Comparison of nail lacquer clobetasol efficacy at 0,05%, 1% and 8% in nail psoriasis treatment: prospective, controlled and randomized pilot study

BACKGROUND: Nail psoriasis may affect up to 90% of patients with psoriasis in the course of the disease throughout their lives and it is often a therapeutic challenge to dermatologists. Topical treatments described in the literature have demonstrated variable efficacy, and unsatisfactory results have been associated to inefficient penetration of the active ingredient into the nail plate and proximal nail fold. Recently the use of clobetasol on nail lacquer vehicle has been suggested, with satisfactory results and no side effects. OBJECTIVE: To determine the efficacy and safety of clobetasol in nail lacquer vehicle in three concentrations (0.05%, 1% and 8%) in patients with nail psoriasis. METHODS: Prospective, controlled, randomized pilot study in fifteen patients with nail bed and/or nail matrix psoriasis in both hands, subdivided into three groups: A(0.05% clobetasol nail lacquer), B(1% clobetasol nail lacquer) and C(8% clobetasol nail lacquer). All groups used clobetasol nail lacquer on the left hand and base coat nail lacquer as control on the right, twice a week for 16 weeks. Clinical evaluation was done by photographic records and the NAPSI score of both treated and control hands, as well as modified NAPSI score of the most affected nail of the treated hand. RESULTS: Group C showed a statistically relevant clinical response compared to the other groups, reflected in the improvement of clinical parameters, of treated hand NAPSI score, when compared to the control hand, and modified NAPSI score of the most affected nail in the treated hand. CONCLUSION: The 8% clobetasol nail lacquer was effective and safe, and it can be considered a good option of topical therapy in the treatment of nail psoriasis.

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The Effect of Reflexology on Lactation in Women Who Had Cesarean Section: A Randomized Controlled Pilot Study

Complementary Medicine Research ◽

10.1159/000513924 ◽

2021 ◽

pp. 1-8

Author(s):

Sevde Aksu ◽

Pelin Palas Karaca

Keyword(s):

Pilot Study ◽

Cesarean Section ◽

Intervention Group ◽

Control Group ◽

Breast Pain ◽

Randomized Controlled ◽

Significant Difference ◽

The Right ◽

Documentation Tool ◽

And Control

Aim: The research was conducted as a randomized controlled pilot study to evaluate the effects of reflexology on lactation in mothers who delivered by cesarean section (CS). Methods: A single-blind randomized controlled experimental study was conducted with a total of 60 postpartum women in the reflexology application (n = 30) and control groups (n = 30). After the CS, the mothers in the control group were given approximately 3-h routine nursing care after recovering from the effects of anesthesia; the introductory information form was applied, and the Breastfeeding Charting System and Documentation Tool (LATCH) and visual analog scale (VAS) for the signs of the onset of lactation were implemented on the first and second days. Reflexology was applied to the women in the intervention group after an average of 3 h following the mother’s condition had become stable and she had recovered from the effects of anesthesia. Reflexology was applied a total of 20 min – 10 min for the right foot, 10 min for the left foot – twice a day with 8-h intervals on the first and second days after CS. After the last reflexology application, the LATCH and VAS for the signs of the onset of lactation were applied. Results: Of the women, 70% breastfed their babies within 60 min after delivery; 46.7% of the mothers received breastfeeding training and 81.7% needed support for breastfeeding after the CS. The LATCH breastfeeding scores of the women in the intervention group on both days were significantly higher compared to those of the women in the control group (p < 0.001). On the first day after the CS, apart from breast pain, there was no significant difference between the two groups in terms of breast heat and breast tension (p > 0.05). On the second day after the CS, apart from breast tension, there was no significant difference between the groups in terms of breast heat and breast pain (p < 0.05). In the study, women in the intervention group were found to have higher scores in terms of all three symptoms compared to the control group (p < 0.05). Conclusions: In the study, it was determined that LATCH scores and signs of the onset of breastfeeding increased in the mothers who received reflexology after CS.

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Right- and Left-hand Dominance in Navigation

Journal of Navigation ◽

10.1017/s0373463300026734 ◽

1972 ◽

Vol 25 (3) ◽

pp. 359-369

Author(s):

L. F. E. Coombs

Keyword(s):

