Mastectomy versus conservative surgical treatment: the impact on the quality of life of women with breast cancer

OBJECTIVES: to compare the impact of mastectomy and conservative surgery on the quality of life of patients with breast cancer. METHODS: an assessment was made of the quality of life of patients undergoing mastectomy or segmentary mastectomy, at the Pouso Alegre Clinical Hospital, in the Brazilian State of Minas Gerais, using SF-36. The patients were grouped by age (<50 years and >50 years) and years of schooling (<8 years and >8 years). The Mann-Whitney test was used to compare the groups with regard to the age and schooling domains of SF-36. RESULTS: a significant difference between the two groups was found in the domains of "physical functioning" (p=0.04) and "pain" (p=0.01): with the patients undergoing a mastectomy registering the worst scores. Young patients who had undergone a mastectomy displayed the worst quality of life in terms of "physical functioning" (p=0.03), "pain" (p=0.01) and "social functioning" (p=0.01); those undergoing conservative surgery aged over 50 years scored worst on "role emotional" (p=0.05). Patients undergoing a mastectomy with lower levels of schooling scored lower in "physical functioning" (p=0.01), "role physical" (p=0.05) and "pain" (p=0.05). Among those who had attended school for more than eight years, those having undergone a mastectomy scored less in the "pain" domain (p=0.04). CONCLUSIONS: patients who had undergone a mastectomy had worse results in the physical component of the evaluation of quality of life and this negative impact was more strongly felt among younger patients and those with lower levels of schooling.

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Quality of life during the first 6 months of interferon-b treatment in patients with MS

Multiple Sclerosis Journal ◽

10.1177/135245850000600508 ◽

2000 ◽

Vol 6 (5) ◽

pp. 338-342

Author(s):

J HA Arnoldus ◽

J Killestein ◽

L EMA Pfennings ◽

B Jelles ◽

B MJ Uitdehaag ◽

...

Keyword(s):

Quality Of Life ◽

Depressive Symptoms ◽

Side Effects ◽

Physical Functioning ◽

Bodily Pain ◽

Significant Linear Trend ◽

Role Physical ◽

Sf 36 ◽

The Impact

Objectives: To determine the quality of life (QoL) of MS patients during the initial 6 months of treatment with interferon-b (IFN-b). Furthermore, to determine whether changes in QoL relate to disability, emotional state, therapeutic expectations or side effect profile. Background: IFN-b has been shown to have beneficial effects on the course of MS. Since the aim of IFN-b treatment is not to cure but to slow down the disease it is important to know how this treatment affects QoL. Surprisingly, the impact of treatment with IFN-b on QoL measures has not been extensively studied so far. Methods: Case report documentation, including EDSS, SF-36 and MADRAS scores, of 51 relapsing-remitting MS patients treated with IFN-b was obtained at baseline and at months 1, 3 and 6. Patients also filled in a form about their expectations of therapy and a questionnaire on side effects. Results: During treatment there was a significant linear trend indicating improvement in the role-physical functioning (RPF) scale of the SF-36 (F1,50=4.9, P=0.032). A transient decrease at month 1 was found in the scale for bodily pain, indicating more experienced pain (F1,50=19.8, P50.001). Subgroup analysis showed that patients with most depressive symptoms on the MADRAS at baseline contributed most to the increase in RPF scores over time (F1,24=5,6 P=0.026). Furthermore, we found associations between adverse event scores and several domains of QoL. Conclusions: Our findings suggest that IFN-b therapy has an impact on QoL of MS patients in that it improves role-physical functioning and transiently worsens experienced bodily pain. QoL during treatment with IFN-b is influenced by depressive symptoms at baseline as well as by treatment-associated side-effects.

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Impact of Comorbidities on Quality Of Life in Breast Cancer Patients

Indian Journal of Cardiovascular Disease in Women WINCARS ◽

10.1055/s-0038-1656491 ◽

2016 ◽

Vol 01 (04) ◽

pp. 025-028

Author(s):

