scholarly journals CORRECTION OF ANTIOXIDANT SYSTEM STATE IN PATIENTS WITH MICROBIAL ECZEMA

2019 ◽  
Vol 22 (5-6) ◽  
pp. 167-171
Author(s):  
M. M Tlish ◽  
Elena K. Popandopulo
Keyword(s):  
Antioxidant System ◽  
Standard Therapy ◽  
Metabolic Disorders ◽  
Clinical Manifestations ◽  
Pathological Process ◽  
Control Group ◽  
System State ◽  
Inflammatory Dermatosis ◽  
Before And After ◽  
Positive Effect

Antioxidant system dysfunction is a significant factor in the pathogenesis of inflammatory dermatosis. Despite an impressive number of studies on the causes and chronization of microbial eczema, the development of a comprehensive approach to therapy taking into account metabolic disorders remains a pressing task. Material and metods. In the course of this study, the effectiveness and expediency of including in microbial eczema therapy a preparation of antioxidant action of dimethyloxobutylphosphonyldimethylate (DFD) was evaluated based on the dynamics of antioxidant system dysfunction indices, markers of syndrome of endogenous intoxication and clinical manifestations. The material for the study was the blood of patients with microbial eczema taken before and after treatment. Dynamics of parameters of enzymatic and non-enzymatic units of antioxidant system dysfunction, level middle mass molecules were analyzed against the background of standard therapy and with inclusion of DFD. Results. Inhibition of antioxidant system dysfunction activity compared to the control group was detected in the blood of all microbial eczema patients prior to treatment. No antioxidant status was observed after the standard therapy course despite achieving clinical improvement. The inclusion of DFD in complex microbial eczema therapy had a positive effect on the state of antioxidant system dysfunction and the dynamics of the skin pathological process.

scholarly journals Influence on Forgiveness, Character Strengths and Satisfaction with Life of a Short Mindfulness Intervention via a Spanish Smartphone Application

2021 ◽  
Vol 18 (2) ◽  
pp. 802
Author(s):  
Juan Pablo Pizarro-Ruiz ◽  
Nuria Ordóñez-Camblor ◽  
Mario Del-Líbano ◽  
María-Camino Escolar-LLamazares
Keyword(s):  
Negative Affect ◽  
Satisfaction With Life ◽  
Character Strengths ◽  
Well Being ◽  
Smartphone Application ◽  
Control Group ◽  
Psychological Practice ◽  
Before And After ◽  
Reducing Stress ◽  
Positive Effect

Mindfulness-based interventions (MBI) are a recognized effective psychological practice characterized by attention control, awareness, acceptance, non-reactivity, and non-judgmental thinking obtained through the practice of meditation. They have been shown to be useful in reducing stress and enhancing well-being in different contexts. In this research, the effectiveness of an MBI was evaluated on variables that can promote successful job performance such as mindfulness trait, positive and negative affect, forgiveness, personality strengths and satisfaction with life. The intervention was carried out through a smartphone application called “Aire Fresco” (Fresh Air) during 14 days in the middle of the quarantine produced by the Covid-19 pandemic. The study sample was composed of 164 Spanish people who were distributed in two groups: control group and experimental group, which were evaluated before and after the intervention. The MANCOVA performed showed an overall positive effect of the intervention on the variables evaluated. The different ANCOVAs carried out showed that the intervention was beneficial in increasing mindfulness trait, reducing negative affect or increasing life satisfaction, among others. Our study is, as far as we know, the first to demonstrate the effectiveness of a brief intervention in mindfulness conducted using a smartphone application in Spanish.

scholarly journals Effects of pre-extraction intermittent PTH administration on extraction socket healing in bisphosphonate administered ovariectomized rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jae-Young Kim ◽  
Hyo-Won Jang ◽  
Jung-In Kim ◽  
In-Ho Cha
Keyword(s):  
Tooth Extraction ◽  
Bisphosphonate Therapy ◽  
Ovariectomized Rats ◽  
Control Group ◽  
Micro Ct ◽  
Micro Computed Tomography ◽  
Extraction Socket ◽  
Before And After ◽  
Socket Healing ◽  
Positive Effect

