scholarly journals Enterococci and their role in perinatal pathology

2015 ◽  
Vol 64 (5) ◽  
pp. 48-54
Author(s):  
Kristina Albertovna Oganyan ◽  
Ol’ga Nikolaevna Arzhanova ◽  
Svetlana L’vovna Zatsiorskaya ◽  
Alevtina Mikhailovna Savicheva
Keyword(s):  
Pregnant Women ◽  
Preterm Labor ◽  
Perinatal Outcomes ◽  
Urogenital Tract ◽  
Premature Labor ◽  
Fetal Hypoxia ◽  
Perinatal Pathology ◽  
Normal Microflora ◽  
Opportunistic Bacteria ◽  
Threatened Preterm Labor

Enterococcus are opportunistic bacteria and are members of the normal microflora of the gastrointestinal tract of humans and animals. The prevalence of enterococcal infections in pregnant women is approximately 28 %. Enterococcus, colonizing the urogenital tract pregnant women mostly do not show pathogenic effect, however, it is known that they can lead to the development of such complications of pregnancy as threatened preterm labor, placental insufficiency, hypotrophy of the fetus. Of complications in childbirth most common in premature labor, untimely discharge of amniotic fluid, fetal hypoxia. According to the literature cause of neonatal bacteremia and sepsis in 10 % of cases are enterococcus. Thus, for the prevention of complications of pregnancy, delivery and perinatal outcomes in the allocation of Enterococcus urogenital tract to undergo antibacterial therapy, given the sensitivity to antibiotics.

scholarly journals Determinants of Psychosocial Resilience Resources in Obese Pregnant Women with Threatened Preterm Labor—A Cross-Sectional Study

2021 ◽  
Vol 18 (20) ◽  
pp. 10590
Author(s):  
Agnieszka Bień ◽  
Ewa Rzońca ◽  
Joanna Grzesik-Gąsior ◽  
Agnieszka Pieczykolan ◽  
Ewa Humeniuk ◽  
...  
Keyword(s):  
Locus Of Control ◽  
Pregnant Women ◽  
Self Efficacy ◽  
Preterm Labor ◽  
Health Locus Of Control ◽  
Dispositional Optimism ◽  
Moderate Level ◽  
Premature Labor ◽  
Threatened Preterm Labor ◽  
Psychosocial Resilience

Background: The purpose of the study was to assess the level of such psychosocial resilience resources as self-efficacy, dispositional optimism, and health locus of control in pregnant women with obesity with threatened premature labor. Methods: The study was performed in the years 2017–2020 in a group of 328 pregnant women hospitalized due to threatened preterm labor and diagnosed with obesity before the pregnancy. The following instruments were applied: the Life Orientation Test, the Generalized Self-Efficacy Scale, and the Multidimensional Health Locus of Control Scale. Results: Obese pregnant women with threatened premature labor have a moderate level of generalized self-efficacy (28.02) and a moderate level of dispositional optimism (16.20). Out of the three health locus of control dimensions, the highest scores were recorded in the “internal control” subscale (26.08). Statistically significant predictors for the self-efficacy variable model included: satisfactory socio-economic standing (ß = 0.156; p = 0.004), being nulliparous (ß = –0.191; p = 0.002), and the absence of comorbidities (ß = –0.145; p = 0.008). Higher levels of dispositional optimism were found in women who were married (ß = 0.381; p = 0.000), reported a satisfactory socio-economic standing (ß = 0.137; p = 0.005), were between 23 and 27 weeks pregnant (ß = –0.231; p = 0.000), and had no comorbidities (ß = –0.129; p = 0.009). Conclusions: Generalized self-efficacy in obese women with threatened preterm labor is associated with satisfactory socio-economic standing, being nulliparous, and the absence of chronic disease. Dispositional optimism in obese pregnant women with threatened preterm labor is determined by their marital status, socio-economic standing, gestational age, and the absence of comorbidities.

