scholarly journals A case of diquat poisoning in pigs

2019 ◽  
Vol 64 (No. 11) ◽  
pp. 505-511
Author(s):  
Z Siroka ◽  
M Svoboda ◽  
Z Svobodova ◽  
I Nagl
Keyword(s):  
Toxic Substance ◽  
Large Body ◽  
Skin Lesions ◽  
Acute Poisoning ◽  
Pathological Examination ◽  
Tissue Destruction ◽  
Large White ◽  
Surface Areas ◽  
Stomach Fundus ◽  
White Foam

Diquat is a bipyridyl compound which belongs to the group of herbicides. Its activity is based on the liberation of the superoxide anion radical and, subsequently, hydrogen peroxide, leading to tissue destruction by oxidative stress. Acute poisoning is associated with high mortality within several hours to a few days. The reported case of poisoning occurred on a commercial farm. The fattening pigs of the Landrace and Large White breeds were affected. The pigs were kept on a deep litter. Reglone (active ingredient diquat dibromide, 200 g/l) was used on the farm fields to desiccate the clover crop. The dry clover straw was harvested and stored for approximately a month and then used as a litter. In total, 50 pigs were affected. The onset of the poisoning was very fast. Within eight hours after the litter administration, 20 animals died. The only clinical sign seen was severe haemorrhagic dermatitis. The pathological examination revealed acute superficial haemorrhagic dermatitis on the belly, the snout and the ears of the affected pigs. Hyperaemia of the tonsils, pharynx and oesophagus was diagnosed, as well as a pronounced hyperaemia of the stomach fundus. In the distal part of the trachea, there was a dense, white foam. The lungs were congested, with focal emphysema. The liver was slightly hyperaemic. The histological examination revealed a massive haemostasis in liver and diffuse acute polymorphonuclear hepatitis. The other organs were without changes. The examination revealed acute poisoning caused by the large body surface areas contacting with a toxic substance. The pigs that survived were immediately removed to a non-contaminated area. The changes on their skin were not so extensive compared to the dead ones. Within 5–7 days after the exposure to diquat, the skin lesions healed.

scholarly journals Development of a Vascularized Skin Construct Using Adipose-Derived Stem Cells from Debrided Burned Skin

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Rodney K. Chan ◽  
David O. Zamora ◽  
Nicole L. Wrice ◽  
David G. Baer ◽  
Evan M. Renz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Burn Injury ◽  
Point Of Care ◽  
Normal Skin ◽  
Large Body ◽  
Skin Substitutes ◽  
Surface Areas ◽  
Burned Skin ◽  
Stem Cell Isolation ◽  
Isolation Device

Large body surface area burns pose significant therapeutic challenges. Clinically, the extent and depth of burn injury may mandate the use of allograft for temporary wound coverage while autografts are serially harvested from the same donor areas. The paucity of donor sites in patients with burns involving large surface areas highlights the need for better skin substitutes that can achieve early and complete coverage and retain normal skin durability with minimal donor requirements. We have isolated autologous stem cells from the adipose layer of surgically debrided burned skin (dsASCs), using a point-of-care stem cell isolation device. These cells, in a collagen—polyethylene glycol fibrin-based bilayer hydrogel, differentiate into an epithelial layer, a vascularized dermal layer, and a hypodermal layer.All-trans-retinoicacid and fenofibrate were used to differentiate dsASCs into epithelial-like cells. Immunocytochemical analysis showed a matrix- and time-dependent change in the expression of stromal, vascular, and epithelial cell markers. These results indicate that stem cells isolated from debrided skin can be used as a single autologous cell source to develop a vascularized skin construct without culture expansion or addition of exogenous growth factors. This technique may provide an alternative approach for cutaneous coverage after extensive burn injuries.

scholarly journals A Case of Giant Posterior Mediastinal Mass: Gastrointestinal Stromal Tumor Developed in Neurofibromatosis Type 1 Patient.

