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2021 ◽  
Author(s):  
hengstla not provided
Keyword(s):  
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scholarly journals Acceptance and Intake of COVID-19 Vaccines among Older Germans

2021 ◽  
Vol 10 (7) ◽  
pp. 1388
Author(s):  
Marta Malesza ◽  
Erich Wittmann
Keyword(s):  
Side Effects ◽  
Long Term Effects ◽  
Negative Side ◽  
Factors Influencing ◽  
Vaccination Acceptance ◽  
Negative Side Effects

The main aim of this study was to investigate the various factors influencing COVID-19 vaccination acceptance and actual intake among older Germans aged over 75 years old (n = 1037). We found that the intention to get vaccinated or intake of the COVID-19 vaccine were positively related to the perceptions of becoming infected, perceptions of the severity of the potential long-term effects, the vaccine’s efficacy, and the benefits of vaccination. Meanwhile, the intention to get the vaccine or vaccine intake were decreased by perceptions of the negative side-effects and the general impediments to vaccination.

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2022 ◽  
Author(s):  
health not provided
Keyword(s):  
Weight Loss ◽  
United Kingdom ◽  
Side Effects ◽  
Fat Cells ◽  
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scholarly journals A Multi-Objective Approach to Mitigate Negative Side Effects

2020 ◽  
Author(s):  
Sandhya Saisubramanian ◽  
Ece Kamar ◽  
Shlomo Zilberstein
Keyword(s):  
Side Effects ◽  
Empirical Evaluation ◽  
Primary Objective ◽  
Maximum Deviation ◽  
Negative Side ◽  
Multi Objective ◽  
Markov Decision ◽  
Secondary Objective ◽  
Negative Side Effects ◽  
The Impact

Agents operating in unstructured environments often create negative side effects (NSE) that may not be easy to identify at design time. We examine how various forms of human feedback or autonomous exploration can be used to learn a penalty function associated with NSE during system deployment. We formulate the problem of mitigating the impact of NSE as a multi-objective Markov decision process with lexicographic reward preferences and slack. The slack denotes the maximum deviation from an optimal policy with respect to the agent's primary objective allowed in order to mitigate NSE as a secondary objective. Empirical evaluation of our approach shows that the proposed framework can successfully mitigate NSE and that different feedback mechanisms introduce different biases, which influence the identification of NSE.

Metaphor and (Dis)belief

2019 ◽  
pp. 117-136
Author(s):  
Jeanne Gaakeer
Keyword(s):  
Side Effects ◽  
Practical Wisdom ◽  
Legal Rule ◽  
Negative Side ◽  
Psychological Phenomenon ◽  
Professional Needs ◽  
Belief Perseverance ◽  
Negative Side Effects ◽  
The Individual ◽  
Insight Into

In chapter 7 the importance of insight into how metaphor works in law (“seeing resemblance” according to Ricoeur) is elaborated upon in relation to the legal professional’s development of practical wisdom. The chapter discusses how metaphoric insight is both cognitive and perceptual. It argues that the professional needs to develop his or her legal imagination to be able to perceive similarity in what is initially thought of as dissimilarity to bridge the gap between the generality of the legal rule and the particularity of the individual situation in the case at hand. The chapter also connects the topic of metaphor to an understanding the psychological phenomenon of cognitive dissonance and its negative side-effects such as the confirmation bias and belief perseverance as the obverse phenomena of what Coleridge called poetic faith, i.e. the ability to comprehend contraries and to deal with uncertainties before jumping to conclusions.

Why Municipal Cooperation Matters

2016 ◽  
pp. 140-152 ◽  
Author(s):  
Filipe Teles ◽  
Pekka Kettunen
Keyword(s):  
Side Effects ◽  
Research Agenda ◽  
State Of The Art ◽  
Common Phenomenon ◽  
Costs And Benefits ◽  
Negative Side ◽  
Provision Of Services ◽  
Negative Side Effects ◽  
The Impact ◽  
Perceived Costs

It is a common phenomenon that municipalities cooperate with each other. Cooperation eventually brings about the gains of efficiency or makes it possible to deliver services. We can however assume that cooperation may also fail, cause unwarranted negative side-effects and diminish the democratic capacity of the participating municipalities. The aim of this paper is to present the literature and available scholarship on the topic, and discuss the research agenda on inter-municipal cooperation, especially through the analysis of its scope, motivations, and perceived costs and benefits. The approach to the problem will be based in multidisciplinary contributions of existing research, which involves theoretical arguments related to the advantages of cooperation, the impact on democracy and accountability, as well as the discussion of public vs private provision of services. The conclusions should enable a serious reflection about Inter-Municipal Cooperation state of the art.

Therapeutic issues

2019 ◽  
pp. 993-1040
Author(s):  
David Semple ◽  
Roger Smyth
Keyword(s):  
Weight Gain ◽  
Medication Adherence ◽  
Side Effects ◽  
Sexual Dysfunction ◽  
Kidney Disease ◽  
Off Label ◽  
Negative Side ◽  
Negative Side Effects ◽  
Potential Interactions ◽  
In Pregnancy

This chapter covers therapeutic issues in psychiatry, from medication adherence, off-label prescribing and associated legal considerations, negative side effects such as weight gain and sexual dysfunction in different forms of psychiatric medicines, potential interactions or contraindications for prescribing, and specific side effects. Special prescribing cases, such as psychiatric medicine in pregnancy and breastfeeding patients or those with heart, liver, or kidney disease, are explained.

scholarly journals World Agricultural Markets: Implications for U.S. Food and Agricultural Policy

