The need for a multidisciplinary approach to the diagnosis and treatment procedures of isolated lesions of the oral mucosa in herpetiform Dühring dermatitis

The defeat of the oral mucosa in herpetiform Dhring dermatitis is a rare pathology. According to the literature, it is detected in 9.6% 10% of cases. Granular deposits of immunoglobulin A in the papillae of the dermis in herpetiform Dhring dermatitis are associated with gluten enteropathy, lead to the development of inflammatory processes on the skin and oral mucosa and the appearance of polymorphic itchy rashes and chronic recurrent course of the disease. The article describes a clinical case of a patient diagnosed with herpetiform dermatitis, manifestations in the oral cavity (ICD-10 L13.0X code). The need for a multidisciplinary approach to the diagnosis, differential diagnosis, treatment and dynamic observation of isolated lesions of the oral mucosa in herpetiform Dhring dermatitis is indicated. A scheme of measures required by a dentist is developed.

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The case of detection and differential diagnosis of Hypell-Lindau disease in a patient as a result of a comprehensive examination of a patient in a chronic critical condition

Physical and rehabilitation medicine, medical rehabilitation ◽

10.36425/rehab33952 ◽

2020 ◽

Author(s):

A Yakovleva

Keyword(s):

Differential Diagnosis ◽

Surgical Treatment ◽

Family History ◽

Critical Condition ◽

Clinical Case ◽

Multidisciplinary Approach ◽

Von Hippel Lindau ◽

Live Births ◽

Comprehensive Examination ◽

Von Hippel Lindau Syndrome

According to evidence in the literature occurrence of the Hippel Lindau disease changes from 1: 33000 - 1: 36000 (population frequency) to 1 in 39000 live births. Up to 20% of them have not family history. Hereditary predisposition of most patients with systemic angioreticulomatosis has patterns and attributes. Diversity of forms and infrequent cases of the Hippel Lindau disease complicate timely diagnosis. Untimely control of condition of patient with the Hippel Lindau disease increases the probability of complications in surgical treatment. It can be the reason of early disability too. The presented clinical case reflects the need for a multidisciplinary approach to the management of patients with von Hippel-Lindau syndrome.

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Loeys–Dietz syndrome (literature review and case description)

Pediatric Traumatology Orthopaedics and Reconstructive Surgery ◽

10.17816/ptors16047 ◽

2020 ◽

Vol 8 (1) ◽

pp. 83-94

Author(s):

Olga E. Agranovich ◽

Sergey Yu. Semenov ◽

Eugeniya F. Mikiashvili ◽

Svetlana V. Sarantseva

Keyword(s):

Differential Diagnosis ◽

Connective Tissue ◽

Literature Review ◽

Clinical Case ◽

Multidisciplinary Approach ◽

Clinical Observation ◽

Autosomal Dominant ◽

Connective Tissue Disorder ◽

Dynamic Monitoring ◽

Case Description

Background. The LoeysDietz syndrome is a rare autosomal dominant connective tissue disorder characterized by the pathology of the cardiovascular system in combination with various anomalies of the musculoskeletal system. In modern literature, there is neither any information about the frequency of pathology nor any algorithm of examination and treatment for patients with this syndrome. Clinical case. The article presents a clinical observation of a 7-year-old patient with LoeysDietz syndrome with a genetically confirmed diagnosis. Discussion. This article provided a literature review, examined diagnosis issues and differential diagnosis, and presented the clinical picture of the syndrome. The main symptoms of LoeysDietz syndrome are artery aneurysms (most often in the aortic root), arterial tortuosity (mainly the vessels of the neck), hypertelorism, and bifid (split) or broad uvula. However, the combination of these symptoms is not found in all patients with this disease. Conclusions. The article emphasized the importance of a genetic verification of the disease, as well as a multidisciplinary approach to treatment with mandatory dynamic monitoring by specialists such as a cardiologist, neurologist, orthopedist, and pediatrician, which help prevent the development of complications and increase the life expectancy of this group of patients.