Prophylaxis of obstetric and perinatal pathology at women with pathological increase of body weight during pregnancy

2018 ◽  
pp. 7-79
Author(s):  
S.Yu. Vdovichenko ◽  
◽  
T.D. Fakhrutdinova ◽  
Keyword(s):  
Health Care ◽  
Body Weight ◽  
Pregnant Women ◽  
Key Words ◽  
Perinatal Outcomes ◽  
Perinatal Complications ◽  
Perinatal Pathology ◽  
Fetoplacental Complex ◽  
The Right ◽  
Selection Of

The objective: depression of obstetric and perinatal complications at pregnant women with pathological increase of body weight during pregnancy on the basis of studying of clinical-functional, endocrinologic, metabolic, morphological features of condition of fetoplacental complex and development of advanced algorithm of treatment-and-prophylactic actions. Materials and methods. We conducted examination of 264 patients who consisted on the account concerning pregnancy in female consultations of Kiev. By a method of selection of 178 women were included in retrospective research and 86 – in prospective. The main group was made by 39 pregnant women with whom led individual discussions, control – 142 women, that received traditional references in female consultation. Results. Use of the algorithm improved by us allows to improve obstetric (decrease of frequency of a preeclampsia by 12.3%; anomalies of a patrimonial deyalnost for 8.4%) and perinatal outcomes (depression of level of an asphyxia at a delivery for 9.4% and post-natal adaptation for 7.8%) deliveries of women with an excessive increase of body weight during pregnancy. Conclusion. The received results grant the right to recommend the algorithm improved by us for wide use in practical health care. Key words: obstetric and perinatal pathology, pathological increase of body weight, prophylaxis.

scholarly journals THE EFFECT OF RECTAL PROGESTERONE ON DOPPLER PARAMETERS OF THE UTERINE ARTERIES FOR THE PREVENTION OF PRETERM DELIVERY IN IRAQI POPULATION

2018 ◽  
Vol 11 (10) ◽  
pp. 545
Author(s):  
Fatin Shallal Farhan ◽  
Ban Hadi Hameed ◽  
Muna Abdulghani Zghair
Keyword(s):  
Pregnant Women ◽  
Preterm Labor ◽  
Resistance Index ◽  
Control Group ◽  
Study Group ◽  
Duration Of Treatment ◽  
Uterine Arteries ◽  
Doppler Study ◽  
Threatened Preterm Labor ◽  
Doppler Indices

Objective: The effectiveness of progesterone in the prevention of threatened preterm labor has been established for many years, but the preferable route, dose, and duration of treatment are until now under the evaluation of researches. The aim of this study was to determine the effect of rectal progesterone on Doppler indices of the uterine arteries in pregnant women with threatened preterm delivery.Methods: A prospective case–control study was conducted at the obstetric ward and the Outpatients Department of Al-Yarmouk Teaching Hospital in Baghdad for the period of 1 year from April 1, 2017, to April 1, 2018. 100 women were enrolled in the study, 50 of them were pregnant women with a diagnosis of preterm labor assigned as a study group and the other 50 were apparently healthy pregnant women of the same gestational age assigned as a control group. Doppler study of uterine arteries was done to all participants, and the results were compared for both groups. The patients with preterm labor received nifedipine tocolysis initially until contractions subsided and Doppler study had been repeated for those women after 1 week of rectal progesterone therapy.Results: The study group had a significantly higher resistance index (RI) than the control group (0.58 vs. 0.52) as p<0.05, in spite of the pulsatility index (PI) being higher for the study group compared to the control group (0.78 vs. 0.77) but this difference was not statistically significant. The RI before the therapy (0.58) was significantly higher than the index after therapy (0.52), and the PI was again significantly higher before therapy (0.78) than after therapy (0.71) as p<0.05. During the follow-up period, 3 (6.5%), 4 (8.7), and 39 (84.8%) patients delivered within 1 week, after 1 week, and at term, respectively.Conclusion: Rectal progesterone can arrest threatened preterm labor, and this effect is possible in part explained by its action on uterine arteries.

scholarly journals Comparison of Nifedipine and Isoxsuprine to Cervical Length in Threatened Preterm Labor

2021 ◽  
Vol 4 (1) ◽  
pp. 56-63
Author(s):  
Triyoga Pramadana ◽  
◽  
Anita Rachmawati ◽  
Dini Pusianawati
Keyword(s):  
Pregnant Women ◽  
General Hospital ◽  
Preterm Labor ◽  
Cervical Length ◽  
P Value ◽  
Inclusion Criteria ◽  
Key Word ◽  
Before And After ◽  
Threatened Preterm Labor ◽  
Length Changes

Objective: This study aimed to determine differences in cervical length changes between administration of nifedipine and isoxsuprine. Method: Subjects of the study were pregnant women who meet the inclusion criteria (n=16). Treatments were given for 48 hours. Parameters measured was the cervical length before and after the administration of nifedipine and isoxsuprine. This study was conducted in Dr. Hasan Sadikin General Hospital from January until April 2020. Result: Less shortening of the cervical length after administration of tocolytic isoxsuprin for 48 hours compared with tocolytic nifedipine and statistically significant with p value of 0.0001 (p<0.05) using Paired T tests. Conclusion: Isoxsuprin is more effective to prevent shortening of the cervical length compared to nifedipine in cases of threatened preterm labor. Key word: Nifedipine, Isoxsuprine, cervical length, threatened preterm labor

