scholarly journals 1% ivermectin in combination therapy regimens for rosacea

2020 ◽  
pp. 17-23
Author(s):  
E. A. Khlystova ◽  
A. L. Savastenko
Keyword(s):  
Quality Of Life ◽  
Comparative Analysis ◽  
Combination Therapy ◽  
Combination Treatment ◽  
Clinical Manifestations ◽  
Life Quality ◽  
Clinical Results ◽  
Control Group ◽  
Before And After

Introduction. The article provides latest data on modern methods of treating rosacea. The results of own clinical observations of patients with moderate to severe papulopustular rosacea receiving combination treatment and a comparative analysis of the efficacy of various therapy regimens are presented.Objective of the study. The aim of the study was to conduct a comparative analysis of the therapeutic efficacy of combination therapy using the ivermectin 1% topical drug combined with systemic therapy drugs (doxycycline, minocycline, isotretinoin).Materials and methods. We observed 37 patients with moderate to severe papulo-pustular rosacea subtype. The patients were divided into 4 groups (A, B, C, D). Patients in the control group received monotherapy with 1% ivemectin topical drug, patients in the other groups received combination therapy (1% ivermectin combined with low-dose doxycycline, minocycline and isotretinoin). The efficacy of the therapy was evaluated by measuring rosacea severity on the Scale for Diagnostic Assessment of Rosacea (SDAR), clinical manifestations according to the IGA (Investigator Global Assessment) criteria, and by assessing the patients' quality of life using the DLQI (Dermatology Life Quality Index) questionnaire before and after 3-month treatment.Results. The comparative analysis of changes in severity indicators of the skin process and quality of life in patients with moderate to severe papulopustular rosacea after topical and combination therapy showed that the results of the treatment in patients receiving combination therapy were more significant than those in the group receiving monotherapy.Conclusion. The concomitant use of 1% ivermectin and systemic drugs is most effective in patients with severe papulopustular rosacea subtype. The combination treatment tailored to the clinical forms and severity of rosacea allows to optimize the clinical results of the therapy, which significantly affects the patients' quality of life and opens up potential for an individual approach in the algorithms for the treatment of rosacea.

scholarly journals The Effects of “Ceria” Chemotherapy Effect Management on the Life Quality Improvement of Children with Cancer

2019 ◽  
Vol 1 (1) ◽  
pp. 87-96
Author(s):  
Siti Lestari ◽  
Sri Hartini Mardi Asih ◽  
Rusmiyati Rusmiyati
Keyword(s):  
Quality Of Life ◽  
Quality Improvement ◽  
Treatment Group ◽  
Muscle Relaxation ◽  
Life Quality ◽  
Progressive Muscle Relaxation ◽  
Control Group ◽  
Children With Cancer ◽  
Before And After

The prevalence of cancer in children is now increasing and followed by an increasing number of them who undergo chemotherapy. The effect of chemotherapy can reduce the children’s quality of life, hence it requires the contribution of nurses in improving health services to children with cancer. The purpose of the study was to analyze the effect management of “Ceria” chemotherapy : (C)egah Sariawan (preventing mucositis), Cegah (E)kstravasasi (preventing extravacation), (R)elaksasi (Progressive Muscle Relaxation to reduce fatigue), Cegah (I)nfeksi (preventing infection), (A)kupresur (acupressur to reduce nausea and vomiting) on the life quality of children with cancer. The method applied was experimental research using control group design with pretest posttest. The treatment group received intervention in the form of “Ceria” chemotherapy effect management from the researchers while the control group did not receive intervention treatment. The selection of research subjects for the treatment and control groups was done randomly. The children’s quality of life was measured before and after one week of intervention using PedsQL (Children's Quality of Life Inventory). The participants were 76 children (38 in the treatment  group and 38 in the control group). The results of the paired t test showed that there were significant mean differences of life quality before and after "Ceria" chemotherapy effects management on children with cancer (p = 0,0001; sig = 0.05), the highest life quality improvement was found on children who experienced progressive muscle relaxation. This study concludes that "Ceria" chemotherapy effect management  can improve the life quality of children with cancer. Therefore, the reseachers recommend nurses to apply “Ceria” chemotherapy effect management to improve the life quality of children with cancer.   Keywords: cancer, children, quality of life,  "Ceria" chemotherapy effect management

