scholarly journals Epidemiological and clinical features of lymphoproliferative diseases in the head and neck region

2021 ◽  
Vol 16 (3) ◽  
pp. 105-117
Author(s):  
F. Sh. Kamolova ◽  
A. M. Mudunov ◽  
P. A. Zeynalova ◽  
L. Yu. Grivtsova ◽  
G. F. Allakhverdieva ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Head And Neck ◽  
Clinical Features ◽  
Clinical Manifestations ◽  
World Health ◽  
Lymphoproliferative Diseases ◽  
Diagnostic Quality ◽  
Detection Frequency ◽  
Neck Area ◽  
Hodgkin's Lymphomas

Background. Lymphomas are a heterogeneous group of the lymphoid and hematopoietic system tumors. Neoplastic process often develops in head and neck area, including the integumentary tissues, orbit, nasal cavity, paranasal sinuses, oral cavity, pharynx, salivary glands, thyroid gland, as well as neck lymph nodes. The difficulties of head and neck lymphomas diagnosis are significant, since very often there is a combined non-tumor pathology. The high heterogeneity of lymphomas in the head and neck area requires structuring knowledge about their epidemiology and clinical manifestations.Objective: to study the epidemiological and clinical features of the head and neck lymphoproliferative diseases, which will lead to an improvement in diagnostic quality of this nosology’s.Materials and methods. The frequency of head and neck lymphoproliferative diseases detection was estimated based on the study of epicrisis and clinical data of 174 patients hospitalized at the N.N. Blokhin National Medical Research Center of Oncology in the period from 2000 to 2020.Results. Taking into account the modern clinical and morphological classification of lymphomas of the World Health Organization (2017), information about the features of localization, characteristic signs of extranodal foci and lymph nodes is presented. Detection frequency of various subtypes non-Hodgkin’s and Hodgkin’s lymphomas were determined on a sufficient cohort of patients.Conclusion. Based on the analysis of clinical and morphological features of head and neck lymphomas, epidemiological and clinical features are described in detail, and differences in the symptoms and clinical manifestations of non-Hodgkin’s and Hodgkin’s lymphomas with a predominant head and neck involvement are revealed.

Recurrent Neck Lymphangioma in a Young Adult: Twenty-Three Years After Successful Treatment

2018 ◽  
Vol 53 (2) ◽  
pp. 170-176 ◽  
Author(s):  
Thomas Kotsis ◽  
Georgios Exarchos ◽  
Linda Metaxa ◽  
Stylianos Triantos
Keyword(s):  
Differential Diagnosis ◽  
Surgical Treatment ◽  
Young Adult ◽  
Head And Neck ◽  
Lymphatic System ◽  
Clinical Manifestations ◽  
Cervical Region ◽  
Neck Area ◽  
Life Threatening ◽  
New Onset

Lymphangiomas are rare benign malformations of the lymphatic system, commonly present in children, over the head and neck area. Occasionally, they can grow significantly in size and especially those located over the cervical region can cause airway obstruction and become life-threatening. Recurrent lymphangiomas usually occur during the early postsurgical period and 80% of them within the first 3 to 5 years. However, in a new onset of clinical manifestations affecting the head and neck, even many years after the successful surgical treatment, a recurrent lymphangioma should be considered in the differential diagnosis. We present herein the second reported case, to our knowledge, of a recurrent left-sided neck lymphangioma in a young man, 23 years after a successful surgical treatment that initially took place 6 weeks after his birth.

scholarly journals Co-existence of multisystem inflammatory syndrome in children associated with COVID-19 and scrub typhus infection: a case series

2021 ◽  
Author(s):  
Sarbani M. Roy ◽  
Sushama Sahoo
Keyword(s):  
Clinical Features ◽  
Scrub Typhus ◽  
Virus Disease ◽  
Clinical Manifestations ◽  
Case Series ◽  
World Health ◽  
Laboratory Findings ◽  
Term Outcome ◽  
Corona Virus ◽  
Inflammatory Syndrome

We are in the midst of pandemic of corona virus disease (COVID-19), caused by the novel coronavirus severe acute respiratory syndrome corona virus-2 (SARS-CoV-2). A clinical entity with hyperinflammatory syndrome, defined by World Health Organization (WHO) as multisystem inflammatory syndrome in children (MIS-C) and adolescents, temporarily related to COVID-19, is being reported in this pandemic from several countries. MIS-C has overlapping clinical features of Kawasaki disease (KD). KD has been described in association with various organisms including dengue, scrub typhus. MIS-C with concomitant infection has rarely been reported in literature till date. We report on ten sick pediatric patients presented with clinical features of MIS-C, in whom diagnosis of concomitant scrub typhus were also made. This retrospective study was conducted in the department of pediatric medicine of a medical college, in a district town of West Bengal, India. SARS-CoV-2 immunoglobulin G level was elevated in all of them and they were also positive with Scrub typhus serology. We reviewed and analysed their basic informations, clinical manifestations, epidemiological history, laboratory findings, treatment and short term outcome. Median age was 24 months (range 4 months-8 years), male: female was 1:1. All the patients survived. Concomitant tropical infection in a patient with MIS-C may play an important role in determining the prognosis of such patients. Early detection and intervention will result in better management and intact survival of them.

