scholarly journals Sedative antidepressants and insomnia

2011 ◽  
Vol 33 (1) ◽  
pp. 91-95 ◽  
Author(s):  
Walter André dos Santos Moraes ◽  
Patrick Rademaker Burke ◽  
Pablo Lorenzon Coutinho ◽  
Christian Guilleminault ◽  
Aline Gomes Bittencourt ◽  
...  
Keyword(s):  
Sleep Problems ◽  
Treatment Strategies ◽  
Antidepressant Drugs ◽  
Receptor Subtypes ◽  
Controlled Clinical Trials ◽  
Literature Searches ◽  
Treatment Of Depression ◽  
The Relationship ◽  
5Ht2 Receptor ◽  
Insomnia Symptoms

OBJECTIVE: The present review addresses the relationship between sleep and depression and how serotonergic transmission is implicated in both conditions. METHOD: Literature searches were performed in the PubMed and MedLine databases up to March 2010. The terms searched were "insomnia", "depression", "sedative antidepressants" and "serotonin". In order to pinpoint the sedative antidepressants most used to treat insomnia, 34 ISI articles, mainly reviews and placebo-controlled clinical trials, were selected from 317 articles found in our primary search. RESULTS: Sleep problems may appear months before the diagnosis of clinical depression and persist after the resolution of depression. Treatment of insomnia symptoms may improve this comorbid disease. Some antidepressant drugs can also result in insomnia or daytime sleepiness. Serotonin (5-HT) demonstrates a complex pattern with respect to sleep and wakefulness that is related to the array of 5-HT receptor subtypes involved in different physiological functions. It is now believed that 5HT2 receptor stimulation is subjacent to insomnia and changes in sleep organization related to the use of some antidepressants. CONCLUSION: Some drugs commonly prescribed for the treatment of depression may worsen insomnia and impair full recovery from depression. 5-HT2 receptor antagonists are promising drugs for treatment strategies since they can improve comorbid insomnia and depression.

scholarly journals Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1975
Author(s):  
Soraia Silva ◽  
Joana Bicker ◽  
Amílcar Falcão ◽  
Ana Fortuna
Keyword(s):  
Circadian Rhythms ◽  
Intracellular Signaling ◽  
Scientific Evidence ◽  
Antidepressant Drugs ◽  
Positive Influence ◽  
Drug Dosing ◽  
Signaling Systems ◽  
Treatment Of Depression ◽  
Target Molecules ◽  
The Relationship

Scientific evidence that circadian rhythms affect pharmacokinetics and pharmacodynamics has highlighted the importance of drug dosing-time. Circadian oscillations alter drug absorption, distribution, metabolism, and excretion (ADME) as well as intracellular signaling systems, target molecules (e.g., receptors, transporters, and enzymes), and gene transcription. Although several antidepressant drugs are clinically available, less than 50% of depressed patients respond to first-line pharmacological treatments. Chronotherapeutic approaches to enhance the effectiveness of antidepressants are not completely known. Even so, experimental results found until this day suggest a positive influence of drug dosing-time on the efficacy of depression therapy. On the other hand, antidepressants have also demonstrated to modulate circadian rhythmicity and sleep–wake cycles. This review aims to evidence the potential of chronotherapy to improve the efficacy and/or safety of antidepressants. It includes pre-clinical and clinical studies that demonstrate the relevance of determining the most appropriate time of administration for antidepressant drugs. In parallel, their positive influence on the resynchronization of disrupted circadian rhythms is also herein discussed. It is expected that this review will promote the investigation of chronotherapy for the treatment of depression, contribute to a better understanding of the relationship between antidepressants and circadian rhythms, and consequently promote the development of new therapeutics.

scholarly journals Management and Treatment of Human Lice

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Abdoul Karim Sangaré ◽  
Ogobara K. Doumbo ◽  
Didier Raoult
Keyword(s):  
Treatment Strategies ◽  
Review Literature ◽  
The Body ◽  
Controlled Clinical Trials ◽  
Pediculus Humanus ◽  
Literature Searches ◽  
New Treatment ◽  
High Standards ◽  
New Strategies

Of the three lice (head, body, and pubic louse) that infest humans, the body louse is the species involved in epidemics of louse-borne typhus, trench fever, and relapsing fever, but all the three cause pediculosis. Their infestations occur today in many countries despite great efforts to maintain high standards of public health. In this review, literature searches were performed through PubMed, Medline, Google Scholar, and EBSCOhost, with key search words of “Pediculus humanus”, “lice infestation”, “pediculosis”, and “treatment”; and controlled clinical trials were viewed with great interest. Removing lice by hand or with a lice comb, heating infested clothing, and shaving the scalp were some of the oldest methods of controlling human lice. Despite the introduction of other resources including cresol, naphthalene, sulfur, mercury, vinegar, petroleum, and insecticides, the numbers of lice infestation cases and resistance have increased. To date, viable alternative treatments to replace insecticides have been developed experimentallyin vitro. Today, the development of new treatment strategies such as symbiotic treatment and synergistic treatment (antibiotics + ivermectin)in vitrohas proved effective and is promising. Here, we present an overview on managing and treating human lice and highlight new strategies to more effectively fight pediculosis and prevent resistance.