Strengthening the pharmacological potential of drug therapy in treatment of patients with chronic pancreatitis by using therapeutic physical factors

2020 ◽  
pp. 8-14
Author(s):  
R. M. Mallaeva ◽  
A. N. Makhinko ◽  
M. B. Uzdenov
Keyword(s):  
Quality Of Life ◽  
Chronic Pancreatitis ◽  
Drug Therapy ◽  
Clinical Manifestations ◽  
Medical Rehabilitation ◽  
Control Group ◽  
Physical Factors ◽  
Standard Drug ◽  
Pharmacological Potential

The purpose of the study is to improve rehabilitation treatment of patients with chronic pancreatitis (CP) at inpatient stage by strengthening pharmacological potential of drug therapy due to inclusion of therapeutic physical factors (TPF) in therapeutic programs. Materials and methods. 159 patients with acute CP were observed. By simple randomization, 4 groups were formed: the control group (MG, 39 people) received standard drug therapy; 1st comparison group (GC1; 38 people) additionally received TPF; GC2 (40 people) in addition to treatment in GC1 had drinking mineral water «Slavyanovskaya»; in main group (42 people) in addition to the treatment in GC2 got preformed peloidotherapy on the cervical-collar zone. All the patients underwent the evaluation of clinical score and quality of life before and after medical rehabilitation. Results. In MG, clinical symptomatology leveling was by 78,2% (p<0,01), in GC1 — by 71,5% (p<0,01), GC2 — by 62,3% (p<0,01), CG — by 57,2% (p<0,01) on average immediately after the treatment, which was in a clear correlation with indicators of quality of life. In the long term (in 6 and 12 months), the advantage of combination therapy was noted with the same validity, the preservation of the achieved positive result was mostly noted in the MG: after 6 months the improvement in physical health compared to the initial values was noted by 34,4% (p<0,01), after 12 months — by 24,0% (p<0,05); mental — by 32,3% (p<0,01) and 22,5% (p<0,05), respectively. In both comparison groups, positive dynamics was 10–12% lower, and in the control group, after 6 months, there was only a tendency to improve quality of life indicators. Conclusion. The inclusion of TPF in the programs of the inpatient stage of medical rehabilitation of patients with chronic pancreatitis by strengthening the pharmacological potential of drug therapy contributes to the leveling of clinical manifestations (abdominal pain, dyspepsia and diarrhea), the result of which is an improvement in the quality of life of this category of patients.

The effects of breathing exercises on respiratory functions, functional capacity and quality of life in vehicle spray painters

2021 ◽  
Vol 28 (12) ◽  
pp. 1-8
Author(s):  
Burak Yilmaz ◽  
Cagtay Maden ◽  
Begümhan Turhan
Keyword(s):  
Quality Of Life ◽  
Functional Capacity ◽  
Control Group ◽  
Study Group ◽  
Breathing Exercises ◽  
Sf 36 ◽  
Significant Difference ◽  
Before And After ◽  
Respiratory Exercises

Background/aims Workers engaged in vehicle spray painting are at a risk of developing respiratory problems because of the solvents in the spray paints. Changes in respiratory functions and functional capacities caused by spray painting can be improved with respiratory exercises. The aim of this study was to examine the effects of respiratory exercises on the respiratory functions, functional capacity and quality of life in vehicle spray painters. Methods A total of 70 volunteers with similar characteristics participated in the study. The groups were divided into two groups randomly (35 study group, 35 control group). Respiratory functions (value of forced expiratory volume percentage in 1 second [FEV1]), forced vital capacity percentage [FVC], FEV1/FVC percentage, peak expiratory flow percentage [PEF (%)] and maximum voluntary ventilation percentage [MVV (%)]), functional capacity (6-Minute Walk Test) and quality of life (Short Form Health Survey [SF-36]) were evaluated. The study group undertook supervised breathing exercises 3 days a week for 6 weeks. The same exercises were given to the control group as a home programme. Home programmes were followed up by telephone calls. Evaluations were performed again after 6 weeks. Results In the study group, FEV1 (%) increased more than in the control group (P<0.05). The increase in PEF (%) was similar in both groups (P>0.05). In the study group, FEV1/FVC (%) and MVV (%) were significantly different before and after the intervention (P<0.05), but there was no difference in the control group (P>0.05). There was a greater increase in the study group than in the control group (P<0.05). 6-Minute Walk Test distance (m) before and after the intervention in both groups were similar (P>0.05). Before and after the intervention, a significant difference was found in the vitality and the social function domains of the SF-36 in the study group. In the comparisons of groups, a significant difference was found in the study group in the role-emotional, social function and bodily pain domains of the SF-36 after the intervention (P<0.05). Conclusions Breathing exercises can be recommended for vehicle spray painters to avoid an increase in respiratory resistance and to improve their quality of life.