Monica Irukulla ◽

Rama Vaghmare ◽

Deepa Joseph ◽

Syed Ahmed ◽

Jyothi Jonnadula ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Patients ◽

Physical Functioning ◽

Bodily Pain ◽

Evidence Base ◽

Breast Cancer Patients ◽

Co Morbidity ◽

The Impact

AbstractIntroduction: Comorbidities are common among cancer patients and with an aging population are becoming more prevalent. These can potentially affect the stage at diagnosis, treatment and outcomes of people with cancer. Despite the intimate relationship between comorbidity and cancer, there is limited consensus on how to record, interpret or manage comorbidities in the context of cancer. Addressing the impact of comorbid conditions in cancer patients warrants improvement in the evidence base from which to make treatment decisions for those with comorbidities.Methods: In this prospective study, 64 patients with breast cancer, underwent QOL assessment using FACT –B questionnaire at three time points- pre-radiation and three and six months post radiation.Results: 29(46%) patients had comorbidities of which 23 (35%) had cardiovascular comorbidities and 6 had other comorbidities. The co-morbidities were negatively associated with multiple domains of quality of life, including physical functioning, general health, bodily pain. Patients with diabetes and hypertension had significantly lower scores in physical functioning in comparison to patients without diabetes and hypertension, but improved after treatment. In majority of patients the overall scores were less in patients with co-morbidities compared to patients without any co-morbidity.Conclusion: Comorbidities can significantly affect the quality of life in patients with comorbidities. Hence greater research into the QOL issues for better patient care and symptom management especially during the transitioning phase from active care to follow up will help clinicians improve the quality of care and interdisciplinary co-ordination.

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Quality of Life in Patients with Psoriasis Seen in the Department of Dermatology, Antananarivo, Madagascar

BioMed Research International ◽

10.1155/2020/9292163 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

Fandresena Arilala Sendrasoa ◽

Naina Harinjara Razanakoto ◽

Volatantely Ratovonjanahary ◽

Onivola Raharolahy ◽

Irina Mamisoa Ranaivo ◽

...

Keyword(s):

Quality Of Life ◽

Negative Impact ◽

Young Patients ◽

The Body ◽

University Hospital ◽

Medical Decision ◽

Cross Sectional ◽

The Difference ◽

The Impact

Background. Psoriasis is a chronic, inflammatory, and multifactorial dermatosis that impairs quality of life (QoL). Health-related QoL has become an important element in medical decision-making along with the effectiveness and the harmlessness of the treatments. Objective. To assess the impact of psoriasis in the QoL of patients with psoriasis by using the DLQI scales. Methods. A cross-sectional study from January to June 2018 was conducted in the Department of Dermatology of the University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar, including patients more than 18 years old with mild to severe psoriasis. The severity of psoriasis was assessed using the “Psoriasis Area and Severity Index (PASI)”. QoL of patients with psoriasis was evaluated by using the DLQI scales. Results. 80 patients were included, their mean age was 36.5 years, and the male to female was 1.5 : 1. The mean DLQI score was 13.8. Symptoms, feelings, and psychic were the most altered dimensions. QoL was impaired in young patients, single, having medium level education. Even though patients with disease duration more than 5 years had higher DLQI score than other patients, the difference was not statistically significant (p=0.36). Furthermore, the clinical presentation of psoriasis did not influence the patient’s QoL (p=0.73). Patients with nail involvement had QoL impaired but the difference with another localization was not statistically significant (p=0.2). The quality of life was influenced by body area involved. The higher the body surface area involved, the more QoL is impaired (p=0.002). Furthermore, the higher the PASI, the more QoL is altered (p=0.002). Conclusion. Psoriasis has a negative impact in the quality of life in Malagasy patients with psoriasis, especially in younger and single patients. Worse quality of life is correlated to severity of psoriasis.

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Assessment of anxiety and quality of life in fibromyalgia patients

Sao Paulo Medical Journal ◽

10.1590/s1516-31802004000600005 ◽

2004 ◽

Vol 122 (6) ◽

pp. 252-258 ◽

Cited By ~ 53

Author(s):

Tathiana Pagano ◽

Luciana Akemi Matsutani ◽

Elisabeth Alves Gonçalves Ferreira ◽

Amélia Pasqual Marques ◽

Carlos Alberto de Bragança Pereira

Keyword(s):