Left Hand ◽

The Road ◽

Fine Control ◽

Sufficient Degree ◽

The Right ◽

Evolutionary Paths ◽

And Control ◽

Rule Making ◽

And Training ◽

Dominant Side

This is a survey of a subject for which there are few positive conclusions on the reasons for existing controls and control practices. The position of the operator of a vehicle or craft, the preferred side for the control or conning position and the ‘rules-of-the-road’ for land and water transport and also air transport seemed to have evolved through innate and conditioned human preferences such as ‘handedness’, through customs and traditions and, possibly to a lesser extent, by arbitrary rule making. In general, man is outwardly laterally symmetrical but has a dominant side and a preferred-hand. Within the majority of ethnic groups right-hand preferring people make up 90 per cent of a population. However, despite innate preferences about which there is inconclusive evidence and the influences of a ‘right-handed’ world imposed upon the maturing child, man can acquire through learning and training a sufficient degree of ambidexterity to operate effectively the controls of complex man/machine interfaces. As long as tools, vehicles and all other artifacts remained essentially simple to use or operate they could be controlled, governed or steered by either hand or by one hand—usually the preferred—or by both hands. However, the preferred hand with any of these combinations would ‘lead’ and would provide precision or ‘fine’ control. The introduction of writing and similar tasks requiring coordination of mind, hand and eye has always reinforced the ‘right-handed’ world. For convenience this survey is divided into three major evolutionary paths: sword, steering oar and left-hand circuit.

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Do the “Spreadability” and Finger Length of Cellists and Guitarists Change Due to Practice?

Medical Problems of Performing Artists ◽

10.21091/mppa.2000.1005 ◽

2000 ◽

Vol 15 (1) ◽

pp. 23-30

Author(s):

Renate Kloeppel

Keyword(s):

Teaching Methods ◽

Large Scale ◽

Control Group ◽

Left Hand ◽

Finger Length ◽

Left Elbow ◽

Comparison Groups ◽

The Right ◽

And Control

It is a widely held opinion among musicians that extreme joint positions increase the flexibility in the corresponding joints. There are also occasional views that extensive use of the fingers starting in childhood may lead to increased finger length. These opinions have implications for teaching methods; however, in spite of extensive examinations of the shapes of musicians’ hands, to date there have been almost no objective findings. There have been large-scale examinations of the angle of supination of the left elbow of violinists, with the finding that primarily genetic factors are responsible. In order to answer the question whether external factors can influence joint configurations of the hand as well as finger length, the active finger spreads and finger lengths of 210 subjects (cellists, guitarists, and control subjects) were measured. The working hypothesis was that there would be an increase in finger spread in the left hand fingers compared with the right if the frequent extreme positions taken on the fingerboard did in fact influence finger spread. The nonmusician control group, however, would not be expected to show this difference, or at least not to the same extent as in the musicians. Similar differences should apply to finger length, if this is influenced by long-term practicing on these instruments. A majority of the measurements of all three groups demonstrated a greater spreadability of the fingers of the left hand than of the right. In contrast to the comparison groups, there was a significantly greater span between the left hand index and small fingers of cellists. This span was not measured in the guitarists because it does not apply in their playing as it does for cellists. In addition, the measurements of the right-left differences in the finger lengths of the cellists when compared with the nonmusician group showed significantly longer fingers on the left than the right. This difference is probably caused by better-developed fingertips of the cellists. Further research is needed to discern whether the spreadability could be improved through specific training programs.

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Redistribution

10.1093/oso/9780190616847.003.0004 ◽

2017 ◽

Author(s):

Lora Deahl ◽

Brenda Wristen

Keyword(s):

Alternative Strategies ◽

Adaptive Approach ◽

Left Hand ◽

Power And Control ◽

Wide Range ◽

Piano Literature ◽

Specific Alternative ◽

The Right ◽

And Control

Chapter 4, the first of several chapters devoted to specific alternative strategies for small-handed players, shows how redistributing notes--taking notes with the left hand that are meant to be taken by the right, or the reverse--can mitigate or even eliminate problems caused by small handedness. To redistribute notes, the pianist must mentally reconfigure note distributions printed on the score and translate that information into action. The difficulty of this task may explain why redistribution is underutilized as an adaptive approach. Inventive solutions to common challenges found in a wide range of pedagogical and concert piano literature are presented. Specific areas of focus include: uncrossing parts; eliminating stretches in chords and arpeggios; facilitating leaps or hand shifts; increasing accuracy, power, and control; maintaining more neutral hand and wrist positions; facilitating trills and tremolos; maintaining legato and line; and projecting harmony.