scholarly journals Satisfaction with Quality of Life in Patients with Minimum Cicatricial Damage of the Face and Neck

2018 ◽  
Vol 7 (1) ◽  
pp. 75-90 ◽  
Author(s):  
A. Iaremenko ◽  
E. Isaeva ◽  
T. Kolegova ◽  
E. Sitkina ◽  
Yu. Vasilieva
Keyword(s):  
Quality Of Life ◽  
Physical Condition ◽  
Traditional Method ◽  
Comparison Group ◽  
Short Form ◽  
Life Quality ◽  
Control Group ◽  
Surgical Methods ◽  
The Face

Satisfaction with quality of life and self-attitude in patients operated by «traditional» (conventional surgical methods) and endoscopically assisted methods are considered in the article. Differences in the quality of life in patients, self-attitude to ones appearance are described. 65 patients were surgically operated and examined. Control group – patients operated by «traditional» techniques (35 patients), the average age of patients was 38 ± 11,1 years. The comparison group – patients operated using endoscopically assisted methods (30 patients), the average age of patients was 44 ± 17,7 years. Psychodiagnostic methods: 1. N. E. Vodopyanova`s scale of life quality; 2. The Short Form-36; 3. S.R. Panteleev`s Assessment of self-relationship. Complaints of paresthesia and pain experienced by patients who underwent a “traditional” operation were revealed as a result of the examination. Operated on with an endoscopically assisted method patients did not present any complaints. Differences between the assessment of the life quality and self-relationship in examined groups were found. Operated on with an endoscopically assisted method patients evaluated life quality, satisfaction with their appearance and physical condition higher than patients operated on with a “traditional” method.

scholarly journals The Effect of Respiratory Rehabilitation Training on the Life Quality of Pneumoconiosis Patients

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Lijun Chen ◽  
Wang Xu ◽  
Xiaoyong Ma ◽  
Genggeng Yu ◽  
Jianfeng Wang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Knowledge ◽  
Pulmonary Ventilation ◽  
Life Quality ◽  
Control Group ◽  
Observation Group ◽  
Rehabilitation Training ◽  
Pulmonary Ventilation Function ◽  
Respiratory Rehabilitation

Objective: To explore the effect of respiratory rehabilitation training on the quality of life of pneumoconiosis patients. Methods: 76 pneumoconiosis patients who were treated in our hospital from April 2017 to December 2019 were selected as the research object, and randomly divided into 2 groups according to the order of admission by coin tossing, 38 cases in each group. The control group carried out health knowledge education on the basis of conventional treatment, and the observation group combined with respiratory rehabilitation training on the basis of the control group to compare the quality of life and lung function of the two groups of patients. Results: After 2 months of nursing care, scores of GQOLI-74 scale and pulmonary ventilation function indexes in the observation group were higher than those in the control group, with statistically significant differences (P<0.05). Conclusion: Respiratory rehabilitation training can improve pulmonary ventilation function of pneumoconiosis patients, improve the quality of life of patients, has good clinical application value.

scholarly journals Rehabilitation Nursing Intervention Can Improve Dysphagia and Quality of Life of Patients Undergoing Radiotherapy for Esophageal Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Xiange Zeng ◽  
Ling Li ◽  
Wenjing Wang ◽  
Lihui Zhu
Keyword(s):  
Quality Of Life ◽  
Esophageal Cancer ◽  
Intervention Group ◽  
Life Quality ◽  
Nursing Intervention ◽  
Control Group ◽  
Swallowing Function ◽  
Acute Radiation Injury ◽  
Random Number Table