Quality Of Life ◽

Outpatient Service ◽

Test Group ◽

Control Group ◽

Control Groups ◽

Sf 36 ◽

Significant Difference ◽

And Control ◽

The Impact

CONTEXT: Fibromyalgia is a syndrome characterized by chronic, diffuse musculoskeletal pain, and by a low pain threshold at specific anatomical points. The syndrome is associated with other symptoms such as fatigue, sleep disturbance, morning stiffness and anxiety. Because of its chronic nature, it often has a negative impact on patients' quality of life. OBJECTIVE: To assess the quality of life and anxiety level of patients with fibromyalgia. TYPE Of STUDY: Cross-sectional. SETTING: Rheumatology outpatient service of Hospital das Clínicas (Medical School, Universidade de São Paulo). METHODS: This study evaluated 80 individuals, divided between test and control groups. The test group included 40 women with a confirmed diagnosis of fibromyalgia. The control group was composed of 40 healthy women. Three questionnaires were used: two to assess quality of life (FIQ and SF-36) and one to assess anxiety (STAI). They were applied to the individuals in both groups in a single face-to-face interview. The statistical analysis used Student's t test and Pearson's correlation test (r), with a significance level of 95%. Also, the Pearson chi-squared statistics test for homogeneity, with Yates correction, was used for comparing schooling between test and control groups. RESULTS: There was a statistically significant difference between the groups (p = 0.000), thus indicating that fibromyalgia patients have a worse quality of life and higher levels of anxiety. The correlations between the three questionnaires were high (r = 0.9). DISCUSSION: This study has confirmed the efficacy of FIQ for evaluating the impact of fibromyalgia on the quality of life. SF-36 is less specific than FIQ, although statistically significant values were obtained when analyzed separately, STAI showed lower efficacy for discriminating the test group from the control group. The test group showed worse quality of life than did the control group, which was demonstrated by both FIQ and SF-36. Even though STAI was a less efficient instrument, it presented significant results, showing that fibromyalgia patients presented higher levels of anxiety, both on the state and trait scales. Thus, patients with fibromyalgia had higher levels of tension, nervousness, preoccupation and apprehension, and higher propensity towards anxiety. CONCLUSION: The three instruments utilized showed efficiency in evaluating fibromyalgia patients. FIQ was found to be the most efficient instrument for discriminating and assessing the impact of fibromyalgia on their quality of life. It can be concluded that such patients have a worse quality of life and higher levels of anxiety.

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Comorbid Migraine is Associated with a Negative Impact on Quality of Life in Patients with Major Depression

Cephalalgia ◽

10.1111/j.1468-2982.2005.00985.x ◽

2006 ◽

Vol 26 (1) ◽

pp. 26-32 ◽

Cited By ~ 29

Author(s):

C-I Hung ◽

C-Y Liu ◽

J-L Fuh ◽

Y-Y Juang ◽

S-J Wang

Keyword(s):

Quality Of Life ◽

Negative Impact ◽

Short Form ◽

Physical Symptom ◽

Sf 36 ◽

Related Quality ◽

Health Related ◽

And Gender ◽

The Impact

This study investigated the impact of migraine on health-related quality of life (HRQoL) among patients with major depressive disorder (MDD). We prospectively enrolled 151 consecutive psychiatric out-patients meeting DSM-IV criteria for MDD. Migraine and other headache types were diagnosed based on the International Classification of Headache Disorders, 2nd edition (2004). The Short Form-36 (SF-36) was administered as a generic instrument of HRQoL. Among 151 patients with MDD, migraine ( N = 73, 48.3%) was very common. Comorbidity of migraine predicted a significantly negative impact on all physical subscales and vitality but not on the other mental subscales of the SF-36 after controlling for depression, age and gender. The presence of migraine should be considered as an important physical symptom in clinic-based MDD samples. Simultaneous management of depression and severe headaches, especially migraine, might improve HRQoL in patients with MDD.

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Vibration disease: quality of life

Sanitarnyj vrač (Sanitary Inspector) ◽

10.33920/med-08-2005-02 ◽

2020 ◽

pp. 24-31

Author(s):

Sergey Babanov ◽

Nataliya Tatarovskaya

Keyword(s):

Quality Of Life ◽

Physical Functioning ◽

The Body ◽

Systemic Effects ◽

Local Vibration ◽

Vibration Disease ◽

Sf 36 ◽

The Impact

The article presents data on the impact of vibration disease on the quality of life of patients. The main changes in the quality of life parameters of patients based on the results of the study using the SF-36 questionnaire are described. The quality of life of patients with various types of vibration disease is compared. It is established that industrial vibration (both General and local) in addition to the classical changes characteristic of vibration disease from exposure to local vibration (WBL), vibration disease from exposure to vibration (VBOW) first and second degrees (vascular, neurological) substantially violates the quality of life of patients, with the most pronounced changes are characteristic for WBOW, which confirms the systemic effects of vibration and its effects on the body working. The quality of life of sick WIDOWS is significantly reduced, although significant differences are observed only on the scales of «physical functioning» and «physical component of health».

