Prevalence of oral hemangioma, vascular malformation and varix in a Brazilian population

Hemangioma, vascular malformation and varix are benign vascular lesions, common in the head and neck regions. Studies about the prevalence of these lesions in the oral cavity are scarce. The aim of this study was to estimate the prevalence of and to obtain clinical data on oral hemangioma, vascular malformation and varix in a Brazilian population. Clinical data on those lesions were retrieved from the clinical forms from the files of the Oral Diagnosis Service, School of Dentistry, Federal University of Minas Gerais, Brazil, from 1992 to 2002. Descriptive analysis was performed. A total of 2,419 clinical forms in the 10-year period were evaluated, of which 154 (6.4%) cases were categorized as oral hemangioma, oral vascular malformation or oral varix. Oral varix was the most frequent lesion (65.6%). Females had more oral hemangioma and oral varix than males. Oral vascular malformation and oral varix were more prevalent in the 7th and 6th decades, respectively. Oral hemangioma and oral varix were more prevalent in the ventral surface of the tongue and oral vascular malformation, in the lips. Oral hemangioma was treated with sclerotherapy (54.5%), and vascular malformation was managed with sclerotherapy and surgery (19.4% each). The data of this study suggests that benign vascular lesions are unusual alterations on the oral mucosa and jaws.

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Immunohistochemical expression of endocan, as a marker of assessment of angiogenic potential in benign vascular lesions (hemangioma, lymphangioma and lobular capillary hemangioma) of head and neck region

Journal of Baghdad College of Dentistry ◽

10.26477/jbcd.v30i4.2556 ◽

2018 ◽

Vol 30 (4) ◽

pp. 61-64

Author(s):

Jawaher M Tater ◽

Bashar H Abdullah ◽

Wisam A Hussain

Keyword(s):

Endothelial Cell ◽

Head And Neck ◽

Vascular Malformation ◽

Neck Region ◽

Pyogenic Granuloma ◽

Capillary Hemangioma ◽

Vascular Lesions ◽

Lobular Capillary Hemangioma ◽

Head And Neck Region ◽

Angiogenic Potential

BACKGROUND: Vascular tumors are a heterogeneous group of diseases with biological behavior ranging from a hamartomatous growth to frank malignant. The pathophysiology of lymphangioma, vascular malformation and hemangioma is interconnected, blood vessels known to be the site of origin of hamartomas, venous malformations and some neoplasms as benign, tumor-like growth of vessels (hemangiomas). Angiogenesis is the process of formation of new blood vessels from an existing structure. Aims of study Assessment of angiogenic potential in benign vascular lesions (hemangioma, lymphangioma and lobular capillary hemangioma) of head and neck region. Materials and Methods: Twenty-two formalin-fixed paraffin-embedded tissue blocks of Hemangioma/vascular malformation, thirty of lobular capillary hemangioma and another twenty of lymphangioma to be stained with Endothelial cell-Specific Molecule-1 (ESM-1) monoclonal antibody. Results: Microvessel density expressed by Endothelial cell-Specific Molecule-1 (ESM-1) immunomarker was found in all cases with mean density of (37.44±23.16) for lobular capillary hemangioma and (25.02±13.89) for hemangioma and (6.34±3.52) for lymphangioma. According to post hoc test ESM-1 marker expression showed a high significant difference between (hemangioma and lymphangioma=0.001), (lymphangioma, pyogenic granuloma=0.000), and it was significantly different between (hemangioma, pyogenic granuloma=0.011) Conclusions: The obvious capillary growth in lobular capillary hemangioma revealed that lobular capillary hemangioma showed the highest activity of angiogenic potential in comparison to hemangioma and lymphangioma.

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Squamous cell carcinomas of the head and neck: descriptive analysis of 1293 cases

The Journal of Laryngology & Otology ◽

10.1017/s0022215100137843 ◽

1997 ◽

Vol 111 (6) ◽

pp. 531-535 ◽

Cited By ~ 12

Author(s):

Sevgi Y. Kurtulmaz ◽

Haldun Ş. Erkal ◽

Meltem Serin ◽

Atilla H. Elhan ◽

Ahmet Çakmak

Keyword(s):