1984 ◽  
Vol 16 (1) ◽  
pp. 91-97
Author(s):  
T. Kelley White
Keyword(s):  
Side Effects ◽  
Agricultural Policy ◽  
Agricultural Sector ◽  
Market Forces ◽  
Farm Sector ◽  
Negative Side ◽  
Policy Goals ◽  
Negative Side Effects ◽  
Food And Agricultural Policy ◽  
The U.S

In the absence of agricultural policy, the behavior of the agricultural sector is dictated by market forces. Any agricultural policy, other than one of “hands off—let the market forces rule,” is dependent upon programmatic tools which in one way or another attempt to interfere or modify behavior of the sector. If it is government's objective to design and implement a set of programs which will distort market behavior so as to achieve policy goals with minimum negative side effects, it is essential that policymakers understand the kind of market environment within which the U.S. farm sector exists and how this market is likely to behave, given alternative interferences.

scholarly journals Class Strategies in Chavista Venezuela: Pragmatic and Populist Policies in a Broader Context

2018 ◽  
Vol 46 (1) ◽  
pp. 167-189
Author(s):  
Steve Ellner
Keyword(s):  
Side Effects ◽  
Full Advantage ◽  
Extended Period ◽  
Social Programs ◽  
Ruling Elite ◽  
Negative Side ◽  
Crony Capitalism ◽  
Negative Side Effects ◽  
Hugo Chavez

The governments of Hugo Chávez and Nicolás Maduro responded to the opposition’s attempts at regime change by implementing pragmatic policies favoring businesspeople who refused to participate in destabilization actions, as well as populist social measures benefiting the nonprivileged. Both sets of policies have to be placed in political context. The characterization of allegedly pro-government businesspeople as a new ruling elite referred to as the boliburguesía fails to take into account the sharp tensions between them and the Chavista leadership. The primary importance of social programs in the Chavista political triumphs over an extended period of time and of the periodic initiatives that sparked life into individual programs implicitly rules out claims regarding the government’s failure to alleviate poverty or achieve other social objectives. The Chavista governments failed to take full advantage of favorable periods and junctures when the opposition was demoralized following defeats in order to correct the negative side effects of pragmatic and populist class policies, such as bureaucratization and crony capitalism. Los gobiernos de Hugo Chávez y Nicolás Maduro respondieron a los intentos de la oposición por el cambio de régimen implementando políticas pragmáticas que favorecían a los empresarios que se negaban a participar en acciones de desestabilización, así como medidas sociales populistas que beneficiaban a los no privilegiados. Ambos conjuntos de políticas deben situarse en un contexto político. La caracterización de empresarios supuestamente progubernamentales como una nueva elite gobernante conocida como la boliburguesía no toma en cuenta las fuertes tensiones entre ellos y la dirigencia chavista. La importancia primordial de los programas sociales en los triunfos políticos chavistas a lo largo de un período prolongado y de las iniciativas periódicas que avivaron los programas individuales contrarresta la afirmación sobre la incapacidad del gobierno para aliviar la pobreza o alcanzar otros objetivos sociales. Los gobiernos chavistas no aprovecharon al máximo los períodos y coyunturas favorables cuando la oposición se desmoralizó tras las derrotas con el fin de corregir los efectos negativos de las políticas pragmáticas y populistas, como la burocratización y el capitalismo amiguista.

Biological Significance of Reducing Glucose Degradation Products in Peritoneal Dialysis Fluids

2000 ◽  
Vol 20 (5_suppl) ◽  
pp. 23-27 ◽  
Author(s):  
Anders Wieslander ◽  
Torbjörn Linden ◽  
Barbara Musi ◽  
Ola Carlsson ◽  
Reinhold Deppisch
Keyword(s):  
Peritoneal Dialysis ◽  
Side Effects ◽  
Host Defense ◽  
Degradation Products ◽  
Biological Significance ◽  
Peritoneal Membrane ◽  
Negative Side ◽  
Glucose Degradation Products ◽  
Negative Side Effects

Carbohydrates are not stable when exposed to energy; they degrade into new molecules. In peritoneal dialysis (PD) fluids, degradation of glucose occurs during the heat sterilization procedure. The biological consequences of this degradation are side effects such as impaired proliferation and impaired host defense mechanisms, demonstrated in vitro for a great variety of cells. Several highly toxic compounds—such as formaldehyde and 3-deoxyglucosone—have been identified in PD fluids. Carbonyl compounds, apart from being cytotoxic, are also well-known promoters of irreversible advanced glycation end-products (AGEs), which might participate in the long-term remodeling of the peritoneal membrane. Various approaches can be used to reduce the formation of glucose degradation products (GDPs) during heat sterilization. Some examples are shortening the sterilization time, lowering the pH, removing catalyzing substances, and increasing glucose concentration. The latter three factors are employed in the multi-compartment bag with a separate chamber containing pure glucose at high concentration and low pH. Gambrosol trio, a PD fluid produced in this way, shows reduced cytotoxicity, normalized host defense reactions, less AGE formation, and reduced concentrations of formaldehyde and 3-deoxyglucosone. Moreover, in the clinical situation, the fluid turns out to be more biocompatible for the patient, causing less mesothelial cell damage, which in the long term could lead to a more intact peritoneal membrane. Conclusion Glucose degradation products in heat-sterilized fluids for peritoneal dialysis are cytotoxic, promote AGE formation, and cause negative side effects for the patient. Using improved and well-controlled manufacturing processes, it is possible to produce sterile PD fluids with glucose as the osmotic agent but without the negative side effects related to GDPs.

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