2021 ◽  
Author(s):  
Volkan ASLAN ◽  
Fatih Gürler ◽  
ozan yazıcı ◽  
özlem erdem ◽  
ali çelik ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Genetic Disorders ◽  
Neurofibromatosis Type ◽  
Skin Lesions ◽  
Posterior Mediastinum ◽  
Pathological Examination ◽  
Imatinib Treatment ◽  
First Case ◽  
Posterior Mediastinal

Abstract Introduction: Gastrointestinal Stromal Tumors mostly located in the stomach and esophageal GIST is extremely rare. Various genetic disorders increase the risk of developing GIST, among these, NF-1 is the most common. A case of posterior mediastial GIST developing in the neurofibromatosis patient has not been reported yet.Case: A 48-year-old male patient is being evaluated with complaints of dyspnea and progressive dysphagia. Computed tomography detected a cystic, lobulated contour mass that was located at the posterior mediastinum and measuring 11 x 14x12 cm. The giant semisolid mass has been dissected from adjacent the vertebra, the esophagus, pericardium and inferior pulmonary vein and Histopathological examination revealed GİST. Pathological examination of skin lesions confirmed NF-1. Finally, NF-1-associated posterior mediastinal GIST was diagnosed and adjuvant imatinib treatment was initiated. Conclusion: To the best our knowledge, this patient was the first case, who diagnosed with posterior mediastinal GIST developing on the basis of NF-1.

scholarly journals Two cases of thyroid sarcoidosis presentation as painful, recurrent goiter in patients with Graves' disease

2012 ◽  
Vol 56 (3) ◽  
pp. 209-214 ◽  
Author(s):  
Piotr Kmieć ◽  
Marta Lewandowska ◽  
Anna Dubaniewicz ◽  
Krystyna Mizan-Gross ◽  
Artur Antolak ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Thyroid Tissue ◽  
Skin Lesions ◽  
Needle Aspiration ◽  
Pulmonary Sarcoidosis ◽  
Pathological Examination ◽  
Graves Disease ◽  
Invasive Treatment ◽  
High Resolution Computed Tomography ◽  
Adult Lives

Sarcoidosis rarely involves the thyroid gland. Pain in the thyroid gland area was only sporadically reported in patients suffering from this disease. The aim of this paper is to report and discuss the cases of two female patients with Graves' disease who presented painful, rapidly growing, recurrent goiters (after strumectomy in their early adult lives). Invasive treatment was applied and sarcoidosis was revealed histologically. The first patient suffered from dysphagia and dyspnoea due to large goiter; skin lesions were present as well. Sarcoidosis was diagnosed in histological examination of the thyroid tissue specimens. Steroid treatment was ineffective; thus, the thyroid was removed. Two years later thyroid sarcoidosis recurred as a painful goiter and surgical treatment was applied once again. In the second case, thyroid ultrasound findings suggesting malignancy, and prompted the decision to perform thyroidectomy despite the fact that FNAB (fine needle aspiration biopsy) revealed cells indicative of a "granulomatous disease in the post-resection scar" and results of the thorax high-resolution computed tomography scan suggested pulmonary sarcoidosis. Pathological examination confirmed sarcoidosis. However, a papillary cancer focus was also found.

Is the High Cost of Body/Caudal Fin Undulatory Swimming due to increased Friction Drag or Inertial Recoil?

1992 ◽  
Vol 162 (1) ◽  
pp. 157-166 ◽  
Author(s):  
PAUL W. WEBB
Keyword(s):  
Lepomis Macrochirus ◽  
Large Body ◽  
Energy Losses ◽  
Bluegill Sunfish ◽  
Friction Drag ◽  
Body Depth ◽  
Surface Areas ◽  
Wetted Surface Area ◽  
Undulatory Swimming ◽  
Inertial Energy

Deep-bodied fish, such as the bluegill sunfish {Lepomis macrochirus), are considered to have relatively larger wetted surface areas for their size than fusiform fish. On the basis of the boundary layer thinning hypothesis attributing high power requirements of undulatory swimming to enhanced friction drag, power (=drag) coefficients should be higher for such fish. Areas are typically normalized with total length, L, as L2 for comparison among species. Bluegill had a wetted surface area of 0.65 L2, compared with areas of about 0.41 L2 for trout of similar mass. However, absolute areas and volume2/3 of bluegill and trout were similar. Power requirements and power coefficients calculated from kinematics during steady swimming were lower for bluegill sunfish than for cruisers, such as trout, and power coefficients were also lower than those of accelerators, such as tiger musky. Large body depth also damps inertial recoil arising from the side force generated largely by the tail. Inertial energy losses appear to be more important contributors than friction to mechanical power requirements.