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Assessment of Quality of Life in MA.17: A Randomized, Placebo-Controlled Trial of Letrozole After 5 Years of Tamoxifen in Postmenopausal Women

Journal of Clinical Oncology ◽

10.1200/jco.2005.11.181 ◽

2005 ◽

Vol 23 (28) ◽

pp. 6931-6940 ◽

Cited By ~ 167

Author(s):

Timothy J. Whelan ◽

Paul E. Goss ◽

James N. Ingle ◽

Joseph L. Pater ◽

Dongsheng Tu ◽

...

Keyword(s):

Quality Of Life ◽

Bodily Pain ◽

Response Analysis ◽

Life Questionnaire ◽

Change Scores ◽

Estrogen Synthesis ◽

Sf 36 ◽

Significant Difference ◽

The Impact

Purpose To evaluate the impact of letrozole compared with placebo after adjuvant tamoxifen on quality of life (QOL) in the MA.17 trial. Methods Patients completed the Short Form 36-item Health Survey (SF-36) and the Menopause Specific Quality of Life Questionnaire (MENQOL) at baseline, 6 months, and annually. Mean change scores from baseline were compared between groups for summary measures and domains. A response analysis compared the proportion of patients who demonstrated an important change in QOL. Results Of 5,187 randomly assigned women in the trial, 3,612 (69.9%) participated in the QOL substudy: 1,799 were allocated to placebo and 1,813 were allocated to letrozole. No differences were seen between groups in mean change scores from baseline for the SF-36 physical and mental component summary scores at 6, 12, 24, and 36 months. Small (< 0.2 standard deviations) but statistically significant differences in mean change scores from baseline were seen for the SF-36 domains of physical functioning (12 months), bodily pain (6 months) and vitality (6 and 12 months), and the MENQOL vasomotor (6, 12, and 24 months) and sexual domains (12 and 24 months). On the response analysis, a significant difference was seen between groups for the bodily pain domain (percentage of patients reporting a worsening of QOL, 47% placebo v 51% letrozole; P = .009) and the vasomotor domain (22% placebo v 29% letrozole; P = .001). Conclusion Letrozole did not have an adverse impact on overall QOL. Small effects were seen in some domains consistent with a minority of patients experiencing changes in QOL compatible with a reduction in estrogen synthesis.

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Health related quality of life in COVID-19 survivors discharged from acute hospitals: results of a short-form 36-item survey

F1000Research ◽

10.12688/f1000research.50781.1 ◽

2021 ◽

Vol 10 ◽

pp. 282

Author(s):

Alessia Saverino ◽

Eva Zsirai ◽

Raphael Sonabend ◽

Lorenza Gaggero ◽

Isabella Cevasco ◽

...

Keyword(s):

Quality Of Life ◽

Physical Functioning ◽

Short Form ◽

Health Related Quality ◽

Short Form 36 ◽

Sf 36 ◽

Related Quality ◽

Health Related ◽

The Impact

Background: Health-related quality of life (HRQL) is important for evaluating the impact of a disease in the longer term across the physical and psychological domains of human functioning. The aim of this study is to evaluate HRQL in COVID-19 survivors in Italy using the short form 36-items questionnaire (SF-36). Methods: This is an observational study involving adults discharged home following a coronavirus disease 2019 (COVID-19)-related hospital admission. Baseline demographic and clinical data including the Cumulative Illness Rating Scale (CIRS) and the Hospital Anxiety and Depression Scale (HADS) were collected. The validated Italian version of SF-36 was administered cross-sectionally. The SF-36 contains eight scales measuring limitations in physical and social functioning, the impact on roles and activities, fatigue, emotional well-being, pain and general health perception. Results: A total of 35 patients, with a mean age of 60 years, completed the SF-36. The results showed difficulties across the physical and psychological domains, particularly affecting the return to previous roles and activities. A higher burden of co-morbidities as well as a more severe muscle weakness was associated to a lower physical functioning. Younger age, rather than older, correlated to a perceived greater limitation in physical functioning and vitality. Conclusions: COVID-19 survivors particularly the ones of working age may need support for resuming their premorbid level of functioning and returning to work.