AbstractThe purpose of this study was to investigate the effect of administering intermittent parathyroid hormone (iPTH) before tooth extraction versus after tooth extraction on the risk of developing MRONJ in experimental animal model. Twenty-five ovariectomized rats received 6 weeks of bisphosphonate therapy. They were classified into 3 groups, based on the timing of the medication, as Control, Pre-PTH and Post-PTH groups. For Control group, normal saline was administered before and after tooth extraction. iPTH was administered during 4 weeks before tooth extraction for Pre-PTH group and after tooth extraction for Post-PTH group. The animals were euthanized 8 weeks after tooth extraction. Macroscopic, histological, micro-computed tomography (micro-CT), and histomorphometric examinations were conducted. The incidences of impaired healing were 11.11% both in Pre-PTH and Post-PTH groups, which was lower than the Control group (42.86%). Bone healing in the extraction socket, based on micro-CT and histomorphometry evaluations, was best in Post-PTH and worst in Control group. The Pre-PTH group showed moderate healing pattern. Despite of limitations in this study, the authors identified Pre-PTH group seems to have positive effect on extraction socket healing. With regard to timing, administering iPTH after tooth extraction was superior to applying it before tooth extraction.

scholarly journals The Effect of Memory Strategy Training on Vocabulary Learning by EFL Female Students of the College of Languages and Translation: An Experimental Study

2018 ◽  
Author(s):  
Arab World English Journal ◽  
Ghadah Fahad Alzaidi
Keyword(s):  
Traditional Instruction ◽  
Strategy Training ◽  
Control Group ◽  
King Saud University ◽  
New Words ◽  
Before And After ◽  
Post Test ◽  
Students Attitudes ◽  
Positive Effect ◽  
Experimental Group

The purpose of this study was to investigate the effectiveness of memory strategies (MSs)in improving students' ability to recall and spell newly learned vocabulary items. The researcheronly considered three types of MSs: grouping, placing new words in to a context and structuredreviewing. In addition, the study used a questionnaire that explored students' attitudes towardsMSs in general, and towards the specific MSs that they have been trained to use, as well as therelationship between MSs and motivation and between MSs and anxiety. intact groups (63 students in total) were selected from level three of the College of Languages and Translation (COLT) at King Saud University (KSU), Kingdom of Saudi Arabia. The two groups were assigned to the experimental group (36 students) and the control group(27students). The control group received traditional instruction that depended on the textbook without any MS training, whereas the experimental group received a combination of traditional instruction and MS training. A pre- and post-test were administered to both groups before and after the experiment to examine students' ability to recall the meaning of vocabulary items and their ability to spell them correctly. The experiment lasted for fourteen weeks through which the participants received seven MS training sessions. The study found out that MS training was effective in improving students' ability to recall the meaning of vocabulary items when needed and their ability to spell them correctly. Moreover, the results showed that the subjects of the experimental group showed positive attitude towards MSs and most of them agreed on the positive effect that MSs had on raising their motivation and reducing their anxiety while learning vocabulary.

scholarly journals Influence of B. bovis hairworms on biochemical parameters of blood of patients with bovicolosis of calves

2019 ◽  
Vol 21 (94) ◽  
pp. 163-168
Author(s):  
A. M. Shevchenko
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Clinical Manifestations ◽  
Mean Value ◽  
Pathological Process ◽  
Control Group ◽  
Glucose Content ◽  
Normal Limits ◽  
Negative Effect ◽  
Biochemical Research