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Laterality Differences for Speed but Not for Control in Sequential Finger Tapping

Perceptual and Motor Skills ◽

10.2466/pms.1988.67.3.927 ◽

1988 ◽

Vol 67 (3) ◽

pp. 927-933 ◽

Cited By ~ 2

Author(s):

Linda Z. Podbros ◽

Maria A. Wyke

Keyword(s):

Motor Activity ◽

Finger Tapping ◽

Cerebral Function ◽

Sequential Order ◽

Left Hand ◽

Right Hand ◽

The Right ◽

And Control ◽

Normal Adults ◽

Complex Movement

Multiple or sequential finger tapping is preferential to the dominant right hand with respect to speed. However, in more complex movement, variables other than speed become important. The present investigation uses a sequential finger-rapping task which permits assessment of between-hands differences with respect to rate and control of movement, with and without vision. 36 right-handed normal adults rapidly tapped their fingers in sequential order on a block (2.54 cm. sq.), trying not to move the block. Analyses of variance (mode × hand) performed for taps and shift of the block show the right hand to be faster than the left hand with and without vision, adding further to the notion that the left hemisphere predominates in increases in rapid movement and in sequencing aspects of motor activity. However, while both hands were steadier with vision than without, there were no between-hand differences with regard to control, suggesting equivalency of cerebral function for factors of manual sequencing other than speed.

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POSSIBILITIES AND PERSPECTIVES OF HUMAN TYPOLOGIES TAKING INTO ACCOUNT IN DENTISTRY

Wiadomości Lekarskie ◽

10.36740/wlek201905224 ◽

2019 ◽

Vol 72 (5) ◽

pp. 1079-1082

Author(s):

Julia V. Sidash ◽

Elena V. Tkachenko

Keyword(s):

Facial Expression ◽

Plastic Surgery ◽

Computer Modeling ◽

Left Hand ◽

Internal Locus ◽

Prosthetic Dentistry ◽

The Face ◽

Control Locus ◽

The Right ◽

And Control

Introduction: Such sciences as differential physiology, differential psychology, differential anatomy and chemistry are developed greatly nowadays. They deal to human typologies. The scientific works big amount concerning dentistry in this aspect allows speaking about differentiated dentistry. The aim: To assess control locus in the UMSA Ukrainian students dependently on their dominant extremity as well as to assess and to compare face asymmetry expression in the guys and girls from Egypt and Ukraine studying at different courses. Materials and methods: 50 Ukrainian students from dental faculty different courses in the 1st series of the experiments, 18 girls and 18 guys from Egypt and Ukraine in the 2nd series. Methods: - determining the dominant extremity and control locus by survey; - computer modeling for facial expression assessment. Results: 43 students (85%, p<0,01) independently on dominant extremity demonstrate control internal locus and only 7 people (comprising 15%, p<0,01), 6 people (90%, p<0,01) from which were left-handers and all ambidexters) – the external one. These were the 1st experimental series results. We received following results in the experiment second part. Faces of the students from Egypt, guys in bigger extent, were more asymmetrical. We were taking photos of the students and then were measuring longitudinal and transversal sizes of face right and left halves. 10 guys from Egypt (55,6%, p<0,01) and 5 girls from Ukraine (27,78%, p<0,01) were distinguished by bigger longitudinal and transversal sizes as well as looked less harmonic while coinciding the face left halves than the right ones that can be explained in part by primary usage of left side while masticating as well as left hand usage at writing (in part in the Egyptian guys). Conclusions: We consider that our work can have significance in Maxillary-Facial and Plastic Surgery, Transplantology, Orthopedy, Prosthetic Dentistry, Neurology as well as Cosmetology and Psychology.

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Calcipotriene 0.005%/Betamethasone Dipropionate 0.064% Foam as a Treatment for Nail Psoriasis

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.5.5.17 ◽

2021 ◽

Vol 5 (5) ◽

pp. 559-562

Author(s):

Shifa Akhtar ◽

Mariana Perez ◽

Jessica Sharma ◽

Agnese Canazza ◽

Martin Zaiac

Keyword(s):

Vitamin D ◽

Nail Plate ◽

Case Series ◽

Betamethasone Dipropionate ◽

Efficacy And Safety ◽

High Potency ◽

Nail Psoriasis ◽

Cosmetic Appearance ◽

Vitamin D Analog ◽

Vitamin D Analogue

Combination topical corticosteroids and vitamin D analog treatments for nail psoriasis are widely used in cream and ointment vehicles, but patients may prefer a foam vehicle due to ease of application and favorable cosmetic appearance. Calcipotriene 0.005%/betamethasone dipropionate 0.064% (Cal/BD) aerosol foam is an FDA approved therapy for plaque psoriasis, but may also be an effective treatment for nail psoriasis in a novel aerosol foam. We present a case series of 3 patients with mild to moderate nail psoriasis who responded positively to treatment with Cal/BD aerosol foam applied 1-2 times daily to affected nails for at least 6 weeks. Reduction of nail plate surface abnormalities and a decrease in inflammation of the nail folds were assessed with clinical evaluation and dermoscopy, and documented with serial photography. While further research on the efficacy and safety of Cal/BD aerosol foam as a treatment for nail psoriasis is needed, this report suggests its potential as a combination topical vitamin D analogue and high potency steroid in a foam vehicle.

