Hyperbilirubinemia Reduces the Streptozotocin-Induced Pancreatic Damage through Attenuating the Oxidative Stress in the Gunn Rat

Background: Diabetes is directly involved in oxidative stress production. Therefore, this work was conducted to investigate the histopathological changes which occur in parenchymatous and to evaluate the antioxidant effect of quercetin in alloxan induced diabetes in male albino rats.Methods: Thirty-six male albino rats were divided into six groups of 6 rats in each group and treated as follows: a control group, quercetin group, diabetic control group, diabetic with quercetin group, diabetic with insulin group, diabetic with quercetin plus insulin group, alloxan was administered as a single dose (140 mg/kg body weight) to induce diabetes.Results: Result showed histopathological changes which included degenerative to necrotic changes of the liver, kidney and pancreas and this are due to the effect of oxidative stress that occurred from diabetes by alloxan. Conversely, quercetin significantly modulated improved histopathological changes founded on this study with or without of insulin, furthermore, results showed that damaged tissues where improved when groups of rats treated with quercetin and insulin together.Conclusions: It has been concluded that the quercetin could be promising antioxidants for reducing the risk of oxidation induced by diabetes that lead to nephrotoxicity, hepatotoxicity and pancreatic damage.

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Oligonol Attenuates Diabetes-Induced Pancreatic Damage by Inhibiting Inflammatory Responses via Oxidative Stress-Dependent MAPK/NF-kB Signaling

10.20944/preprints201705.0208.v1 ◽

2017 ◽

Cited By ~ 1

Author(s):

Chan Hum Park ◽

Joo Young Lee ◽

Sung Ho Shin ◽

Min Yeong Kim ◽

Eun Suk Lee ◽

...

Keyword(s):

Oxidative Stress ◽

Body Weight ◽

Inflammatory Responses ◽

Ros Generation ◽

Thiobarbituric Acid Reactive Substance ◽

Tbars Level ◽

Nuclear Factor ◽

Nuclear Factor Kappa ◽

Pancreatic Damage ◽

Stress Dependent

Oligonol is a low-molecular-weight polyphenol derived from lychee fruit. This study was conducted to examine whether oligonol has an ameliorative effect on diabetes-induced pancreatic damage via oxidative stress-induced inflammation. Oligonol was orally administered at 10 or 20 mg/kg body weight/day for 10 days to streptozotocin-induced diabetic rats, and changes in serum glucose, C-peptide, insulin, reactive oxygen species (ROS), and thiobarbituric acid-reactive substance (TBARS) levels as well as body weight and food and water consumption were assessed. Furthermore, rat pancreases were analyzed for weight, ROS generation, TBARS level, insulin content, and protein expressions of phosphor (p)-p38, p-extracellular-signal regulated kinase 1/2, p-inhibitor of nuclear factor kappa Bα, nuclear factor-kappa Bp65, cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor-α, and interleukin-6. Markers of diabetes were shown to be decreased by oligonol administration and histological damage in the pancreas was also ameliorated. These results indicate that oligonol exerts antidiabetic activities, which may be mediated via antioxidative, stress-related, anti-inflammatory signaling.

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Oligonol, a low-molecular-weight polyphenol derived from lychee peel, attenuates diabetes-induced pancreatic damage by inhibiting inflammatory responses via oxidative stress-dependent mitogen-activated protein kinase/nuclear factor-kappa B signaling

Phytotherapy Research ◽

10.1002/ptr.6194 ◽

2018 ◽

Vol 32 (12) ◽

pp. 2541-2550 ◽

Cited By ~ 2

Author(s):

Chan Hum Park ◽

Kyeong Hun Park ◽

Seung Gil Hong ◽

Jae Su Lee ◽

Jeong Hyun Baek ◽

...

Keyword(s):

Oxidative Stress ◽

Molecular Weight ◽

Nuclear Factor Kappa B ◽

Inflammatory Responses ◽

Mitogen Activated Protein Kinase ◽

Low Molecular Weight ◽

Nuclear Factor ◽

Pancreatic Damage ◽

Mitogen Activated Protein ◽

Stress Dependent

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Phototherapy with blue and green mixed-light is as effective against unconjugated jaundice as blue light and reduces oxidative stress in the Gunn rat model

Early Human Development ◽

10.1016/j.earlhumdev.2015.04.010 ◽

2015 ◽

Vol 91 (7) ◽

pp. 381-385 ◽

Cited By ~ 7

Author(s):

Yumiko Uchida ◽

Yukihiro Morimoto ◽

Takao Uchiike ◽

Tomoyuki Kamamoto ◽

Tamaki Hayashi ◽

...