The purpose of the work was to identify the features of the pathological process and changes in the main indicators of blood of cattle for the damage by its hairworms B. bovis. Scientific researches were conducted in the conditions of the Ploskivske BPPZ of the Brovarsky District of the Kyiv Region and the Laboratory of Biochemical Research of the National Cancer Institute. To do this, two groups of young cattle, black-and-white breeds up to one year old with 7 heads in each, were created. The experimental group included calves spontaneously invasive with hairworms. The control group was free of animal parasites. For this, they were previously, in two months, subjected to two-fold treatment with Insecticide Tactics (MSD, the Netherlands). Selected animals on the principle of analogues. All calves were in the same sanitary and hygienic conditions and received the same feed according to the diet. It was found that the glucose content in a sick young bovine animal was 6.25% (P < 0.5) higher than that in calf-free calves. There was a probable difference in the level of urea in the blood of animals, where the average level in the infected calves was 12.69% (P < 0.001) higher than in the control animals. The tendency to decrease by 15.31% (P < 0.5) was found in the average values of serum creatinine in calves in sick animals compared with the group of animals that served as controls and were free from parasites. In blood serum, calves infected with hairworms was found a slightly higher (4.25%, P < 0.5) level of total bilirubin than those found free from parasites. Indicators of serum cholesterol levels in blood serum of experimental animals were within normal limits. However, it was significantly lower by 14.71% (P < 0.05) in animals affected by parasites. The albumin-globulin ratio in our studies in invasive calves was 9.8% (P < 0.01) higher than that of control animals. In experimental calves with clinical manifestations of bovycolous, the average index of alkaline phosphatase content was 17.58% (P < 0.5) lower than its mean value in blood serum free of invasion by parasites of animals. Thus, among the biochemical parameters of serum of blood of invasive calves, a probable increase in urea and albumin to globulin ratios and a decrease in cholesterol was observed, indicating a negative effect of the hairworms on the organism of animals.

scholarly journals 1% ivermectin in combination therapy regimens for rosacea

2020 ◽  
pp. 17-23
Author(s):  
E. A. Khlystova ◽  
A. L. Savastenko
Keyword(s):  
Quality Of Life ◽  
Comparative Analysis ◽  
Combination Therapy ◽  
Combination Treatment ◽  
Clinical Manifestations ◽  
Life Quality ◽  
Clinical Results ◽  
Control Group ◽  
Before And After

Introduction. The article provides latest data on modern methods of treating rosacea. The results of own clinical observations of patients with moderate to severe papulopustular rosacea receiving combination treatment and a comparative analysis of the efficacy of various therapy regimens are presented.Objective of the study. The aim of the study was to conduct a comparative analysis of the therapeutic efficacy of combination therapy using the ivermectin 1% topical drug combined with systemic therapy drugs (doxycycline, minocycline, isotretinoin).Materials and methods. We observed 37 patients with moderate to severe papulo-pustular rosacea subtype. The patients were divided into 4 groups (A, B, C, D). Patients in the control group received monotherapy with 1% ivemectin topical drug, patients in the other groups received combination therapy (1% ivermectin combined with low-dose doxycycline, minocycline and isotretinoin). The efficacy of the therapy was evaluated by measuring rosacea severity on the Scale for Diagnostic Assessment of Rosacea (SDAR), clinical manifestations according to the IGA (Investigator Global Assessment) criteria, and by assessing the patients' quality of life using the DLQI (Dermatology Life Quality Index) questionnaire before and after 3-month treatment.Results. The comparative analysis of changes in severity indicators of the skin process and quality of life in patients with moderate to severe papulopustular rosacea after topical and combination therapy showed that the results of the treatment in patients receiving combination therapy were more significant than those in the group receiving monotherapy.Conclusion. The concomitant use of 1% ivermectin and systemic drugs is most effective in patients with severe papulopustular rosacea subtype. The combination treatment tailored to the clinical forms and severity of rosacea allows to optimize the clinical results of the therapy, which significantly affects the patients' quality of life and opens up potential for an individual approach in the algorithms for the treatment of rosacea.

scholarly journals The role of plant stanols in the primary prevention of hypercholesterolemia in patients with arterial hypertension

2019 ◽  
Vol 18 (3) ◽  
pp. 5-10
Author(s):  
A. S. Safaryan ◽  
T. V. Kamyshova ◽  
D. V. Nebieridze ◽  
V. D. Sargsyan
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Clinical Manifestations ◽  
Hdl Cholesterol ◽  
Average Level ◽  
Control Group ◽  
Study Group ◽  
Plant Stanols ◽  
Before And After ◽  
Lipid Parameters