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Improving Hand-Grip Strength and Blood Pressure in Adults: Results From an AgingPLUS Pilot Study

Innovation in Aging ◽

10.1093/geroni/igaa057.1966 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 587-587

Author(s):

Abigail Nehrkorn-Bailey ◽

Garrett Forsyth ◽

Barry Braun ◽

Kimberly Burke ◽

Manfred Diehl

Keyword(s):

Blood Pressure ◽

Pilot Study ◽

Grip Strength ◽

Linear Growth ◽

Hand Grip Strength ◽

Control Group ◽

Activity Data ◽

Left Hand ◽

Hand Grip ◽

The Right

Abstract Based on adult inactivity, a new intervention named AgingPLUS was created, targeting motivational barriers to physical activity. Data come from a pilot study (N = 116), with 56 participants randomized to the AgingPLUS group (Mage = 63.52 years, SD = 7.89 years), and 60 randomized to the active control group (Mage = 63.06 years, SD = 8.30 years). Multi-group linear growth curve analyses examined improvements in hand-grip strength and blood pressure from pretest (Week 0) to immediate (Week 4) and delayed posttest (Week 8). Findings showed that only participants in the AgingPLUS group had significant improvements in hand-grip strength for the right (B = 1.34, p < .001) and left hand (B = 1.73, p < .001), as well as significant reductions in systolic (B = -3.28, p < .05) and diastolic blood pressure (B = -1.92, p < .01). These findings provide support for the efficacy of AgingPLUS.

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A kézhigiénés technika vizsgálata elektronikus ellenőrző berendezés segítségével 26 magyarországi betegellátó intézményben

Orvosi Hetilap ◽

10.1556/650.2017.30792 ◽

2017 ◽

Vol 158 (29) ◽

pp. 1143-1148

Author(s):

Ákos Lehotsky ◽

Júlia Morvai ◽

László Szilágyi ◽

Száva Bánsághi ◽

Alíz Benkó ◽

...

Keyword(s):

Hand Hygiene ◽

Healthcare Workers ◽

Infection Prevention ◽

Electronic Devices ◽

Left Hand ◽

Right Hand ◽

Wide Range ◽

The Individual ◽

The Right ◽

And Control

Abstract: Introduction: Hand hygiene is probably the most effective tool of nosocomial infection prevention, however, proper feedback and control is needed to develop the individual hand hygiene practice. Aim: Assessing the efficiency of modern education tools, and digital demonstration and verification equipment during their wide-range deployment. Method: 1269 healthcare workers took part in a training organized by our team. The training included the assessment of the participants’ hand hygiene technique to identify the most often missed areas. The hand hygiene technique was examined by a digital device. Results: 33% of the participants disinfected their hands incorrectly. The most often missed sites are the fingertips (33% on the left hand, 37% on the right hand) and the thumbs (42% on the left hand, 32% on the right hand). Conclusion: The feedback has a fundamental role in the development of the hand hygiene technique. With the usage of electronic devices feedback can be provided efficiently and simply. Orv Hetil. 2017; 158(29): 1143–1148.

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Modulation of Cortical Activity During Different Imitative Behaviors

Journal of Neurophysiology ◽

10.1152/jn.00248.2002 ◽

2003 ◽

Vol 89 (1) ◽

pp. 460-471 ◽

Cited By ~ 184

Author(s):

Lisa Koski ◽

Marco Iacoboni ◽

Marie-Charlotte Dubeau ◽

Roger P. Woods ◽

John C. Mazziotta

Keyword(s):

Posterior Parietal Cortex ◽

Right Hemisphere ◽

Brain Activity ◽

Mirror Neuron ◽

Left Hand ◽

Right Hand ◽

Tightly Coupled ◽

Posterior Parietal ◽

The Right ◽

And Control

Imitation is a basic form of motor learning during development. We have a preference to imitate the actions of others as if looking in a mirror (specular imitation: i.e., when the actor moves the left hand, the imitator moves the right hand) rather than with the anatomically congruent hand (anatomic imitation: i.e., actor and imitator both moving the right hand). We hypothesized that this preference reflects changes in activity in previously described frontoparietal cortical areas involved in directly matching observed and executed actions (mirror neuron areas). We used functional magnetic resonance imaging to study brain activity in normal volunteers imitating left and right hand movements with their right hand. Bilateral inferior frontal and right posterior parietal cortex were more active during specular imitation compared with anatomic imitation and control motor tasks. Furthermore this same pattern of activity was also observed in the rostral part of the supplementary motor area (SMA-proper) of the right hemisphere. These findings suggest that the degree of involvement of frontoparietal mirror areas in imitation depends on the nature of the imitative behavior, ruling out a linguistic mediation of these areas in imitation. Moreover, activity in the SMA appears to be tightly coupled to frontoparietal mirror areas when subjects copy the actions of others.

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