Presence and Persistence of Sleep-Related Symptoms and Suicidal Ideation in Psychiatric Inpatients

Crisis ◽  
2014 ◽  
Vol 35 (6) ◽  
pp. 398-405 ◽  
Author(s):  
Michael R. Nadorff ◽  
Thomas E. Ellis ◽  
Jon G. Allen ◽  
E. Samuel Winer ◽  
Steve Herrera
Keyword(s):  
Risk Factor ◽  
Suicidal Ideation ◽  
Inpatient Treatment ◽  
Improve Method ◽  
Sleep Problems ◽  
Psychiatric Inpatients ◽  
Poor Sleep ◽  
Treatment Termination ◽  
Suicidal Patients ◽  
The Relationship

Background: Although sleep is an important risk factor for suicidal behavior, research has yet to examine the association between sleep problems and suicidality across the course of inpatient treatment. This study examined the relationship among sleep-related symptoms and suicidal ideation across inpatient treatment. Aims: To examine whether poor sleep at admission longitudinally predicts less improvement in suicidal ideation over the course of treatment. Further, to examine whether suicidal ideation is reduced in patients whose sleep does not improve. Method: The study utilized the Beck Depression Inventory (BDI)-II, which contains items measuring depressive symptoms, sleep-related symptoms, and suicidal ideation. The study sample consisted of 1,529 adult psychiatric inpatients. Patients were assessed at admission, biweekly, and at treatment termination. Results: Admission fatigue, loss of energy, and change in sleep pattern were associated with higher levels of suicidal ideation at admission and discharge. Fatigue at admission predicted suicidal ideation at termination independent of admission depression and suicidal ideation. Individuals whose sleep did not improve over the course of treatment had significantly higher suicidal ideation scores at termination relative to those whose sleep symptoms improved, after controlling for sleep, depression, and suicidal ideation scores at admission. Conclusion: These findings suggest that persistence of sleep-related symptoms warrants clinical attention in the treatment of suicidal patients.

The causal relationship between envy and depression: A cross-lagged regression analysis

2020 ◽  
Vol 48 (12) ◽  
pp. 1-9
Author(s):  
Xinsheng Jiang ◽  
Jinyu Wang
Keyword(s):  
Regression Analysis ◽  
Social Comparison ◽  
Causal Relationship ◽  
Undergraduate Students ◽  
Gender Effect ◽  
Comparison Theory ◽  
Treatment Of Depression ◽  
Nonclinical Sample ◽  
Upward Social Comparison ◽  
The Relationship

The causal relationship between envy and depression is currently far from clear. We conducted a cross-lagged regression analysis of data on envy and depression, obtained from a nonclinical sample of 260 undergraduate students at two time points spaced 14 months apart. From the perspective of social comparison theory, the results show that although after 14 months envy positively predicted depression, depression did not predict envy. The envy–depression relationship is, thus, a unidirectional causality. In addition, there was no overall gender effect on the relationship between envy and depression. Our finding of the effect of upward social comparison on the envy–depression relationship provides guidance for the treatment of depression in clinical practice.

Relationship between insomnia and tobacco smoking in alcohol-dependent patients

2017 ◽  
Vol 41 (S1) ◽  
pp. S398-S398
Author(s):  
A. Wnorowska ◽  
A. Jakubczyk ◽  
A. Klimkiewicz ◽  
A. Mach ◽  
K. Brower ◽  
...  
Keyword(s):  
Tobacco Use ◽  
Tobacco Smoking ◽  
Sleep Problems ◽  
Psychiatric Symptoms ◽  
Tobacco Dependence ◽  
Multivariate Regression Analysis ◽  
Brief Symptom Inventory ◽  
Study Group ◽  
The Relationship ◽  
Alcohol Dependent