Synovial sarcoma of the pharynx and oesophagus

1983 ◽  
Vol 97 (12) ◽  
pp. 1173-1176 ◽  
Author(s):  
B. V. Palmer ◽  
A. Levene ◽  
H. J. Shaw
Keyword(s):  
Lymph Nodes ◽  
Head And Neck ◽  
Synovial Sarcoma ◽  
Clinical Features ◽  
Synovial Sarcomas

SummaryTwo patients with synovial sarcomas of the pharynx and oesophagus respectively are reported and their clinical features are described. These tumours in the head and neck rarely metastasize to lymph nodes and their management is discussed.

scholarly journals Clinical features of sarcoidosis in head and neck area

2020 ◽  
Author(s):  
T Send ◽  
M Bertlich ◽  
D Skowasch ◽  
M Jakob ◽  
F Bootz
Keyword(s):  
Head And Neck ◽  
Clinical Features ◽  
Neck Area

The Brain Transcription Factor OTX1 Is Activated in Specific Non-Hodgkin Lymphoma Subtypes and Normally Expressed in a Germinal Center-Restricted Small Subpopulation of CD138+ Plasmacell-Like Cells.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2618-2618
Author(s):  
Filippo Russo ◽  
Daniela Omodei ◽  
Dario Acampora ◽  
Rosaria De Filippi ◽  
Valeria Severino ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
B Cell ◽  
Germinal Center ◽  
B Cell Lymphoma ◽  
World Health ◽  
Non Hodgkin Lymphoma ◽  
Bcl6 Expression ◽  
Health Organization ◽  
Hodgkin's Lymphomas ◽  
Proliferating Cell

Abstract OTX1 and OTX2 are transcription factors containing a bicoid-like homeodomain and play crucial roles in brain development and in few other body districts as in the case of OTX1, which is required in hematopoiesis for development of the erythroid compartment. Previous studies indicated that in human OTX2 is functionally involved in the generation of anaplastic medulloblastomas; OTX1 expression strongly correlates with nodular/desmoplastic medulloblastomas; and none of them is expressed in other brain tumors. Here we have investigated whether OTX1 and/or OTX2 may potentially be involved in tumors of nonneural origin by focusing on human B-cell non-Hodgkin’s lymphomas (NHLs). We analyzed 184 cases (fig 1)encompassing different NHL subtypes according to the World Health Organization classification and discovered that, while OTX2 expression was never detected, OTX1 was selectively activated in virtually all cases of Diffuse Large B Cell Lymphoma, Burkitt Lymphoma and a relevant fraction of Follicular Cell Lymphomas. In DLBCL lymph nodes and tissue infiltrations, OTX1 protein was detected in the nucleus of PAX5+-CD20+ cancer cells. Conversely, in nonmalignant lymph nodes and tonsils, OTX1 was expressed in a numerically very small and non-proliferating cell population restricted to the germinal center. These OTX1+ cells were CD138+-IgG+, about 50% of them also co-expressed both CD10 and CD20 and none of them exhibited PAX5 or BCL6 expression, thus suggesting that OTX1 expression identifies a subset of GC-restricted plasmacell-like cells (fig 2). Interestingly, in contrast with lymphomas, in these cells the OTX1 protein was prevalently localized to the cytoplasm. Collectively, our data suggest that activation of OTX1 expression and its nuclear localization represent together a newly described molecular event occurring in specific NHL subtypes of GC and early post-GC origin (FCL, DLBCL, BL), and lead us to hypothesize that it may be potentially involved (directly or indirectly) in the initiation and/or maintenance of these tumors. Figure Figure Figure Figure

scholarly journals Clinicolaboratory Profile, Treatment, Intensive Care Needs, and Outcome of Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2: A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Vijai Williams ◽  
Nabaneeta Dash ◽  
Renu Suthar ◽  
Vichithra Mohandoss ◽  
Nishant Jaiswal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Intensive Care ◽  
Clinical Features ◽  
Myocardial Dysfunction ◽  
Random Effect Model ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
World Health ◽  
Research Database ◽  
Care Needs

