Md. Haroon Ur Rashid ◽  
Md. Kamrul Hasan
Keyword(s):  
Bone Marrow ◽  
Physical Examination ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
Bone Marrow Examination ◽  
Challenging Problem ◽  
Trephine Biopsy ◽  
Life Threatening ◽  
Underlying Pathology ◽  
Careful History

Pancytopenia is an important clinico-haematological entity and striking feature of many serious and life-threatening illnesses. Many haematological and non-haematological diseases involve the bone marrow primarily or secondarily and cause pancytopenia. Decrease in haemopoietic cell production, ineffective haemopoiesis and peripheral sequestration or destruction of the cells are the main pathophysiology of pancytopenia. The cause of pancytopenia thus may be lying in the bone marrow or in the periphery or both. Careful history, physical examination, simple blood work, review of the peripheral blood smear, sometimes bone marrow examination and trephine biopsy are required for diagnosis. Treatment and prognosis depend on the severity of pancytopenia and underlying pathology.

A Serological Storm

1970 ◽  
Vol 9 (2) ◽  
Author(s):  
Bertha Wong MD ◽  
Maria Bagovich MD ◽  
Ivan Blasutig PhD ◽  
Simon Carette MD MPhil
Keyword(s):  
Differential Diagnosis ◽  
Hepatitis C Virus ◽  
Immune System ◽  
Hepatitis C ◽  
Hcv Infection ◽  
Clinical Context ◽  
Autoantibody Profile ◽  
Life Threatening ◽  
Clinically Significant ◽  
Sensory Polyneuropathy

This article describes a patient presenting with a sensory polyneuropathy and multiple autoantibodies, leading to the diagnosis of hepatitis C virus (HCV) infection. His widely positive autoantibody profile in the absence of clinically significant rheumatic disease illustrates the importance of interpreting autoimmune serology in the appropriate clinical context and the concept of HCV being a non-specific activator of the immune system. In addition, it highlights the importance of considering untreated HCV infection in the differential diagnosis of rheumatic complaints, particularly if the workup reveals multiple autoantibodies, as HCV is a potentially severe and life-threatening disease, which can be appropriately managed with effective antiviral therapy.

scholarly journals Oral and Maxillo-Facial Manifestations of Systemic Diseases: An Overview

Medicina ◽  
2021 ◽  
Vol 57 (3) ◽  
pp. 271
Author(s):  
Saverio Capodiferro ◽  
Luisa Limongelli ◽  
Gianfranco Favia
Keyword(s):  
Early Diagnosis ◽  
Oral Cavity ◽  
Head And Neck ◽  
Clinical Outcomes ◽  
Systemic Disease ◽  
Clinical Manifestations ◽  
Systemic Diseases ◽  
Special Issue ◽  
Hard Tissues ◽  
Current Special Issue

Many systemic (infective, genetic, autoimmune, neoplastic) diseases may involve the oral cavity and, more generally, the soft and hard tissues of the head and neck as primary or secondary localization. Primary onset in the oral cavity of both pediatric and adult diseases usually represents a true challenge for clinicians; their precocious detection is often difficult and requires a wide knowledge but surely results in the early diagnosis and therapy onset with an overall better prognosis and clinical outcomes. In the current paper, as for the topic of the current Special Issue, the authors present an overview on the most frequent clinical manifestations at the oral and maxillo-facial district of systemic disease.

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