Keyword(s):

Oxidative Stress ◽

Blue Light ◽

Rat Model ◽

Gunn Rat

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Vitamin B12 Attenuates Acute Pancreatitis by Suppressing Oxidative Stress and Improving Mitochondria Dysfunction via CBS/SIRT1 Pathway

Oxidative Medicine and Cellular Longevity ◽

10.1155/2021/7936316 ◽

2021 ◽

Vol 2021 ◽

pp. 1-13

Author(s):

Jiyan Yuan ◽

Zeliang Wei ◽

Guang Xin ◽

Xubao Liu ◽

Zongguang Zhou ◽

...

Keyword(s):

Oxidative Stress ◽

Acute Pancreatitis ◽

Vitamin B12 ◽

Specific Inhibitor ◽

Inflammatory Disorder ◽

Pancreatic Damage ◽

Acinar Cell Necrosis ◽

Substantial Morbidity

Acute pancreatitis is an inflammatory disorder of the pancreas associated with substantial morbidity and mortality, which is characterized by a rapid depletion of glutathione (GSH). Cysthionine-β-synthase (CBS) is a key coenzyme in GSH synthesis, and its deficiency is related to a variety of clinical diseases. However, whether CBS is involved in the pathogenesis of acute pancreatitis remains unclear. First, we found that CBS was downregulated in both in vivo and in vitro AP models. The pancreatic damage and acinar cell necrosis related to CBS deficiency were significantly improved by VB 12, which stimulated clearance of reactive oxygen species (ROS) by conserving GSH. Furthermore, EX-527 (a specific inhibitor of SIRT1) exposure counteracted the protective effect of VB 12 by promoting oxidative stress and aggravating mitochondrial damage without influencing CBS, indicating that vitamin B12 regulates SIRT1 to improve pancreatical damage by activating CBS. In conclusion, we found that VB 12 protected acute pancreatitis associated with oxidative stress via CBS/SIRT1 pathway.

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Nonylphenol induces pancreatic damage in rats through mitochondrial dysfunction and oxidative stress

Toxicology Research ◽

10.1039/c6tx00450d ◽

2017 ◽

Vol 6 (3) ◽

pp. 353-360 ◽

Cited By ~ 5

Author(s):

Xueji Li ◽

Liting Zhou ◽

Yiping Ni ◽

Aiqing Wang ◽

Mingjiang Hu ◽

...

Keyword(s):

Oxidative Stress ◽

Mitochondrial Dysfunction ◽

Environmental Contaminants ◽

Endocrine Disrupting Chemical ◽

Pancreatic Damage ◽

Endocrine Disrupting ◽

And Oxidative Stress

The organic alkylphenol 4-nonylphenol (NP) is regarded to be an endocrine disrupting chemical (EDC), one of the widely diffused and stable environmental contaminants.

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Octreotide alleviates pancreatic damage caused by paraquat in rats by reducing inflammatory responses and oxidative stress

Environmental Toxicology and Pharmacology ◽

10.1016/j.etap.2020.103456 ◽

2020 ◽

Vol 80 ◽

pp. 103456

Author(s):

Yanxia Gao ◽

Linlin Hou ◽

Yibo Wang ◽

Shigong Guo ◽

Ding Yuan ◽

...

Keyword(s):

Oxidative Stress ◽

Inflammatory Responses ◽

Pancreatic Damage ◽

And Oxidative Stress

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Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp (Ctenopharyngodon idellus) via suppression of oxidative stress, inflammation and apoptosis

Food & Function ◽

10.1039/d0fo01638a ◽

2020 ◽

Vol 11 (10) ◽

pp. 8547-8559

Author(s):

Hongjing Zhao ◽

Yu Wang ◽

Mengyao Mu ◽

Menghao Guo ◽

Hongxian Yu ◽

...

Keyword(s):

Oxidative Stress ◽

Secondary Metabolites ◽

Human Health ◽

Grass Carp ◽

Aquatic Environment ◽

Ctenopharyngodon Idellus

Antibiotics are used worldwide to treat diseases in humans and other animals; most of them and their secondary metabolites are discharged into the aquatic environment, posing a serious threat to human health.

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Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

Biochemical Journal ◽

10.1042/bcj20190591 ◽

2019 ◽

Vol 476 (24) ◽

pp. 3705-3719 ◽

Cited By ~ 2

Author(s):

Avani Vyas ◽

Umamaheswar Duvvuri ◽

Kirill Kiselyov

Keyword(s):

Oxidative Stress ◽

Head And Neck ◽

Transcriptional Activation ◽

Platinum Resistance ◽

Mrna Levels ◽

Strong Positive Correlation ◽

Platinum Compounds ◽

Copper Chelation ◽

Novel Approach ◽

Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

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