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Differences in Multi-Faceted Lifestyles in Response to the COVID-19 Pandemic and Their Association with Depression and Quality of Life of Older Adults in South Korea: A Cross-Sectional Study

Nutrients ◽

10.3390/nu13114124 ◽

2021 ◽

Vol 13 (11) ◽

pp. 4124

Author(s):

Kang-Hyun Park ◽

Ah-Ram Kim ◽

Min-Ah Yang ◽

Ji-Hyuk Park

Keyword(s):

Quality Of Life ◽

Older Adults ◽

South Korea ◽

Negative Impact ◽

World Health ◽

Cross Sectional ◽

Significant Difference ◽

The World ◽

The Impact

Background: The World Health Organization declared COVID-19 a global pandemic on 11 March 2020, due to the number of newly reported confirmed cases and the rapid increase in deaths. Therefore, countries around the world limited their population to policies such as “social distancing” or “staying at home” to prevent the spread of the virus. The purpose of this study was to evaluate differences in lifestyle pre and post the outbreak COVID-19 among older adults in South Korea and to identify the impact of lifestyle differences on depression and quality of life. Methods: An online single questionnaire covering sociodemographic data, lifestyle details, depression status, and quality of life level was distributed using mailing lists and social media. To assess lifestyles differences in older people pre and post the outbreak of COVID-19 pandemic, the online single questionnaire was used post COVID-19 pandemic. Based on the participants’ memories, they responded lifestyles at two time points (pre and post COVID-19 pandemic). Results: The results showed that there was a significant decrease in physical activity and activity participation during the pandemic. In terms of nutrition, there was no statistically significant change pre and post the outbreak COVID-19, except for the intake of protein, fat, and vitamins. Additionally, the results showed that the resulting lifestyle differences seem to have had a negative impact on depression and quality of life among older adults in South Korea. Conclusion: There was a significant difference the lifestyle patterns among the participants in South Korea between the current period and pre COVID-19 pandemic. Additionally, it is observed that these differenced lifestyles were associated with depression and quality of life among the participants. Our findings may help to develop public health programs that support healthy lifestyles in pandemic conditions.

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TENDENCY TO BRUXISM IN PHYSIOTHERAPY TEACHERS AND CONSEQUENCES IN THE QUALITY OF LIFE

Manual Therapy Posturology & Rehabilitation Journal ◽

10.17784/mtprehabjournal.2016.14.443 ◽

2020 ◽

pp. 1-5

Author(s):

Joelma Magalhães da Costa ◽

Aline de Carvalho Santos ◽

Renata Bezerra Braga ◽

Tairine Correa de Melo ◽

Raisa Seabra Carvalho ◽

...

Keyword(s):

Quality Of Life ◽

Negative Impact ◽

Statistical Significance ◽

Female Gender ◽

Life Questionnaire ◽

Self Perception ◽

Cross Sectional ◽

Sf 36 ◽

Significant Difference

Introduction: Bruxism is characterized by the parafunctional act of tightening or grinding the teeth, which may occur in a conscious or unconscious way, during sleep or in wakefulness. It has become a growing concern in recent years due to its negative impact on quality of life (QOL) and also because it is considered an important risk factor for temporomandibular disorders. Objective: This study aimed to evaluate the QOL related to bruxism in physiotherapy teachers from a private institution through a questionnaire and their perception for such parafunction. Method: A cross-sectional, quantitative and exploratory study. The self-perception of bruxism was assessed through three questions from the Fonseca Anamnestic Indexand the perspective of QLV through the Quality of Life Questionnaire (SF-36), with a sample of 38 teachers of both genders. Results: Based on the results found, the level of statistical significance was set at p<0,05 for all tests. Among the 38 interviewees, 47,4% (n = 18) of professionals were observed with bruxism, with a higher prevalence in the female gender. Regarding the comparisons of QOL in relation to bruxism, a statistically significant difference was found in relation to the dimension of Pain (p=0,014), in which the mean for the bruxism group was (59,8) and without bruxism (78,5). Conclusion: There is a relation of the bruxism with the quality of life of the interviewees, and this habit mainly interferes in the domain of pain. Another aspect that was shown to be significantly associated with bruxism was nervous tension, in which the tense and nervous professionals were associated with self-perception of bruxism.

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