IntroductionInsomnia and tobacco use are frequent and important problems in alcohol-dependent patients. However, the relationship between sleep problems and cigarette smoking was not thoroughly investigated in this population.AimThe purpose of the study was to investigate the relationship between tobacco smoking and severity of insomnia in alcohol-dependent patients in treatment. We also aimed at assessing other predictors of insomnia in this population.MethodsThe study group comprised 384 alcohol-dependent patients. Standardized tools were used to assess: tobacco dependence (Fagerström Test for Nicotine Dependence [FTND]), sleep problems (Athens Insomnia Scale [AIS]), severity of alcohol dependence (Michigan Alcohol Screening Test [MAST]) and drinking quantities before entering treatment (Timeline Follow Back [TFLB]). Other comorbid psychiatric symptoms were assessed using Brief Symptom Inventory (BSI) and Barratt's Impulsiveness Scale (BIS-11).ResultsThe study group included 79.1% of current smokers, 62% of participants reported insomnia (AIS). The mean FTND score was 6.05 ± 2.18. The multivariate regression analysis revealed that the severity of tobacco dependence was significantly associated with the severity of insomnia (FTND, beta = 0.140, P = 0.013). Other factors associated with insomnia that remained significant in multivariate model were severity of psychopathological symptoms (BSI, beta = 0.422, P < 0.0005) and intensity of drinking (TLFB, beta = 0.123, P = 0.034).ConclusionTobacco use may predict severity of insomnia in alcohol-dependent patients. This finding may have important clinical implications and influence strategies applied in treatment of alcohol use disorders.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals The Relationship between Adverse Childhood Experiences and Sleep Problems among Adolescent Students: Mediation by Depression or Anxiety

2020 ◽  
Vol 18 (1) ◽  
pp. 236
Author(s):  
E-Jin Park ◽  
Shin-Young Kim ◽  
Yeeun Kim ◽  
Dajung Sung ◽  
Bora Kim ◽  
...  
Keyword(s):  
Adverse Childhood Experiences ◽  
Sleep Problems ◽  
Short Form ◽  
Community Sample ◽  
Mediating Effect ◽  
Self Report ◽  
Depression And Anxiety ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
The Relationship

Adverse childhood experiences (ACEs) are known to be closely related to depression, anxiety and sleep problems. However, it remains unclear whether adolescents with ACEs have sleep problems regardless of depression or anxiety or under a mediating effect from depression or anxiety. Therefore, our aim was to examine whether depression or anxiety mediates the relationship between ACEs and sleep problems in adolescents by using a community sample. The Early Trauma Inventory Self Report–Short Form (ETISR-SF) and List of Threatening Experiences Questionnaire (LTE-Q) were used to assess traumatic ACEs. Ultimately, data from 737 students (M = 448, F = 289, 15.1 ± 1.4 years old) were included in the statistical analysis. A total of 576 (78.1%) participants reported that they had experienced one or more ACEs. Adolescents with ACEs had higher levels of depression, anxiety and sleep problems than did adolescents without ACEs, and boys tended to experience more trauma than girls. Depression and anxiety partially mediated the relationship between ACEs and sleep problems. The results of this study suggest the need for depression and anxiety interventions for adolescents with ACEs to reduce the long-term consequences, including sleep problems and physical health problems.

scholarly journals Firing responses mediated via distinct nicotinic acetylcholine receptor subtypes in rat prepositus hypoglossi nuclei neurons

2018 ◽  
Vol 120 (4) ◽  
pp. 1525-1533
Author(s):  
Yue Zhang ◽  
Yuchio Yanagawa ◽  
Yasuhiko Saito
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Firing Frequency ◽  
Membrane Properties ◽  
Receptor Subtypes ◽  
Nicotinic Acetylcholine ◽  
Firing Patterns ◽  
Prepositus Hypoglossi ◽  
Specific Antagonist ◽  
The Relationship

We previously reported that cholinergic current responses mediated via nicotinic acetylcholine (ACh) receptors (nAChRs) in the prepositus hypoglossi nucleus (PHN), which participates in gaze control, can be classified into distinct types based on different kinetics and are mainly composed of α7- and/or non-α7-subtypes: fast (F)-, slow (S)-, and fast and slow (FS)-type currents. In this study, to clarify how each current type is related to neuronal activities, we investigated the relationship between the current types and the membrane properties and the firing responses that were induced by each current type. The proportion of the current types differed in neurons that exhibited different afterhyperpolarization (AHP) profiles and firing patterns, suggesting that PHN neurons show a preference for specific current types dependent on the membrane properties. In response to ACh, F-type neurons showed either one action potential (AP) or multiple APs with a short firing duration, and S-type neurons showed multiple APs with a long firing duration. The firing frequency of F-type neurons was significantly higher than that of S-type and FS-type neurons. An α7-subtype-specific antagonist abolished the firing responses of F-type neurons and reduced the responses of FS-type neurons but had little effect on the responses of S-type neurons, which were reduced by a non-α7-subtype-specific antagonist. These results suggest that the different properties of the current types and the distinct expression of the nAChR subtypes in PHN neurons with different membrane properties produce unique firing responses via the activation of nAChRs. NEW & NOTEWORTHY Prepositus hypoglossi nucleus (PHN) neurons show distinct nicotinic acetylcholine receptor (nAChR)-mediated current responses. The proportion of the current types differed in the neurons that exhibited different afterhyperpolarization profiles and firing patterns. The nAChR-mediated currents with different kinetics induced firing responses of the neurons that were distinct in the firing frequency and duration. These results suggest that the different properties of the current types in PHN neurons with different membrane properties produce unique firing responses via the activation of nAChRs.

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