Effectiveness and Safety of Isoxsuprine Hydrochloride as Tocolytic Agent in Arresting Active/Threatened Preterm Labor and Its Role in Maintenance Tocolysis—A Prospective, Open-Label Study

2019 ◽  
Author(s):  
Purushottam B. Jaju
Keyword(s):  
Preterm Labor ◽  
Latency Period ◽  
Perinatal Outcomes ◽  
Open Label ◽  
Gestation Age ◽  
Fetal Infection ◽  
Tocolytic Agent ◽  
Fetal Birth Weight ◽  
Short And Long Term ◽  
Threatened Preterm Labor

Abstract Objective The aim of the study is to obtain insights on the short and long-term safety and effectiveness of isoxsuprine hydrochloride as a tocolytic agent in the management of PTL. Study Design In this prospective, single-center, noncomparative study, patients (with preterm labor at gestational age of 24–37 weeks) were administered intravenous (IV) infusion of 40-mg isoxsuprine hydrochloride until uterine quiescence, followed by intramuscular (IM) injection of isoxsuprine hydrochloride 10 mg/4-hourly for first 24 hours and maintained with retard 40-mg sustained release capsule (two times a day) till the time of delivery or 37 completed weeks of pregnancy. Results All patients (n = 50) achieved successful tocolysis in 24 hours and 48 hours postadministration of isoxsuprine hydrochloride (IV/IM/oral). Mean (±SD) gestation age at the time of delivery was 39.8 ± 2.1 weeks, with latency period of 58.5 ± 18.7 days. Pregnancy outcomes were normal in all the patients and no congenital anomaly/fetal infection was reported. Mean (±SD) fetal birth weight was 2.7 ± 0.3 kg; mean (±SD) Apgar score at 1 and 5 minutes were 7.5 ± 0.6 and 9.2 ± 0.4, respectively. Maternal tachycardia and vomiting (8.0% each) were the commonly reported adverse drug reactions, which were resolved with dose adjustment. Conclusion Isoxsuprine was found to be an effective and well-tolerated tocolytic agent in arresting PTL, in turn resulting in the overall improvement in maternal and perinatal outcomes.

scholarly journals Hubungan Anemia pada Ibu Hamil dengan Kejadian Persalinan Prematur di RSUD Dr. Moewardi Surakarta

2020 ◽  
Vol 3 (2) ◽  
pp. 68
Author(s):  
Saskia Nandatari ◽  
Yudhistya N Insan ◽  
Widardo Widardo
Keyword(s):  
Pregnant Women ◽  
Preterm Labor ◽  
Stress Hormones ◽  
Case Control ◽  
Observational Research ◽  
Premature Labor ◽  
Research Subjects ◽  
Purposive Sampling ◽  
Control Approach ◽  
Significant Difference