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Clinical case: Complicated differential diagnosis between postsurgical and functional hypoparathyroidism.

Endocrine Abstracts ◽

10.1530/endoabs.70.ep74 ◽

2020 ◽

Author(s):

Elena Kovaleva ◽

Anna Eremkina ◽

Julia Krupinova ◽

Natalia Mokrysheva

Keyword(s):

Differential Diagnosis ◽

Clinical Case

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How will artificial intelligence and bioinformatics change our understanding of IgA in the next decade?

Seminars in Immunopathology ◽

10.1007/s00281-021-00847-y ◽

2021 ◽

Author(s):

Roman David Bülow ◽

Daniel Dimitrov ◽

Peter Boor ◽

Julio Saez-Rodriguez

Keyword(s):

Artificial Intelligence ◽

Multidisciplinary Approach ◽

Immunoglobulin A ◽

Improve Patient Care ◽

Integrated Analysis ◽

Clinical Expertise ◽

End Stage ◽

The Complement System ◽

Improve Patient ◽

Generation Sequencing

AbstractIgA nephropathy (IgAN) is the most common glomerulonephritis. It is characterized by the deposition of immune complexes containing immunoglobulin A (IgA) in the kidney’s glomeruli, triggering an inflammatory process. In many patients, the disease has a progressive course, eventually leading to end-stage kidney disease. The current understanding of IgAN’s pathophysiology is incomplete, with the involvement of several potential players, including the mucosal immune system, the complement system, and the microbiome. Dissecting this complex pathophysiology requires an integrated analysis across molecular, cellular, and organ scales. Such data can be obtained by employing emerging technologies, including single-cell sequencing, next-generation sequencing, proteomics, and complex imaging approaches. These techniques generate complex “big data,” requiring advanced computational methods for their analyses and interpretation. Here, we introduce such methods, focusing on the broad areas of bioinformatics and artificial intelligence and discuss how they can advance our understanding of IgAN and ultimately improve patient care. The close integration of advanced experimental and computational technologies with medical and clinical expertise is essential to improve our understanding of human diseases. We argue that IgAN is a paradigmatic disease to demonstrate the value of such a multidisciplinary approach.

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Acute Disseminated Encephalomyelitis (ADEM): A Demyelinating Disease with Specific Morphological Features

International Journal of Surgical Pathology ◽

10.1177/1066896921993562 ◽

2021 ◽

pp. 106689692199356

Author(s):

Fleur Cordier ◽

Lars Velthof ◽

David Creytens ◽

Jo Van Dorpe

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Differential Diagnosis ◽

Clinical Case ◽

Demyelinating Disease ◽

Acute Disseminated Encephalomyelitis ◽

Demyelinating Diseases ◽

Demyelinating Disorder ◽

Immune Mediated ◽

The Central Nervous System

Acute disseminated encephalomyelitis (ADEM) is a rare immune-mediated inflammatory and demyelinating disorder of the central nervous system. Its characteristic perivenular demyelination and inflammation aid in the differential diagnosis with other inflammatory demyelinating diseases. Here, we present a clinical case of ADEM, summarize its histological hallmarks, and discuss pitfalls concerning the most important neuropathological differential diagnoses.

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Lipschütz Ulcer: An Unusual Diagnosis that Should Not be Neglected

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0041-1729147 ◽

2021 ◽

Vol 43 (05) ◽

pp. 414-416

Author(s):

Daniela Alexandra Gonçalves Pereira ◽

Eliana Patrícia Pereira Teixeira ◽

Ana Cláudia Martins Lopes ◽

Ricardo José Pina Sarmento ◽

Ana Paula Calado Lopes

Keyword(s):