Aim. To assess the efficacy and safety of plant stanols in patients with arterial hypertension (AH) and disorders of lipid metabolism, without clinical manifestations of atherosclerosis.Material and methods. The study included 40 patients — men at the age of 50-55 years, with AH (stage 1) and cholesterol above 5,0 mmol/l and LDL cholesterol above 3,0 mmol/l with low and medium risk (SCORE — 1-4%). Patients with coronary artery disease and other clinical manifestations of atherosclerosis, secondary hypertension, liver diseases, diabetes mellitus, secondary dyslipoproteinemia, cardiovascular diseases requiring constant therapy, bronchial asthma were excluded from the study. Patients were randomized into 2 groups of 20 people. In the study group of patients within 3 months received plant stanols (2 tab./day), in the control group — only healthy diet. In addition, patients with high blood pressure received antihypertensive therapy. Assessment of lipid parameters (total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides) was performed at baseline and after 3 months. At the beginning of the study, after 3 months of the study patients underwent a full medical examination. Safety control of plant stanols was carried out by determination of liver enzymes (aspartic transaminase (AST), alanine transaminase (ALT)), before and after the completion of the study.Results. Patients of two groups were comparable in baseline characteristics (lipid parameters, blood pressure level). After 3 months of research beginning patients from study group have statistically significant decrease of total cholesterol and LDL cholesterol. The average level of total cholesterol before treatment was 5,8±0,32 mmol/l, and after treatment — 5,3±0,32 mmol/l, p<0,001. The average level of LDL cholesterol before treatment was 3,6±0,26 mmol/l, and after treatment — 3,3±0,25 mmol/l, p<0,001. According to other lipid parameters (HDL cholesterol, triglycerides) significant differences are not obtained. As a result, there was a significant reduction in the total risk from 4% to 3,1%. As for the control group, the dynamics of lipid parameters were practically not observed. For example, the average level of total cholesterol before treatment was 5,7±0,39 mmol/l, and after treatment — 5,6±0,42 mmol/l. The average level of LDL cholesterol before treatment was 3,6±0,21 mmol/l, and after treatment — 3,6±0,21 mmol/l. The differences between the study and control groups in the reduction of total and LDL cholesterol were highly significant (p<0,001). The study did not reveal the dynamics of liver enzymes. The level of AST before treatment in the study group was 28,4±6,54, and after treatment — 29,5±5,56. ALT levels were 32,3±7,38 and 33,9±5,65, before and after the study, respectively.Conclusion. The study shows the high efficacy and safety of plant stanols. We found a significant decrease of the two most important parameters of lipid metabolism — total cholesterol and LDL cholesterol.

scholarly journals Osteopathic Correction in Complex Therapy of Patients with Mild Cognitive Impairment

2017 ◽  
pp. 40-47
Author(s):  
O. F. Anufriev ◽  
V. O. Belash ◽  
V. M. Utochkin
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Focus Group ◽  
Depression Scale ◽  
Control Group ◽  
Somatic Dysfunction ◽  
Complex Therapy ◽  
Before And After ◽  
Group 2 ◽  
Positive Effect

Goal of research - the study aims to evaluate the effectiveness and scientifi c basis for the use of osteopathic correction in the treatment of cognitive impairment.Materials and methods. Two groups of patients participated in the study: Group 1 (focus group) included 22 patients with a syndrome of mild cognitive impairment who received medication and osteopathic correction; Group 2 (control group) consisted of 22 patients who received medication only. The groups were comparable in age, sex, and severity of cognitive impairment. All patients observed before and after treatment underwent complex osteopathic and neuropsychological examinations.Results. The study found that the inclusion of osteopathic correction in the treatment of patients with mild cognitive impairment has a positive effect on the dynamics of a number of neuropsychological tests. In particular, there is a statistically signifi cant increase in the indicators based on the results of the Montreal Cognitive Evaluation Scale; there is a decrease in the overall anxiety level based on the results of the Hospital Alarm and Depression Scale. Moreover, the focus group shows a statistically signifi cant decrease in the severity of somatic dysfunction in the head and neck area, both structural and visceral components, which was not observed in the control group.Conclusion. The results from the study suggest recommending the inclusion of osteopathic correction in the complex therapy for patients with mild cognitive impairment.