Oral Cavity ◽

Head And Neck ◽

Squamous Cell ◽

Primary Tumour ◽

Descriptive Analysis ◽

Female Ratio ◽

T Stage ◽

Medical Reports ◽

Advanced Stages ◽

Male To Female

AbstractMedical reports of 1293 patients with squamous cell carcinoma (SCC) of the head and neck were retrospectively evaluated. The patients were classified according to their age, sex, primary tumour localization and tumoral stage. There were 1181 males (91.3 per cent) and 112 females (8.7 per cent), with a male to female ratio of 10.5:1. The peak incidences for all primary tumour localizations were observed in the fifth decade. Most common primary tumour localizations were the larynx (71.1 per cent), the nasopharynx (10.1 per cent) and the oral cavity (8.8 per cent). Of all patients in whom staging was complete, 43.1 per cent presented at early and 56.9 per cent at advanced stages. The proportion of patients presenting with metastatic neck nodes was 34.4 per cent and the incidence of metastatic neck nodes increased with increasing T stage. The supraglottic region was the most common primary site among all laryngeal SCC, with a supraglottic to glottic SCC ratio of 1.5:1. Glottic SCC presented at earlier stages compared to supraglottic SCC. The incidence of nodal metastases increased with increasing T stage for SCC of the larynx, the oral cavity and the oropharynx.

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Oral and Maxillo-Facial Manifestations of Systemic Diseases: An Overview

Medicina ◽

10.3390/medicina57030271 ◽

2021 ◽

Vol 57 (3) ◽

pp. 271

Author(s):

Saverio Capodiferro ◽

Luisa Limongelli ◽

Gianfranco Favia

Keyword(s):

Early Diagnosis ◽

Oral Cavity ◽

Head And Neck ◽

Clinical Outcomes ◽

Systemic Disease ◽

Clinical Manifestations ◽

Systemic Diseases ◽

Special Issue ◽

Hard Tissues ◽

Current Special Issue

Many systemic (infective, genetic, autoimmune, neoplastic) diseases may involve the oral cavity and, more generally, the soft and hard tissues of the head and neck as primary or secondary localization. Primary onset in the oral cavity of both pediatric and adult diseases usually represents a true challenge for clinicians; their precocious detection is often difficult and requires a wide knowledge but surely results in the early diagnosis and therapy onset with an overall better prognosis and clinical outcomes. In the current paper, as for the topic of the current Special Issue, the authors present an overview on the most frequent clinical manifestations at the oral and maxillo-facial district of systemic disease.

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Ultrasound‐guided fine needle aspiration cytology of angiosarcoma of head and neck: a review of cytomorphologic features and discussion of diagnostic pitfall of aspiration cytology of vascular lesions

Diagnostic Cytopathology ◽

10.1002/dc.24767 ◽

2021 ◽

Author(s):

Binny Khandakar ◽

Hua Chen

Keyword(s):

Head And Neck ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

Vascular Lesions ◽

Ultrasound Guided ◽

Aspiration Cytology ◽

Fine Needle ◽

Diagnostic Pitfall ◽

Needle Aspiration Cytology

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Neoadjuvant immunotherapy in resectable head and neck cancer: oral cavity carcinoma as a potential research model

Therapeutic Advances in Medical Oncology ◽

10.1177/1758835920984061 ◽

2021 ◽

Vol 13 ◽

pp. 175883592098406

Author(s):

Vanesa Gutiérrez Calderón ◽

Alexandra Cantero González ◽

Laura Gálvez Carvajal ◽

Yolanda Aguilar Lizarralde ◽

Antonio Rueda Domínguez

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Head And Neck ◽

Surgical Resection ◽

Squamous Cell ◽

Immune Checkpoint ◽

Immune Checkpoint Inhibitors ◽

Checkpoint Inhibitors ◽

Research Model

Squamous cell carcinoma of oral cavity (OCSCC) accounts for approximately 25% of cases of head and neck squamous cell carcinoma (HNSCC). Tobacco and alcohol consumption are the main risk factors for both cancers. Surgical resection, combined with adjuvant radiotherapy or radiochemotherapy in patients with high risk of relapse, is the key element in management in the initial stages. However, despite the availability of aggressive multidisciplinary treatments, advanced resectable OCSCC carries poor prognosis; only half of the patients are disease-free 5 years after the surgery. Immunotherapy based on the use of immune checkpoint inhibitors has been proven to be effective in a wide variety of tumours, including recurrent and metastatic HNSCC. These positive results resulted in investigations into its effectiveness in earlier stages of the disease with OCSCC emerging as an interesting research model because of the accessible location of the tumours. This article reviews the potential advantages of emerging immunotherapeutic agents [mainly monoclonal antibodies against programmed cell death-1 ( PD-1) immune checkpoint inhibitors] as neoadjuvant treatment for OCSCC at locoregional stages as well as the ongoing clinical trials, challenges in evaluating tumour response, and possible predictive biomarkers of response with highlights regarding the role of oral microbiota as modulators of immune response. The efficacy and safety of anti- PD-1 drugs in these patients have been proven in preliminary trials. If there is a decrease in the relapse rate and an improvement in the overall survival after surgical resection in ongoing trials, preoperative immunotherapy may be established as a treatment option for patients with early stages of the disease.