Seroprevalence and Dermatopathology of Sarcoptes scabiei var. suis Infestation in Pigs

2020 ◽  
Author(s):  
Prasenjit Debnath ◽  
Kalyan Sarma ◽  
Rahul Singh Arya ◽  
Chethan G E ◽  
Basanta Saikia ◽  
...  
Keyword(s):  
Developmental Stages ◽  
Skin Diseases ◽  
Skin Lesions ◽  
Epidemiological Studies ◽  
Sarcoptes Scabiei ◽  
Sarcoptic Mange ◽  
Control Measures ◽  
Large White ◽  
Wild Pigs ◽  
Common Causes

Skin diseases can have an adverse impact on the production in a swine herd by causing decrease in growth rate and feed efficiency. Sarcoptes scabiei var. suis is one of the most common causes of mange in domestic and wild pigs. Keeping this point in view, a study on seroprevalence and dermatopathology of Sarcoptes scabiei var. suis infestation in the pig population of Tripura has been undertaken. The presence of anti Sarcoptes antibodies (Immunoglobulin G) was detected by commercially available kit. In the present study, 189 pigs (11.81%) were found to be seropositive against Sarcoptes scabiei infestation out of 1600 screened pigs. Thirty one pigs out of 189 were found to be clinically positive and confirmed by microscopic examination. Examination of the skin scraping revealed various developmental stages viz., egg, larva, protonymph and adult of Sarcoptes mite. Occurrence of sarcoptic mange was found to be highest in young age group (67.72%, 128/189), male pigs (56.08%, 106/189) and Large White Yorkshire breed (47.08%). The highest and lowest occurrence of sarcoptic mange was noticed in winter (41.27%) and monsoon (7.94%) season, respectively. Clinical lesions were distributed most commonly in ear pinna (87.10%, 27/31) region. The presence of anti Sarcoptes antibodies was found to be highest in pigs having severe generalized skin lesions (70.0%). Histopathology of skin biopsy revealed a tunnel like ulcerated lesion in the skin with severe inflammatory cell infiltration in the core. The present study shows the high seroprevalence of Sarcoptes scabiei var. suis in pigs in Tripura state and recommends for proper control measures. However, epidemiological studies involving larger population are required for comprehensive results.

scholarly journals Determination of piglets’ rectal temperature and respiratory rate through skin surface temperature under climatic chamber conditions

2015 ◽  
Vol 35 (6) ◽  
pp. 979-989 ◽  
Author(s):  
Gustavo M. Mostaço ◽  
Késia O. da S Miranda ◽  
Isabella C. F. da S Condotta ◽  
Douglas D’Alessandro Salgado
Keyword(s):  
Respiratory Rate ◽  
Rectal Temperature ◽  
Skin Surface ◽  
Data Logger ◽  
Large White ◽  
Infrared Thermometer ◽  
Precise Control ◽  
Animal Farming ◽  
Surface Areas

ABSTRACT In animal farming, an automatic and precise control of environmental conditions needs information from variables derived from the animals themselves, i.e. they act as biosensors. Rectal temperature (RT) and respiratory rate (RR) are good indicators of thermoregulation in pigs. Since there is a growing concern on animal welfare, the search for alternatives to measure RT has become even more necessary. This research aimed to identify the most adequate body surface areas, on nursery-phase pigs, to take temperature measurements that best represent the correlation of RT and RR. The main experiment was carried out in a climate chamber with five 30-day-old littermate female Landrace x Large White piglets. Temperature conditions inside chamber were varied from 14 °C up to 35.5 °C. The measurements were taken each 30 minutes, over six different skin regions, using a temperature data logger Thermochron iButton® - DS1921G (Tb) and an infrared thermometer (Ti). As shown by the results, the tympanic region is the best one for RT and RR monitoring using an infrared thermometer (TiF). In contrast, when using temperature sensors, the ear (TbE) is preferred to be used for RT predictions and the loin region (TbC) for RR.