Emergency Department ◽

Differential Diagnosis ◽

Clinical Course ◽

Malignant Tumors ◽

Sudden Onset ◽

Drug Reactions ◽

Genital Ulceration ◽

Sexually Transmitted ◽

Inflammatory Processes ◽

Genital Ulcers

AbstractThe diagnosis of genital ulcers remains a challenge in clinical practice. Lipschütz ulcer is a non-sexually transmitted rare and, probably, underdiagnosed condition, characterized by the sudden onset of vulvar edema along with painful necrotic ulcerations. Despite its unknown incidence, this seems to be an uncommon entity, with sparse cases reported in the literature. We report the case of an 11-year-old girl who presented at the emergency department with vulvar ulcers. She denied any sexual intercourse. The investigation excluded sexually transmitted infections, so, knowledge of different etiologies of non-venereal ulcers became essential. The differential diagnoses are extensive and include inflammatory processes, drug reactions, trauma, and malignant tumors. Lipschütz ulcer is a diagnosis of exclusion. With the presentation of this case report, the authors aim to describe the etiology, clinical course, and outcomes of this rare disease, to allow differential diagnosis of genital ulceration.

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Psychological treatment of trihotillomania: A case study

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.369 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S417-S417

Author(s):

T. Sarmiento Luque ◽

J.M. Sanchez

Keyword(s):

Public Health ◽

Clinical Case ◽

Psychological Treatment ◽

Cognitive Behavioral ◽

Clinical Aspects ◽

Hair Pulling ◽

Behavioral Techniques ◽

Competing Interest ◽

Treatment Procedures

This paper presents a clinical case of trichotillomania. Therefore, the aim of this study is to present in detail the procedure followed in a case of trichotillomania in a public health context, using cognitive-behavioral techniques, in order to deepen the knowledge of the efficacy of these treatment procedures and demonstrate the feasibility of implementation.The results obtained show significant improvements in different clinical aspects: first, the hair pulling behavior disappeared completely; moreover, anxiety diminished significantly and mood normalized. All these results allow us to conclude that the intervention was successful.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Congenital optic disc coloboma

Russian ophthalmology of children ◽

10.25276/2307-6658-2021-1-33-39 ◽

2021 ◽

pp. 33-39

Author(s):

A.O. Nazarenko ◽

◽

E.E. Sidorenko ◽

D.V. Miguel ◽

A.S. Smartsev ◽

...

Keyword(s):

Differential Diagnosis ◽

Optic Nerve ◽

Clinical Picture ◽

Clinical Case ◽

Charge Syndrome ◽

Diagnostic Methods ◽

Newly Diagnosed ◽

Optic Nerve Atrophy ◽

Optic Disc Coloboma ◽

Optic Nerve Coloboma

A clinical case of observation of a 3-year-old child with a newly diagnosed optic nerve coloboma and multiple malformations is considered. The clinical picture and diagnostic methods necessary for the diagnosis are reflected. On the example of this child, the differential diagnosis with Charge syndrome is considered. Key words: coloboma, optic nerve coloboma, partial optic nerve atrophy, astigmatism, Charge syndrome.

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Clinical case of recurrent vomiting in a child: diagnostic search from functional gastrointestinal disorders to piloid astrocytoma

Practical medicine ◽

10.32000/2072-1757-2021-1-78-81 ◽

2021 ◽

Vol 19 (1) ◽

pp. 78-81

Author(s):

E. N. Voronina ◽

◽

D. V. Pechkurov ◽

A. A. Tyazheva ◽

E. V. Kozarez ◽

...

Keyword(s):

Differential Diagnosis ◽

Nutritional Status ◽

Clinical Case ◽

Anxiety Symptom ◽

Functional Gastrointestinal Disorders ◽

Integrated Approach ◽

Gastrointestinal Disorders ◽

Wide Range ◽

High Prevalence ◽

Recurrent Vomiting

The urgency of the problem of recurrent vomiting in children is due not only to the high prevalence of this syndrome, but also to a wide range of reasons for its development. The article presents a clinical case of observation of a child with recurrent vomiting syndrome. It shows the dynamics of the disease, the importance of identifying such «anxiety symptom» as the nutritional status violation. In this case, the cause of vomiting of central genesis was not immediately taken into account, although differential diagnosis presupposes an integrated approach, and doctors' oncological alertness should be constantly preserved even in pediatrics.

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