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Cutaneous and hepatic vascular lesions due to a recurrent somatic GJA4 mutation reveal a pathway for vascular malformation

Human Genetics and Genomics Advances ◽

10.1016/j.xhgg.2021.100028 ◽

2021 ◽

pp. 100028

Author(s):

Nelson Ugwu ◽

Lihi Atzmony ◽

Katharine Ellis ◽

Gauri Panse ◽

Dhanpat Jain ◽

...

Keyword(s):

Vascular Malformation ◽

Vascular Lesions

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Human Papillomavirus in Various Lesions of the Head and Neck

Otolaryngology ◽

10.1177/019459988509300310 ◽

1985 ◽

Vol 93 (3) ◽

pp. 342-346 ◽

Cited By ~ 18

Author(s):

Melvin Strauss ◽

A. Bennett Jenson

Keyword(s):

Human Papillomavirus ◽

Oral Cavity ◽

Head And Neck ◽

Adult Onset ◽

Childhood Onset ◽

Oncogenic Potential ◽

Suggestive Evidence ◽

Malignant Lesions ◽

Epithelial Lesions

The association of human papillomavirus with benign and malignant epithelial lesions of the head and neck has been studied by a peroxidase-antiperoxidase technique having immunospecificity against genus-specific structural antigens of the papillomaviruses. More than 360 specimen blocks from 144 patients were evaluated. There was evidence of human papillomavirus antigen in three out of eight patients with childhood-onset laryngeal papillomas (37.5%) and in four out of eight patients with adult-onset papillomas (50%). A patient with an unusual flat, wartlike lesion appearing as an oral cavity leukoplakia had detectable papillomavirus antigen in it. None of the 13 cases of inverting papilloma or any of the malignant lesions studied showed evidence for the presence of papillomavirus antigen. There is currently only suggestive evidence for the oncogenic potential of human papillomavirus in the head and neck.

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Re: Photodynamic therapy in the treatment of multiple primary tumours in the head and neck, located to the oral cavity and oropharynx

Clinical Otolaryngology ◽

10.1111/j.1749-4486.2008.01608.x ◽

2008 ◽

Vol 33 (2) ◽

pp. 159-160

Author(s):

A.R. Anderson ◽

N.D. Stafford

Keyword(s):

Photodynamic Therapy ◽

Oral Cavity ◽

Head And Neck ◽

Multiple Primary

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PREVALANCE OF HEAD AND NECK CANCER IN UPPER ASSAM: AN INSTITUTIONAL STUDY.

10.36106/ijsr/0807612 ◽

2021 ◽

pp. 50-51

Author(s):

Ayesha Agarwal ◽

Trishan Paul ◽

Rudra Kanta Gogoi ◽

Rheetwik Baruah ◽

Chiranjeev Baruah

Keyword(s):

Oral Cavity ◽

Head And Neck ◽

Treatment Options ◽

Population Based ◽

Population Based Study ◽

Medical College ◽

Starting Point ◽

High Prevalence ◽

North Eastern ◽

Total Body

In India, head and neck cancers (HNCA) account for 14.3% cancers at all sites. In North-eastern India, there is a high prevalence of HNCA which can be associated with pervasive habit of using tobacco, lime and betel. The alarmingly high prevalence of cancers of head and neck in this part of India has prompted us to take up this study. Ahospital-based study on prevalence of cancer in various head and neck regions like oropharynx, oral cavity, pharynx, larynx, salivary glands and nasal cavity was conducted in Department of Radiation Oncology, Assam Medical College and Hospital from June 2020 to May 2021.The prevalence is found to be signicantly high at 57.59%, affecting males more than females in the age group of 50-59 years. HNCA of hypopharynx and oral cavity constituted a major burden of total body cancer. This study hopes to quantify and analyse the HNCAspectrum and should help as a starting point for a much needed population based study in this region. Acomprehensive effort is required to identify the cause of such high prevalence of HNCAin this region of India, generate awareness and treatment options suited to meet this challenge.

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