scholarly journals Primary thyroid tuberculosis: a rare etiology of hypothyroidism and anterior cervical mass mimicking carcinoma

2009 ◽  
Vol 53 (4) ◽  
pp. 475-478 ◽  
Author(s):  
Bradley Paulino da Silva ◽  
Erico Gurgel Amorim ◽  
Elizabeth João Pavin ◽  
Antonio Santos Martins ◽  
Patrícia Sabino de Matos ◽  
...  
Keyword(s):  
Radical Neck Dissection ◽  
Fine Needle Biopsy ◽  
Lymph Node Involvement ◽  
Primary Hypothyroidism ◽  
Pathological Examination ◽  
Tissue Destruction ◽  
Cervical Mass ◽  
Caseous Necrosis ◽  
Node Involvement ◽  
Thyroid Tuberculosis

OBJECTIVE: The involvement of the thyroid by tuberculosis (TB) is rare. Hypothyroidism caused by tissue destruction is an extremely rare report. Our aim was to report a patient with primary thyroid TB emphasizing the importance of diagnosis, despite the rarity of the occurrence. CASE REPORT: Women, 62 years old, showing extensive cervical mass since four months, referring lack of appetite, weight loss, dysphagia and dysphonia. Laboratorial investigation revealed primary hypothyroidism. Cervical ultrasound: expansive lesion in left thyroid lobe, involving adjacent muscle. Computed tomography scan: 13 cm diameter cervical mass with central necrosis. Fine needle biopsy: hemorrhagic material. Surgery: total thyroidectomy, left radical neck dissection and protective tracheotomy. The pathological examination showed chronic granulomatous inflammatory process with areas of caseous necrosis and lymph node involvement. The thyroid baciloscopy was positive. Pulmonary disease was absent. The patient was treated with antituberculosis drugs. CONCLUSIONS: Thyroid TB is not frequent, and should be considered as differential diagnosis of hypothyroidism and anterior cervical mass.

Diagnosis of amyopathic dermatomyositis after two intrauterine fetal deaths

2020 ◽  
pp. 1753495X2092950
Author(s):  
M Alonso-Espías ◽  
N Martínez-Sánchez ◽  
A Robles-Marhuenda ◽  
ME Martín-Boado ◽  
RM Regojo-Zapata ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Mononuclear Cells ◽  
Inflammatory Myopathy ◽  
Perinatal Outcomes ◽  
Skin Lesions ◽  
Pathological Examination ◽  
Amyopathic Dermatomyositis ◽  
Maternal Origin ◽  
Intervillous Space ◽  
Uncommon Condition

Chronic histiocytic intervillositis (CHIV) is an uncommon condition, characterized by an infiltrate of mononuclear cells of maternal origin in the intervillous space that has been related to placenta insufficiency and poor perinatal outcomes. The aetiology is unclear, although maternal immunological aggression toward fetal tissues has been proposed. Dermatomyositis (DM) is a multisystem autoimmune inflammatory myopathy. Different autoantibodies have been associated with particular clinical phenotypes; presence of anti-melanoma differentiation-associated gen 5 (MDA5) antibody has been associated with rapidly progressive interstitial lung disease and severe skin lesions, none of which the woman had. Described here is a case of a woman diagnosed with amyopathic DM with positive anti-MDA5 antibodies after two intrauterine fetal deaths. Pathological examination of the placenta in both pregnancies showed CHIV. The presence of a potential relationship between both processes is discussed.

scholarly journals Clinico-histopathological correlation of pigmented skin lesions: A hospital based study at BPKIHS