Objective. To seek the improvement of rehabilitation nursing intervention on dysphagia and quality of life of patients with esophageal cancer undergoing radiotherapy. Methods. A total of 109 patients with esophageal cancer undergoing radiotherapy were selected as research objects. According to the random number table, they were separated into the control group (CG) and intervention group (IG), with 45 cases in CG and 64 cases in IG. In CG, patients were given routine nursing intervention, while those in IG were given rehabilitation nursing intervention. After intervention, the degree of acute radiation injury and the improvement of swallowing function were observed to compare the self-nursing ability, quality of life, and incidence of complications between the two groups. Results. The degree of injury in CG was heavier than that in IG. The improvement of swallowing function in IG was better than that in CG. The scores of self-nursing ability and life quality in IG were higher than those in CG, with statistically significant differences ( p < 0.05 ). The incidence of complications in IG was obviously lower than that in CG ( p < 0.05 ). Conclusion. Rehabilitation nursing intervention can ameliorate dysphagia, improve the quality of life, and reduce the incidence of complications for patients with esophageal cancer undergoing radiotherapy. It is worthy of clinical application.

scholarly journals Study and methodology for research of the life quality in students

2019 ◽  
Vol 95 (9) ◽  
pp. 879-884
Author(s):  
Valery I. Popov ◽  
E. P. Melikhova
Keyword(s):  
Quality Of Life ◽  
Comparative Analysis ◽  
Life Quality ◽  
Evaluation Approach ◽  
Methodological Approaches ◽  
Young Students

In this article there is reported a comparative analysis of methodological approaches to the assessment of the quality of life. There are present results of studies of quality of life of young students, performed with the use of compared methodological approaches (questionnaires) and allowing to construct the evaluation approach to the study of the quality of life in students.

scholarly journals Compressive Stockings After Hindfoot and Ankle Surgery

2018 ◽  
Vol 3 (3) ◽  
pp. 2473011418S0023
Author(s):  
Florian Grubhofer ◽  
Stephan Wirth
Keyword(s):  
Quality Of Life ◽  
Clinical Results ◽  
Control Group ◽  
End Points ◽  
High Compliance ◽  
Group I ◽  
Sf 36 ◽  
Ankle Surgery ◽  
Group Ii

Category: Hindfoot Introduction/Purpose: Swelling and pain are common after foot and ankle procedures. We hypothesized that compressive stockings (CS) treatment after hindfoot surgery would positively influence patient outcomes. Methods: We undertook this randomized controlled trial in 87 consecutive patients to analyze the clinical effect of CS after hindfoot and ankle surgery and evaluate CS-wearing compliance using sensors that were implanted into CS. Ankle swelling, pain status, quality of life (SF-36 score), and the American Orthopaedic Foot & Ankle Score (AOFAS) were set as the primary end points. The CS wearing time in hours and percentage were investigated as the secondary end points. All participants with CS (group I) were informed about the implanted sensor after the CS were taken off. A subgroup analysis of group I was performed to detect differences between patients with high vs low compliance. Results: At 12 weeks, the results of ankle swelling (mean 234 mm in group I and 232 mm in group II), pain in the visual analog scale (1.7 group I vs 1.9 in group II), the SF-36 score (38 points in group I vs 30 points in group II), and the AOFAS score (a mean of 76 points in both groups) showed no statistical differences between the 2 groups. The mean wearing time was 136 (range, 0-470) hours, which corresponds to a compliance rate of 65%. Sixteen participants had high compliance (>80%, >170 hours), and 21 patients had low or noncompliance. The clinical results of patients with high wearing compliance were not significantly better compared to the results of patients with low compliance. Conclusion: CS therapy after ankle and hindfoot surgery was associated with a low wearing compliance and did not influence ankle swelling, function, pain, and the quality of life compared to the control group. Furthermore, the clinical results of patients with high compliance were not better compared to the results of patients with low or noncompliance wearing behavior.