<p><strong>Pendahuluan</strong>: Persalinan prematur adalah persalinan yang terjadi pada usia kehamilan sebelum 37 minggu. Persalinan prematur disebabkan oleh berbagai faktor, salah satunya yaitu anemia. Anemia dalam kehamilan merupakan masalah yang cukup sering terjadi terutama di negara berkembang. Anemia dalam kehamilan merupakan keadaan dimana nilai Hemoglobin ibu hamil dibawah 11 g/dl. Keadaan ini mengakibatkan penurunan jumlah oksigen yang dibawa ke janin sehingga mengakibatkan terjadinya hipoksia pada janin. Tujuan penelitian ini adalah untuk mengetahui hubungan antara anemia pada ibu hamil dengan kejadian persalinan prematur di RSUD Dr. Moewardi Surakarta.</p><p><strong>Metode Penelitian</strong>: Penelitian observasional analitik dengan pendekatan <em>case control,</em> dilakukan pada bulan Agustus-September 2019 di RSUD Dr. Moewardi. Subjek penelitian adalah pasien yang mengalami persalinan prematur dan persalinan tidak prematur dalam kurun waktu Juni 2017 sampai dengan Juni 2019 di RSUD Dr. Moewardi. Penelitian dilakukan dengan mengolah data rekam medis. Pada penelitian dipilih sebanyak 70 sampel penelitian, yang terdiri masing-masing 35 sampel untuk kelompok kasus dan kontrol. Sampel diambil menggunakan <em>purposive sampling. </em>Data kemudian dianalisis menggunakan uji Korelasi Koefisien Kontingensi<em> </em>Uji Kappa dan uji T-<em>test</em> Tidak Berpasangan.</p><p><strong>Hasil</strong>: Didapatkan korelasi antara anemia dengan kejadian persalinan prematur bermakna secara statistik. Nilai korelasi sebesar 0,031 menunjukkan korelasi positif dengan kekuatan korelasi yang signifikan dan bermakna secara klinis. Selain itu, didapatkan perbedaan yang bermakna dan signifikan antara rata-rata nilai Hemoglobin ibu hamil dengan persalinan prematur dan tidak prematur, dengan nilai p sebesar 0,003.</p><p><strong>S</strong><strong>impulan</strong>: Terdapat hubungan yang signifikan dan bermakna secara klinis antara anemia pada ibu hamil dengan kejadian persalinan prematur di RSUD Dr. Moewardi Surakarta pada Juni 2017 – Juni 2019.</p><p> </p><p>Background: Premature labor is labor that occurs at gestational age before 37 weeks. Premature labor is caused by various factors, one of which is anemia. Anemia in pregnancy, hemoglobin condition of pregnant women under 11 g / dl which is quite common, especially in developing countries. This situation results in a decrease in the amount of oxygen carried to the fetus, resulting in hypoxia in the fetus and stimulates stress hormones associated with labor induction. The purpose of this study was to determine the relationship between anemia in pregnant women with the incidence of preterm labor in Dr. Moewardi Surakarta.</p><p>Methods: This study was analytic observational research with case-control approach, conducted in August-September 2019 at Dr. Moewardi. Research subjects were patients who experienced preterm labor and non-preterm labor in the period June 2017 to June 2019 at the RSUD Dr. Moewardi. The study was conducted by processing medical record data. In this study 70 research samples were chosen, consisting of 35 samples for the case and control groups. Samples were taken using purposive sampling. Data were then analyzed using the Kappa Test Contingency Coefficient Correlation test and the unpaired T-test.</p><p>Result: The correlation between anemia and preterm labor was statistically significant. Correlation value (p=0.031) shows a positive correlation with the strength of the correlation that is significant and clinically meaningful. In addition, a significant and significant difference was found between the average hemoglobin value of pregnant women with preterm and non-preterm labor, with a value (p = 0.003).</p><p>Conclusion: There is a significant and significant relationship between anemia in pregnant women and the incidence of preterm labor in Dr. Moewardi Surakarta in June 2017 - June 2019, where anemia in pregnant women increases the risk of preterm labor.</p>

scholarly journals Threatened Preterm Labor: Which are become Preterm Labor?

2020 ◽  
pp. 216-222
Author(s):  
Cut M. Yeni ◽  
Rismawati Tambunan ◽  
Hasanuddin
Keyword(s):  
Pregnant Women ◽  
Preterm Labor ◽  
Case Control ◽  
Cervical Length ◽  
Wilcoxon Test ◽  
Fetal Fibronectin ◽  
Whitney Test ◽  
Vaginal Ph ◽  
Chi Squared ◽  
Threatened Preterm Labor