2019 ◽  
Vol 9 (2) ◽  
pp. 1550-1554
Author(s):  
Isha Bohra ◽  
Punam Paudyal ◽  
Anju Pradhan ◽  
Dhan Kesar Khadka
Keyword(s):  
Malignant Tumors ◽  
Skin Lesions ◽  
Pathological Examination ◽  
Cross Sectional ◽  
Histopathological Correlation ◽  
Melanocytic Lesions ◽  
Benign Pathology ◽  
Seborrhoeic Keratosis ◽  
Pigmented Skin Lesions ◽  
Age Range

Background: Pigmented skin lesions refers to melanocytic as well as nonmelanocytic lesions. Pigmentation is not just a cosmetic deformity but can also reflect underlying benign pathology as nevi or malignant lesions as melanoma. With this study we intend to evaluate the spectrum of pigmented skin lesions and to correlate the clinical diagnosis with the histological diagnosis. Materials and Methods: This is a hospital based cross sectional descriptive study where clinicohistopathological evaluation of 46 cases of pigmented skin lesions were analyzed on paraffin embedded tissue sections for a duration of 1 year at the Department of Pathology, B. P. Koirala Institute of Health Sciences. Results: Out of the 46 cases evaluated there were 32 cases of melanocytic lesions comprising of benign melanocytic nevi (n=27), malignant melanoma (n=5) and 14 cases of nonmelanocytic lesions including basal cell carcinoma and seborrhoeic keratosis (5 cases each). Angiokeratoma (n=1), sebaceous hyperplasia (n=1), trichoepitheloma (n=1) and venous haemangioma (n=1). The age range was from 8-83 years with slight female predominance (52.2%) and the most common site involved was head and neck (58.7%). 76.1% of the patients belonged to the Terai region. Clinicohistopathological correlation showed positive correlation in 26 cases (56.5%) and negative correlation in 20 cases (43.5%). Conclusions: Pigmented skin lesions are common presenting problem, while majority are benign a small minority can be malignant. So, clinically pigmented skin lesions should be submitted for pathological examination in order not to miss a small percentage of malignant tumors and to differentiate melanocytic lesions from its nonmelanocytic mimickers.

Treatment and Prophylaxis of Pityriasis Versicolor with Oral Fluconazole

2003 ◽  
Vol 1 (3) ◽  
pp. 129-132 ◽  
Author(s):  
N. Cassano ◽  
V. D'Argento ◽  
F. Loconsole ◽  
G.A. Vena
Keyword(s):  
Oral Treatment ◽  
Large Body ◽  
Pityriasis Versicolor ◽  
Primary Efficacy ◽  
Once Daily ◽  
Oral Fluconazole ◽  
Surface Areas ◽  
End Of Treatment ◽  
Efficacy Parameter ◽  
Preliminary Study

Treatment with oral antifungals is usually preferred when pityriasis versicolor (PV) affects large body surface areas, especially in chronic or recurrent cases. In this study, we evaluated the effectiveness of fluconazole in the treatment and prophylaxis of patients with chronic or recurrent, mostly extensive, PV. Treatment regimen consisted of fluconazole 100mg once daily for 10 consecutive days; 3–4 weeks after the end of treatment, patients were evaluated for clinical and mycological response (visit T1). Patients with mycological eradication received fluconazole 200mg/day (100mg twice a day) for two consecutive days per month for 5 months. Clinical and mycological evaluations were performed after 2 months (T2) and 5 months (T3) from visit T1. Mycological efficacy was assessed using microscopic examination and represented the primary efficacy parameter; therefore, positive microscopy at any visit was reason for withdrawal from the study. At visit T1 60 subjects were evaluated; most patients (94 %) were clinically cured or improved. Similar clinical response rates were observed at visits T2 and T3. The proportion of patients with eradication of Malassezia was 92 % at T1 visit, 88 % at T2 visit, and 91 % at T3 visit. No relevant adverse events occurred. The results of this open preliminary study suggest that an oral treatment with fluconazole 100mg/day for 10 days is effective in PV. A maintenance monthly treatment with fluconazole 200mg/day for two consecutive days can be very useful to prevent recurrence of PV.

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