scholarly journals Effects of a Rehabilitation Programme with a Nasal Inspiratory Restriction Device on Exercise Capacity and Quality of Life in COPD

2020 ◽  
Vol 17 (10) ◽  
pp. 3669 ◽  
Author(s):  
Aurelio Arnedillo ◽  
Jose L. Gonzalez-Montesinos ◽  
Jorge R. Fernandez-Santos ◽  
Carmen Vaz-Pardal ◽  
Carolina España-Domínguez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Muscle Strength ◽  
Exercise Capacity ◽  
Rehabilitation Program ◽  
Inspiratory Muscle ◽  
Control Group ◽  
6Mwt Distance ◽  
Before And After ◽  
Inspiratory Muscle Strength

Objective: The objective was to assess the effects of a nasal restriction device for inspiratory muscle training, called Feelbreathe®, added to a rehabilitation program (RP) on exercise capacity, quality of life, dyspnea and inspiratory muscle strength in patients with stable COPD. Methods: Patients were randomized into three groups, one performed a supervised RP using the Feelbreathe® device (FB group), the second group developed the same RP with oronasal breathing without FB (ONB group) and the third was the control group (CG). We evaluated inspiratory muscle strength (PImax), dyspnea (mMRC), quality of life (CAT) and exercise capacity (6MWT) before and after 8-week of RP. Results: A total of 16 patients completed the study, seven in FB group, five in ONB group and four in the CG. After the RP, the FB group showed a significant increase in PImax (93.3 ± 19.1 vs. 123.0 ± 15.8 mmHg) and in the 6MWT distance (462.9 ± 71.8 m vs. 529.1 ± 50.1 m) and a decrease in the CAT score (9.7 ± 6.5 vs. 5.9 ± 6.0) and in the mMRC dyspnea score. FB provides greater improvement in PImax, dyspnea, quality of life and 6MWT than ONB. Conclusions: The Feelbreathe® device provides greater improvements in quality of life, dyspnea, exercise capacity and inspiratory muscle strength compared to patients that did not use it.

scholarly journals Evaluation of a Novel Quality of Life Scale for Schoolchildren with Nonstrabismic Binocular Vision Anomalies

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Jiali Hu ◽  
Guokun Wang ◽  
Zhe Zhou ◽  
Yan Sun ◽  
Qingling Zhang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Binocular Vision ◽  
Discriminant Validity ◽  
Life Quality ◽  
Life Assessment ◽  
Average Score ◽  
Control Group ◽  
Quality Of Life Scale ◽  
Life Scale

Background. The professional Quality of Life Scale (QLS) can provide a valuable reference for the diagnosis of visual function anomalies. In the present study, we aimed to design a novel QLS to specially quantify the life quality of schoolchildren with nonstrabismic binocular vision anomalies (NSBVAs) in China. Methods. The novel QLS, named QOL-CVF20, was established based on classical vision-related scales and the administration of the questionnaire to 116 schoolchildren with NSBVAs and 100 healthy schoolchildren in China. The diagnostic reference value between QOL-CVF20 and VF-14 was evaluated on the questionnaires to 240 schoolchildren with NSBVAs and 238 healthy schoolchildren. Results. All the subjects could complete the QOL-CVF20 questionnaires independently. QOL-CVF20 had good structural validity, content validity, and discriminant validity, when it was applied in Chinese schoolchildren. The average score of the NSBVA group was significantly lower than that of the control group (49.0±6.9 vs. 69.7±6.7, respectively; P<0.01). Moreover, the average score of cured NSBVA schoolchildren after treatment (61.8±22.6) was significantly improved (P<0.01). Receiver operating characteristic curve analysis showed that QOL-CVF20 reflected strong separation between the NSBVA and healthy groups (AUC=0.901). Meanwhile, QOL-CVF20 could detect individuals with NSBVAs with specificity of 0.847 and sensitivity of 0.846. The critical value of 58.50 in QOL-CVF20 could be effectively applied for quality of life assessment in schoolchildren with NSBVAs. Conclusions. QOL-CVF20 could quantify the life quality of schoolchildren with NSBVAs and might be served as a valuable reference for early diagnosis and clinical evaluation of NSBVAs.

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