Effect of acupressure on post tonsillectomy pain in adolescents: a randomized, single-blind, placebo-controlled trial study

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Somaye Pouy ◽  
Abolfazl Etebarian Khorasgani ◽  
Ali Azizi-Qadikolaee ◽  
Yasaman Yaghobi
Keyword(s):  
Pain Control ◽  
Controlled Trial ◽  
Intervention Group ◽  
Routine Care ◽  
Control Group ◽  
Significant Difference ◽  
The World ◽  
Before And After ◽  
Positive Effect ◽  
Single Blind

Abstract Introduction Tonsillectomy is one of the most common pediatric surgeries in the world and pain control following tonsillectomy is very important. Objective The aim of this study is to investigate the effect of acupressure on the amount of pain following tonsillectomy in children. Method One hundred and forty-four children aged 5–12 years old were assigned into one of three groups: interventions, control and placebo. In the intervention group, acupressure was applied at three acupoints and in the placebo group, sham acupressure was applied. In the control group routine care only was applied. Results There was a significant difference between an average of changes in pain score before and after the intervention during the 3 time periods after the tonsillectomy operation in the acupressure group (p = 0.002). Conclusion The results showed that acupressure had a positive effect on pain reduction after tonsillectomy in children in the intervention group.

Relationship Satisfaction Can Help to Maintain the Positive Effect of Childbirth on Parental Self-Esteem

2020 ◽  
pp. 194855062097153
Author(s):  
Mario Wenzel ◽  
Doris Staab ◽  
Zarah Rowland ◽  
Manon A. van Scheppingen
Keyword(s):  
Relationship Satisfaction ◽  
Transition To Parenthood ◽  
Self Esteem ◽  
Control Group ◽  
Positive Effects ◽  
Before And After ◽  
Adaptive Processes ◽  
Baseline Levels ◽  
Positive Effect

The transition to parenthood is accompanied by declined self-esteem levels, which may be explained by parents’ relationship satisfaction. However, prior research examined self-esteem only shortly before and after childbirth and had no or only unmatched childless respondents as a control group, limiting the possibility to examine long-term adaptive processes and the causal interpretation of the associations. Thus, we used panel data (10 years, 4,075 individuals, and 16,122 observations) to compare self-esteem and relationship satisfaction trajectories of parents with matched childless respondents using propensity score matching. We found a quadratic trajectory for parents’ self-esteem, which declined and increased before birth and declined and returned to baseline levels after birth. In contrast, matched childless respondents’ self-esteem decreased linearly before childbirth and then recovered. The quadratic postpartum process in parents was significantly associated with reduced relationship satisfaction. Thus, a fulfilling relationship may help to maintain the positive effects of childbirth on self-esteem in parents.

A Pilot Study on the Effect of Rapport on the Task Performance of an Elderly Confused Population

1988 ◽  
Vol 55 (5) ◽  
pp. 255-258 ◽  
Author(s):  
Linda Porszt-Miron ◽  
Majka Florian ◽  
Jean Burton
Keyword(s):  
Task Performance ◽  
Effective Interaction ◽  
Control Group ◽  
Helping Professions ◽  
Group Leaders ◽  
Control Subjects ◽  
Clinical Observations ◽  
Before And After ◽  
Experimental Subjects ◽  
Positive Effect

Rapport has been viewed traditionally by the helping professions as a prerequisite to effective interaction between therapist and patient. Clinical observations indicate that confused elderly residents of a Home for the Aged have the capacity to establish warm personal relationships with their therapists and caregivers. In order to determine if this apparent rapport has a positive effect on task performance, six confused subjects were assigned either to an experimental or control group. They were administered the Picture Identification Task before and after receiving a program designed to establish rapport with their respective leaders. All testing was done by the experimental group leaders. Thus the experimental subjects had rapport with the administrators, while the control subjects did not. The data indicated that experimental subjects decreased their inappropriate behaviours, were able to respond quicker, and made better use of nonverbal test cues at posttest. Control subjects did not demonstrate these changes. It was concluded that rapport can facilitate some task behaviours despite cognitive impairment.

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