Objective: The research was aimed to show about characteristics of subject, fetal fibronectin, vaginal pH, cervical length of women with threatened preterm labor, and which are become preterm labor? Preterm labor is occurs most often in 20 weeks gestation to less than 37 weeks gestation. This condition is concerned about Obstetric problem and associated with significant neonatal morbidity and mortality.Methods: This study used the design of case control where preterm pregnant women who become research subjects divided into two groups with threat and without the threat of pre-term labor. Fetal fibronectin , vaginal pHand cervical length than in both groups were evaluated as a risk factor for preterm labor. Mann-Whitney test , Wilcoxon test and Chi-squared test were used as statistical tests with a confidence level of 95%.Results: A total of 86 preterm pregnant women involved in this study with an average age 30 , 5 ± 6.25 (group threat) 32.16 ± 5.25 (non-threatening). Comparison of fetal fibronectin (p = 0.005), vaginal PH(p <0.001) and length of the cervix (p <0.001) between the two groups showed a significant difference. A total of 8 subjects of the 43 in the group of pregnant women with the threat pretem labor experiencing preterm labor .Conclusion: The size of a short cervical length, an increase in the pH of the vaginal secretions and increased levels of fetal fibronectin  is a clinical indicator for screening during pregnancy to assess the risk of a preterm labor .Keywords: cervical length, fetal fibronectin, pretermlabor , vaginal pH of the secretions. Abstrak Tujuan: Persalinan preterm adalah persalinan yang terjadi padausia kehamilan 20 hingga kurang dari37 minggu. Kondisi inimerupakanpermasalahan yang sangat mengkhawatirkan dalam bidang kebidanan dan dikaitkan dengan morbiditas dan kematian neonatal yang signifikan. Evaluasi dan skrining terhadap berbagai faktor resiko terjadinya ancaman persalinan preterm adalah hal terpenting dalam mencegah berbagai komplikasi yang mungkin timbul.Metode: Penelitian ini menggunakan desain case control dimana wanita hamil preterm yang menjadi subjek penelitian terbagi menjadi dua yakni kelompok dengan ancaman dan tanpa ancaman persalinan preterm. Fetal fibronectin, pH sekret vagina dan panjang serviks dibandingkan diatara kedua kelompok sebagai faktor resiko ancaman persalinan preterm. Mann-Whitney test, Wilcoxon test dan Chi – squared digunakan sebagai uji statistik dengan tingkat kepercayaan 95%.Hasil: Sebanyak 86 wanita hamil preterm terlibat dalam penelitian ini dengan rerata usia 30,5 ± 6,25 (kelompok ancaman) 32,16 ± 5,25 (tanpa ancaman). Perbandingan Fetal fibronectin (p=0,005), pH sekret vagina (p<0,001) dan panjang serviks (p<0,001) antar kedua kelompok menunjukkan adanya perbedaan yang bermakna. Sebanyak 8 subjek dari 43 pada kelompok wanita hamil pretem dengan ancaman persalinan preterm yang mengalami persalinan pretermKesimpulan:Ukuran panjang serviks yang pendek, peningkatan pH sekret vagina dan peningkatan kadar fetal fibronectin merupakan indikator klinis untuk skrining selama kehamilan guna menilai resiko terjadinya persalinan pretermKata kunci: fetal fibronectin, persalinan preterm, Ph vagina, panjang cerviks  

Systemic erythematosus lupus and pregnancy outcomes in a Colombian cohort

Lupus ◽  
2021 ◽  
pp. 096120332110614
Author(s):  
Valeria Erazo-Martínez ◽  
Ivana Nieto-Aristizábal ◽  
Isabella Ojeda ◽  
Michelle González ◽  
Cristian C Aragon ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Pregnant Women ◽  
Lupus Erythematosus ◽  
Preterm Labor ◽  
Activity Index ◽  
Perinatal Outcomes ◽  
Disease Activity Index ◽  
Obstetric Outcomes ◽  
Maternal Complications ◽  
Fetal Survival

Objective Pregnant women with SLE have higher probabilities of maternal complications. SLE during pregnancy has alternating patterns of remission and flare-ups; however, most pregnant SLE patients tend to worsen with associated poor obstetric and perinatal outcomes. This study aimed to describe obstetric outcomes in pregnant women with SLE. Methods This retrospective study was performed between 2011 and 2020 at a highly complex referral health center in Cali, Colombia. Pregnant women with a diagnosis of SLE were included. Demographic, clinical, and laboratory features and obstetric and fetal outcomes, including intensive care unit (ICU) characteristics, were evaluated. Results Forty-eight pregnant women with SLE were included. The median age was 29 (25–33.7) years. The SLE diagnosis was made before pregnancy in 38 (79.1%) patients, with a median disease duration of 46 (12–84) months. Thirteen (27.1%) patients had lupus nephritis. Preterm labor (34, 70.8%), preeclampsia (25, 52%), and preterm rupture of membranes (10, 20.8%) were the most common obstetric complications. A relationship between a greater systemic lupus erythematosus pregnancy disease activity index (SLEPDAI) and the development of hypertensive disorders during pregnancy was established (preeclampsia = p < 0.0366; eclampsia = p < 0.0153). A relationship was identified between lupus nephritis (LN) and eclampsia ( p < 0.01), preterm labor ( p < 0.045), and placental abruption ( p < 0.01). Seventeen (35.4%) patients required ICU admission; 52.9% of them were due to AID activity, 17.6% for cardiovascular damage, 11.7% for septic shock, and 5.8% for acute kidney failure. Fetal survival was 89.5% ( N = 43/48). Among the live births, two (4.2%) newborns were diagnosed with neonatal lupus, and two (4.2%) were diagnosed with congenital heart block. One maternal death was registered due to preeclampsia and intraventricular hemorrhage. Conclusions This study is the first to describe SLE during pregnancy in Colombia. SLE was the most prevalent AID in this cohort, and complications included preterm labor, preeclampsia, and postpartum hemorrhage. A higher SLEPDAI and lupus nephritis predicted adverse maternal outcomes.

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