AbstractThis study was aimed to summarize the current data on clinicolaboratory features, treatment, intensive care needs, and outcome of pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2; PIMS-TS) or multisystem inflammatory syndrome in children (MIS-C). Articles published in PubMed, Web of Science, Scopus, Google Scholar, and novel coronavirus disease 2019 (COVID-19) research database of World Health Organization (WHO), Centers for Disease Control and Prevention (CDC) database, and Cochrane COVID-19 study register between December 1, 2019 and July 10, 2020. Observational studies involving patients <21 years with PIMS-TS or MIS-C were reported the clinicolaboratory features, treatment, intensive care needs, and outcome. The search identified 422 citations and finally 18 studies with 833 participants that were included in this study, and pooled estimate was calculated for parameters of interest utilizing random effect model. The median age was 9 (range: 8–11) years. Fever, gastrointestinal symptoms, rash, conjunctival injection, and respiratory symptoms were common clinical features. Majority (84%) had positive SARS-CoV-2 antibody test and only one-third had positive reverse transcript polymerase chain reaction (RT-PCR). The most common laboratory abnormalities noted were elevated C-reactive protein (CRP), D-dimer, procalcitonin, brain natriuretic peptide (BNP), fibrinogen, ferritin, troponin, interleukin 6 (IL-6), lymphopenia, hypoalbuminemia, and thrombocytopenia. Cardiovascular complications included shock (65%), myocardial dysfunction (61%), myocarditis (65%), and coronary artery abnormalities (39%). Three-fourths of children required admission to pediatric intensive care unit (PICU) where they received vasoactive medications (61%) and mechanical ventilation (25%). Treatment strategies used included intravenous immunoglobulin (IVIg; 82%), steroids (54%), antiplatelet drugs (64%), and anticoagulation (51%). Mortality for patients with PIMS-TS or MIS-C was low (n = 13). In this systematic review, we highlight key clinical features, laboratory findings, therapeutic strategies, intensive care needs, and observed outcomes for patients with PIMS-TS or MIS-C. Commonly observed clinical manifestations include fever, gastrointestinal symptoms, mucocutaneous findings, cardiac dysfunction, shock, and evidence of hyperinflammation. The majority of children required PICU admission, received immunomodulatory treatment, and had good outcome with low mortality.

COVID 19: REALS AND CHALLENGES AGAINST DOCTORS

2020 ◽  
Vol 2 (1) ◽  
pp. 65-87
Author(s):  
Zen Ahmad
Keyword(s):  
Virus Disease ◽  
Clinical Manifestations ◽  
World Health ◽  
Unknown Etiology ◽  
Wuhan City ◽  
Traditional Markets ◽  
Pneumonia Case ◽  
The World ◽  
New Type ◽  
Health Organization

Corona Virus Disease (Covid-19) is a contagious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which was discovered in December 2019 in China. This disease can cause clinical manifestations in the airway, lung and systemic. The World Health Organization (WHO) representative of China reported a pneumonia case with unknown etiology in Wuhan City, Hubei Province, China on December 31, 2019. The cause was identified as a new type of coronavirus on January 7, 2020 with an estimated source of the virus from traditional markets (seafood market). ) Wuhan city

Cytopathology Lymphadenopathy Feature in HIV Positve Patient: Diagnosis Tools Comorbidities

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Hasrayati Agustina ◽  
Yenni Wisudarma ◽  
Ris Kristiana ◽  
Bethy S. Hernowo
Keyword(s):  
Lymph Nodes ◽  
Medical Records ◽  
Fine Needle Aspiration Biopsy ◽  
Clinical Manifestations ◽  
Needle Aspiration ◽  
Hiv Positive ◽  
Tuberculous Lymphadenitis ◽  
Patient Diagnosis ◽  
Granulomatous Lymphadenitis ◽  
Anatomical Pathology

Lymphadenopathy is enlarged lymph nodes caused by infection, inflammation or malignancy. On HIV positive patients, lymphadenopathy is one of the most common clinical manifestations and it is usually persistent. Fine-needle aspiration biopsy (FNAB) is an effective cytology technique in determining the diagnosis of lymphadenopathy. This study aimed to describe the cytopathology of lymphadenopathy in HIV positive patients. This is a descriptive study of 21 cases of lymphadenopathy in patients with HIV positive who underwent FNAB examination in Anatomical Pathology Department of Dr.Hasan Sadikin Hospital between 2013-2014. Medical data was taken from the patient medical records including age, sex, location, size and cytopathological diagnosis. Cytopathology overview of FNAB specimens were reassessed by 2 pathologists. In this study, lymphadenopathy in HIV positive patients were mainly found in men (n = 15.71%) with an average age between 20-30 years. The most frequent location was the neck (n = 20.95.2%). The lymph nodes size were found between 0.5-3 cm. Most diagnosis was tuberculous lymphadenitis (n = 15.71%) with the most common cytology feature was granulomatous lymphadenitis (n = 5.33.3%) and suppurative lymphadenitis (n = 5.33.3%). FNAB examination in lymphadenopathy is very helpful to identify the cause of infection in HIV positive patients. Keywords: FNAB, HIV, lymphadenopathy, cytopathology

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